Oral vitamin B1-substitution does not decrease genetically determined cleft rate in mice (A/WySn)

Conclusion Our results suggest a time-dependent influence of thiamine on CL/P appearance in female mice. The prophylactic/periconceptional, but not the therapeutic supplementation, starting point can be proposed as a crucial step for regular facial and palatal fusion in embryonic development. The absolute rate of CL/P was not reduced, and the concentration of the water-soluble thiamine could not increase in the amniotic fluid. Thus the proposed local effect of thiamine failed in the development of genetically determined mice. (Source: Journal of Cranio Maxillofacial Surgery)

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