Prophylactic Cranial Irradiation for Resectable Small Cell Lung Cancer

Following definitive chemoradiation for small cell lung cancer (SCLC), prophylactic cranial irradiation (PCI) has been established as standard of care in those patients whose tumors respond to treatment. In the modern era, however, a subset of patients may receive upfront resection for SCLC, yet the role of PCI in these patients has not been elucidated. In this review, we examined the literature to better define the role of PCI in this subset of patients. For patients with T2 or higher disease, incomplete resection, or those not receiving adjuvant chemotherapy, PCI is expected to offer a clinical benefit.

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