Application of 'Omics' and Systems Biology to Sarcoidosis Research.

Application of 'Omics' and Systems Biology to Sarcoidosis Research.

Ann Am Thorac Soc. 2017 Oct 20;:

Authors: Crouser ED, Fingerlin TE, Yang IV, Maier LA, Nana-Sinkam P, Collman RG, Kaminski N

Abstract
Sarcoidosis is a complex, polygenic disease of unknown cause with diverse clinical phenotypes, ranging from self-limited, asymptomatic disease to life altering symptoms and early disease-related mortality. It is unlikely that a single common environmental exposure (e.g., infection, antigen) entirely explains the disease, and numerous genetic mutations are associated with the disease. As such, it reasonable to assume, as with other phenotypically diverse diseases, that distinct genetic mechanisms and related biological biomarkers will serve to further define sarcoidosis sub-phenotypes and mechanisms and to guide personalized care. The fields of 'omics' and systems biology research are widely applied to understand polygenic and phenotypically diverse diseases, such as sarcoidosis. 'Omics' refers to technologies that allow comprehensive profiling of sets of molecules in an organism. Systems biology applies advanced computational approaches to make sense of the enormous data sets that are typically generated from 'omics platforms. The primary objectives of this manuscript are to review the available 'omics tools, assess the current status of 'omics and systems biology research in the field of sarcoidosis, and to consider how this technology could be applied to advance the mechanistic underpinning and treatment of sarcoidosis. An emphasis is be placed on leveraging these research tools to develop better treatments and biomarkers for extreme life-altering sarcoidosis phenotypes, which are overrepresented in underserved populations.

PMID: 29053026 [PubMed - as supplied by publisher]

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