Androgen receptor (AR) signaling is a key driver of prostate cancer (PCa), and androgen-deprivation therapy (ADT) is a standard treatment for patients with advanced and metastatic disease. However, patients receiving ADT eventually develop incurable castration-resistant PCa (CRPC). Here we report that the chromatin modifier LSD1, an important regulator of AR transcriptional activity, undergoes epigenetic reprogramming in CRPC. LSD1 reprogramming in this setting activated a subset of cell cycle genes including CENPE, a centromere binding protein and mitotic kinesin. CENPE was regulated by the co-binding of LSD1 and AR to its promoter, which was associated with loss of RB1 in CRPC. Notably, genetic deletion or pharmacological inhibition of CENPE significantly decrease tumor growth. Our findings show how LSD1-mediated epigenetic reprogramming drives CRPC, and they offer a mechanistic rationale for its therapeutic targeting in this disease.
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2xpNkuQ
via IFTTT
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Αρχειοθήκη ιστολογίου
-
►
2023
(272)
- ► Φεβρουαρίου (141)
- ► Ιανουαρίου (131)
-
►
2022
(2066)
- ► Δεκεμβρίου (80)
- ► Σεπτεμβρίου (170)
- ► Φεβρουαρίου (190)
- ► Ιανουαρίου (203)
-
►
2021
(7399)
- ► Δεκεμβρίου (186)
- ► Σεπτεμβρίου (472)
- ► Φεβρουαρίου (851)
-
►
2020
(2517)
- ► Δεκεμβρίου (792)
- ► Σεπτεμβρίου (21)
- ► Φεβρουαρίου (28)
-
►
2019
(12076)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (4765)
- ► Ιανουαρίου (5155)
-
►
2018
(3144)
- ► Δεκεμβρίου (3144)
-
▼
2017
(66935)
- ► Δεκεμβρίου (1995)
-
▼
Σεπτεμβρίου
(12424)
-
▼
Σεπ 15
(543)
- IJMS, Vol. 18, Pages 1991: Identification of Circu...
- Bioprospecting of Novel and Bioactive Compounds fr...
- Prostate cancer screening by prostate-specific ant...
- Evaluating the impact of a walking program in a di...
- Effectiveness of a 16-month multi-component and en...
- Chemotherapy for advanced HER2-negative breast can...
- Policies and strategies to facilitate secondary us...
- Ethics in Social Networking and Business 2: The Fu...
- Academic Entrepreneurship: How to Bring Your Scien...
- The muscle regulatory transcription factor MyoD pa...
- Decline patterns and risk assessment of 10 multi-c...
- Association of the Alternative Healthy Eating Inde...
- 'Just like a normal pain, what do people with diab...
- Burden of non-adherence to latent tuberculosis inf...
- A protocol of a cross-sectional study evaluating a...
- Combining CD4 recovery and CD4: CD8 ratio restorat...
- Qualitative interview study of parents perspective...
- Nasotracheal intubation over a bougie vs. non-boug...
- Successful twice interrupted therapy of HCV infect...
- Combined caesarean with splenectomy in pregnancy w...
- Renal cell carcinoma with isolated metastasis to s...
- Chondromalacia patellae
- Architectural delineation and molecular identifica...
- Dlx3b/4b is required for early-born but not later-...
- Regulatory RNPs: a novel class of ribonucleoprotei...
- EsGLUT4 and CHHBP are involved in the regulation o...
- Phosphorylation of SNAP-23 regulates its dynamic m...
- The probability of wing damage in the dragonfly Sy...
- Distinct intestinal adaptation for vitamin B12 and...
- Fat-containing cells are eliminated during Dictyos...
- Standard metabolic rate predicts growth trajectory...
- The expression of Ldh-c in the skeletal muscle of ...
- PQN-75 is expressed in the pharyngeal gland cells ...
- Differential expression of sirtuin 2 and adipocyte...
- WASP-Arp2/3-dependent actin polymerization influen...
- An ex vivo model using human peritoneum to explore...
- The effects of the exopolysaccharide and growth ra...
- CORRECTION: Surviving murine experimental sepsis a...
