Biomedicines, Vol. 8, Pages 250: Highlighting Huma...
Biomedicines, Vol. 8, Pages 250: Highlighting Human Enzymes Active in Different Metabolic Pathways and Diseases: The Case Study of EC 1.2.3.1 and EC 2.3.1.9Biomedicines, Vol. 8, Pages 250: Highlighting Human Enzymes Active in Different Metabolic Pathways and Diseases: The Case Study of EC 1.2.3.1 and EC 2.3.1.9 Biomedicines doi: 10.3390/biomedicines8080250 Authors: Giulia Babbi Davide Baldazzi Castrense Savojardo Martelli Pier Luigi Rita Casadio Enzymes are key proteins performing the basic functional...
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Clinical AnatomyThe overlooked reproductive function of the human clitoris‐ the news media responses to the published reviewA brief survey of how the news media reported and misreported on the publication of the review that revealed the overlooked empirical evidence for the reproductive function of the human clitoris. This article is protected by copyright. All rights reserved.Clinical AnatomyMon Jul 27, 2020 13:14Mark above section as read Case Reports in OphthalmologyA Case of Pediatric Cyanoacrylate...
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Behavioural Brain ResearchNeuropharmacological assessment in mice and molecular docking of piperazine derivative LQFM212Publication date: Available online 28 July 2020Source: Behavioural Brain ResearchAuthor(s): Lorrane Kelle da Silva Moreira, Adriane Ferreira de Brito, Crisciele Fontana, Flávio Souza de Carvalho, Germán Sanz, Boniek Gontijo Vaz, Luciano Morais Lião, Fábio Fagundes da Rocha, Hugo Verli, Ricardo Menegatti, Elson Alves CostaBehavioural Brain ResearchTue Jul 28, 2020 14:53Mark above...
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SAGE Publications Inc: Technology in Cancer Research & Treatment: Table of ContentsEvaluation of Delta4DVH Anatomy in 3D Patient-Specific IMRT Quality AssuranceTechnology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Purpose:To evaluate the performance of Delta4DVH Anatomy in patient-specific intensity-modulated radiotherapy quality assurance.Materials and Methods:Dose comparisons were performed between Anatomy doses calculated with treatment plan dose measured...
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Dysphagia - RehabilitationFunctional Outcomes of the Hyaluronic Acid Injections in Patients Who Underwent Partial Laryngectomy.Related Articles Functional Outcomes of the Hyaluronic Acid Injections in Patients Who Underwent Partial Laryngectomy. J Voice. 2020 Jul 22;: Authors: Alaskarov E, Öztürk Ö, Batıoğlu-Karaaltın A, Gülmez ZD, Erdur ZB, İnan HC Abstract OBJECTIVE: The purpose of this study was to investigate the effects of hyaluronic acid injection on dysphagia, aspiration, and voice problems...
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Oral and Maxillofacial SurgeryHealing at implants installed from ~ 70- to < 10-Ncm insertion torques: an experimental study in dogsAbstract Objective To evaluate histologically the early healing at implants installed with different insertion torques Material and methods Three months after the extraction of the mandibular premolars and of the first molars, two implants were installed monolaterally in the premolar and two in the molar regions of the edentulous alveolar ridge of...Oral and Maxillofacial...
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Hormon- und StoffwechselforschungEndogenous NUCB2/Nesfatin-1 Regulates Energy Homeostasis Under Physiological Conditions in Male RatsHorm Metab ResDOI: 10.1055/a-1196-2059Nesfatin-1 is the proteolytic cleavage product of Nucleobindin 2, which is expressed both in a number of brain nuclei (e. g., the paraventricular nucleus of the hypothalamus) and peripheral tissues. While Nucleobindin 2 acts as a calcium binding protein, nesfatin-1 was shown to affect energy homeostasis upon central nervous administration...
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Folia Phoniatrica et LogopaedicaIntroduction of the Objective Structured Clinical Examination in Speech and Language Therapy Education: Student PerspectivesBackground/Aims: The Objective Structured Clinical Examination (OSCE) has an established history of assessing clinical competence for medical and allied healthcare professionals. No research has investigated the use of the OSCE within speech and language therapy undergraduate education. This study aimed to evaluate undergraduate speech and language...
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Clinical Oral Implants ResearchPlatform switching in two‐implant bar‐retained mandibular overdentures: 1‐year results from a split‐mouth randomized controlled clinical trial.Abstract Objectives The concept of platform switching is widely applied in current implant dentistry, however, the influence on peri‐implant bone level alterations (ΔIBL), especially in the field of implant overdentures (IODs), remains inconclusive. Therefore, the present study aimed to test the alternative hypothesis that there...
