Disseminated histoplasmosis in a cat rescued in Fortaleza, Brazil, and successfully treated with itraconazole – First case report identified molecularly: Publication date: Available online 2 October 2020Source: Medical Mycology Case ReportsAuthor(s): Liliane Lima da Silva Lomônaco, Stefanie Bressan Waller, Marlete Brum Cleff, Angelita dos Reis Gomes, Barbara Wilka Leal Silva, Rosane de Oliveira Cruz, Talles Monte de Almeida, Amanda Leal de Vasconcellos, Wesley Lyeverton Correia Ribeiro, Renata Osório...
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Paraneoplastic Cerebellar Ataxia Can Affect Prognosis in High-Grade Serous Ovarian Cancer: A Case Report.: Paraneoplastic Cerebellar Ataxia Can Affect Prognosis in High-Grade Serous Ovarian Cancer: A Case Report.Case Rep Oncol. 2020 May-Aug;13(2):1006-1012Authors: Liapi A, Sarivalasis AAbstract The reported case is a 61-year-old woman, admitted for gradual onset of gait disturbances and dysphonia. The serum immunological panel revealed anti-Yo autoantibodies, suggestive of a paraneoplastic...
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Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.Related Articles Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model. Head Neck. 2019 05;41(5):1260-1269 Authors: Yang CY, Lin CK, Hsieh CC, Tsao CH, Lin CS, Peng B, Chen YT, Ting CC, Chang WC, Lin GJ, Sytwu HK, Chen YW Abstract BACKGROUND: Aberrant expression of decoy...
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Effectiveness of the No action level protocol for head & neck patients - Time considerations.: Effectiveness of the No action level protocol for head & neck patients - Time considerations.Rep Pract Oncol Radiother. 2020 Sep-Oct;25(5):828-831Authors: Kukolowicz P, Mietelska M, Kiprian DAbstract Background: The No Action Protocol (NAL) was used to diminish the systematic set-up error. Recently, owing to the development of image registration technologies, the on-line positioning control...
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Targeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti-PD-1 Resistance in Head and Neck Cancer.: Related ArticlesTargeting EZH2 Enhances Antigen Presentation, Antitumor Immunity, and Circumvents Anti-PD-1 Resistance in Head and Neck Cancer.Clin Cancer Res. 2020 01 01;26(1):290-300Authors: Zhou L, Mudianto T, Ma X, Riley R, Uppaluri RAbstract PURPOSE: Anti-programmed death-1 (PD-1) receptor-based therapeutics improve survival in patients with recurrent head...
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Long-term results of a prospective phase II study on volume de-escalation in neoadjuvant chemoradiotherapy of rectal cancer.: Long-term results of a prospective phase II study on volume de-escalation in neoadjuvant chemoradiotherapy of rectal cancer.Pract Radiat Oncol. 2020 Sep 28;:Authors: Michele F, Carlo G, Roberto C, Marco C, Damiano C, Pasquale T, Barnaba F, Germana RC, Edy I, Teresa CG, Raffaele G, Bruno BZ, Maria DR, Lucio T, Sara RAbstract PURPOSE: In the current study, we evaluated...
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Cytology-based screening for anal intraepithelial neoplasia in women with a history of cervical intraepithelial neoplasia or cancer.: Cytology-based screening for anal intraepithelial neoplasia in women with a history of cervical intraepithelial neoplasia or cancer.Cancer Cytopathol. 2020 Oct 01;:Authors: Wohlmuth C, Ghorab Z, Shier M, Tinmouth J, Salit IE, Covens A, Zhang L, Vicus DAbstract BACKGROUND: High-risk human papillomavirus (HPV) has been identified in the pathogenesis of anal...
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An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation.: An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation.Blood Adv. 2020 Oct 13;4(19):4679-4692Authors: Marion W, Boettcher S, Ruiz-Torres S, Lummertz da Rocha E, Lundin V, Morris V, Chou S, Zhao AM, Kubaczka C, Aumais O, Zhang Y, Shimamura A, Schlaeger TM, North TE, Ebert BL, Wells SI, Daley GQ, Rowe RGAbstract...
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Visual functions in children with craniopharyngioma at diagnosis: A systematic review.: Visual functions in children with craniopharyngioma at diagnosis: A systematic review.PLoS One. 2020;15(10):e0240016Authors: Nuijts MA, Veldhuis N, Stegeman I, van Santen HM, Porro GL, Imhof SM, Schouten-van Meeteren AYNAbstract Childhood craniopharyngioma is a rare and slow growing brain tumour, often located in the sellar and suprasellar region. It commonly manifests with visual impairment, increased...
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Theranostics in Nuclear Medicine: Emerging and Re-emerging Integrated Imaging and Therapies in the Era of Precision Oncology.: Theranostics in Nuclear Medicine: Emerging and Re-emerging Integrated Imaging and Therapies in the Era of Precision Oncology.Radiographics. 2020 Oct;40(6):1715-1740Authors: Gomes Marin JF, Nunes RF, Coutinho AM, Zaniboni EC, Costa LB, Barbosa FG, Queiroz MA, Cerri GG, Buchpiguel CAAbstract Theranostics refers to the pairing of diagnostic biomarkers with therapeutic...
