The inhibitory effects of deep-sea water on doxorubicin ‑induced epithelial-mesenchymal transition.

The inhibitory effects of deep-sea water on doxorubicin‑induced epithelial-mesenchymal transition. Oncol Rep. 2017 Jun 16;: Authors: Chun SY, Kim S, Nam KS Abstract It has been revealed that the induction of epithelial‑mesenchymal transition (EMT) is associated with drug resistance, leading to tumor recurrence and metastasis. Recent studies have shown that chemotherapeutic agents, besides their therapeutic effects, can induce EMT and enhance invasive and metastatic properties of tumor cells. Previously, we revealed that deep-sea water (DSW) exhibited antimetastatic effects in several human cancer cell lines. In the present study, we investigated the effects of DSW on doxorubicin-induced EMT in MCF-7 human breast cancer cells. When treated with doxorubicin, MCF-7 ce...

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