The slc4a2b gene is required for hair cell development

a.lsfakia shared this article with you from Inoreader The slc4a2b gene is required for hair cell development in zebrafish. Via pubmed: familial hearing los... The slc4a2b gene is required for hair cell development in zebrafish. Aging (Albany NY). 2020 Oct 12;12: Authors: Qian F, Wang X, Yin Z, Xie G, Yuan H, Liu D, Chai R Abstract Hair cells (HCs) function as important sensory receptors that can detect movement in their immediate environment. HCs in the inner ear can sense acoustic signals, while in aquatic vertebrates HCs can also detect movements, vibrations, and pressure gradients in the surrounding water. Many genes are responsible for the development of HCs, and developmental defects in HCs can lead to hearing loss and other sensory dysfunctions. Here, we found that the solute carrier family 4, member 2b (slc4a2b) gene, which is a member of the anion-exchange family, is expressed in the otic vesicles and lateral line neuromasts in developing zebrafish embryos. An in silico analysis showed that the slc4a2b is evolutionarily conserved, and we found that loss of function of slc4a2b resulted in a decreased number of HCs in zebrafish neuromasts due to increased HC apoptosis. Taken together, we conclude that slc4a2b plays a critical role in the development of HCs in zebrafish. PMID: 33044947 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.