Circadian rest-activity rhythm in chronic obstructive pulmonary disease.

Circadian rest-activity rhythm in chronic obstructive pulmonary disease.

Chronobiol Int. 2017 Oct 20;:1-5

Authors: Nunes DM, Gonçalves BSB, Tardelli Peixoto CA, De Bruin VMS, Louzada FM, De Bruin PFC

Abstract
To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean [RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0.242 ± 0.097 vs 0.182 ± 0.063) and L5 (36.849 ± 18.239 vs 19.888 ± 12.268) and lower RAm (0.696 ± 0.134 vs 0.833 ± 0.093) than controls. Future studies on the effects of chronotherapy measures in COPD are warranted.

PMID: 29053034 [PubMed - as supplied by publisher]

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