Molecules, Vol. 25, Pages 2151: Infusions of Herbal Blends as Promising Sources of Phenolic Compounds and Bioactive PropertiesMolecules, Vol. 25, Pages 2151: Infusions of Herbal Blends as Promising Sources of Phenolic Compounds and Bioactive Properties Molecules doi: 10.3390/molecules25092151 Authors: Finimundy Pereira Dias Caleja Calhelha Sokovic Stojković Carvalho Rosa Barros Ferreira Several plants have been used for medicinal applications and have been traditionally consumed as decoctions and...
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Journal of Clinical Medicine,JCM, Vol. 9, Pages 1348: Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral RegurgitationJCM, Vol. 9, Pages 1348: Functional Role of Natriuretic Peptides in Risk Assessment and Prognosis of Patients with Mitral Regurgitation Journal of Clinical Medicine doi: 10.3390/jcm9051348 Authors: Giovanna Gallo Maurizio Forte Rosita Stanzione Maria Cotugno Franca Bianchi Simona Marchitti Andrea Berni Massimo Volpe Speranza Rubattu The...
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International Journal of Molecular Sciences,IJMS, Vol. 21, Pages 3258: Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer CellsIJMS, Vol. 21, Pages 3258: Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21093258 Authors: Min Jung Kim Jong Rip Choi Nara Tae Tae Min Wi Kristine M. Kim Dae Hee Kim Eung Suk Lee Mucin1...
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Humanities, Vol. 9, Pages 39: Consuming Desire in Under the Skin: Humanities, Vol. 9, Pages 39: Consuming Desire in Under the SkinHumanities doi: 10.3390/h9020039Authors: Yael Maurer Jonathan Glazer's 2013 film Under the Skin is a Gothicized science fictional narrative about sexuality, alterity and the limits of humanity. The film's protagonist, an alien female, passing for an attractive human, seduces unwary Scottish males, leading them to a slimy, underwater/womblike confinement where their bodies...
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Cells, Vol. 9, Pages 1132: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal RecyclingCells, Vol. 9, Pages 1132: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling Cells doi: 10.3390/cells9051132 Authors: Xiaolong Wang Meiqian Weng Yuting Ke Ellen Sapp Marian DiFiglia Xueyi Li Coordinated actions of Rab and Rho are necessary for numerous essential cellular processes ranging from vesicle budding to whole cell movement. How Rab and Rho are choreographed is poorly...
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Diagnostics, Vol. 10, Pages 278: Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children: Diagnostics, Vol. 10, Pages 278: Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in ChildrenDiagnostics doi: 10.3390/diagnostics10050278Authors: Alina Grama Lucia Burac Cornel Olimpiu Aldea Bogdan Bulata Dan Delean Gabriel Samasca Carmen Abrudan Claudia Sirbe Tudor Lucian Pop This study aimed to analyse vitamin d-binding protein (Gc-globulin) serum levels in...
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Biomolecules, Vol. 10, Pages 714: Phage Display Selection, Identification, and Characterization of Novel Pancreatic Cancer Targeting PeptidesBiomolecules, Vol. 10, Pages 714: Phage Display Selection, Identification, and Characterization of Novel Pancreatic Cancer Targeting Peptides Biomolecules doi: 10.3390/biom10050714 Authors: Mallika C. Asar April Franco Mette Soendergaard Pancreatic cancer is characterized by a 5-year survival rate of 3%, in part due to inadequate detection methods. The small...
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Antioxidants, Vol. 9, Pages 379: Aralia continentalis kitagawa Extract Attenuates the Fatigue Induced by Exhaustive Exercise through Inhibition of Oxidative Stress: Antioxidants, Vol. 9, Pages 379: Aralia continentalis kitagawa Extract Attenuates the Fatigue Induced by Exhaustive Exercise through Inhibition of Oxidative StressAntioxidants doi: 10.3390/antiox9050379Authors: Yang Lee Adam Kim The present study aimed to evaluate the anti-fatigue effects of Aralia continentalis kitagawa (AC)...
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Biology, Vol. 9, Pages 95: 3-Iodothyronamine Affects Thermogenic Substrates' Mobilization in Brown Adipocytes: Biology, Vol. 9, Pages 95: 3-Iodothyronamine Affects Thermogenic Substrates' Mobilization in Brown AdipocytesBiology doi: 10.3390/biology9050095Authors: Manuela Gencarelli Annunziatina Laurino Elisa Landucci Daniela Buonvicino Costanza Mazzantini Grazia Chiellini Laura Raimondi We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown adipocytes...
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Antibiotics, Vol. 9, Pages 230: Urinary Pharmacokinetic and Pharmacodynamic Profiles of Fosfomycin against Extended-Spectrum β-Lactamase-Producing Escherichia coli with Canine Ex Vivo Modeling: A Pilot StudyAntibiotics, Vol. 9, Pages 230: Urinary Pharmacokinetic and Pharmacodynamic Profiles of Fosfomycin against Extended-Spectrum β-Lactamase-Producing Escherichia coli with Canine Ex Vivo Modeling: A Pilot Study Antibiotics doi: 10.3390/antibiotics9050230 Authors: Harada Shimizu Kawaguchi Furuhashi...
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pubmed: "world neurosurg"[jo...A Novel Risk Calculator for Suboccipital Decompression for Adult Chiari Malformation.Related ArticlesA Novel Risk Calculator for Suboccipital Decompression for Adult Chiari Malformation. World Neurosurg. 2020 Apr 29;: Authors: Feghali J, Marinaro E, Lubelski D, Luciano MG, Huang J Abstract BACKGROUND: Patient counselling and selection for surgical therapy in adult Chiari malformation type I (CM-1) remains debatable. We aimed to develop a clinical calculator predicting...
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A systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall.: Related ArticlesA systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall.Eur Arch Otorhinolaryngol. 2020 May 02;:Authors: De Virgilio A, Russo E, Costantino A, Malvezzi L, Colombo G, Cugini G, Miceli S, Rossi V, Spriano G, Mercante GAbstract OBJECTIVE: To perform a systematic review of the literature available...
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Use of viruses for interrogating viscera-specific projections in central nervous system: Publication date: Available online 3 May 2020Source: Journal of Neuroscience MethodsAuthor(s): Li Fan, Boqi Xiang, Jun Xiong, Zhigang He, Hongbing Xiang
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Journal of plastic, reconstructive & aesthetic surgery : JPRAS,A plastic surgery service response to COVID-19 in one of the largest teaching hospitals in Europe.Related ArticlesA plastic surgery service response to COVID-19 in one of the largest teaching hospitals in Europe. J Plast Reconstr Aesthet Surg. 2020 Apr 21;: Authors: Armstrong A, Jeevaratnam J, Murphy G, Pasha M, Tough A, Conway-Jones R, Mifsud RW, Tucker S Abstract COVID-19 is presenting a colossal challenge to frontline NHS staff....
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Academic Radiology,Impact of Age, Race, and Socioeconomic Status on Women's Perceptions and Preferences Regarding Communication of Estimated Breast Cancer RiskPublication date: Available online 4 May 2020Source: Academic RadiologyAuthor(s): N. Amornsiripanitch, S.M. Ameri, R.J. GoldbergAcademic RadiologyMon May 04, 2020 16:35Full Resolution Simulation for Evaluation of Critical Care Imaging Interpretation; Part 1: Fixed Effects Identify Influences of Exam, Specialty, Fatigue, and Training on Resident...
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ClinicalTrials,Enhanced Hood PPE to Minimize COVID-19 Transmission to Front-line Health Care WorkersCondition: Covid19Interventions: Device: current IPAC-UHN PPE; Device: modified IPAC-UHN PPESponsor: University Health Network, TorontoNot yet recruitingClinicalTrialsMon May 04, 2020 16:40Prevention of Oral DNA Damage by Black RaspberriesConditions: Oral Cancer; Smoking; DNA Damage; Oxidative StressIntervention: Dietary Supplement: BRB LozengesSponsors: Milton S. Hershey Medical Center;...
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Skull Base,Contributing factors for delayed postoperative cerebrospinal fluid leaks and suggested treatment algorithm.Related ArticlesContributing factors for delayed postoperative cerebrospinal fluid leaks and suggested treatment algorithm. Int Forum Allergy Rhinol. 2020 May 03;: Authors: London NR, Mohyeldin A, Montaser AS, Tanjararak K, Prevedello DM, Otto BA, Carrau RL Abstract BACKGROUND: Delayed postoperative cerebrospinal fluid (CSF) leaks are uncommon and largely unstudied complications....
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SMILR Aggravates the Progression of Atherosclerosis by Sponging miR-10b-3p to Regulate KLF5 Expression: Abstract Over the past few decades, long noncoding RNAs (lncRNAs) have been widely accepted to be involved in various diseases, and smooth muscle enriched long noncoding RNA (SMILR) was reported to participate in the proliferation of vascular smooth muscle cells (VSMCs). Nevertheless, the molecular mechanisms of SMILR in atherosclerosis (AS) have not been fully explored. In this study, VSMCs...
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ScienceDirect Publication: International Immunopharmacology,Venom components of the scorpion <em>Centruroides limpidus</em> modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometryPublication date: July 2020Source: International Immunopharmacology, Volume 84Author(s): Julián M. Cota-Arce, Daniela Zazueta-Favela, Fernando Díaz-Castillo, Samanta Jiménez, Johanna Bernáldez-Sarabia, Nadia L. Caram-Salas, Kee W.L. Dan, Galileo...
