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Epigenetic Changes by DNA methylation in Chronic and Intermittent Hypoxia.
Am J Physiol Lung Cell Mol Physiol. 2017 Aug 24;:ajplung.00325.2017
Authors: Nanduri J, Semenza GL, Prabhakar NR
Abstract
DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation. This article presents a brief update on emerging evidence suggesting that changes in DNA methylation contribute to pathologies caused by chronic IH and potentially mediate adaptations to chronic sustained hypoxia by affecting the hypoxia-inducible factor (HIF) signaling pathway.
PMID: 28839104 [PubMed - as supplied by publisher]
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