The Notch-3 receptor: a molecular switch to tumorigenesis?

The Notch pathway is an evolutionarily conserved signalling system that regulates cell proliferation, differentiation, cell fate determination and stem/progenitor cell self-renewal in both embryonic and adult organs [1,2];but is also essential to the regulation of blood vessel structure [3,4]. The Notch pathway is activated by the interaction between its ligands (Jagged 1 & 2, and Delta-like homologues 1-4) and receptors (Notch-1 to 4) which induces cleavage of the Notch receptors and culminates in the release of the Notch Intracellular domain (NICD).

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