Systemic Inflammatory Response to Different Sclerosing Agents as a Predictor of Pleurodesis Outcome

xlomafota13 shared this article with you from Inoreader Systemic Inflammatory Response to Different Sclerosing Agents as a Predictor of Pleurodesis Outcome Via In vivo (Athens, Greece) In Vivo. 2021 Jul-Aug;35(4):2391-2398. doi: 10.21873/invivo.12516. ABSTRACT BACKGROUND/AIM: The objectives of this study were to evaluate systemic inflammation using different sclerosing agents and to estimate the prediction of systemic inflammation for the efficacy of pleurodesis. PATIENTS AND METHODS: Ninety-six patients with recurrent and symptomatic malignant pleural effusion were enrolled in this retrospective study. We used serum C-reactive protein (CRP) levels, serum leukocyte counts and neutrophil-to-lymphocyte ratios (NLRs) as parameters of systemic inflammatory reactions. Evaluations of these parameters were performed before and 24 h after pleurodesis. RESULTS: Pleurodesis was successful in 81 (84.4%) patients. The non-graded talc induced the highest changes in serum CRP levels, total white blood cell and neutrophil counts compared to other agents, while mitoxantrone induced the lowest. Graded talc and bleomycin i nduced the same levels of changes in serum CRP levels and serum leukocyte counts. The change in serum NLR was the same for all agent groups. Logistic regression confirmed that a change in serum CRP levels [odds ratio (OR)=0.92, p=0.002] and previous chemotherapy (OR=3.31, p=0.012) were independent predictors of pleurodesis efficacy. CONCLUSION: Pleurodesis agents induced a systemic inflammatory response at different levels. The change in serum CRP levels could be useful for predicting the success of pleurodesis. PMID:34182522 | DOI:10.21873/invivo.12516 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.