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Sustained response to erlotinib and rapamycin in a patient with pediatric anaplastic oligodendroglioma.: Sustained response to erlotinib and rapamycin in a patient with pediatric anaplastic oligodendroglioma.Pediatr Blood Cancer. 2020 Oct 01;:e28750Authors: Geben LC, Mobley BC, Brockman AA, Pastakia D, Naftel R, Ihrie RA, Esbenshade AJAbstract One goal of precision medicine is to identify mutations within individual tumors to design targeted treatment approaches. This report details the...
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RBE for proton radiation therapy - a Nordic view in the international perspective.: RBE for proton radiation therapy - a Nordic view in the international perspective.Acta Oncol. 2020 Oct 01;:1-6Authors: Toma-Dasu I, Dasu A, Vestergaard A, Witt Nyström P, Nyström HAbstract BACKGROUND: This paper presents an insight into the critical discussions and the current strategies of the Nordic countries for handling the variable proton relative biological effectiveness (RBE) as presented at The Nordic...
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Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study.: Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study.J Clin Endocrinol Metab. 2020 Sep 30;:Authors: Shi X, Li CW, Tan LC, Wen SS, Liao T, Zhang Y, Chen TZ, Ma B, Yu PC, Lu ZW, Qu N, Wang Y, Shi RL, Wang YL, Ji QH, Wei WJAbstract CONTEXT: PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT are considered as major immune...
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Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance.: Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development...
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The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia.: The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia.BMC Cancer. 2020 Sep 30;20(1):940Authors: Oosterom N, Fiocco M, Kloos RQH, van der Sluis IM, Pieters R, van Zelst BD, Smith DEC, van den Heuvel-Eibrink MM, de Jonge R, Heil SGAbstract BACKGROUND: After High-Dose Methotrexate (HD-MTX), folinic...
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Leveraging TCGA gene expression data to build predictive models for cancer drug response.: Leveraging TCGA gene expression data to build predictive models for cancer drug response.BMC Bioinformatics. 2020 Sep 30;21(Suppl 14):364Authors: Clayton EA, Pujol TA, McDonald JF, Qiu PAbstract BACKGROUND: Machine learning has been utilized to predict cancer drug response from multi-omics data generated from sensitivities of cancer cell lines to different therapeutic compounds. Here, we build machine...
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Pyoderma Gangrenosum After Abdominal Free Tissue Transfer for Breast Reconstruction: Case Series and Management Guidelines.: Related ArticlesPyoderma Gangrenosum After Abdominal Free Tissue Transfer for Breast Reconstruction: Case Series and Management Guidelines.Ann Plast Surg. 2019 07;83(1):63-68Authors: Li WY, Andersen JC, Jung J, Andersen JSAbstract INTRODUCTION: Pyoderma gangrenosum following free tissue transfer for breast reconstruction is rare. This unusual ulcerative condition...
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Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions.: Molecular Profiling of Salivary Oncocytic Mucoepidermoid Carcinomas Helps to Resolve Differential Diagnostic Dilemma With Low-grade Oncocytic Lesions.Am J Surg Pathol. 2020 Sep 29;:Authors: Skálová A, Agaimy A, Stanowska O, Baneckova M, Ptáková N, Ardighieri L, Nicolai P, Lombardi D, Durzynska M, Corcione L, Laco J, Koshyk O, Žalud R, Michal M, Vanecek...
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Histopathologic Characterization of Bladder Perivascular Epithelioid Cell Neoplasms (PEComa): A Series of 11 Cases With a Subset Having TFE3 Rearrangements.: Histopathologic Characterization of Bladder Perivascular Epithelioid Cell Neoplasms (PEComa): A Series of 11 Cases With a Subset Having TFE3 Rearrangements.Am J Surg Pathol. 2020 Sep 29;:Authors: Neumann NM, Haffner MC, Argani P, Kao CS, Epstein JIAbstract Perivascular epithelioid cell neoplasms (PEComas) of the bladder are extremely...
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Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation.: Tea Drinking and Risk of Cancer Incidence: A Meta-Analysis of Prospective Cohort Studies and Evidence Evaluation.Adv Nutr. 2020 Oct 01;:Authors: Zhao LG, Li ZY, Feng GS, Ji XW, Tan YT, Li HL, Gunter MJ, Xiang YBAbstract Here we provide a comprehensive meta-analysis to summarize and appraise the quality of the current evidence on the associations of tea drinking in relation to...
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[Weight loss, diarrhea and dystrophic alterations of the fingernails in an 80-year-old male patient].: [Weight loss, diarrhea and dystrophic alterations of the fingernails in an 80-year-old male patient].Internist (Berl). 2020 Oct 01;:Authors: Strohmeier MAbstract Cronkhite-Canada syndrome (CCS) is a rare noninherited condition characterized by gastrointestinal polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss and diarrhea. We report the case of an 80-year-old patient...