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Associating radioiodine therapy in hyperthyroidism with cancer mortality: robust or random results of a statistical analysis?: Related ArticlesAssociating radioiodine therapy in hyperthyroidism with cancer mortality: robust or random results of a statistical analysis?Hell J Nucl Med. 2020 Jan-Apr;23(1):94-95Authors: Iakovou I, Giannoula E, Chatzipavlidou V, Sachpekidis CAbstract Dear Editor, Recently, Kitahara et al. (2019) published an article in JAMA Internal Medicine entitled "Association...
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Psycho-Oncology,Relationship Between Cognitive Functioning, Mood, and Other Patient Factors on Quality of Life in Metastatic Brain CancerAbstract PURPOSE Neurocognitive functioning (NCF), mood disturbances, physical functioning, and social support all share a relationship with health‐related quality of life (HRQOL). However, investigations into these relationships have not been conducted in persons with brain metastases (BM). PATIENTS and METHODS Ninety‐three newly diagnosed persons with BM were...
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Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) in a Pediatric Patient: A Genetic Diagnosis: Publication date: Available online 4 May 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Neha Yakhmi, Alan P. Knutsen
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Distribution and Prognostic Significance of Estrogen Receptor α (ERα), Estrogen Receptor β (ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma: Purpose. The primary aim of this study was to determine the incidence of estrogen receptor α (ERα), estrogen receptor β (ERβ), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic...
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G3: Genes, Genomes, Genetics current issue,A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic MorphologyAnalysis of patient-derived DNA samples has identified hundreds of variants that are likely involved in neuropsychiatric diseases such as autism spectrum disorder (ASD) and schizophrenia (SCZ). While these studies couple behavioral phenotypes to individual genotypes, the number and diversity of candidate...
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Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor: Publication date: Available online 3 May 2020Source: Annals of Diagnostic PathologyAuthor(s): Bohuslava Vankova, Kristyna Behenska, Meret Bauer, Monika Sedivcova, Magdalena Daumova, Abbas Agaimy, Michal Michal, Ondrej Daum
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Sexual addiction, compulsivity, and impulsivity among a predominantly female sample of adults who use the internet for sex.: Related ArticlesSexual addiction, compulsivity, and impulsivity among a predominantly female sample of adults who use the internet for sex.J Behav Addict. 2020 Apr 01;9(1):83-92Authors: Levi G, Cohen C, Kaliche S, Sharaabi S, Cohen K, Tzur-Bitan D, Weinstein AAbstract Background and Aims: Compulsive sexual behavior is characterized by extensive sexual behavior and unsuccessful...
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Oculomotor Neurofibroma: A Different Histology Implying an Unsatisfying Clinical Outcome: Publication date: July 2020Source: World Neurosurgery, Volume 139Author(s): Fumihiro Matano, Paolo di Russo, Atsushi Okano, Thibault Passeri, Nicolas Penet, Arianna Fava, Breno Camara, Marc Polivka, Lorenzo Giammattei, Sébastien Froelich
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Prosthesis Survival Rates and Prosthetic Complications of Implant‐Supported Fixed Dental Prostheses in Partially Edentulous Patients: AbstractPurposeTo determine the prevalence and distribution of prosthetic complications affecting implant‐supported fixed dental prostheses (ISFDPs).Materials and MethodsSubjects previously treated with one or more ISFDP(s) were identified from an electronic health record search and recalled for comprehensive clinical examination. Past prosthesis failures and complications...
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Translucency, flexural strength, fracture toughness, fracture load of 3-unit FDPs, Martens hardness parameter and grain size of 3Y-TZP materials: Publication date: Available online 4 May 2020Source: Dental MaterialsAuthor(s): Nina Lümkemann, Regina Pfefferle, Eva Jerman, Beatrice Sener, Bogna Stawarczyk
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MRI surveillance following concurrent cochlear implantation in cases of vestibular schwannoma resection: Publication date: Available online 4 May 2020Source: American Journal of OtolaryngologyAuthor(s): Nofrat Schwartz, Meredith A. Rooth, Margaret T. Dillon, Brandan P. O'Connell, Matthew M. Dedmon, Benjamin Y. Huang, Kevin D. Brown
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Detection and Prognosis of Prostate Cancer Using Blood-Based Biomarkers: Prostate cancer (PCa) is second only to lung cancer as a cause of death. Clinical assessment of patients and treatment efficiency therefore depend on the disease being diagnosed as early as possible. However, due to issues regarding the use of prostate-specific antigen (PSA) for screening purposes, PCa management is among the most contentious of healthcare matters. PSA screening is problematic primarily because of diagnosis...
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Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone: AbstractPurposeThis study aimed to explore the genetic alterations and to identify good responders in the experimental arm in the tumor samples from newly diagnosed glioblastoma (GBM) patients enrolled in JCOG0911; a randomized phase II trial was conducted to compare the efficacy of interferonβ (IFNβ) plus temozolomide (TMZ) with that of TMZ alone.ExperimentaldesignOf...
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Nicotinamide N‐methyltransferase decreases 5‐fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect: AbstractEsophageal squamous cell carcinoma (ESCC) is a common malignant tumor with poor prognosis. And different individuals respond to the same drug differently. Increasing evidence has confirmed that metabolism reprogramming was involved in the drug sensitivity of tumor cells. However, the potential molecular mechanism...
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Ear and Hearing - Published Ahead-of-Print,Response to Letter to the Editor: Do Pediatric Cochlear Implant Recipients Display Domain-General Sequencing Difficulties? A Comment on Davidson et al. (2019)No abstract availableEar and Hearing - Published Ahead-of-PrintThu Apr 30, 2020 03:00Letter to the Editor: Do Pediatric Cochlear Implant Recipients Display Domain-General Sequencing Difficulties? A Comment on Davidson et al. (2019)No abstract availableEar and Hearing - Published Ahead-of-PrintThu Apr...
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Salivary Tumor Necrosis Factor‐alpha to detect the Severity of Erectile Dysfunction: A Randomized Clinical Trial: AbstractAimThis study aimed to provide evidence on the impact of chronic periodontitis (CP) on the severity of erectile dysfunction (ED) through the assessment of the salivary level of tumor necrosis factor‐alpha (TNF‐α).Methods140 patients with chronic periodontitis and erectile dysfunction were enrolled in this study then randomly allocated to the control group (70 participants received...
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Classification overview1. Orofacial pain associated with disorders of dentoalveolar and associated structures1.1 Dental pain1.1.1 Pulpal pain1.1.1.1. Pulpal pain attributed to hypersensitivity1.1.1.1.1 Pulpal pain attributed to a crack in the enamel1.1.1.1.2 Pulpal pain attributed to exposed dentin1.1.1.1.2.1 Pulpal pain attributed to tooth wear or abrasion1.1.1.1.2.2 Pulpal pain attributed to fracture resulting in exposed dentin1.1.1.1.2.3 Pulpal pain attributed to developmental dental hard tissue...
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Angewandte Chemie International Edition,Magnetically Induced Alignment of Natural Products for Stereochemical Structure Determination via NMRAnisotropic NMR has gained increasing popularity to determine the structure and specifically the configuration of small flexible, non‐crystallizable molecules. However, it suffers from the necessity to dissolve the analyte in special media such as liquid crystals or polymer gels. Generally, small degrees of alignment are also caused by an anisotropic magnetic...
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Robotic‐assisted transmaxillary approach for removal of juvenile nasopharyngeal angiofibroma of the pterygopalatine and infratemporal fossa: AbstractEndoscopic transmaxillary approaches to remove juvenile nasopharyngeal angiofibromas (JNAs) have been described previously and are used for tumors that extend laterally in the pterygopalatine fossa (PPF) and infratemporal fossa (ITF). There is no previous description of robotic‐assisted JNA removal in the literature. The video will demonstrate the success...
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The Laryngoscope,Nasal Airflow Changes With Bioabsorbable Implant, Butterfly, and Spreader GraftsObjectives/Hypothesis Internal nasal valve compromise is a major cause of nasal obstruction, with a growing number of ways to treat this condition. In this study, we compared the effects of butterfly graft, spreader graft, and the bioabsorbable nasal implant on nasal airflow resistance. Study Design Cadaver study. Methods Computational fluid dynamics (CFD) simulations were completed from nine preoperative...
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Mucosal Immunology - Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formationMucosal Immunology, Published online: 04 May 2020; doi:10.1038/s41385-020-0290-xSingle cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formationMucosal Immunology - Issue - nature.com science feedsMon May 04, 2020 03:00Single...
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The impact of bilingualism on the narrative ability and the executive functions of children with autism spectrum disorders: Publication date: Available online 3 May 2020Source: Journal of Communication DisordersAuthor(s): Eleni Peristeri, Eleni Baldimtsi, Maria Andreou, Ianthi Maria Tsimpli
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European Journal of Surgical Oncology (EJSO),Is endoscopic resection more effective than laparoscopic resection in gastric gastrointestinal stromal tumours?Publication date: Available online 4 May 2020Source: European Journal of Surgical OncologyAuthor(s): Peiwen Li, Wenya Li, Bin MaEuropean Journal of Surgical Oncology (EJSO)Mon May 04, 2020 19:29Poor nutritional status and sarcopenia influences survival outcomes in gastric carcinoma patients undergoing radical surgeryPublication date: Available...
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Targeting Casein Kinase 2 with Quercetin or Enzymatically Modified Isoquercitrin as a Strategy for Boosting the Type 1 Interferon Response to Viruses and Promoting Cardiovascular Health: Publication date: Available online 4 May 2020Source: Medical HypothesesAuthor(s): James J. DiNicolantonio, Mark F. McCarty
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Radiation Molecular Biology,The Role of Facility Variation on Racial Disparities in Use of Hypofractionated Whole Breast RadiotherapyPublication date: Available online 4 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Anna M. Laucis, Reshma Jagsi, Kent A. Griffith, Michael M. Dominello, Eleanor M. Walker, Eyad I. Abu-Isa, Joshua T. Dilworth, Frank Vicini, Paul G. Kocheril, Cynthia H. Browne, Melissa A. Mietzel, Jean M. Moran, James A. Hayman, Lori J. Pierce,...
