Truncating CDKN1A mutations: an insight into the biology of urinary tract carcinomas?

xlomafota13 shared this article with you from Inoreader Truncating <em>CDKN1A</em> mutations: an insight into the biology of urinary tract carcinomas? Via American Journal of Cancer Research Am J Cancer Res. 2021 Dec 15;11(12):6214-6217. eCollection 2021. ABSTRACT A recent in silico study by Arnoff and El-Deiry found that urothelial carcinomas of the bladder and upper tract as well as chromophobe renal cell carcinoma are more likely than other malignancies to harbor alterations in the CDKN1A gene, encoding for the cyclin-dependent kinase inhibitor p21Waf1, a major target of p53 regulatory pathways. Most of these mutations were truncating and thus presumably resulting in loss of p21Waf1 function. Herein, we discuss the prognostic and therapeutic implications of these findings. PMID:35018253 | PMC:PMC8727807 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.