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Clinicopathologic and molecular characterization of USP6-rearranged soft tissue neoplasms: The evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity.: Clinicopathologic and molecular characterization of USP6-rearranged soft tissue neoplasms: The evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity.Histopathology. 2020 Sep 30;:Authors: Wang JC, Li WS, Kao YC, Lee JC, Lee PH, Huang SC, Tsai JW, Chen CC, Chang...
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Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study.: Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study.J Clin Endocrinol Metab. 2020 Sep 30;:Authors: Shi X, Li CW, Tan LC, Wen SS, Liao T, Zhang Y, Chen TZ, Ma B, Yu PC, Lu ZW, Qu N, Wang Y, Shi RL, Wang YL, Ji QH, Wei WJAbstract CONTEXT: PD-1, CTLA-4, TIM-3, LAG-3 and TIGIT are considered as major immune...
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Angiosarcoma of the Auricle in a Patient with Xeroderma Pigmentosum Variant.: Angiosarcoma of the Auricle in a Patient with Xeroderma Pigmentosum Variant.Case Rep Dermatol. 2020 May-Aug;12(2):144-149Authors: Onishi M, Tsunoda K, Maeda F, Moriwaki S, Amano HAbstract Xeroderma pigmentosum (XP) is an inherited autosomal recessive disorder characterized by photosensitivity and an increased risk of developing multiple skin neoplasms at sites exposed to the sun. We report a 73-year-old Japanese...
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Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC.: Do Not Ignore Tuberculosis of the Parotid Gland When Meeting Obvious Infiltration of Neutrophils in a Suspicious Swelling by FNAC.Ear Nose Throat J. 2020 Oct 01;:145561320964267Authors: Yang F, Wu M, Peng Y, Dong X, Ge YAbstract Parotid gland tuberculosis constantly results in unnecessary medical examinations and surgery because of its similarities in the presentation...
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Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck?: Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck?Cancers (Basel). 2020 Sep 28;12(10):Authors: Longo F, Perri F, Caponigro F, Della Vittoria Scarpati G, Guida A, Pavone E, Aversa C, Muto P, Giuliano M, Ionna F, Solla RAbstract Head...
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Esthesioneuroblastoma in children, adolescents and young adults.: Related ArticlesEsthesioneuroblastoma in children, adolescents and young adults.Bull Cancer. 2020 Sep;107(9):934-945Authors: Dumont B, Lemelle L, Cordero C, Couloigner V, Bernard S, Cardoen L, Brisse HJ, Jehanno N, Fréneaux P, Helfre S, Rouffiange L, Réguerre Y, Orbach DAbstract The esthesioneuroblastoma (ENB) is characterized as a rare malignant sinonasal tumor of neuroectodermal origin. Its starting point is the olfactory...
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[A Case of Rectal Neuroendocrine Carcinoma Treated with Multidisciplinary Therapy but with a Poor Prognosis].: Related Articles[A Case of Rectal Neuroendocrine Carcinoma Treated with Multidisciplinary Therapy but with a Poor Prognosis].Gan To Kagaku Ryoho. 2020 Aug;47(8):1261-1263Authors: Kurayoshi M, Nakahara M, Okuda H, Shidahara Y, Hirohata R, Ono K, Hirata F, Abe T, Fujikuni N, Sasada T, Yamaki M, Amano H, Noriyuki TAbstract A 70-year-old man presented to our hospital with weight loss....
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[Laparoscopic Hepatic Resection for a Hepatic Perivascular Epithelioid Cell Tumor-A Case Report].: Related Articles[Laparoscopic Hepatic Resection for a Hepatic Perivascular Epithelioid Cell Tumor-A Case Report].Gan To Kagaku Ryoho. 2020 Aug;47(8):1229-1231Authors: Funamizu N, Omura K, Osada H, Igarashi K, Wakabayashi GAbstract A 50-year-old female who had a liver tumor was referred to our hospital for further examination. Abdominal CT and MRI revealed a 2 cm tumor in liver segment 2 that...
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[Combination Therapy of Bevacizumab plus Paclitaxel Was Effective for a Metastatic Choroidal Tumor Secondary to Breast Cancer in a Patient with Ocular Symptoms].: Related Articles[Combination Therapy of Bevacizumab plus Paclitaxel Was Effective for a Metastatic Choroidal Tumor Secondary to Breast Cancer in a Patient with Ocular Symptoms].Gan To Kagaku Ryoho. 2020 Aug;47(8):1221-1224Authors: Hattori M, Shirahane K, Sakai M, Sassa Y, Nishihara Y, Aibe H, Masuda M, Mori DAbstract A 44-year-old...