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Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain), Plasmonic Nanobiosensors for Detection of MicroRNA Cancer Biomarkers in Clinical SamplesAnalyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00193G, PaperBridget M Crawford, Hsin-Neng Wang, Christina Stolarchuk, Richard Von Furstenberg, Pietro Strobbia, dadong zhang, xiaodi qin, kouros owzar, katherine garman, Vo-Dinh TuanMicroRNA (miRNA) play an important role in the regulation...
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NeuroImage,A probabilistic atlas of finger dominance in the primary somatosensory cortexPublication date: Available online 4 May 2020Source: NeuroImageAuthor(s): George C. O'Neill, Ayan Sengupta, Michael Asghar, Eleanor L. Barratt, Julien Besle, Denis Schluppeck, Susan T. Francis, Rosa M. Sanchez PanchueloNeuroImageMon May 04, 2020 21:12Towards clinical applications of movie fMRIPublication date: Available online 4 May 2020Source: NeuroImageAuthor(s): Simon B. Eickhoff, Michael Milham, Tamara VanderwalNeuroImageMon...
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Flexible Throat Sensor Powered by AI to Track COVID-19 Symptoms: As COVID-19 continues to infect more people around the world, there are still few reliable ways to spot the early onset of the disease and to monitor its symptoms in detail, particularly at a distance and while patients are at home. Now, researchers at Northwestern University have partnered with the Shirley Ryan AbilityLab (formerly Rehabilitation Institute of Chicago) to develop a tiny flexible electronic device that can track coughing,...
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VentFree Respiratory Muscle Stimulator Gets FDA Emergency OK for COVID-19: Liberate Medical, a company based outside of Louisville, Kentucky, won FDA Emergency Use Authorization for its VentFree Respiratory Muscle Stimulator that aims to reduce how long patients stay on ventilators. It works to keep the abdominal muscles from atrophying by delivering electric stimulation to the relevant muscles in tune with mechanical ventilation. The device delivers stimulation in a non-invasive fashion and the...
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Effects of glucose variability on hematopoietic stem/progenitor cells in patients with type 1 diabetes: AbstractBackground and purposeDiabetes reduces the levels of hematopoietic stem/progenitor cells (HSPCs), which can contribute to organ and tissue homeostasis. Among patients with diabetes, lower HSPC levels predict the development or worsening of micro- and macro-angiopathy. High glucose variability is also associated with diabetic complications and we have previously shown that acute hypoglycaemia...
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An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia: AbstractUnlike disorders of primary cilium, primary ciliary dyskinesia (PCD) has a much narrower clinical spectrum consistent with the limited tissue distribution of motile cilia. Nonetheless, PCD diagnosis can be challenging due to the overlapping features with other disorders and the requirement for sophisticated tests that are only available in specialized centers. We performed exome sequencing on all patients with...
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Diagnostic Cytopathology,Space occupying lesion of brain: An unusual site for a common infectionAbstract Filariasis is a public health menace and is a cause for concern due to its endemicity in tropical and subtropical countries of Africa, Asia, and Western Pacific. Even in endemic areas, it is rare to find filariasis in fluid specimens especially cerebrospinal fluid. Herein, we report a case of unsuspected filarial parasitic infection in an adult male admitted as a case of space occupying lesion...
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An exome-first approach to aid in the diagnosis of primary ciliary dyskinesia: AbstractUnlike disorders of primary cilium, primary ciliary dyskinesia (PCD) has a much narrower clinical spectrum consistent with the limited tissue distribution of motile cilia. Nonetheless, PCD diagnosis can be challenging due to the overlapping features with other disorders and the requirement for sophisticated tests that are only available in specialized centers. We performed exome sequencing on all patients with...
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Archives of Physical Medicine and Rehabilitation,Is it Time to Replace the Oswestry Index with PROMIS Physical Function Computer Adaptive Test?Publication date: Available online 4 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Léon Rijk, Joost T.P. Kortlever, George W. Tipton, David Ring, Mark V. Queralt, Michael M. Farris, Lee.E. Moroz, Enrique B. Pena, Devender Singh, John K. StokesArchives of Physical Medicine and RehabilitationMon May 04, 2020 22:35FAMILY HISTORY...
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Per‐rectal passage of intestinal cast: an unusual complication of pseudomembranous enterocolitis in an immunocompromised patient and literature review:
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Surgical neurology international,Endoscopic transnasal resection of an anterior planum sphenoidale meningiomaEndoscopic transnasal resection of an anterior planum sphenoidale meningioma Category: Article Type: Turki Elarjani, Sami Khairy, Saad Alsaleh, Abdulrazzag AjlanDepartment of Neurosurgery, King Faisal Specialist Hospital and Research Centre,Department of Neurosurgery, King Abdulaziz Medical City, Ministry of National Guard – Health Affairs,Departments of Otolaryngology, King Khalid University...Surgical...
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The Journal of Immunology current issue,Phosphoflow Protocol for Signaling Studies in Human and Murine B Cell Subpopulations [NOVEL IMMUNOLOGICAL METHODS]Key PointsMethod for highly sensitive detection of phosphorylation in B cell subpopulations. B cell subpopulations show different phosphorylation levels upon BCR stimulation.The Journal of Immunology current issueMon May 04, 2020 23:00Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic...
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Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: AbstractPurposeThe aim of the presented study was to evaluate the differences between selected biochemical markers in infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) and their impact on patient prognosis.MethodsA total of 57 cooled newborns were divided into groups according to Sarnat staging of HIE (A, moderate vs. B, severe). The differences between groups were evaluated depending...
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Annals of Internal Medicine Current Issue,Annals Clinical Decision Making: Using a Diagnostic TestDiagnostic testing is an essential tool in clinical decision making. This article in the Annals Clinical Decision Making series reviews core principles underlying the approach to choosing and interpreting diagnostic tests for individual patients.Annals of Internal Medicine Current Issue00:52Correction: In the Clinic: Acute Colonic DiverticulitisAnnals of Internal Medicine Current Issue00:52Love in the...
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CPBMF65, a synthetic human uridine phosphorylase-1 inhibitor, reduces HepG2 cell proliferation through cell cycle arrest and senescence: SummaryHepatocellular carcinoma (HCC) is the most prevalent type of tumor among primary liver tumors and is the second highest cause of cancer-related deaths worldwide. Current therapies are controversial, and more research is needed to identify effective treatments. A new synthetic compound, potassium 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-olate (CPBMF65),...
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Eosinophilic Esophagitis: Eosinophilic esophagitis (EoE) is a relatively new disease that has reached an incidence similar to that of Crohn disease and ulcerative colitis. With this increased presence, greater recognition is essential. This applies both to children with nonspecific but potentially debilitating symptoms and to adults who have spent years behaviorally compensating for narrow esophageal strictures. The pathogenesis of EoE is rapidly being unraveled and is based on initiation of a type...
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In vitro three‐dimensional culture systems of salivary glands: Dry mouth can be caused by salivary gland hypofunction due to Sjögren's syndrome (SS) or radiation therapy for head and neck cancer, and it can also be a side effect of medications. The use of sialagogues effectively increases saliva secretion in patients with dry mouth. However, the application of sialagogues is not always satisfactory because of their side effects, such as sweating, nausea, runny nose and diarrhea. Two‐dimensional (2D)...
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Pathology International,In vitro three‐dimensional culture systems of salivary glandsDry mouth can be caused by salivary gland hypofunction due to Sjögren's syndrome (SS) or radiation therapy for head and neck cancer, and it can also be a side effect of medications. The use of sialagogues effectively increases saliva secretion in patients with dry mouth. However, the application of sialagogues is not always satisfactory because of their side effects, such as sweating, nausea, runny nose and diarrhea....
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Age‐related EBV‐associated B‐cell lymphoproliferative disorders and other EBV + lymphoproliferative diseases: New insights into immune escape and immunodeficiency through staining with anti‐PD‐L1 antibody clone SP142: Epstein–Barr virus (EBV) is prevalent among healthy individuals, and is implicated in numerous reactive and neoplastic processes in the immune system. The authors originally identified a series of senile or age‐related EBV‐associated B‐cell lymphoproliferative disorders (LPD) bearing...
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Isradipine Versus Placebo in Early Parkinson Disease A Randomized Trial: Background:Studies suggest that dihydropyridine calcium-channel blockers may be associated with reduced risk for Parkinson disease (PD).Objective:To assess the effect of isradipine, a dihydropyridine calcium-channel blocker, on the rate of clinical progression of PD.Design:Multicenter, randomized, parallel-group, double-blind, placebo-controlled trial. (ClinicalTrials.gov: NCT02168842)Setting:57 Parkinson Study Group sites in...
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Unilateral Facial Paralysis During an Airline Flight: Background: A medical emergency during a commercial airline flight may require an unplanned landing, which disrupts travel plans and is expensive.Objective: To alert clinicians to a condition that can mimic acute stroke but does not require an unplanned aircraft landing.Case Report: Shortly after reaching cruising altitude on a recent airline flight, I responded to a flight attendant's request for "a doctor on board." She reported that a passenger...
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Annals of Internal Medicine Online First,Receipt of Prevention Services and Testing for Sexually Transmitted Diseases Among HIV-Positive Men Who Have Sex With Men, United StatesAnnals of Internal Medicine Online First01:08A Cautionary Tale: The 2019 Orphaning of Hahnemann's Graduate Medical TraineesHahnemann University Hospital provided care for Philadelphians starting in 1848, but its recent history has been riddled with financial turmoil that culminated in its rapid closure in summer 2019. As...
