miR-30a inhibits glioma progression and stem cell ‑like properties by repression of Wnt5a.

miR-30a inhibits glioma progression and stem cell‑like properties by repression of Wnt5a. Oncol Rep. 2017 Jun 16;: Authors: Zhang Y, Wu Z, Li L, Xie M Abstract miR-30a has been found to be dysregulated in diverse cancers and involved in the regulation of tumor progression. However, there is scarce research on the role of miR-30a in glioma. In the present study, we assessed the expression level of miR-30a in glioma tissues and cell lines. The microRNA microarray analysis revealed low expression of miR-30a in glioma tissues and cells vs. the control. Furthermore, we found that stable miR-30a inhibited cell proliferation, G1 phase arrest and stem cell-like formation in glioma. Moreover, to investigate the molecular mechanism of miR-30a on glioma cell phenotypes, we iden...

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