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[Treatment of testicular germ cell tumors relapse].: Related Articles[Treatment of testicular germ cell tumors relapse].Bull Cancer. 2020 Sep;107(9):912-924Authors: Carbonnaux M, Vinceneux A, Peyrat P, Fléchon AAbstract Seminomatous (SGCT) and non-seminomatous (NSGCT) germ cell tumors (GCT) are rare but their incidence are increasing. We will discuss different therapeutic strategies in relapse disease: patients with stage I germ cell tumor have an excellent prognosis with a cure rate approaching...
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Mammary analogue secretory carcinoma: A case report.: Related ArticlesMammary analogue secretory carcinoma: A case report.Tunis Med. 2020 Feb;98(2):168-171Authors: Hedhli F, Ouertani H, Gargouri F, Naija S, Casiraghi O, Valent A, Khatteche BAbstract BACKGROUND: Mammary analogue secretory carcinoma is a rare new entity of low-grade malignant tumor of salivary glands. It shared the same histologic features and the chromosomal translocation t(12;15)(p13;q25) as secretory carcinoma of the breast....
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Digestive Duplication: A rare cause of abdominal mass in an infant.: Related ArticlesDigestive Duplication: A rare cause of abdominal mass in an infant.Tunis Med. 2020 Feb;98(2):164-167Authors: Gbande P, Sonhaye L, Tchaou M, Dossou FC, Adjenou KVAbstract INTRODUCTION: Intestinal duplications are rare malformations and hail sites are the most common. Today, the diagnosis is made in antenatal because of the performances of antenatal ultrasound. OBSERVATION: This was a 15-month-old...
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Coexistence of anal malignant melanoma and papillary renal cell cancer: An interesting coexistence.: Related ArticlesCoexistence of anal malignant melanoma and papillary renal cell cancer: An interesting coexistence.J Cancer Res Ther. 2020 Jan-Mar;16(1):189-191Authors: Mirili C, Yilmaz AAbstract Coexistence of malignant melanoma and renal cell cancer (RCC) is a rare phenomenon, but this issue becomes increasingly popular. The objective of the current study is to present a case with coexistent...
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Brentuximab vedotin demonstrates an objective response in a patient with refractory CD30+ primary mediastinal B-cell lymphoma.: Related ArticlesBrentuximab vedotin demonstrates an objective response in a patient with refractory CD30+ primary mediastinal B-cell lymphoma.J Cancer Res Ther. 2020 Jan-Mar;16(1):183-185Authors: Badri N, Ngamdu KS, Torabi A, Guar SAbstract Diffuse large B-cell lymphomas (DLBCL) with MYC translocations combined with translocations involving BCL-2 or BCL-6 are referred...
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A rare and unusual presentation of Epstein-Barr virus-associated diffuse large B-cell lymphoma involving colon as the primary site.: Related ArticlesA rare and unusual presentation of Epstein-Barr virus-associated diffuse large B-cell lymphoma involving colon as the primary site.J Cancer Res Ther. 2020 Jan-Mar;16(1):167-169Authors: Modi V, Bajaj N, Lakkasani S, Shaaban HS, Guron GAbstract Lymphoproliferative malignancies can involve both nodal- and extra-nodal tissues. The most common extranodal...
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Extramedullary plasmacytoma of the nasal cavity and ethmoidal sinus in human immunodeficiency virus-positive patient.: Related ArticlesExtramedullary plasmacytoma of the nasal cavity and ethmoidal sinus in human immunodeficiency virus-positive patient.J Cancer Res Ther. 2020 Jan-Mar;16(1):157-160Authors: Adoga AA, Silas OA, Yaro JPAbstract Extramedullary plasmacytoma (EMP) occurring in the nose and paranasal sinus regions are rare with a male preponderance in the fifth and seventh decades...
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Rare mutations of epidermal growth factor receptor in epidermal growth factor receptor-tyrosine kinase inhibitor-naive non-small cell lung carcinoma and the response to erlotinib therapy.: Related ArticlesRare mutations of epidermal growth factor receptor in epidermal growth factor receptor-tyrosine kinase inhibitor-naive non-small cell lung carcinoma and the response to erlotinib therapy.J Cancer Res Ther. 2020 Jan-Mar;16(1):132-138Authors: Sari M, Aydiner AAbstract Context: Epidermal...
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Evolution of the treatment of primary central nervous system lymphoma in a Regional Cancer Center of South India: Impact of high-dose methotrexate on treatment outcome.: Related ArticlesEvolution of the treatment of primary central nervous system lymphoma in a Regional Cancer Center of South India: Impact of high-dose methotrexate on treatment outcome.J Cancer Res Ther. 2020 Jan-Mar;16(1):13-17Authors: Rudresha AH, Chaudhuri T, Lakshmaiah KC, Babu G, Lokesh KN, Rajeev LKAbstract Objective:...
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Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families.: Related ArticlesTumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families.Breast Cancer Res. 2020 04 15;22(1):36Authors: Van Marcke C, Helaers R, De Leener A, Merhi A, Schoonjans CA, Ambroise J, Galant C, Delrée P, Rothé F, Bar I, Khoury E, Brouillard P, Canon JL, Vuylsteke P, Machiels JP, Berlière M, Limaye N, Vikkula...
