The many postures of noncanonical Wnt signaling in development and diseases

Publication date: September 2017 Source:Biomedicine & Pharmacotherapy, Volume 93 Author(s): Qian Xiao, Zhengxi Chen, Xiaozhuang Jin, Runyi Mao, Zhenqi Chen Wnt signaling regulates many aspects of vertebrate development. Its dysregulation causes developmental defects and diseases including cancer. The signaling can be categorized in two pathways: canonical and noncanonical. Canonical pathway plays a key role in regulating proliferation and differentiation of cells whilst noncanonical Wnt signaling mainly controls cellular polarity and motility. During development, noncanonical Wnt signaling is required for tissue formation. Recent studies have shown that noncanonical Wnt signaling is involved in adult tissue development and cancer progression. In this review, we try to describe and...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2t5WStC
via IFTTT