Bioinformatic search for Ca 2+ - and calmodulin-dependent protein kinases potentially associated with the regulation of plant cytoskeleton

Abstract

The paper presents the results of a bioinformatic search for Ca²⁺- and calmodulin-dependent protein kinases from Arabidopsis thaliana, which may potentially participate in cytoskeleton regulation. Homologues were chosen based on their similarity with the calmodulin-dependent protein kinases from Homo sapiens and Mus musculus, which modulate the structure and dynamic behavior of the cytoskeleton. In total, the sequences for the catalytic domains of 41 animal protein kinases and their known 42 plant homologues have been aligned. The closest animal and plant homologues have been determined using the methods of phylogenetic clusterization. According to the bioinformatic research results, the following plant protein kinases were selected as the most probable regulators of the plant cytoskeleton: CPK7, CPK14, CPK32, CPK17, CPK34, CPK20, CPK27, CPK16, CPK18, CPK28, CPK7, CRK2, CRK4, and CRK6.

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