Peripheral T-cell lymphomas:focusing on novel agents in relapsed and refractory disease

Peripheral T-cell non-Hodgkin lymphomas (PTCL) are a heterogeneous group of mature T-cell neoplasms, mostly of nodal origin, generally associated with a poor prognosis and displaying a wide geographical heterogeneity, accounting for 5% to 10% of all aggressive lymphomas in Europe and in the United States, whereas being most widely represented (up to roughly 20%) in Asia, where some peculiar forms of disease (adult T-cell leukemia/lymphoma, ATLL; or neoplasms of the NK/T-cell origin) are prevalent [1–3].

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