Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes

Aims. We investigated the association between ubiquitin-conjugating enzyme E2Z (UBE2Z) gene SNP rs46522 and the risk of CAD in a Chinese Han population with type 2 diabetes and explored a possible interactive effect with environmental risk factors of CAD. Methods. 665 patients with T2D were enrolled; 390 were CAD patients and 275 were non-CAD patients. Genotype analysis of rs46522 (T>C) was performed using PCR-RFLP. Results. The SNP rs47522 was associated with the risk of CAD supposing recessive inheritance model (TT versus CC+CT, , 95%CI 1.039–1.570, ) and codominant model (TT versus CT, , 95%CI 1.088–2.570, ) after adjustment for confounders of CAD. A synergistic effect of rs46522 and BMI was discovered (, p for interreaction = 0.028). In subgroup analysis, minor allele T was significantly associated with CAD in overweight and obesity subgroup (), and the association was also proved in recessive model (, 95%CI 1.075–2.196, ). Smokers with genotype TT had threefold risk of CAD in comparison to nonsmokers with genotype TC or CC (). Conclusions. The SNP rs46522 in UBE2Z gene is associated with the risk of CAD in the individuals of Chinese Han descent with type 2 diabetes and is of synergistic effect with BMI.

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