[ASAP] Kinetic Resolution of Allylic Alcohol with Chiral BINOL-Based Alkoxides: A Combination of Experimental and Theoretical Studies

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12796

from A via a.sfakia on Inoreader http://bit.ly/2EY1KWB

[ASAP] Toward Anion-p Interactions Directed Self-Assembly with Predesigned Dual Macrocyclic Receptors and Dianions

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12018

from A via a.sfakia on Inoreader http://bit.ly/2s0UmlC

[ASAP] Tuning P2-Structured Cathode Material by Na-Site Mg Substitution for Na-Ion Batteries

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b08638

from A via a.sfakia on Inoreader http://bit.ly/2LHEyND

[ASAP] Pressure-Engineered Structural and Optical Properties of Two-Dimensional (C4H9NH3)2PbI4 Perovskite Exfoliated nm-Thin Flakes

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b07765

from A via a.sfakia on Inoreader http://bit.ly/2s4c9Zm

[ASAP] Tip-Enhanced Raman Imaging of Single-Stranded DNA with Single Base Resolution

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b11506

from A via a.sfakia on Inoreader http://bit.ly/2rZH5tJ

[ASAP] Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO2

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12140

from A via a.sfakia on Inoreader http://bit.ly/2LESYhu

[ASAP] Deconvoluting Surface-Bound Quinone Proton Coupled Electron Transfer in Unbuffered Solutions: Toward a Universal Voltammetric pH Electrode

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b11518

from A via a.sfakia on Inoreader http://bit.ly/2LI7W6H

[ASAP] Correction to “Bismuth as a New Chloride-Storage Electrode Enabling the Construction of a Practical High Capacity Desalination Battery”

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b13455

from A via a.sfakia on Inoreader http://bit.ly/2EZuO0G

A warped disk around an infant protostar

A warped disk around an infant protostar

A warped disk around an infant protostar, Published online: 31 December 2018; doi:10.1038/s41586-018-0819-2

Observations at millimetre wavelengths reveal a young protostar surrounded by a disk with two differently tilted regions.

from A via a.sfakia on Inoreader https://go.nature.com/2TmzZeu

Structural basis of Notch recognition by human γ-secretase

Structural basis of Notch recognition by human γ-secretase

Structural basis of Notch recognition by human γ-secretase, Published online: 31 December 2018; doi:10.1038/s41586-018-0813-8

The cryo-electron microscopy structure of human γ-secretase in complex with its substrate Notch reveals pronounced structural rearrangements compared to the apo enzyme, including formation of a β-sheet involving residues from both enzyme and substrate.

from A via a.sfakia on Inoreader https://go.nature.com/2TkBQjH

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

Tissue-resident memory CD8⁺ T cells promote melanoma–immune equilibrium in skin

Tissue-resident memory CD8⁺ T cells promote melanoma–immune equilibrium in skin, Published online: 31 December 2018; doi:10.1038/s41586-018-0812-9

A transplantable mouse model of persistent cutaneous melanoma shows that immune-mediated tumour suppression can result in a state of melanoma–immune equilibrium, and that tissue-resident memory T cells are essential drivers of this equilibrium state.

from A via a.sfakia on Inoreader https://go.nature.com/2CGqiSq

Structure of the post-translational protein translocation machinery of the ER membrane

Structure of the post-translational protein translocation machinery of the ER membrane

Structure of the post-translational protein translocation machinery of the ER membrane, Published online: 31 December 2018; doi:10.1038/s41586-018-0856-x

Structure of the post-translational protein translocation machinery of the ER membrane

from A via a.sfakia on Inoreader https://go.nature.com/2CGqcu2

A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)

Objectives

To study exposure-response relations between cumulative organic dust exposure and incident chronic obstructive pulmonary disease (COPD) among subjects employed in the Danish farming and wood industry.

Methods

We studied exposure-response relations between cumulative organic dust exposure and incident COPD (1997–2013) among individuals born during 1950–1977 in Denmark ever employed in the farming or wood industry (n=1 75 409). Industry-specific employment history (1964–2007), combined with time-dependent farming and wood industry-specific exposure matrices defined cumulative exposure. We used logistic regression analysis with discrete survival function adjusting for age, sex and calendar year. Adjustment for smoking status was explored in a subgroup of 4023 with smoking information available.

Results

Cumulative organic dust exposure was inversely associated with COPD (adjusted rate ratios (RR_adj (95% CIs) of 0.90 (0.82 to 0.99), 0.76 (0.69 to 0.84) and 0.52 (0.47 to 0.58) for intermediate-low, intermediate-high and high exposure quartiles, respectively, compared with the lowest exposure quartile). Lagging exposure 10 years was not consistently suggestive of an association between cumulative exposure and COPD; RR_adj (95% CI): 1.05 (0.94 to 1.16), 0.92 (0.83 to 1.02) and 0.63 (0.56 to 0.70). Additional stratification by duration of employment showed no clear association between organic dust exposure and COPD except for the longer exposed (15–40 years) where an inverse association was indicated. Subgroup analyses showed that smoking had no impact on exposure-response estimates.

Conclusions

Our findings show no increased risk of COPD with increasing occupational exposure to organic dust in the farming or wood industry.

Potential residual confounding by smoking can, however, not be ruled out.

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[ASAP] Realizing High Thermoelectric Performance in p-Type SnSe through Crystal Structure Modification

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12450

from A via a.sfakia on Inoreader http://bit.ly/2EW8Fjg

[ASAP] Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b10939

from A via a.sfakia on Inoreader http://bit.ly/2EW8Pam

[ASAP] Competition between Normative and Drug-Induced Virus Self-Assembly Observed with Single-Particle Methods

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b10131

from A via a.sfakia on Inoreader http://bit.ly/2F2ik8G

[ASAP] What Are the Radical Intermediates in Oxidative -Heterocyclic Carbene Organocatalysis?

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b11824

from A via a.sfakia on Inoreader http://bit.ly/2EYsJCh

[ASAP] Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers

Journal of the American Chemical Society

DOI: 10.1021/jacs.8b12801

from A via a.sfakia on Inoreader http://bit.ly/2F2i9u2

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

from A via a.sfakia on Inoreader https://go.nature.com/2rZRtl4

Structure of the post-translational protein translocation machinery of the ER membrane

from A via a.sfakia on Inoreader https://go.nature.com/2SuA0Nc