Escaping BRAF inhibition: a “linc” with non-coding RNAs?

One of the major challenges in the field remains the defeat of resistance towards BRAF inhibition, mainly caused by the high heterogeneity and plasticity of melanoma cells. Understanding mechanisms of drug resistance and finding new strategies to block the relapse are therefore major concerns in the melanoma field. So far however, most of the focus remained on the identification of genetic events affecting proteins-coding genes.

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