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L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms Secondary Analysis of a Randomized Trial: Background:L-thyroxine does not improve hypothyroid symptoms among adults with subclinical hypothyroidism (SCH). However, those with greater symptom burden before treatment may still benefit.Objective:To determine whether L-thyroxine improves hypothyroid symptoms and tiredness among older adults with SCH and greater symptom burden.Design:Secondary analysis of the...
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Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice: AbstractThe gut microbiota plays an important role in colorectal cancer (CRC), and the use of probiotics might be a promising intervention method. The aim of our study was to investigate the beneficial effect of Bifidobacterium bifidum CGMCC 15068 on an azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced...
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Septin 9 Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma: Nasopharyngeal carcinoma (NPC) is highly prevalent in Southeast Asia, and an unfavorable outcome is usually attributed to advanced stage NPC. Current methods for the early diagnosis of NPC have limitations in clinical practice. The aim of this study was to investigate the diagnostic ability of Septin 9 methylation for NPC. A quantitative methylation-sensitive...
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Association of IL-1β, IL-6, TNF-α, and TGFβ1 Gene Polymorphisms with Recurrent Spontaneous Abortion in Polycystic Ovary Syndrome: Recurrent spontaneous abortion (RSA) is a common pregnancy-associated complication of polycystic ovary syndrome (PCOS) which is an endocrine malfunction disease. Patients with PCOS may have several underlying contributing and interrelated factors, which have been reported in women with RSA. The incidence rate between PCOS and RSA remains uncertain. The aim of this study...
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Macular and Retinal Nerve Fibre Layer Thickness in Pregnant Women with Gestational Diabetes Mellitus
Macular and Retinal Nerve Fibre Layer Thickness in Pregnant Women with Gestational Diabetes Mellitus: Amir Tengku-Fatishah,1,2 Nik Lah Nik-Ahmad-Zuky,3,4 Ismail Shatriah1,21Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia; 2Ophthalmology Clinic, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia; 3Department of Obstetric and Gynecology, School of Medical Sciences, Universiti Sains Malaysia, Kubang...
09:48
Oral & Maxillofacial Surgery,Computer-guided contouring of craniofacial fibrous dysplasia involving the zygoma using a patient-specific surgical depth guideThe aim of this study was to introduce a new computer-guided technique for contouring and shaving of craniofacial fibrous dysplasia involving the zygoma. Computer-guided contouring was performed for five patients with unilateral craniofacial fibrous dysplasia involving the zygoma, using a patient-specific surgical depth guide. This patient-specific...
09:48
Oral and Maxillofacial Surgery,MSX1 is differentially expressed in the deepest impacted maxillary third molarsAn impacted third molar is one of the most common dental abnormalities. Among the reasons for impaction the most common are: insufficient space, time of eruption, improper position of the tooth bud, and genetic disruptions. To investigate if runt-related transcription factor 2 (RUNX2), bone morphogenetic protein 2 (BMP2), and msh homeobox 1 (MSX1) are differently expressed depending on the...
09:47
International journal of basic and clinical endocrinology,Clinical outcomes and characteristics of P30L mutations in congenital adrenal hyperplasia due to 21-hydroxylase deficiencyAbstract Despite numerous studies in the field of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, some clinical variability of the presentation and discrepancies in the genotype/phenotype correlation are still unexplained. Some, but not all, discordant phenotypes caused by mutations with known enzyme...
09:47
Hormon- und Stoffwechselforschung,Successful Management of Recurrent Subacute Thyroiditis by Adding Colchicine to Glucocorticoid Treatment: A Case Series StudyHorm Metab ResDOI: 10.1055/a-1148-2260Although subacute thyroiditis (SAT) is thought to be a self-limited inflammatory thyroid disease, the recurrence rate of SAT is approximately 10–20%. It is difficult for these patients to stop glucocorticoid treatment, and they are usually bothered with recurrent pain and the side effects of glucocorticoids...
09:46
Hellenic Anticancer Institute , The Application of a Low-temperature Physical Plasma Device Operating Under Atmospheric Pressure Leads to the Production of Toxic NO2Background: Physical plasma is a mixture of reactive particles and electromagnetic radiation. Due to the antimicrobial, immunomodulatory, anti-inflammatory, wound-healing promoting, and antineoplastic effects of body tempered physical plasma under atmospheric pressure (cold atmospheric plasma: CAP), CAP therapy is increasingly becoming...
09:46
Hellenic Anticancer Institute , Expression of MicroRNA in Locoregional Recurrent Rectal CancerBackground/Aim: miRNA expression patterns vary within primary rectal cancers and play a pivotal role in carcinogenesis. It is unknown, however, if these regulatory changes also play a role in local recurrent rectal cancers. In this study, the expression of various angiogenetic small non-coding ribonucleic acids, namely miRNA-21, miRNA-215, miRNA-221, and miRNA-222 were analysed in cancerous and healthy...
09:45
Velocity influences the relative contributions of visual and vestibular cues to self-acceleration: AbstractSelf-motion perception is based on the integration of visual (optic flow) and vestibular (inertial) sensory information. Previous research has shown that the relative contribution of visual and vestibular cues can change in real time based on the reliability of that information. The present study assessed whether initial velocity and acceleration magnitude influence the relative contribution...
09:44
Cancer,Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signallingBritish Journal of Cancer, Published online: 05 May 2020; doi:10.1038/s41416-020-0852-4Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signallingCancer03:00Survival benefit of tamoxifen in male breast cancer: prospective cohort...
09:44
Hippocampal and prefrontal contributions to spatial and non‐spatial memory retrieval: Examination of Immediate Early Gene (IEG), NMDA receptor and environmental interactions.: AbstractAnimals can use a range of strategies to recall important locations. These include simple stimulus‐response strategies and more complex spatial (place) strategies, which are thought to have distinct neural substrates. The hippocampus – and NMDA receptor activation therein – is considered to be crucial for spatial, but...
09:43
Clinical Cancer Research Online First Articles,Role of MPR as an early signal for efficacy in neoadjuvant studiesOverall survival and disease-free survival have been the gold standard primary endpoints for neoadjuvant clinical trials. Major pathologic response is a clinically proven surrogate of efficacy and when used as the primary endpoint, can allow for more efficient evaluation of drugs in the neoadjuvant setting.Clinical Cancer Research Online First ArticlesMon May 04, 2020 16:55Collectively...
09:43
Percutaneous CT-guided lumbar trans-facet pedicle screw fixation in lumbar microinstability syndrome: feasibility of a novel approach: AbstractStudy designProspective experimental uncontrolled trial.BackgroundLumbar microinstability (MI) is a common cause of lower back pain (LBP) and is related to intervertebral disc degeneration that leads to inability to adequately absorb applied loads. The term "microinstability" has recently been introduced to denote a specific syndrome of biomechanical dysfunction...
09:43
Diagnosing Thyrotropin-Secreting Pituitary Adenomas by Short-Term Somatostatin Analogue Test: Thyroid, Ahead of Print. AbstractBackground: Diagnosis of thyrotropin (TSH)-secreting pituitary adenomas (TSHoma) before surgery remains a challenge, especially for microadenomas. We aimed to establish a short-term somatostatin analogue (SSA) test to differentiate TSHomas from other causes of syndromes of inappropriate secretion of TSH (IST), mainly resistance to thyroid hormone β (RTHβ).Materials and Methods: We...
09:41
Obesity Is Associated with BRAFV600E-Mutated Thyroid Cancer: Thyroid, Ahead of Print. AbstractBackground: Thyroid cancer incidence has increased in many parts of the world since the 1980s, as has the prevalence of obesity. Evidence suggests that people with greater body size have higher thyroid cancer risk. However, it is unclear whether this association is causal or is driven by over-diagnosis of indolent cancers, because overweight/obese people use health services more frequently than those of...
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liebertpub1,Use of Molecular Diagnostic Tests in Thyroid Nodules with Hürthle Cell-Dominant CytologyThyroid, Ahead of Print.liebertpub1Mon May 04, 2020 10:00Obesity Is Associated with BRAFV600E-Mutated Thyroid CancerThyroid, Ahead of Print.liebertpub1Mon May 04, 2020 10:00Diagnosing Thyrotropin-Secreting Pituitary Adenomas by Short-Term Somatostatin Analogue TestThyroid, Ahead of Print.liebertpub1Mon May 04, 2020 10:00Characterization of Allele-Specific Regulation of Telomerase Reverse Transcriptase...
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Use of Molecular Diagnostic Tests in Thyroid Nodules with Hürthle Cell-Dominant Cytology: Thyroid, Ahead of Print.
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bioRxiv Subject Collection: Evolutionary Biology,Temporal signal and the phylodynamic threshold of SARS-CoV-2 [NEW RESULTS]The ongoing SARS-CoV-2 outbreak marks the first time that large amounts of genome sequence data have been generated and made publicly available in near real-time. Early analyses of these data revealed low sequence variation, a finding that is consistent with a recently emerging outbreak, but which raises the question of whether such data are sufficiently informative for phylogenetic...
09:39
Journal of Neurotrauma,Repetitive Mild Traumatic Brain Injury and Transcription Factor ModulationJournal of Neurotrauma, Ahead of Print.Journal of NeurotraumaMon May 04, 2020 10:00Influence of Simulated Pre-Hospital Transport, Time to Analysis, and Storage Temperature on S100 Calcium-Binding Protein B ValuesJournal of Neurotrauma, Ahead of Print.Journal of NeurotraumaMon May 04, 2020 10:00A Cervical Spinal Cord Hemi-Contusion Injury Model Based on Displacement Control in Non-Human Primates (Macaca...