- Local Dentist to Offer Free Dental Services
- IJMS, Vol. 18, Pages 1980: The Beneficial Effects ...
- IJMS, Vol. 18, Pages 1984: iTRAQ-Based Quantitativ...
- Why Vending Machines are Not Bodegas
- Assignment of the absolute configuration of hepato...
- Why Vending Machines are Not Bodegas
- Project LifeSkills - a randomized controlled effic...
- A prospective cohort study on ambient air pollutio...
- The associations between workplace bullying, saliv...
- Body mass index and type 2 diabetes in Thai adults...
- Model of ontogenetic variability of the functional...
- Melatonin as a marker of severity of cardiac disor...
- Study into ratios of mineral metabolism in patient...
- Role of ceramide in the aging-related decrease of ...
- Content of proinflammatory cytokines, peroxiredoxi...
- Analysis of catamnesis of combatants–pensioners of...
- Emotional burnout syndrome in elderly women–physic...
- Indicators of comorbidity in chronic broncho-obstr...
- Archaic stereotypes and modern approaches in under...
- Aging of dogs and Drosophila as described based on...
- Endocrinology of cancer and age: Early and late de...
- Adaptation to intermittent hypoxia-hyperoxia impro...
- Apolipoprotein L1 confers pH-switchable ion permea...
- 18F-Fluorodeoxyglucose Positron Emission Tomograph...
- Long-Term Antithyroid Drug Treatment: A Systematic...
- Comparison of Core-Needle Biopsy and Fine-Needle A...
- Impact of feeding chromium supplemented flaxseed b...
- Radioactive seed migration following parotid gland...
- Risk Prediction of Cervical Cancer and Precancers ...
- These Unprecedented Times
- Functionalized poly(3-hydroxybutyric acid) bodies ...
- Dangling regimes after free flap reconstruction of...
- Peripheral T-cell lymphomas:focusing on novel agen...
- Chemotherapy for advanced HER2-negative breast can...
- Levosimendan combined with epinephrine improves re...
- An undergraduate Otolaryngology curriculum compari...
- Bile acids: a potential role in the pathogenesis o...
- Assessment of carotid artery intima‐media thicknes...
- Single‐sided deafness affects language and auditor...
- Local extension staging of sinonasal tumours: retr...
- Adaptation and validation of the Singing Voice Han...
- An evaluation of the quality of evidence available...
- Effect on mortality of elective parathyroid surger...
- The value of direct audiology access for magnetic ...
- Dura and sinus compression with a transcutaneous b...
- Congenital anosmia: our experience of eleven patie...
- UK tertiary centre experience of outcomes from oss...
- Short‐term results from seventy‐six patients recei...
- Squamous cell carcinoma associated with inverted p...
- Functional magnetic resonance imaging in seven bor...
- Balloon tuboplasty in patients with Eustachian tub...
- A retrospective analysis of seven patients with ac...
- Workload and costs of audiological assessment on t...
- The role of sentinel lymph node biopsy in the mana...
- Insulin effect on hearing recovery in idiopathic s...
- Chemotherapy for advanced HER2-negative breast can...
- Peripheral T-cell lymphomas:focusing on novel agen...
- Pharmacological blockade of cholesterol traffickin...
- Smac mimetics and type II interferon synergistical...
- MITF suppression improves the sensitivity of melan...
- The two novel DLL4-targeting antibody-drug conjuga...
- Up-regulation of Rho-associated kinase 1/2 by gluc...
-
▼
Σεπ 15
(543)
Ετικέτες
Πληροφορίες
Παρασκευή 15 Σεπτεμβρίου 2017
LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αναζήτηση αυτού του ιστολογίου
! # Ola via Alexandros G.Sfakianakis on Inoreader
-
Publication date: 1 May 2019 Source: Talanta, Volume 196 Author(s): Ruiqing Long, Te Li, Chaoying Tong, Lihui Wu, Shuyun Shi Abstract...
-
Oral Cancer Rapid Test Kit Market Rugged Expansion Foreseen by 2024 MilTech Oral cancer is one of the largest group of cancers ...
-
Related Articles SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,