Publication date: Available online 28 October 2017
Source:Journal of Biomechanics
Author(s): Kathak Vachhani, Andrea Pagotto, Yufa Wang, Cari Whyne, Diane Nam
Fracture healing is a lengthy process which fails in 5-10% of cases. Lithium, a low-cost therapeutic used in psychiatric medicine, up-regulates the canonical Wingless pathway crucial for osteoblastic mineralization in fracture healing. A design-of-experiments (DOE) methodology was used to optimize lithium administration parameters (dose, onset timing and treatment duration) to enhance healing in a rat femoral fracture model. In the previously completed first stage (screening), onset time was found to significantly impact healing, with later (day 7 vs. day 3 post-fracture) treatment yielding improved maximum yield torque. The greatest strength was found in healing femurs treated at day 7 post fracture, with a low lithium dose (20mg/kg) for 2 weeks duration. This paper describes the findings of the second (optimization) and third (verification) stages of the DOE investigation. Closed traumatic diaphyseal femur fractures were induced in 3-month old rats. Healing was evaluated on day 28 post fracture by CT-based morphometry and torsional loading. In optimization, later onset times of day 10 and 14 did not perform as well as day 7 onset. As such, efficacy of the best regimen (20mg/kg dose given at day 7 onset for 2 weeks duration) was reassessed in a distinct cohort of animals to complete the DOE verification. A significant 44% higher maximum yield torque (primary outcome) was seen with optimized lithium treatment vs. controls, which paralleled the 46% improvement seen in the screening stage. Successful completion of this robustly designed preclinical DOE study delineates the optimal lithium regimen for enhancing preclinical long-bone fracture healing.
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ydOlaG
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
-
▼
Οκτωβρίου
(11955)
-
▼
Οκτ 28
(204)
- An Evaluation of Different Bridging Techniques for...
- Use of Fat Grafts in Facial Reconstruction on the ...
- Response to the letter to the editor: “Understandi...
- Microsurgery Fellowship at St Vincent's Hospital, ...
- Significance of the Lateral Thoracic Artery in Pec...
- Gluteal Augmentation With Intramuscular Implants i...
- Reverse Distal Transverse Palmar Arch in Distal Di...
- Does the Sequence of Tattooing and Nipple Reconstr...
- Pediatric Lower Extremity Lawn Mower Injuries and ...
- The Classic Pitanguy Technique and Its Modificatio...
- Identification of Risk Factors in Lymphatic Surger...
- Sweet Syndrome After Bilateral Deep Inferior Epiga...
- The Boreds
- Analysis of Mechanical Behavior of Dermal Fibrobla...
- Free Lateral Digital Flap for Reconstruction of th...
- Acute-Onset Quadriplegia With Recovery After High-...
- The Use of Bilayered Fascia Lata With an Interposi...
- Lesions Associated With Calcium Gluconate Extravas...
- Impact of Abdominal Lipectomy on Post-Sleeve Gastr...
- Chemotherapy Extravasation Management: 21-Year Exp...
- Editorial Board/Reviewing Committee
- Identification and management of inverted or evert...
- Comparison between chloral hydrate and propofol-ke...
- Meningitis, bacterial
- Trees and shrubs used in medieval Poland for makin...
- One hundred years of Quaternary pollen analysis 19...
- Dentist pulled out boy's four teeth 'unnecessarily'
- Editorial Board
- Dental clinics too expensive for many in Qatar
- Unsuccessful Desensitization in a Child with Hyper...
- Association Study of HLA-DQB1*0602 Allele in Irani...
- Anti-inflammatory Property of β-D-Mannuronic Acid ...
- Interleukin-37 Relieves Allergic Inflammation in a...
- Macrophages from Behcet's Disease Patients Express...
- Frequency of Circulatory Regulatory Immune Cells i...
- Hematological Improvement of Patients with Active ...
- Increased Genes Expression Levels of Cytokines Rel...
- The Changes of Th17/Treg and Related Cytokines: IL...
- Investigating the Association of ADAM33 Single Nuc...
- Effect of Nebulized 3% Hypertonic Aline with Salbu...
- Chemical affinity of 10-methacryloyloxydecyl dihyd...