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Biomedicine & PharmacotherapySolving the crisis in psychopharmacological research: Cellular-membrane(s) pharmacology to the rescue?Publication date: October 2020Source: Biomedicine & Pharmacotherapy, Volume 130Author(s): B. Drukarch, G.E. Jacobs, M.M.M. WilhelmusBiomedicine & PharmacotherapyTue Jul 28, 2020 13:29Effects of total saponins from <em>Panacis majoris</em> Rhizoma and its degradation products on myocardial ischemia-reperfusion injury in ratsPublication date: October...
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European Journal of NeuroscienceAn insula‐driven network computes decision uncertainty and promotes abstinence in chronic cocaine usersAbstract The anterior insular cortex (AIC) and its interconnected brain regions have been associated with both addiction and decision‐making under uncertainty. However, the causal interactions in this uncertainty‐encoding neurocircuitry and how these neural dynamics impact relapse remain elusive. Here, we used model‐based fMRI to measure choice uncertainty in a motor...
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pubmed: her2-positive breast...Factors Associated with Pathological Node Negativity in Inflammatory Breast Cancer: Are There Patients Who May be Candidates for a De-Escalation of Axillary Surgery?Related Articles Factors Associated with Pathological Node Negativity in Inflammatory Breast Cancer: Are There Patients Who May be Candidates for a De-Escalation of Axillary Surgery? Ann Surg Oncol. 2020 Jul 24;: Authors: Postlewait LM, Teshome M, DeSnyder SM, Lim B, Kuerer HM, Bedrosian I, Woodward WA,...
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pubmed: cell cycle arrestp19INK4d inhibits proliferation and enhances imatinib efficacy through BCR-ABL signaling pathway in chronic myeloid leukemia.Related Articles p19INK4d inhibits proliferation and enhances imatinib efficacy through BCR-ABL signaling pathway in chronic myeloid leukemia. Blood Cells Mol Dis. 2020 Jul 14;85:102477 Authors: Kuang Y, Han X, Cao P, Xiong D, Peng Y, Liu Z, Xu Z, Liang L, Roy M, Liu J, Nie L, Zhang J Abstract Chronic myeloid leukemia (CML) is a kind of myeloproliferative...
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pubmed: "world neurosurg"[jo...Microsurgical Techniques for Exposing the Internal Maxillary Artery in Cerebral Revascularization Surgery: A Comparative Cadaver Study.Related Articles Microsurgical Techniques for Exposing the Internal Maxillary Artery in Cerebral Revascularization Surgery: A Comparative Cadaver Study. World Neurosurg. 2020 Jul 23;: Authors: Li X, Orscelik A, Vigo V, Kola O, El-Sayed IH, Abla AA, Rubio RR Abstract BACKGROUND: The internal maxillary artery (IMAX) is currently considered...
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OncologyAssociation between male infertility and male-specific malignancies: systematic review and meta-analysis of population-based retrospective cohort studies.Related Articles Association between male infertility and male-specific malignancies: systematic review and meta-analysis of population-based retrospective cohort studies. Fertil Steril. 2020 Jul 21;: Authors: Del Giudice F, Kasman AM, De Berardinis E, Busetto GM, Belladelli F, Eisenberg ML Abstract OBJECTIVE: To investigate the current...
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leak of cerebrospinal fluidCollagen Matrix With Mucoperiosteum Graft as an Effective Fatless Flapless Reconstruction After Endoscopic Pituitary Adenoma Resection.Related Articles Collagen Matrix With Mucoperiosteum Graft as an Effective Fatless Flapless Reconstruction After Endoscopic Pituitary Adenoma Resection. Oper Neurosurg (Hagerstown). 2020 Jul 25;: Authors: Shahein M, Montaser AS, Barbero JMR, Maza G, Todeschini AB, Otto BA, Carrau RL, Prevedello DM Abstract BACKGROUND: Proper skull base...
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Journal of visualized experiments : JoVE,http://www.jove.com/Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix.Related Articles Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix. J Vis Exp. 2020 Jul 10;(161): Authors: Bulusu KV, Racan S, Plesniak MW Abstract The silver carp, Hypophthalmichthys molitrix, is an invasive planktivorous filter feeder fish that infested the natural waterways of the upper...
