miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential

Publication date: 1 October 2017
Source:Cancer Letters, Volume 405
Author(s): Carla Solé, Erika Larrea, Giovanni Di Pinto, Maitena Tellaexte, Charles Henderson Lawrie
MicroRNAs (miRNAs) are small non-coding RNAs that regulate many human genes including those involved in normal B-cell development. When these miRNAs are aberrantly expressed in B-cells they play key pathogenetic roles in the development and maintenance of B-cell lymphomas and by association may serve as useful biomarkers. In this review, we provide an overview of the importance of miRNAs to B-cell lymphomagenesis, as well as considering their use as biomarkers, and their potential usefulness for the clinic.



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