Polypharmacy and sun exposure: Implications for mitochondrial DNA deletions in skin

Publication date: August 2017 Source:Journal of Photochemistry and Photobiology B: Biology, Volume 173 Author(s): Julia Montelin Powers, Gillian Murphy, Nikki Ralph, Susan M. O'Gorman, James E.J. Murphy Most somatic cells contain many copies of mitochondrial DNA (mtDNA). Because of both the high copy number and the lack of repair mechanisms available to mtDNA, damage to it largely goes unrepaired, and can accumulate over time. Large scale deletions are a recognised type of damage sustained by mtDNA as a consequence of exposure to the ultraviolet light in sunlight. A group of patients were identified as having abnormally high levels of either a 4977 base pair deletion (mtDNA4977) or 3895 base pair deletion (mtDNA3895), in mtDNA from sun exposed skin or skin suspected to be a non-melanoma s...

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