09:39
Soft, Wearable, and Pleated Pneumatic Interference Actuator Provides Knee Extension Torque for Sit-to-Stand: Soft Robotics, Ahead of Print. Soft wearable actuators can help connect machines and humans, providing a personalized, ergonomic, and cooperative physical interface between people and their world. Until now, the torque of these interfaces has been limited, restricting their ability to assist the completely paralyzed. This article presents a method for realizing a soft structure that stably...
09:38
Systematic Reviews - Associations of loneliness and social isolation with cardiovascular and metabolic health: a systematic review and meta-analysis protocolA growing number of studies suggest that social isolation and loneliness are associated with premature mortality and are more prevalent among people with mental illness than in the general population, outlinin...Systematic Reviews - Latest ArticlesMon May 04, 2020 03:00The prevalence of type 2 diabetes in people with psychiatric disorders: an...
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Surgical Infections,Comprehensive Approach to Reduce Surgical Site Infections in Patients Undergoing Neurosurgical ProceduresSurgical Infections, Ahead of Print.Surgical InfectionsMon May 04, 2020 10:00Burn Infection and Burn SepsisSurgical Infections, Ahead of Print.Surgical InfectionsMon May 04, 2020 10:00Pro–Con Perspectives on Ethics in Surgical Research: Update from the 39th Annual Surgical Infection Society MeetingSurgical Infections, Volume 21, Issue 4, Page 332-343, May 2020.Surgical InfectionsThu...
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Cancer Biotherapy & Radiopharmaceuticals - Table of Contents,Evaluating Changes in Immune Function and Bone Microenvironment During Radium-223 Treatment of Patients with Castration-Resistant Prostate CancerCancer Biotherapy and Radiopharmaceuticals, Ahead of Print.Cancer Biotherapy & Radiopharmaceuticals - Table of Contents07:01Relapse and Prognosis of Non-Muscle Invasive Bladder Cancer After Combined HOLRBT with Sunitinib and TGC Perfusion ChemotherapyCancer Biotherapy and Radiopharmaceuticals,...
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High Altitude Medicine & Biology - Table of Contents,Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric HypoxiaHigh Altitude Medicine &Biology, Ahead of Print.High Altitude Medicine & Biology - Table of ContentsMon May 04, 2020 10:00COVID-19 Lung Injury Is Different From High Altitude Pulmonary Edema (Re: High Alt Med Biol [Epub ahead of print]; DOI: 10.1089/ham.2020.0055)High Altitude...
09:36
Oncogenesis - MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamicsOncogenesis, Published online: 04 May 2020; doi:10.1038/s41389-020-0227-yMiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamicsOncogenesis - nature.com science feedsMon May 04, 2020 03:00MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule...
09:36
Stem Cells and Development,Natural Killer Cell Alloreactivity Against Human Induced Pluripotent Stem Cells and Their Neuronal Derivatives into Dopaminergic NeuronsStem Cells and Development, Ahead of Print.Stem Cells and DevelopmentMon May 04, 2020 10:00Mark above section as read
09:36
Angiogenic and immunomodulatory biomarkers in axitinib-treated patients with advanced renal cell carcinoma: Future Oncology, Ahead of Print. Aim: Immunomodulatory mechanisms contributing to angiogenic inhibition in renal tumors are not well characterized. We report associations between efficacy and tumor-associated immune cells and mRNA/miRNA expression in patients from AXIS. Materials & methods: Immunohistochemistry (n = 52) and mRNA/miRNA expression analyses (n = 72) were performed on tumor...
09:35
Therapeutic Hypothermia and Temperature Management,An Exploratory Report on Electrographic Changes in the Cerebral Cortex Following Mild Traumatic Brain Injury with Hyperthermia in the RatTherapeutic Hypothermia and Temperature Management, Ahead of Print.Therapeutic Hypothermia and Temperature Management08:16Mark above section as read
09:34
SAGE Publications Ltd: Journal of International Medical Research: Table of Contents, Effect of sitagliptin on expression of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α and irisin in a rat model of type 2 diabetes mellitusJournal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveTo evaluate the effect of sitagliptin on skeletal muscle expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), irisin, and phosphoadenylated...
09:33
Cancer Research current issue,Highlights from Recent Cancer LiteratureCancer Research current issue17hDasatinib Is an Effective Treatment for Angioimmunoblastic T-cell LymphomaRecurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function mutations in TET2 encoding an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val RHOA mutant on a Tet2-null background succumbed to AITL-like T-cell...
09:32
Cancers,Cancers, Vol. 12, Pages 1157: Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by DinaciclibCancers, Vol. 12, Pages 1157: Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib Cancers doi: 10.3390/cancers12051157 Authors: Changhong Ke Huan Hou Jiayu Li Kui Su Chaohong Huang Yue Lin Zhiqiang Lu Zhiyun Du Wen Tan Zhengqiang Yuan Tumour necrosis factor (TNF)-related...
09:31
Gene,Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3Publication date: Available online 4 May 2020Source: GeneAuthor(s): Bojing Li, Mingming Jin, Fanfan Cao, Jie Li, Jian Wu, Limin Xu, Xinghui Liu, Yihai Shi, Weichang ChenGene16hAnalysis of DNA methylation differences in gonads of the large yellow croakerPublication date: Available online 4 May 2020Source: GeneAuthor(s): Amei He, Wanbo Li, Weijia Wang, Kun Ye, Shiqi Gong,...
09:31
European Journal of Cancer,Immune checkpoint inhibitor use and tuberculosis: a systematic review of the literaturePublication date: June 2020Source: European Journal of Cancer, Volume 132Author(s): Jacob Zaemes, Chul KimEuropean Journal of Cancer16hIndirect treatment comparison of nivolumab versus placebo for the adjuvant treatment of melanomaPublication date: June 2020Source: European Journal of Cancer, Volume 132Author(s): Matthew Hemstock, Adenike Amadi, Katrin Kupas, Neil Roskell, Srividya Kotapati,...
09:31
ScienceDirect Publication: Annals of Anatomy - Anatomischer Anzeiger, The use of Plasma Rich in Growths Factors (PRGF) in Guided Tissue Regeneration and Guided Bone Regeneration. A review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humansPublication date: Available online 4 May 2020Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Önder Solakoglu, Guido Heydecke, Niusha Amiri, Eduardo AnituaScienceDirect Publication: Annals of Anatomy...
09:30
Saliva is a non‐negligible factor in the spread of COVID‐19: SummarySARS‐CoV‐2, a novel emerging coronavirus, has caused severe disease (COVID‐19), and rapidly spread worldwide since the beginning of 2020. SARS‐CoV‐2 mainly spreads by coughing, sneezing, droplet inhalation, and contact. SARS‐CoV‐2 has been detected in saliva samples, making saliva a potential transmission route for COVID‐19. The participants in dental practice confront a particular risk of SARS‐CoV‐2 infection due to close contact...
09:29
Molecular Cancer Research current issue,Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung MetastasisPeptidyl arginine deiminase 4 (PAD4/PADI4) is a posttranslational modification enzyme that converts protein arginine or mono-methylarginine to citrulline. The PAD4-mediated hypercitrullination reaction in neutrophils causes the release of nuclear chromatin to form a chromatin network termed neutrophil extracellular traps (NET). NETs...
09:29
Surgical Instructions in Revision Endoscopic Sinus Surgery: Pearls and Pitfalls: AbstractFunctional endoscopic sinus surgery (FESS) has become one of the most common surgical techniques performed by otolaryngologists with significant data demonstrating its efficacy in managing patients with chronic rhinosinusitis (CRS). However, despite this initial success, patients may continue to present with recurrent symptoms and approximately 10–15% of them will require revision surgery. Failure of FESS may...
09:29
Free Radical Biology and Medicine,Protection against renal ischemia and reperfusion injury by short-term time-restricted feeding involves the mitochondrial unfolded protein responsePublication date: Available online 4 May 2020Source: Free Radical Biology and MedicineAuthor(s): Pedro Rojas-Morales, Juan Carlos León-Contreras, Jessica Granados-Pineda, Rogelio Hernandez-Pando, Guillermo Gonzaga, Laura Gabriela Sánchez-Lozada, Horacio Osorio-Alonso, José Pedraza-Chaverri, Edilia TapiaFree Radical Biology...
09:28
Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy: AbstractResponse evaluation for cancer treatment consists primarily of clinical and radiological assessments. In addition, a limited number of serum biomarkers that assess treatment response are available for a small subset of malignancies. Through recent technological innovations, new methods for measuring tumor burden and treatment response are becoming available. By utilization of highly sensitive techniques,...
09:28
NEN : Last 20 articles,Health-related quality of life in patients with Multiple Endocrine Neoplasia type 1Introduction: Multiple Endocrine Neoplasia type 1 (MEN1) is a hereditary endocrine tumor syndrome characterized by the triad of primary hyperparathyroidism (pHPT), duodenopancreatic neuroendocrine tumors (pNETs) and pituitary tumors. Patients are confronted with substantial morbidity and are consequently at risk for an impaired quality of life (QOL). Meticulous assessment of QOL and associated...
09:28
Decreased modulation of segregated SEEKING and selective attention systems in chronic insomnia: AbstractSleep-related attentional bias and instinctual craving-sleep status may be associated with value-driven selective attention network and SEEKING system. We hypothesized that the two networks might be important components and underlie etiology of inability to initiate or/and maintain sleep in patients with chronic insomnia (PIs). Our aim is to investigate whether frequency-frequency couplings(temporal...
