Background, applications and challenges of radiogenomics in genitourinary tumor

xlomafota13 shared this article with you from Inoreader Background, applications and challenges of radiogenomics in genitourinary tumor Via American Journal of Cancer Research Am J Cancer Res. 2021 May 15;11(5):1936-1945. eCollection 2021. ABSTRACT Genitourinary tumors are groups of tumors with high complexity and heterogeneity. For long-term monitoring, biomarkers that can be used in detection, grading and treatment response assessment are needed. With rapid development in imaging technology and cancer genomics, radiogenomics, the combination of "radiology" and "genomics", has emerged as a powerful tool in oncology practice in recent years because imaging can provide some information that genomic test cannot as gene expression and mutation status are usually evaluated on a small portion of the tumor and are usually not powerful enough to reflect tumor heterogeneity. Radiogenomics investigates the correlations between imaging features and gene expression of a disease, especially in oncologic diseases. It aims to detect the disease's mutation status and supplement genomic analysis based on imaging analysis, p roviding additional findings for diagnosis, treatment decisions, evaluation of treatment response and prognosis prediction of the disease. Recent years have seen an increase in the number of studies investigating the application of radiogenomics in genitourinary tumors. Many studies have shown promising results. However, there still exist limitations and challenges. In this review, we will summarize recent applications of radiogenomics in genitourinary tumors and discuss limitiations, challenges and future directions of radiogenomics. PMID:34094662 | PMC:PMC8167692 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.