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anesth pain medSome thoughts on the importance of volume in peripheral nerve blockade.Related Articles Some thoughts on the importance of volume in peripheral nerve blockade. Reg Anesth Pain Med. 2020 Jul 26;: Authors: Orebaugh S PMID: 32713833 [PubMed - as supplied by publisher]anesth pain medTue Jul 28, 2020 14:24Mark above section as read Asian Pacific Organization for Cancer Prevention"Asian Pac J Cancer Prev"[jour]; +41 new citations41 new pubmed citations were retrieved for your search. Click...
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Experimental PhysiologyC‐Kit+ progenitors restore rat asthmatic lung function by modulation of T‐bet and GATA‐3 expressionAbstract The current experiment aims to highlight the regenerative capacity of bone marrow c‐kit positive cells in the restoration of asthmatic pulmonary function in the rat model. Data showed that these cells were successfully recruited to the asthmatic niche after intra‐tracheal administration and accelerate the regeneration of asthmatic lungs by the modulation of inflammation...
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Optimal inaccuracy: estimating male fitness in the movement-assisted dichogamous species Clerodendrum infortunatum [NEW RESULTS]In hermaphroditic species, sexual interference can drive the evolution of dichogamy, where sporophylls (reproductive parts) are separated in time. However, the separation of sporophylls can lead to pollination inaccuracy, especially in movement-assisted dichogamy, where sporophylls alter their position over time. Is pollination inaccuracy minimised by the second sporophyll...
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Teledermatology in the times of COVID‐19 – a systematic reviewSummary The COVID‐19 pandemic restricts the care of dermatological patients in many ways. Teledermatology such as video consultation or "store‐and‐forward" teledermatology could at least partly compensate for this. This systematic review summarizes all published studies on teledermatology during the COVID‐19 pandemic. It is based on a MEDLINE search for articles from 2020 in English and German. Two surveys among dermatologists from the...
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Role of music therapy in reducing the burden of dermatological diseases during COVID‐19Wiley: Dermatologic Therapy: Table of ContentsTue Jul 28, 2020 11:29Comments on ,,Does COVID ‐19 influence sexual behaviours?"Wiley: Dermatologic Therapy: Table of ContentsTue Jul 28, 2020 11:27Electrochemotherapy, a Local Treatment for Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis BullosaABSTRACT Epidermolysis Bullosa (EB) is a rare group of diseases caused by genetic variants in...
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Study on improvement of chiral separation of capillary electrophoresis based on cyclodextrin by deep eutectic solventsPublication date: 1 December 2020Source: Talanta, Volume 220Author(s): Suya Deng, Jingmiao Pan, Min Wang, Yike Huang, Zhining XiaScienceDirect Publication: TalantaTue Jul 28, 2020 14:49Inflammatory biomarker detection in milk using label-free porous SiO<sub>2</sub> interferometerPublication date: 1 December 2020Source: Talanta, Volume 220Author(s): D. Nanda Kumar, Nofar...
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Adult T-cell leukaemia/lymphoma in Brazil: A rare disease or rarely diagnosed?Related Articles Adult T-cell leukaemia/lymphoma in Brazil: A rare disease or rarely diagnosed? Br J Haematol. 2020 02;188(4):e46-e49 Authors: Rosadas C, Puccioni-Sohler M, Oliveira ACP, Casseb J, Sousa M, Taylor GP PMID: 31743423 [PubMed - indexed for MEDLINE]Rare CancersTue Jul 28, 2020 13:36Imaging of DICER1 syndrome.Related Articles Imaging of DICER1 syndrome. Pediatr Radiol. 2019 10;49(11):1488-1505 Authors: Guillerman...
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Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2.Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 Jul 24;: Authors: DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP,...
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[ASAP] A Bioorthogonal Small Molecule Selective Polymeric "Clickase"Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06553Journal of the American Chemical Society: Latest Articles (ACS Publications)Tue Jul 28, 2020 07:00[ASAP] Electronic Structures of Rhenium(II) ß-Diketiminates Probed by EPR Spectroscopy: Direct Comparison of an Acceptor-Free Complex to Its Dinitrogen, Isocyanide, and Carbon Monoxide AdductsJournal of the American Chemical SocietyDOI: 10.1021/jacs.0c04719Journal of the...
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Role of 5G-powered remote robotic ultrasound during the COVID-19 outbreak: insights from two casesThe 2019 Novel Coronavirus disease (COVID-19) broke out in Wuhan, China in December 2019 and spread throughout the world. Early screening and early diagnosis play key roles in prevention and management of the epidemic. Attention should also be paid to the infection of health workers and shortage of medical resources in high-risk areas. Here, we report two cases of patients diagnosed with COVID-19 and...