09:27
ScienceDirect Publication: Clinical Biochemistry,Changes in redox state of albumin before and after kidney transplantation in patients with end-stage renal diseasePublication date: Available online 4 May 2020Source: Clinical BiochemistryAuthor(s): Ryota Tanaka, Tadashi Imafuku, Yosuke Suzuki, Kento Nishida, Kotaro Matsusaka, Toshitaka Shin, Yuhki Sato, Yu Ishima, Hiroshi Watanabe, Hiromitsu Mimata, Toru Maruyama, Hiroki ItohScienceDirect Publication: Clinical Biochemistry15hΣήμανση της παραπάνω...
09:23
Radiation pneumonitis after definitive concurrent chemoradiotherapy with cisplatin/docetaxel for non‐small cell lung cancer: Analysis of dose‐volume parameters: V20 was a significant predictor of grade ≥2 radiation pneumonitis after chemoradiotherapy with cisplatin/docetaxel for stage III non‐small cell lung cancer. Severe radiation pneumonitis that would lead to the permanent discontinuation of treatment per the PACIFIC trial criteria developed in 6 of 37 patients (16.2%) whose V20 values were 35%...
09:22
Annals of Microbiology,Abundance, diversity, and distribution patterns along with the salinity of four nitrogen transformation-related microbes in the Yangtze EstuaryAbstract Purpose The abundance and composition of nitrogen transformation-related microbes with certain environmental parameters for living conditions provide information about the nitrogen cycle in the Yangtze Estuary. The aim of this study was to explore the impacts of salinity on four N-related microbes and reveal the phylogenetic...
09:21
JAMA Online First , COVID-19 and 6 Dimensions of Health Care Poised for a "New Normal"In this Viewpoint, Donald Berwick summarizes the rapid changes the COVID-19 pandemic has wrought on the pace, scientific standards, delivery mechanisms, and working conditions of health care and how it has sharply increased awareness of the societal costs of poor public health preparedness and health inequities.JAMA Online First14hCOVID-19 and the Financial Health of US HospitalsThis Viewpoint reviews the revenue...
09:21
Environmental effects of stratospheric ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2019: Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/D0PP90011G, PerspectiveG. H. Bernhard, R. E. Neale, P. W. Barnes, P. J. Neale, R. G. Zepp, S. R. Wilson, A. L. Andrady, A. F. Bais, R. L. McKenzie, P. J. Aucamp, P. J. Young, J. B. Liley, R. M. Lucas, S. Yazar, L. E. Rhodes, S. N. Byrne, L. M. Hollestein, C. M. Olsen, A. R....
09:20
Robotic‐assisted transmaxillary approach for removal of juvenile nasopharyngeal angiofibroma of the pterygopalatine and infratemporal fossa: AbstractEndoscopic transmaxillary approaches to remove juvenile nasopharyngeal angiofibromas (JNAs) have been described previously and are used for tumors that extend laterally in the pterygopalatine fossa (PPF) and infratemporal fossa (ITF). There is no previous description of robotic‐assisted JNA removal in the literature. The video will demonstrate the success...
09:20
European Attitudes and Outcomes Regarding Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Multinational Survey: AbstractBackgroundBreast implants have been related to breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). While some research has been conducted to study BIA-ALCL incidence, little is known regarding surgeon concern about the disease.ObjectivesThis study aims to determine surgeon concern about BIA-ALCL within the European plastic surgeon community as related...
09:19
The Solutionist Ethic and the Spirit of Digital Capitalism: Why do tech elites believe they are the world's greatest do-gooders and why does it matter what they say and (claim to) think? In this paper, we use the concept of the spirit of capitalism to shed light on the ways in which normative beliefs inform and justify the business models of tech companies. We first reconstruct, systematize and operationalize the concept of the capitalist spirit. We then argue that solutionist ideas have become central...
09:19
Investigation of lyophilized antibody formulations to enable short freeze-drying cycles and storage at room temperature: Antibodies are dominating the biopharmaceutical market and are expected to grow further. Aiming to improve existing treatments, new antibody derivatives of improved efficacy and safety are being developed in a competitive market. Antibody derivatives include but are not limited to antibody-drug conjugates and Fc-fusion proteins. Due to their higher complexity, they are often less...
09:18
Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases: An important class of non-heme dioxygenases contains a conserved Fe binding site that consists of a 2-His-1-carboxylate facial triad. Results from structural biology show that, in the resting state, these proteins are six-coordinate with aqua ligands occupying the remaining three coordination sites. We have utilized biotin-streptavidin (Sav) technology to design new artificial Fe proteins (ArMs) that have many of the same...
09:18
Postgraduate Medical Journal Online First,Regaining balance during 'reality vertigo: six insights gleaned from the front-line to manage pandemic-related anxietyOne month ago, most of us had never heard of 'Zoom'. One month ago, most of us would never imagine that scarcity of toilet paper, masks or ventilators would become a global concern. In academic medicine in the USA 1 month ago, our reality and focus were on caring for patients, equipping trainees with the skills to become good doctors, working...
09:17
Latest Results for The Cerebellum,Clinical and Genetic Characterization of Autosomal Recessive Spinocerebellar Ataxia Type 16 (SCAR16) in TaiwanAbstract Mutations in STUB1 have been identified to cause autosomal recessive spinocerebellar ataxia type 16 (SCAR16), also named as Gordon Holmes syndrome, which is characterized by cerebellar ataxia, cognitive decline, and hypogonadism. Additionally, several heterozygous mutations in STUB1 have recently been described as a cause of autosomal dominant spinocerebellar...
09:17
Cervicofacial non-tuberculous mycobacterial lymphadenitis: clinical determinants of incomplete surgical removal: Publication date: Available online 4 May 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): S.H. Willemse, L.H.E. Karssemakers, M.A.E.M. Oomens, W.H. Schreuder, J.A. Lindeboom, A.J. van Wijk, J. de LangeAuthor links open overlay panelS.H.Willemse1L.H.E.Karssemakers12M.A.E.M.Oomens12W.H.Schreuder12J.A.Lindeboom13A.J.van Wijk4J.de Lange11Department of Oral and...
09:16
An ectomesenchymal chondromyxoid tumour on the lateral border of the tongue: Figures (2)Publication date: Available online 4 May 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Sakurai, K. Nakamori, M. Yamazaki, J.-I. TanumaAuthor links open overlay panelK.Sakurai1K.Nakamori1M.Yamazaki2J.-I.Tanuma21Department of Oral and Maxillofacial Surgery, Regional Independent Administrative Corporation Naha City Hospital, Naha, Okinawa, Japan2Division of Oral Pathology, Faculty...
09:15
ScienceDirect Publication: International Journal of Oral and Maxillofacial Surgery, An ectomesenchymal chondromyxoid tumour on the lateral border of the tonguePublication date: Available online 4 May 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Sakurai, K. Nakamori, M. Yamazaki, J.-I. TanumaScienceDirect Publication: International Journal of Oral and Maxillofacial Surgery13hThe influence of orthognathic surgery on the perception of personality traits: A scoping...
09:14
ScienceDirect Publication: Journal of Controlled Release, Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolyticPublication date: Available online 4 May 2020Source: Journal of Controlled ReleaseAuthor(s): Irene Galiana, Beatriz Lozano-Torres, Mónica Sancho, María Alfonso, Andrea Bernardos, Viviana Bisbal, Manuel Serrano, Ramón Martínez-Máñez, Mar OrzáezScienceDirect Publication: Journal of Controlled Release13hSynthesis of micellar-like terpolymer nanoparticles...
09:13
ScienceDirect Publication: The Journal of Emergency Medicine, Clinical and Cancer-Related Predictors for Venous Thromboembolism in Cancer Patients Presenting to the Emergency DepartmentPublication date: Available online 4 May 2020Source: The Journal of Emergency MedicineAuthor(s): Aiham Qdaisat, Weixin Wu, Jun-zhong Lin, Rawan Al Soud, Zhi Yang, Zhihuang Hu, Shujun Gao, Carol C. Wu, Xiangdong Liu, Julio Silvestre, A. Guido Hita, Jayne Viets-Upchurch, Saif Al Adwan, Nafi' Al Haj Qasem, Maria T. Cruz...
09:13
N-95 respirator: gain in protection, pain in the face?: In the midst of the global COVID-19 pandemic, the availability of well-fitting personal protective equipment (PPE) is essential to protect healthcare workers (HCWs) from the risks of contracting droplets and/or airborne infections from patients under their care. However, prolonged use of PPE, in particular, the N-95 respirator, can lead to the development of device-related pressure ulcers (DRPU) over the face, adding to the numerous physical...
09:12
Diagnostic accuracy of CE Chirp: Publication date: Available online 4 May 2020Figures (7)Hide figuresSource: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Leigh Biagio-de Jager, Zandri van Dyk, Bart HME. VinckAuthor links open overlay panelLeighBiagio-de JageraZandrivan DykaBart HME.VinckbaDepartment of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria, Hatfield, 0028, South AfricabDepartment of Rehabilitation Sciences, Occupational Therapy,...
09:12
Radiomics and deep learning in lung cancer: AbstractLung malignancies have been extensively characterized through radiomics and deep learning. By providing a three-dimensional characterization of the lesion, models based on radiomic features from computed tomography (CT) and positron-emission tomography (PET) have been developed to detect nodules, distinguish malignant from benign lesions, characterize their histology, stage, and genotype. Deep learning models have been applied to automatically segment...
09:09
ScienceDirect Publication: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, <em>MLL</em>-rearranged infant leukaemia: A 'thorn in the side' of a remarkable success storyPublication date: Available online 3 May 2020Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Siobhan Rice, Anindita RoyScienceDirect Publication: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms12hThe molecular basis of specific DNA binding by the BRG1...