- Editorial Board
- Zirconia-incorporated zinc oxide eugenol has impro...
- 3D printed versus conventionally cured provisional...
- Incorporation of antibacterial agent derived deep ...
- Corrosion behavior of titanium in response to sulf...
- Cuspal flexure of composite-restored typodont teet...
- Collagenous matrix supported by a 3D-printed scaff...
- Zirconia surface modification by a novel zirconia ...
- Cytotoxicity and DNA double-strand breaks in human...
- Bioactivity and fluoride release of strontium and ...
- Resveratrol Prevents ROS-Induced Apoptosis in High...
- Quality of Care during Neonatal Resuscitation in K...
- The Hierarchical Iterative Identification Algorith...
- Improvement of the Quality of Surimi Products with...
- Microwave-Assisted Synthesis of Tetrahydrocarbazol...
- Solving Nonlinear Fourth-Order Boundary Value Prob...
- Linked Registries: Connecting Rare Diseases Patien...
- Human Gut Microbiota Associated with Obesity in Ch...
- Endometritis and In Vitro PGE2 Challenge Modify Pr...
- Remaining Useful Life Prediction of Bearing with V...
- Evaluating Swine Injection Technologies as a Workp...
- Debunking the 3 most common oral health myths
- Cutaneous T-cell lymphomas: focusing on novel agen...
- Disability in activities of daily living among adu...
- The clinical development of vaccines for HER2+ bre...
- Quantitative analysis of facial soft tissue perfus...
- Treatment of lower lip pits in Van der Woude syndr...
- Device-associated nosocomial infection in general ...
- Design of experiments confirms optimization of lit...
- Cerebellar ataxia with neuropathy and vestibular a...
- A rare case of bilateral vagus nerve schwanomatosis
- Disability in activities of daily living among adu...
- The clinical development of vaccines for HER2+ bre...
- Cerebellar ataxia with neuropathy and vestibular a...
- Cutaneous T-cell lymphomas: focusing on novel agen...
- A rare case of bilateral vagus nerve schwanomatosis
- This is your body on candy
- Ten recommendations for assessing the comparative ...
- Prostitutes in English city sell their bodies for A 4
- Dengue hemorrhagic fever complicated with transien...
- Disability in activities of daily living among adu...
- The clinical development of vaccines for HER2+ bre...
- Association Between Medicare’s Mandatory Hospital ...
- Experience of using MOSFET detectors for dose veri...
- Early outcomes and impact of a hybrid IC/IS applic...
- VEGF/BMP-2 Loaded Three-Dimensional Model for Enha...
- Clinical significance of tryptophan catabolism in ...
- Assessment of changes in quality of life in patien...
- Plumbagin mediating GLUT1 suppresses the growth of...
- Do Statins Increase the Risk of Esophageal Conditi...
- Burden of Disease of Human Papillomavirus (HPV): H...
- Tumour Lateralization in Cushing's disease by Infe...
- Combination chemotherapy with irinotecan and gemci...
- Ibrutinib does not prolong the corrected QT interv...
- Combination chemotherapy with irinotecan and gemci...
- Ibrutinib does not prolong the corrected QT interv...
- Dentist reveals which Halloween candy you should n...
- The Current State of Epicutaneous Immunotherapy fo...
- Towards global consensus on core outcomes for Hidr...
-
▼
Οκτ 28
(204)
- ► Σεπτεμβρίου (12424)
Ετικέτες
Πληροφορίες
Σάββατο 28 Οκτωβρίου 2017
Design of experiments confirms optimization of lithium administration parameters for enhanced fracture healing
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
- Scholar : Ειδοποίηση Μελετητή - [ Εξωτε - 8/31/2017 - Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182
- Scholar : Ειδοποίηση Μελετητή - [ ΦΩΝΗΤ - 8/31/2017 - Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182
- Scholar : Ειδοποίηση Μελετητή - [ ΑΚΟΥΣ - 8/31/2017 - Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182
- Scholar : Ειδοποίηση Μελετητή - [ ωτα ] - 8/31/2017 - Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182
- Scholar : Ειδοποίηση Μελετητή - [ ΑΚΟΗ ] - 8/31/2017 - Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,