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High hepatocyte growth factor expression in primary tumor predicts better overall survival in male breast cancer.: Related ArticlesHigh hepatocyte growth factor expression in primary tumor predicts better overall survival in male breast cancer.Breast Cancer Res. 2020 03 18;22(1):30Authors: Qiu SQ, van Rooijen J, Nienhuis HH, van der Vegt B, Timmer-Bosscha H, van Leeuwen-Stok E, Walenkamp AME, van Deurzen CHM, de Bock GH, de Vries EGE, Schröder CPAbstract BACKGROUND: Breast cancer is rare...
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Metastatic Cutaneous Basal Cell Carcinoma: Report of 2 Cases Preceding the Hedgehog Pathway Antagonists Era.: Related ArticlesMetastatic Cutaneous Basal Cell Carcinoma: Report of 2 Cases Preceding the Hedgehog Pathway Antagonists Era.Adv Anat Pathol. 2020 Mar;27(2):98-111Authors: Bisceglia M, Panniello G, Nirchio V, Sanguedolce F, Centola M, Ben-Dor DJAbstract Basal cell carcinoma (BCC) of the skin is the most common type of malignant human tumor. However, metastatic BCC is a very rare...
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DNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas.: Related ArticlesDNA Methylation Profiling Identifies Distinct Clusters in Angiosarcomas.Clin Cancer Res. 2020 01 01;26(1):93-100Authors: Weidema ME, van de Geer E, Koelsche C, Desar IME, Kemmeren P, Hillebrandt-Roeffen MHS, Ho VKY, van der Graaf WTA, Versleijen-Jonkers YMH, von Deimling A, Flucke UE, PALGA GroupAbstract PURPOSE: DNA methylation profiling has previously uncovered biologically and clinically meaningful...
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Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study.: Related ArticlesCongenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study.Hepatology. 2020 02;71(2):658-669Authors: Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif...
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Pyoderma Gangrenosum After Abdominal Free Tissue Transfer for Breast Reconstruction: Case Series and Management Guidelines.: Related ArticlesPyoderma Gangrenosum After Abdominal Free Tissue Transfer for Breast Reconstruction: Case Series and Management Guidelines.Ann Plast Surg. 2019 07;83(1):63-68Authors: Li WY, Andersen JC, Jung J, Andersen JSAbstract INTRODUCTION: Pyoderma gangrenosum following free tissue transfer for breast reconstruction is rare. This unusual ulcerative condition...
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Complications of Postoperative Epidural Analgesia For Oncologic Surgery: A Review of 18,895 Cases.: Related ArticlesComplications of Postoperative Epidural Analgesia For Oncologic Surgery: A Review of 18,895 Cases.Clin J Pain. 2019 07;35(7):589-593Authors: Su J, Soliz JM, Popat KU, Gebhardt RAbstract OBJECTIVE: The risks of epidural analgesia (EA) differ depending on the population studied. We describe our experience with postoperative EA for oncologic surgery. MATERIALS AND METHODS:...
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Recurrent Breast Cerebrospinal Fluid Pseudocyst: A Complication of Ventriculoperitoneal Shunt Placement.: Related ArticlesRecurrent Breast Cerebrospinal Fluid Pseudocyst: A Complication of Ventriculoperitoneal Shunt Placement.Ann Plast Surg. 2019 07;83(1):108-111Authors: Zawadiuk LRR, Van Slyke AC, Macadam SAAbstract Ventriculoperitoneal (VP) shunt complications involving the breast are rare, with the majority involving the formation of a cerebrospinal fluid pseudocyst. We present the case...
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Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review.: Related ArticlesAbnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review.Ann Plast Surg. 2019 07;83(1):104-107Authors: Chen Y, Chen Y, Liu YAbstract RATIONALE: Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive...
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Successful rescue therapy with venovenous extracorporeal membrane oxygenation for re-expansion pulmonary oedema in a patient with one lung.: Related ArticlesSuccessful rescue therapy with venovenous extracorporeal membrane oxygenation for re-expansion pulmonary oedema in a patient with one lung.Eur J Cardiothorac Surg. 2019 Mar 01;55(3):582-584Authors: Gray WH, Hackmann AE, Starnes VA, Kiankhooy AAbstract Re-expansion pulmonary oedema following the drainage of pleural fluid is rare. We...
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Effects of cerebellar transcranial direct current stimulation (tDCS) on motor skill learning in swallowing.: Effects of cerebellar transcranial direct current stimulation (tDCS) on motor skill learning in swallowing.Disabil Rehabil. 2020 Oct 01;:1-9Authors: Erfmann KLC, Macrae PR, Jones RD, Guiu Hernandez E, Huckabee MLAbstract OBJECTIVE: This study evaluated the effects of cerebellar tDCS on motor learning for swallowing. METHODS: In a double-blind RCT, 39 healthy adults received...
