Transcriptional and signaling regulation of skin epithelial stem cells in homeostasis, wounds, and cancer

xlomafota13 shared this article with you from Inoreader Transcriptional and signaling regulation of skin epithelial stem cells in homeostasis, wounds, and cancer Via Experimental Dermatology Abstract The epidermis and skin appendages are maintained by their resident epithelial stem cells, which undergo long‐term self‐renewal and multi‐lineage differentiation. Upon injury, stem cells are activated to mediate re‐epithelialization and restore tissue function. During this process, they often mount lineage plasticity and expand their fates in response to damage signals. Stem cell function is tightly controlled by transcription machineries and signaling transductions, many of which derail in degenerative, inflammatory, and malignant dermatologic diseases. Here, by describing both well‐characterized and newly emerged pathways, we discuss the transcriptional and signaling mechanisms governing skin epithelial homeostasis, wound repair, and squamous cancer. Throughout, we highlight common themes underscoring epithelial stem cell plasticity and tissue‐level crosstalk in the context of skin physiology and pathology. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.