Nephrotic syndrome in syngeneic hematopoietic stem cell transplantation recipients: A case report

paythelady.612 shared this article with you from Inoreader Nephrotic syndrome in syngeneic hematopoietic stem cell transplantation recipients: A case report Μέσω pubmed: "world j clin cases"... World J Clin Cases. 2021 Jan 26;9(3):614-622. doi: 10.12998/wjcc.v9.i3.614. ABSTRACT BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is widely used in the treatment of hematological diseases. However, complications after transplantation, such as acute and chronic graft-vs-host disease (GVHD), still seriously affect the quality of life and even threaten the lives of patients. There is evidence that glomerular diseases can manifest as GVHD. However, GVHD should not occur as a result of syngeneic HSCT. CASE SUMMARY: A 20-year-old male diagnosed with T lymphoblastic lymphoma (stage IIIA, aaIPI 1) in September 2013 was treated with six cycles of hyper-CVAD and achieved complete remission. He underwent syngeneic HSCT in June 2014, and had no kidney disease history before the transplant. However, nephrotic syndrome occurred 24 mo later in the patient after syngeneic HSCT. Renal biopsy was performed, which led to a diag nosis of atypical membranous nephropathy. After treatment with glucocorticoids combined with cyclophosphamide and cyclosporine, the nephrotic syndrome was completely relieved. CONCLUSION: We report a case of delayed nephrotic syndrome after syngeneic HSCT. Antibody-mediated autoimmune glomerular disease may be the underlying mechanism. After treatment with immunosuppressive agents, the nephrotic syndrome was completely relieved but further long-term follow-up is still needed. PMID:33553399 | PMC:PMC7829719 | DOI:10.12998/wjcc.v9.i3.614 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.