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Association between external and internal lymphedema and chronic dysphagia following head and neck cancer treatment.: Association between external and internal lymphedema and chronic dysphagia following head and neck cancer treatment.Head Neck. 2020 Oct 01;:Authors: Jeans C, Ward EC, Brown B, Vertigan AE, Pigott AE, Nixon JL, Wratten C, Boggess MAbstract BACKGROUND: To examine the relationship between chronic external and internal head and neck lymphedema (HNL) and swallowing function in...
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Mild atopic dermatitis lacks systemic inflammation, and shows reduced non-lesional skin abnormalities: Publication date: Available online 1 October 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Helen He, Ester Del Duca, Aisleen Diaz, Hyun Je Kim, Jesús Gay-Mimbrera, Ning Zhang, Jianni Wu, Jessica Beaziz, Yeriel Estrada, James G. Krueger, Ana B. Pavel, Juan Ruano, Emma Guttman-YasskyAbstractBackgroundMolecular studies in atopic dermatitis (AD) are largely restricted to patients...
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Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth.Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth. BMC Cancer. 2020 Oct 01;20(1):941 Authors: Metz EP, Wuebben EL, Wilder PJ, Cox JL, Datta K, Coulter D, Rizzino A Abstract BACKGROUND: Quiescent tumor cells pose a major clinical challenge due to their ability...
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A stochastic model for error correction of kinetochore-microtubule attachments in budding yeast.: Related ArticlesA stochastic model for error correction of kinetochore-microtubule attachments in budding yeast.PLoS One. 2020;15(8):e0236293Authors: Banerjee A, Adames N, Peccoud J, Tyson JJAbstract To divide replicated chromosomes equally between daughter cells, kinetochores must attach to microtubules emanating from opposite poles of the mitotic spindle (biorientation). An error correction...
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Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer.: Related ArticlesInvestigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer.Sci Rep. 2019 03 26;9(1):5148Authors: Koosha S, Mohamed Z, Sinniah A, Alshawsh MAAbstract Diosmetin (Dis) is a bioflavonoid with cytotoxicity...
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Tumor penetrating peptide-functionalized Tenascin-C antibody for glioblastoma targeting.: Tumor penetrating peptide-functionalized Tenascin-C antibody for glioblastoma targeting.Curr Cancer Drug Targets. 2020 Oct 01;:Authors: Lingasamy P, Laarmann AH, Teesalu TAbstract BACKGROUND: Conjugation to clinical-grade tumor penetrating iRGD peptide is a widely used strategy to improve tumor homing, extravasation, and penetration of cancer drugs and tumor imaging agents. The C domain of extracellular...
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Dacryoendoscopic examination for location of internal orifice of congenital lacrimal fistula: A case series: Publication date: December 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 139Author(s): Shinjiro Kono, Patricia Ann L. Lee, Hirohiko Kakizaki, Yasuhiro TakahashiAbstractWe examined the location of the internal orifice of congenital lacrimal fistula using a dacryoendoscope in 5 patients. A suture inserted from the skin orifice and passing into the lacrimal drainage...
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Effect of a standardized fluoroscopic procedural approach on fluoroscopy time during infant modified barium swallow studies: Publication date: November 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 138Author(s): Patel Terral, Clemmens Clarice, Bradburn Kathryn, Michael Beckstrand, McGhee Heather, McKelvey Keeley, Simmons Cephus, Hill Jeanne, McGrattan Katlyn ElizabethAbstractBackgroundPediatric dysphagia is a term used to describe dysfunctional feeding and swallowing...
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The Role of Nutritional and Dietary Habits in Etiology in Pediatric Vocal Fold Nodule: Publication date: Available online 1 October 2020Source: Journal of VoiceAuthor(s): Müge Özçelik Korkmaz, Arzu TüzünerSummaryObjectivesIn pediatric pediatric vocal fold nodule (VFN) patients, different causes have been suggested in the development of the vocal cord nodule, including laryngopharyngeal reflux (LPR). It is known that the content of consumed foods, obesity, and other dietary behaviors are among the...
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Ramucirumab: A Review in Hepatocellular Carcinoma.: Related ArticlesRamucirumab: A Review in Hepatocellular Carcinoma.Drugs. 2020 Feb;80(3):315-322Authors: Syed YYAbstract Ramucirumab (Cyramza®), a fully human anti-VEGFR-2 monoclonal antibody, has been approved as monotherapy for the treatment of patients with hepatocellular carcinoma (HCC) and α-fetoprotein levels ≥ 400 ng/mL who have been treated with sorafenib. Ramucirumab significantly prolonged overall survival (OS) and progression-free...
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Short Bowel Syndrome in an Extremely Low Birth Weight Premature Infant with Wernicke Encephalopathy: A Case Report.: Short Bowel Syndrome in an Extremely Low Birth Weight Premature Infant with Wernicke Encephalopathy: A Case Report.Am J Case Rep. 2020 Oct 01;21:e924830Authors: Zhang Y, Zhou B, Wu L, Cao H, Xie G, Fang HAbstract BACKGROUND Short bowel syndrome in infants is relatively rare. It consists of malabsorption caused by a congenital short bowel or extensive resection of a large part...
