Reducing autophagy and inducing G1 phase arrest by aloperine enhances radio-sensitivity in lung cancer cells.

Authors: Xu Z, Yan Y, Zeng S, Qian L, Dai S, Xiao L, Wang L, Yang X, Xiao Y, Gong Z Abstract Aloperine (ALO), an isolated alkaloid from the leaves of Sophora alopecuroides (S. alopecuroides), has been suggested to exhibit anti-inflammatory and antitumor properties, and has been traditionally used to treat various diseases, including cancers. However, little is known about the effects of ALO on the radio-sensitivity of lung cancer cells. In the present study, we confirmed that agent ALO inhibits cell growth, promotes cell aopotosis and induces G1 phase arrest and consequently enhanced the radio-sensitivity in radio-resistant lung cancer cells A549/IR. Mechanically, ALO markedly down-regulates the G1/S transition regulators, CDK4/6 and cyclin D1. Moreover, ALO decreases cell autopha...

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