SARS‐CoV‐2 IgG “heritage” in newborn: a credit of maternal natural infection

alexandrossfakianakis shared this article with you from Inoreader SARS‐CoV‐2 IgG "heritage" in newborn: a credit of maternal natural infection via Journal of Medical Virology Abstract Introduction Description of transplacental passage of specific SARS-CoV-2 IgG from mothers who contracted natural infection to their newborns. Methods Retrospective cohort analysis including pregnant women diagnosed with SARS-CoV-2and their newborns both tested for SARS-CoV2 specific IgG and IgM with antibody titration at delivery. NPS were taken from both mothers and neonates, and tested for SARS-CoV-2 using PCR. Results IgM and IgG were analyzed in maternal and neonatal serum of 143 mother-infant dyads. 86% of women with a positive SARS-CoV-2 PCR > 14 days before delivery developed specific IgG and 84% of their infants showed transplacental passage of IgG. Conclusions Pregnant women infected with SARS-CoV-2 achieve antibody seroconversion following the kinetics described in the general population, and transplacental transfer of IgG specific antibodies occurs. No conclusion can be drawn on passive immunity efficacy or duration. This article is protected by copyright. All rights reserved. View on Web

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