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A 47-Year-Old Hispanic Man Who Developed Cutaneous Vasculitic Lesions and Gangrene of the Toes Following Admission to Hospital with COVID-19 Pneumonia.: A 47-Year-Old Hispanic Man Who Developed Cutaneous Vasculitic Lesions and Gangrene of the Toes Following Admission to Hospital with COVID-19 Pneumonia.Am J Case Rep. 2020 Oct 01;21:e926886Authors: Adekiigbe R, Ugbode F, Seoparson S, Katriyar N, Fetterman AAbstract BACKGROUND Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory...
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The addition of silver nitrate cautery to antiseptic nasal cream for patients with epistaxis: A systematic review and meta-analysis.: The addition of silver nitrate cautery to antiseptic nasal cream for patients with epistaxis: A systematic review and meta-analysis.Int J Pediatr Otorhinolaryngol. 2020 Sep 08;138:110365Authors: Alsaif A, Karam M, Alhaider A, Almazeedi A, Aldubaikhi A, Alfayez AAbstract OBJECTIVE: To compare the outcomes of the addition of silver nitrate cautery versus antiseptic...
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Application of a novel straight leg raise test during high‐resolution manometry can predict esophageal contractile reserve in patients with gastroesophageal reflux disease: This study utilized HRM to investigate if water swallows during SLR can mimic contraction reserve seen with MRS. SLR not only increases esophageal body contractile vigor but also reduces swallows with peristaltic breaks. The result provides evidence that using SLR maneuver, findings similar to MRS can be obtained in patients...
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Cytology‐based screening for anal intraepithelial neoplasia in women with a history of cervical intraepithelial neoplasia or cancer: BackgroundHigh‐risk human papillomavirus (HPV) has been identified in the pathogenesis of anal cancer. The purpose of this study was to assess the prevalence of abnormal anal cytology and HPV in women aged ≥40 years who have a history of high‐grade cervical squamous intraepithelial lesion (SIL) or cancer and to estimate the prevalence of anal intraepithelial neoplasia...
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Evaluation of circulating tumor cell clusters for pan‐cancer noninvasive diagnostic triaging: BackgroundHistopathologic examination (HPE) of tumor tissue obtained by invasive biopsy is the standard for cancer diagnosis but is resource‐intensive and has been associated with procedural risks. The authors demonstrate that immunocytochemistry (ICC) profiling of circulating ensembles of tumor‐associated cells (C‐ETACs) can noninvasively provide diagnostic guidance in solid organ cancers.MethodsThe clinical...
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Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma: AbstractOral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. However, the molecular mechanism underlying its development and progression is yet unclear. Genes that are differentially expressed, that is, differentially expressed genes (DEGs), between normal and diseased tissues are believed to be involved in disease development and progression....
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Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites: AbstractIt is well established that different sites in healthy human skin are colonized by distinct microbial communities due to different physiological conditions. However, few studies have explored microbial heterogeneity between skin sites in diseased skin, such as atopic dermatitis (AD) lesions. To address this issue, we carried out deep analysis of the microbiome and transcriptome in the skin...
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EWSR1‐CREM fusion in pulmonary mesenchymal neoplasm showing distinctive clear cell morphology: EWSR1‐CREM gene fusions were recently discovered in several mesenchymal and epithelial tumors, including myxoid mesenchymal tumors of the central nervous system, rare cases of soft tissue clear cell sarcoma and angiomatoid fibrous histiocytoma, and hyalinizing clear cell carcinoma, which implicates the potential phenotypic diversities of tumors harboring an EWSR1‐CREM fusion. We herein present an exceedingly...
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Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer CellsTechnology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. cAMP response element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2), a member of the novel CRTC family of transcriptional coactivators that activates basic leucine zipper transcription factors, including CREB, is overexpressed in many carcinomas, including...
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MicroRNA-663 Regulates Melanoma Progression by Inhibiting FHL3: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. microRNA-663a (miR-663a) was reported to be highly expressed in cancers. However, its roles in melanoma progression remain unclear. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was conducted to measure miR-663a expression level in melanoma cell lines and normal cells. Cell counting kit-8 assay, wound-healing assay, and transwell...
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A Potential Tumor Suppressor Gene Named miR-508-5p Inhibited the Proliferation and Invasion of Human Melanoma Cells by Targeting KIT: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Melanoma is the main death cause of human skin cancer. Increasing evidences demonstrate that microRNAs act as key roles in mediating tumor occurrence and progression. MiR-508-5p has proved to participate in the development of various types of human malignancies. However, the role...