09:08
PLOS Pathogens: New Articles,Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccinationby Adil Doganay Duru, Renhua Sun, Eva B. Allerbring, Jesseka Chadderton, Nadir Kadri, Xiao Han, Kaliroi Peqini, Hannes Uchtenhagen, Chaithanya Madhurantakam, Sara Pellegrino, Tatyana Sandalova, Per-Åke Nygren, Stephen J. Turner, Adnane Achour Viral escape from CD8+ cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination....
09:08
ScienceDirect Publication: The Journal of Emergency Medicine, Acute Myocarditis Triggers Coronary Artery Spasm: A Rare AssociationPublication date: Available online 4 May 2020Source: The Journal of Emergency MedicineAuthor(s): Yi Tang, Hua Yang, Peng Liu, Yanfeng Zeng, Zhengyu Liu, Mingxiang Tang, Jin He, Jianqiang Peng, Hongwei Pan, Yi Zhang, Zhaofen ZhengScienceDirect Publication: The Journal of Emergency Medicine10hClinical and Cancer-Related Predictors for Venous Thromboembolism in Cancer Patients...
09:07
Percutaneous transhepatic endoscopic lithotripsy of biliary stones with holmium laser for the treatment of recurrent cholangitis: AbstractPurposeTo evaluate the efficacy and safety of percutaneous transhepatic endoscopic holmium laser biliary lithotripsy (PTBL) to treat recurrent cholangitis due to intra/extrahepatic stones, in patients not candidate for traditional endoscopic treatment.Materials and methodsWe retrospectively evaluated 28 patients (M:F = 19:9, mean age = 65 years, SD = 14) undergoing...
09:07
PLOS Genetics: New Articles,A new neuropeptide insect parathyroid hormone iPTH in the red flour beetle <i>Tribolium castaneum</i>by Jia Xie, Ming Sang, Xiaowen Song, Sisi Zhang, Donghun Kim, Jan A. Veenstra, Yoonseong Park, Bin Li In the postgenomics era, comparative genomics have advanced the understanding of evolutionary processes of neuropeptidergic signaling systems. The evolutionary origin of many neuropeptidergic signaling systems can be traced date back to early metazoan evolution...
09:06
ScienceDirect Publication: International Journal of Biological Macromolecules, Structural features of HtpG<sub>Mtb</sub> and HtpG-ESAT6<sub>Mtb</sub> vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulationPublication date: Available online 4 May 2020Source: International Journal of Biological MacromoleculesAuthor(s): Miguel Moreira, Alessia Ruggiero, Luciana Esposito, Han-Gyu Choi, Hwa-Jung Kim, Rita BerisioScienceDirect...
09:06
Hindawi Publishing Corporation,On the Ground State to Hamiltonian Elliptic System with Choquard's Nonlinear TermIn the present paper, we consider the following Hamiltonian elliptic system with Choquard's nonlinear term where is a bounded domain with a smooth boundary, ,, and is the primitive of , similarly for . By establishing a strongly indefinite variational setting, we prove that the above problem has a ground state solution.Hindawi Publishing Corporation1mNumerical Simulation during Short-Shot...
09:05
Low-Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Tinnitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials: Background. Chronic tinnitus affects approximately 10-15% of the population. Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been considered as a promising and well-tolerated therapeutic strategy for chronic tinnitus. However, a recent large-scale multicenter clinical trial showed a negative result. Objective....
09:04
ScienceDirect Publication: International Journal of Biological Macromolecules,Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing applicationPublication date: 1 September 2020Source: International Journal of Biological Macromolecules, Volume 158Author(s): Siyu Wang, Fei Yan, Ping Ren, Yi Li, Qiong Wu, Xuedong Fang, Fangfang Chen, Ce WangScienceDirect Publication: International Journal...
09:03
Untangling the dorsal diencephalic conduction system: a review of structure and function of the stria medullaris, habenula and fasciculus retroflexus: AbstractThe often-overlooked dorsal diencephalic conduction system (DDCS) is a highly conserved pathway linking the basal forebrain and the monoaminergic brainstem. It consists of three key structures; the stria medullaris, the habenula and the fasciculus retroflexus. The first component of the DDCS, the stria medullaris, is a discrete bilateral tract...
09:02
Spatiotemporal Dynamics of Single and Paired Pulse TMS-EEG Responses: AbstractFor physiological brain function a particular balance between excitation and inhibition is essential. Paired pulse transcranial magnetic stimulation (TMS) can estimate cortical excitability and the relative contribution of inhibitory and excitatory networks. Combining TMS with electroencephalography (EEG) enables additional assessment of the spatiotemporal dynamics of neuronal responses in the stimulated brain. This study...
09:02
Journal of Interferon & Cytokine Research - Table of Contents,Interferon-λ Receptor Expression: Novel Reporter Mouse Reveals Within- and Cross-Tissue HeterogeneityJournal of Interferon &Cytokine Research, Ahead of Print.Journal of Interferon & Cytokine Research - Table of Contents8hΣήμανση της παραπάνω ενότητας ως αναγνωσμένης
09:01
Experimental Cell Research,Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemiaPublication date: Available online 4 May 2020Source: Experimental Cell ResearchAuthor(s): Cheng Chen, Li Wang, Lili Li, Aoli Wang, Tao Huang, Jie Hu, Ming Zhao, Feiyang Liu, Shuang Qi, Chen Hu, Wenliang Wang, Jing Liu, Jian Ge, Ruixiang Xia, Wenchao Wang, Qingsong LiuExperimental Cell Research8hEpithelial cell derived microvesicles: A safe delivery platform of CRISPR/Cas9...
09:01
Latest Results for European Journal of Pediatrics,Retinopathy of prematurity treatment in the UK: trends in neonatal anaesthetic support and location of treatment from a national surveillance studyAbstract The aim of this study is to evaluate current anaesthetic practice for retinopathy of prematurity (ROP) interventions in the UK. We collected the data from the 12-month prospective British Ophthalmic Surveillance Unit study carried out in 2013/2014 that were analysed with regard to type of anaesthesia...
09:00
Latest Results for Annals of Surgical Oncology,Robotic Pelvic Exenteration for Locally Advanced Prostate CancerLatest Results for Annals of Surgical Oncology7hPrognostic Impact of Pancreatic Invasion in Duodenal Carcinoma: A Single-Center ExperienceAbstract Background The prognostic factors for duodenal carcinoma (DC) remain unclear because of its rarity. This study aimed to investigate the prognostic impact of pancreatic invasion (PI) on postoperative survival for patients with DC. Methods This...
08:59
CPBMF65, a synthetic human uridine phosphorylase-1 inhibitor, reduces HepG2 cell proliferation through cell cycle arrest and senescence: SummaryHepatocellular carcinoma (HCC) is the most prevalent type of tumor among primary liver tumors and is the second highest cause of cancer-related deaths worldwide. Current therapies are controversial, and more research is needed to identify effective treatments. A new synthetic compound, potassium 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-olate (CPBMF65),...
08:59
Auris Nasus Larynx,Neuropilin-2 promotes growth and progression of papillary thyroid cancer cellsNeuropilin-2 (NRP2) is a coreceptor of vascular endothelial growth factor-C/D (VEGF-C/D) and plays the important role in the development of lymphatic endothelial cells, as well as neuronal development. NRP2 is known to affect aggressiveness by increasing expression in various human cancers, but the role of NRP2 in thyroid cancer is not fully understood. The purpose of this study was to investigate the...
08:58
Otolaryngologic Clinics of North America,Classification of TinnitusTinnitus is spoken of as if it were a single thing, but there are many different causes, likely many different mechanisms, and many different subtypes. This article reviews a broad range of approaches to understand and demarcate different tinnitus subtypes, which will be critical for exploring and finding cures for different subtypes.Otolaryngologic Clinics of North America6hOtolaryngologist as a Political Leader?Otolaryngologists...
08:58
Latest Results for Endocrine,Clinical outcomes and characteristics of P30L mutations in congenital adrenal hyperplasia due to 21-hydroxylase deficiencyAbstract Despite numerous studies in the field of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, some clinical variability of the presentation and discrepancies in the genotype/phenotype correlation are still unexplained. Some, but not all, discordant phenotypes caused by mutations with known enzyme activity have been explained...
08:57
International Journal of Nanomedicine,Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast CancerInternational Journal of Nanomedicine6hNovel N-(Substituted) Thioacetamide Quinazolinone Benzenesulfonamides as Antimicrobial AgentsInternational Journal of Nanomedicine8hPreparation of Brushite Cements with Improved Properties by Adding Graphene Oxide [Corrigendum]International Journal of Nanomedicine8hΣήμανση της παραπάνω ενότητας ως αναγνωσμένης
08:57
Probiotic Potential of Lactobacillus paracasei CT12 Isolated from Water Kefir Grains (Tibicos):AbstractThe water kefir grains are a multi-species starter culture used to produce fermented beverages of sucrose solution with or without fruit extracts. The water kefir grains are known in Mexico as Tibicos, which are mainly used to produce Tepache, a traditional Mexican drink made by fermenting pineapple peel. The microbiota of Tibicos mainly include lactic acid bacteria (LAB) and since most probiotics...
08:56
Adjuvant Postoperative CD40 Agonist and PD-1 Antagonist Combination Therapy in Syngeneic Tongue Cancer Mouse Model: Background/Aim: Using a syngeneic tongue cancer mouse model, the effect of CD40 agonist and PD-1 antagonist combination therapy for local recurrence after surgery was evaluated in a partially depleted CD4 model. Materials and Methods: C3H/HeN mice were injected with 0.05 mg of the anti-mouse CD4 clone GK1.5, causing partial depletion of CD4 cells. Tongue cancer was induced by injecting...