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Ferromagnetically Coupled S = 1 Chains in Crystals of Verdazyl‐Nitronyl Nitroxide DiradicalsThermally stable organic diradicals with a triplet ground state along with large singlet‐triplet energy gap have significant potential for advanced technological applications. A series of phenylene‐bridged diradicals with oxoverdazyl and nitronyl nitroxide units were synthesized via a palladium‐catalyzed cross‐coupling reaction of the corresponding iodoverdazyls with a nitronyl nitroxide‐2‐ide gold(I) complex...
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Nature Communications - current - nature.com science feedsAerobic microbial life persists in oxic marine sediment as old as 101.5 million yearsNature Communications, Published online: 28 July 2020; doi:10.1038/s41467-020-17330-1The discovery of aerobic microbial communities in nutrient-poor sediments below the seafloor begs the question of the mechanisms for their persistence. Here the authors investigate subseafloor sediment in the South Pacific Gyre abyssal plain, showing that aerobic microbial...
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ClinicalTrialsA Study of Pembrolizumab (MK-3475) Plus Carboplatin and Paclitaxel as First-line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (MK-3475-B10/KEYNOTE B10)Condition: Squamous Cell Carcinoma of Head and NeckInterventions: Drug: Pembrolizumab; Drug: Carboplatin; Drug: PaclitaxelSponsor: Merck Sharp & Dohme Corp.Not yet recruitingClinicalTrialsTue Jul 28, 2020 14:52Study of Mucosal Sparing Adjuvant Radiotherapy After Surgical Exploration in HPV+ Head...
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Applied and Industrial MicrobiologyRecovery and maintenance of NESTIN expression in umbilical cord-MSC using a novel culture mediumMesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs are well known by their feature of self-renewal and their differentiation potential. NESTIN is a cytoskeletal pr...Applied and Industrial MicrobiologyTue Jul 28, 2020 03:00Mark above section as read Medical Mycology Case ReportsSuccessful management of cutaneous paralagenidiosis...
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Clinical ImagingCoexistence of radiation-induced glioma and acute pontine infarct 40 years after radiotherapy for glioma: A case reportPublication date: Available online 28 July 2020Source: Clinical ImagingAuthor(s): Isa Cam, Mehmet Gencturk, Alexander M. MckınneyClinical ImagingTue Jul 28, 2020 15:04Pneumatized middle ear ossicle – A normal variantPublication date: Available online 28 July 2020Source: Clinical ImagingAuthor(s): Alok A. Bhatt, Amit Desai, Sukhwinder J.S. Sandhu, Prasanna VibhuteClinical...
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1Clin Epigenetics. 2019 Nov 20;11(1):161. doi: 10.1186/s13148-019-0752-8.Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanomaTobias A W Holderried 1, Luka de Vos 2, Emma Grace Bawden 3 4 5, Timo J Vogt 2, Joern Dietrich 2, Romina Zarbl 2, Friedrich Bootz 2, Glen Kristiansen 6, Peter Brossart 1, Jennifer Landsberg 7, Dimo Dietrich 8Affiliations expandPMID: 31747929 PMCID: PMC6868848 DOI: 10.1186/s13148-019-0752-8Free PMC articleAbstractBackground:...
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American Goiter AssociationInternational histopathology consensus for unilateral primary aldosteronism.International histopathology consensus for unilateral primary aldosteronism. J Clin Endocrinol Metab. 2020 Jul 27;: Authors: Williams TA, Gomez-Sanchez CE, Rainey WE, Giordano TJ, Lam AK, Marker A, Mete O, Yamazaki Y, Zerbini MCN, Beuschlein F, Satoh F, Burrello J, Schneider H, Lenders JWM, Mulatero P, Castellano I, Knösel T, Papotti M, Saeger W, Sasano H, Reincke M Abstract OBJECTIVE: Develop...
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CancerAssociation between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response after neoadjuvant chemoradiotherapy and resectionBritish Journal of Cancer, Published online: 29 July 2020; doi:10.1038/s41416-020-0989-1Association between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response after neoadjuvant chemoradiotherapy and resectionCancer03:00Association between adjuvant chemotherapy and survival...
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BioMed Research InternationalThe Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese PopulationObjective. To shed light on the association between hyperhomocysteinemia (HHcy) and thoracoabdominal aortic aneurysms (TAAAs). Methods. From July 2013 to March 2017, we conducted a matched case–control study involving individuals who presented to the Chinese People's Liberation Army General Hospital and underwent thoracoabdominal magnetic resonance angiography or computed...