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Effectiveness and safety of lomitapide in a patient with familial chylomicronemia syndrome: AbstractBackgroundFamilial chylomicronemia syndrome (FCS) is characterized by severe fasting hypertriglyceridemia, abdominal pain, and recurrent acute pancreatitis. Available triglyceride-lowering drugs are insufficient to avoid pancreatitis. Therefore, there is a significant unmet medical need for effective triglyceride-lowering drugs for patients with FCS. Case reportWe report the second...
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Retrospective analysis of the ultrasound features of resected thyroid nodules: AbstractPurposeSeveral ultrasound (US) risk stratification systems (US-RSSs) have been proposed to stratify the risk of malignancy (ROM) of thyroid nodules. This risk might be overestimated due to selection bias and comparison with the cytological report alone. Our study aimed to compare ROM and diagnostic performance of three guidelines (ATA, AACE/ACE/AME, EUTIRADS) and evaluate the changes in unnecessary biopsy according...
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Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial DesignTAS-119 is a novel orally active, selective inhibitor of Aurora kinase A identified as a clinical candidate for efficacy testing in combination with taxanes. In vitro, TAS-119 enhanced cell growth inhibition of paclitaxel in multiple human cancer cell lines derived from various tissues, including paclitaxel-resistant cell lines. Interestingly,...
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Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design: TAS-119 is a novel orally active, selective inhibitor of Aurora kinase A identified as a clinical candidate for efficacy testing in combination with taxanes. In vitro, TAS-119 enhanced cell growth inhibition of paclitaxel in multiple human cancer cell lines derived from various tissues, including paclitaxel-resistant cell lines. Interestingly,...
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Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo: The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging agents. We have discovered a novel chemical series that potently and selectively inhibits USP7 in biochemical and cellular assays. Our inhibitors...
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Ion Channels and Their Role in the Pathophysiology of Gliomas: Malignant gliomas are the most common primary central nervous system tumors and their prognosis is very poor. In recent years, ion channels have been demonstrated to play important roles in tumor pathophysiology such as regulation of gene expression, cell migration, and cell proliferation. In this review, we summarize the current knowledge on the role of ion channels on the development and progression of gliomas. Cell volume changes through...
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Random survival forest to predict transplant-eligible newly diagnosed multiple myeloma outcome including FDG-PET radiomics: a combined analysis of two independent prospective European trials: AbstractPurposeFluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is included in the International Myeloma Working Group (IMWG) imaging guidelines for the work-up at diagnosis and the follow-up of multiple myeloma (MM) notably because it is a reliable tool as a predictor of prognosis....
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Thermo‐Mechanical Fractional Injury Enhances Skin Surface‐ and Epidermis‐ Protoporphyrin IX Fluorescence: Comparison of 5‐Aminolevulinic Acid in Cream and Gel Vehicles: Background and ObjectivesThermo‐mechanical fractional injury (TMFI) impacts the skin barrier and may increase cutaneous drug uptake. This study investigated the potential of TMFI in combination with 5‐aminolevulinic acid (ALA) cream and gel formulations to enhance Protoporphyrin IX (PpIX) fluorescence at the skin surface and in the...
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NanomaterialsNanomaterials, Vol. 10, Pages 1968: Impact of SiO2 Particles in Polyethylene Textile Membrane for Indoor Personal HeatingNanomaterials, Vol. 10, Pages 1968: Impact of SiO2 Particles in Polyethylene Textile Membrane for Indoor Personal Heating Nanomaterials doi: 10.3390/nano10101968 Authors: Boutghatin Assaf Pennec Carette Thomy Akjouj Djafari Rouhani Keeping the human body in a thermal comfort state inside a room has become a challenge in recent years. While the most common strategy...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 7304: A Perspective on Therapeutic Pan-Resistance in Metastatic CancerIJMS, Vol. 21, Pages 7304: A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21197304 Authors: Dimitrios Korentzelos Amanda M. Clark Alan Wells Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse...
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FoodsFoods, Vol. 9, Pages 1402: Peptide–Mineral Complexes: Understanding Their Chemical Interactions, Bioavailability, and Potential Application in Mitigating Micronutrient DeficiencyFoods, Vol. 9, Pages 1402: Peptide–Mineral Complexes: Understanding Their Chemical Interactions, Bioavailability, and Potential Application in Mitigating Micronutrient Deficiency Foods doi: 10.3390/foods9101402 Authors: Xiaohong Sun Roghayeh Amini Sarteshnizi Ruth T. Boachie Ogadimma D. Okagu Raliat O. Abioye Renata...
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AntibioticsAntibiotics, Vol. 9, Pages 672: Is Early Monitoring Better? Impact of Early Vancomycin Exposure on Treatment Outcomes and Nephrotoxicity in Patients with Methicillin-Resistant Staphylococcus aureus InfectionsAntibiotics, Vol. 9, Pages 672: Is Early Monitoring Better? Impact of Early Vancomycin Exposure on Treatment Outcomes and Nephrotoxicity in Patients with Methicillin-Resistant Staphylococcus aureus Infections Antibiotics doi: 10.3390/antibiotics9100672 Authors: Thanawat Chattaweelarp...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,