GSE87446 Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats

Contributors : Yuping Wang ; Weida Tong ; Binsheng GongSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusEnvironmental chemicals exposure are one of the primary factors for liver toxicity and hepatocarcinoma. Thioacetamide (TAA) is a well-known hepatotoxicant and could be a liver carcinogen in humans.The discovery of early and sensitive biomarkers in liver injury and tumor progression could improve cancer diagnosis, prognosis, and management.In the present study, we studied the dynamic changes in microRNAs (miRNAs) expression and explored the potential mechanistic role of miRNAs in rat liver treated with TAA at multiple doses and time points. Sprague-Dawley rats were administrated with TAA at three doses [low (4.5 mg/kg), middle (15mg/kg) and h...

from ! Medicine by Alexandros G. Sfakianakis via alwin on Inoreader http://ift.tt/2sLbCuV
via IFTTT