Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents

Publication date: Available online 19 June 2017 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): Ján Vančo, Zdeněk Trávníček, Radka Křikavová, Jana Gáliková, Zdeněk Dvořák, Marta Chalupová The platinum(II) iodido complexes 1–5 of the general formula cis-[PtI2(Ln)2], where Ln stands for O-substituted 9-deazahypoxanthine derivatives, were prepared and thoroughly characterized by various techniques, including multinuclear 1D and 2D NMR spectroscopy. The complexes were screened for their anticancer potential in vitro on ten human cancer cell lines, concretely breast adenocarcinoma (MCF7), osteosarcoma (HOS), lung carcinoma (A549), cervix epithelioid carcinoma (HeLa), malignant melanoma (G-361), prostate carcinoma (22Rv1, PC-3), hepatocellular carcinoma (...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2tpXPdb
via IFTTT