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Analytical Chemistry[ASAP] Optimization of <italic toggle="yes">O-</italic>GIG for <italic toggle="yes">O</italic>-Glycopeptide Characterization with Sialic Acid Linkage DeterminationAnalytical ChemistryDOI: 10.1021/acs.analchem.0c01346Analytical ChemistryTue Jul 28, 2020 07:00[ASAP] Direct Determination of Pseudouridine in RNA by Mass Spectrometry Coupled with Stable Isotope LabelingAnalytical ChemistryDOI: 10.1021/acs.analchem.0c02122Analytical ChemistryTue Jul 28, 2020...
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ALCOHOL; +238 new citations238 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/07/28PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.AlcoholTue Jul 28, 2020 17:03Mark above section as read Alcohol...
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Pathogens, Vol. 9, Pages 617: Ivermectin Treatment Response in Onchocerca Volvulus Infected Persons with Epilepsy: A Three-Country Short Cohort StudyPathogens, Vol. 9, Pages 617: Ivermectin Treatment Response in Onchocerca Volvulus Infected Persons with Epilepsy: A Three-Country Short Cohort Study Pathogens doi: 10.3390/pathogens9080617 Authors: Alfred Dusabimana Dan Bhwana Stephen Raimon Bruno P. Mmbando An Hotterbeekx Floribert Tepage Michel Mandro Joseph N. Siewe Fodjo Steven Abrams Robert Colebunders...
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Nutrients, Vol. 12, Pages 2254: A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy HumansNutrients, Vol. 12, Pages 2254: A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical Beverages in Young, Healthy Humans Nutrients doi: 10.3390/nu12082254 Authors: Philippa A. Jackson Emma L. Wightman Rachel Veasey Joanne Forster Julie Khan Caroline...
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Molecules, Vol. 25, Pages 3424: The Secret Lives of Fluorescent Membrane Probes as Revealed by Molecular Dynamics SimulationsMolecules, Vol. 25, Pages 3424: The Secret Lives of Fluorescent Membrane Probes as Revealed by Molecular Dynamics Simulations Molecules doi: 10.3390/molecules25153424 Authors: Hugo A. L. Filipe Maria João Moreno Luís M. S. Loura Fluorescent probes have been employed for more than half a century to study the structure and dynamics of model and biological membranes, using spectroscopic...
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Journal of Clinical MedicineJCM, Vol. 9, Pages 2410: High Effectiveness of a 14-Day Concomitant Therapy for Helicobacter pylori Treatment in Primary Care. An Observational Multicenter StudyJCM, Vol. 9, Pages 2410: High Effectiveness of a 14-Day Concomitant Therapy for Helicobacter pylori Treatment in Primary Care. An Observational Multicenter Study Journal of Clinical Medicine doi: 10.3390/jcm9082410 Authors: Llum Olmedo Rafael Azagra Amada Aguyé Marta Pascual Xavier Calvet Emili Gené Background:...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 5371: The Flavoproteome of the Model Plant Arabidopsis thalianaIJMS, Vol. 21, Pages 5371: The Flavoproteome of the Model Plant Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21155371 Authors: Patrick Schall Lucas Marutschke Bernhard Grimm Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential cofactors for enzymes, which catalyze a broad spectrum of vital reactions. This paper...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 5446: Assessing the Anthropometric Profile of Spanish Elite Reserve Soccer Players by Playing Position over a DecadeIJERPH, Vol. 17, Pages 5446: Assessing the Anthropometric Profile of Spanish Elite Reserve Soccer Players by Playing Position over a Decade International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17155446 Authors: Jon Manuel Vega Asier Gonzalez-Artetxe Jon Ander Aguinaco...
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Cancers, Vol. 12, Pages 2093: Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt?Cancers, Vol. 12, Pages 2093: Head and Neck Cancer Metastasis and the Effect of the Local Soluble Factors, from the Microenvironment, on Signalling Pathways: Is It All about the Akt? Cancers doi: 10.3390/cancers12082093 Authors: Hanan Ahmed Arpa Ghoshal Sarah Jones Ian Ellis Mohammad Islam The signalling pathways involved...
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Antibiotics, Vol. 9, Pages 455: From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine BacteriaAntibiotics, Vol. 9, Pages 455: From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria Antibiotics doi: 10.3390/antibiotics9080455 Authors: José Diogo Santos Inês Vitorino Fernando Reyes Francisca Vicente Olga Maria Lage Oceans cover seventy percent of the planet's surface and besides being an immense reservoir of biological life, they serve as vital...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,