Extended‐release naltrexone for people with alcohol use disorder on therapeutic anticoagulation: A case series

alexandrossfakianakis shared this article with you from Inoreader Extended‐release naltrexone for people with alcohol use disorder on therapeutic anticoagulation: A case series via Journal of Clinical Pharmacy and Therapeutics Guide to XR-NTX Discussion for Patients on Therapeutic Anticoagulation. Abstract What is known and objective Individuals with medication adherence challenges or a preference for long-acting medications may benefit from extended-release naltrexone (XR-NTX) for treatment of alcohol use disorder (AUD). Individuals on therapeutic anticoagulation were excluded from XR-NTX studies and its safety in this population has not been reported. Case summary We conducted structured retrospective chart review of six individuals who received XR-NTX for AUD while on therapeutic anticoagulation between November 2019 and Deccember 2020. We found no documented complications among six individuals who received up to 11 doses of XR-NTX while on therapeutic anticoagulation. What is new and conclusion XR-NTX may be safely tolerated by patients on therapeutic anticoagulation. We need larger studies evaluating XR-NTX administration in patients on therapeutic anticoagulation and those with coagulopathies, including individuals with alcohol-related liver disease, to better quantify risks and benefits for shared decision-making. View on Web

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