Long-term effects of adenotonsillectomy on serum specific immunoglobulin E.

Long-term effects of adenotonsillectomy on serum specific immunoglobulin E.

Pediatr Res. 2017 Jul 12;:

Authors: Song L, Guo J, Liao W, Ye P, Liu L, Chen T, Yang P, Zhong N, Sun B, Zhang X

Abstract
BACKGROUND: The biased immune reactions of the adenotonsillar tissues are not always reflected by the serum IgE; thus, we hypothesize that the systemic atopic status may not be changed after the adenotonsillectomy (AT) in children.
METHODS: Twenty-five with AT and 23 age-matched healthy childrenwere enrolled into this study, followed-up approximately 4 years. Nasal Symptoms Scores (NSS), Quality of Life Scores (QOLS), specific IgE (sIgE), cytokines, and inflammatory cell were documented in all the subjects before and after study.
RESULTS: Fourteen patients and 3 healthycontrols had positive serum sIgE levels (>0.35 kU/l) at the study-start that was not changed by the study-end. Two patients and 2 healthy controls with serum sIgE-negativeshowed the Dermatophagoidespteronyssinus sensitization at the study-end. NSS and QOLS showed significant improvement after the surgery in the sIgE-positive patients (P<0.05), whereas no significant changes were found in the sIgE-negative patients (P=1.00). In addition, the serum sIgE-negative patients showed significantly increases in IL4, IL5, and IL10 levels in the serum (P<0.001), although no significant differences were found post-surgery (P=0.667, 0.408, 0.714, respectively).
CONCLUSIONS: Our study showed that AT did not affect pediatric atopic status. The systemic atopy may be independent of the tonsillar and adenoid tissues in children.Pediatric Research accepted article preview online, 12 July 2017. doi:10.1038/pr.2017.165.

PMID: 28700564 [PubMed - as supplied by publisher]

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