Factors Influencing Total Serum IgE in Adults: The Role of Obesity and Related Metabolic Disorders

Alexandros G.Sfakianakis shared this article with you from Inoreader Factors Influencing Total Serum IgE in Adults: The Role of Obesity and Related Metabolic Disorders Μέσω IAA : Last 20 articles Background and Aim: Few reports have investigated the association between metabolic abnormalities (obesity and related metabolic syndrome) and total serum IgE concentrations. Methods: This cross-sectional study included a random sample of 1,516 adult individuals (44.7% men, aged 18–91 years, median 52 years) from a single municipality in Spain. Serum IgE was measured in the ADVIA Centaur system. Atopy was defined by the presence of positive skin prick tests to a panel of common aeroallergens in the area. Body mass index and data related to the definition of metabolic syndrome were obtained from all participants. Alcohol consumption, smoking, and regular physical exercise were assessed by a questionnaire. Results: Atopy (present in 21.9% of 1,514 evaluable individuals) was the strongest factor determining serum IgE concentrations. Male sex and heavy alcohol drinking were independently associated with higher IgE concentrations, particularly in the non-atopic individuals. Body mass index was positively associated with IgE concentrations, independent of potential confounders, although the effect was only evident among non-atopic individuals. In that group, median IgE concentrations in normal-weight and obese individuals were 15 and 24 kU/L, respectively (p #x3c; 0.001); likewise, obesity was asso ciated with high (#x3e;100 kU/L) IgE concentrations after adjusting for potential confounders (odds ratio: 1.79, 95% confidence interval: 1.26–2.56, p = 0.001). The presence of metabolic syndrome and its components, particularly abdominal obesity and hyperglycaemia, was also positively and independently associated with higher IgE concentrations in non-atopic individuals. Conclusions: Obesity and metabolic syndrome components are associated with high total serum IgE concentrations, particularly in non-atopic individuals. Int Arch Allergy Immunol View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.