08:55
High Nitric Oxide Adaptation in Isogenic Primary and Metastatic Head and Neck Cancer Cells: Background/Aim: Nitric oxide (NO) functions have been studied in many cancer types, but rarely in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the behavior of HNSCC cells following exposure to high NO (HNO). Materials and Methods: Two pairs of isogenic HNSCC cell lines (HN18/HN17, HN30/HN31) were used, and were treated with a NO donor for 72 h. Cell viability, cell cycle,...
08:54
MALAT1 Decreases the Sensitivity of Head and Neck Squamous Cell Carcinoma Cells to Radiation and Cisplatin: Background/Aim: Two-thirds of head and neck squamous cell carcinoma (HNSCC) patients present with locally advanced (LA) stages and have a poor survival rate. The aim of this study was to investigate the roles of the long non-coding RNAs MALAT1 on radiation and cisplatin sensitivity of HNSCC cells. Materials and Methods: Clonogenic, cell viability, and apoptosis assays were performed in cells...
08:53
Phase II Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Unresectable Esophageal Cancer: Background/Aim: We performed a phase II study of triple-drug combination chemoradiotherapy (DCF-R therapy), in which docetaxel was added to the standard chemoradiotherapy (cisplatin [CDDP]/5-fluorouracil [5-FU]) for unresectable advanced esophageal cancer. Patients and Methods: Sixty-one patients with unresectable advanced esophageal cancer underwent the following DCF-R therapy: intravenous...
08:51
Periostin Plays a Key Role in Radioresistance of Head and Neck Cancer Cells Via Epithelial-to-Mesenchymal Transition: Background/Aim: Head and neck squamous cell carcinoma (HNSCC) is an aggressive head and neck malignancy. The aim of this study was to elucidate the role of periostin (POSTN) in the epithelial-to-mesenchymal transition (EMT) process mediating the acquisition of radioresistance in HNSCC. Materials and Methods: The expression levels of EMT hallmark genes including POSTN and Erk/Akt signaling...
08:51
Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/{beta}-Catenin Pathways: Background/Aim: The hormonally-active form of vitamin D, 1,25(OH)2D3, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia. This study sought to determine (i)...
08:37
Resection for Internal Jugular Vein Thrombosis and Cervical Lymph Nodes' Involvement from Gastric Cancer: Background/Aim: Thrombosis internal jugular vein (IJV) with cervical adenopathy, as first manifestation of gastric cancer is rare. We aimed to compare resection of the cervical mass followed by gastrectomy with gastrectomy alone. Patients and Methods: Nine patients presenting thrombosis of the IJV for gastric carcinoma were divided into two groups. Patients in group A (n=3) underwent anticoagulation...
08:36
Anticancer Research current issue,Expression of MicroRNA in Locoregional Recurrent Rectal CancerBackground/Aim: miRNA expression patterns vary within primary rectal cancers and play a pivotal role in carcinogenesis. It is unknown, however, if these regulatory changes also play a role in local recurrent rectal cancers. In this study, the expression of various angiogenetic small non-coding ribonucleic acids, namely miRNA-21, miRNA-215, miRNA-221, and miRNA-222 were analysed in cancerous and healthy...
08:33
Latest Results for Cellular and Molecular Life Sciences,Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutationsAbstract Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in Caucasians, caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF is a multi-organ disease that involves the lungs, pancreas, sweat glands, digestive and reproductive systems and several other tissues. This debilitating condition...
08:29
ACS Nano: Latest Articles (ACS Publications),[ASAP] One Peptide for Them All: Gold Nanoparticles of Different Sizes Are Stabilized by a Common Peptide AmphiphileACS NanoDOI: 10.1021/acsnano.0c01021ACS Nano: Latest Articles (ACS Publications)4h[ASAP] Reconstructed Apoptotic Bodies as Targeted "Nano Decoys" to Treat Intracellular Bacterial Infections within Macrophages and Cancer CellsACS NanoDOI: 10.1021/acsnano.0c00921ACS Nano: Latest Articles (ACS Publications)4h[ASAP] Gas-Permeable, Ultrathin,...
08:29
Cancer Research Online First Articles ,ERK-mediated loss of miR-199a-3p and induction of EGR1 act as a "toggle switch" of GBM cell dedifferentiation into NANOG- and OCT4-positive cellsThere is great interest in understanding how the cancer stem cell population may be maintained in solid tumors. Here we show that tumor cells exhibiting stem-like properties and expression of pluripotency markers NANOG and OCT4 can arise from original differentiated tumor cells freshly isolated from human glioblastomas...
08:28
Planta Medica , Protective Effects of Total Alkaloids from Menispermum dauricum against Airway Inflammation in Asthmatic MicePlanta MedDOI: 10.1055/a-1151-5138 Menispermum dauricum is widely used to treat respiratory inflammation, including laryngopharyngitis, tonsillitis, tracheitis, and bronchitis. Total alkaloids isolated from M. dauricum have shown a variety of beneficial bioactivities. However, available data on the effects of M. dauricum total alkaloids against allergic asthma has not been...
08:26
Elevated TNFRSF4 gene expression is a predictor of poor prognosis in non-M3 acute myeloid leukemia: We used bioinformatic tools to dichotomize 157 non-M3 AML patients from the TCGA dataset based on the presence or absence of TP53 mutations, and screened out a key gene related to TP53 mutation for future analysi...
08:26
JBC Papers in Press, Histone Acetyltransferase 1 is Required for DNA Replication Fork Function and Stability [DNA and Chromosomes]The replisome is a protein complex on the DNA replication fork and functions in a dynamic environment at the intersection of parental and nascent chromatin. Parental nucleosomes are disrupted in front of the replication fork. The daughter DNA duplexes are packaged with an equal amount of parental and newly synthesized histones in the wake of the replication fork through...
08:25
Innovative application of helium-neon laser: enhancing the germination of Adansonia digitata and evaluating the hepatoprotective activities in mice: AbstractThe laser pretreatment of seed is drawing pronounced attention from the scientific community for its positive impact in boosting germination, seedling, and growth of plants. In this study, the laser pretreatment of Adansonia digitata (A. digitata) seeds was evaluated. Eight laser treatments were conducted at different powers, 10, 20, 40, and...
08:24
Placental alkaline phosphatase in cerebrospinal fluid as a biomarker for optimizing surgical treatment strategies for pineal region germ cell tumors: AbstractPineal region germ cell tumors are a heterogenous group of tumors; of these, pure germinoma shows high sensitivity to adjuvant therapy, and the timing and sequence of surgical intervention and adjuvant/neoadjuvant therapy are important for devising a treatment strategy for intracranial germ cell tumors (IGCT). Biopsy is diagnostically useful,...
08:23
Effects of transversus abdominis plane block versus quadratus lumborum block on postoperative analgesia: a meta-analysis of randomized controlled trials: Trunk block technique has been used in postoperative analgesia for patients undergoing surgery, specifically, transversus abdominis plane block (TAPB) and quadratus lumborum block (QLB) have been proved effect...
08:22
Intravenous dexmedetomidine versus tramadol for treatment of shivering after spinal anesthesia: a meta-analysis of randomized controlled trials: Shivering is a frequent complication after spinal anesthesia. Increasing studies have compared the effect of intravenous dexmedetomidine and intravenous tramadol on shivering after spinal anesthesia, hence we ...
08:22
Efficacy and safety of pulsed radiofrequency as a method of dorsal root ganglia stimulation for treatment of non-neuropathic pain: a systematic review: We systematically reviewed the evidence on the efficacy and safety of dorsal root ganglion (DRG) targeted pulsed radiofrequency (PRF) versus any comparator for treatment of non-neuropathic pain.
08:22
Acute airway compromise and coagulopathy: a rare presentation of acquired haemophilia A: Acquired haemophilia A is a rare but important diagnosis, carrying a mortality rate of 22%. Life-threatening sequalae of this diagnosis includes airway compromise, which can rapidly lead to demise of the patient if left untreated. Our case examines an 80-year-old man presenting with a supraglottic haematoma resulting from acquired haemophilia A causing airway compromise and necessitating definitive airway control....
08:21
Family cluster of three recovered cases of pneumonia due to severe acute respiratory syndrome coronavirus 2 infection: The coronavirus disease (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, in late 2019 and has affected more than 1 270 000 people worldwide. The numbers of reported cases continue to rise and threaten global health. Transmissions among family members are frequently observed, although the route of transmission...
08:21
Tako-tsubo syndrome after intraperitoneal hyperthermic chemotherapy (HIPEC) with cisplatin: an unusual complication of cytoreductive surgery plus HIPEC: View allTakotsubo syndrome is a sudden and acute form of heart failure. Symptoms can be similar to a heart attack. It is also known as takotsubo cardiomyopathy, broken heart syndrome, acute stress induced cardiomyopathy, and apical ballooning.What is takotsubo syndrome? - Heart Matters magazine | BHF
08:20
Losing Ground: Current Medicaid Policy Threatens Children's Access to Health CareFrom 2008 through 2016, the number of uninsured children in the United States decreased from 7.6 million to 3.6 million (Alker & Roygardner, 2019). However, since 2017 that trend has reversed. Over 4 million children are now uninsured—the highest rate of uninsured children since the implementation of the Affordable Care Act (ACA)—and over one-quarter of these children are aged under 6 years (Burak, Clark, & Roygardner,...
Mon May 04, 2020 16:36
A Novel Risk Calculator for Suboccipital Decompression for Adult Chiari Malformation.Related ArticlesA Novel Risk Calculator for Suboccipital Decompression for Adult Chiari Malformation. World Neurosurg. 2020 Apr 29;: Authors: Feghali J, Marinaro E, Lubelski D, Luciano MG, Huang J Abstract BACKGROUND: Patient counselling and selection for surgical therapy in adult Chiari malformation type I (CM-1) remains debatable. We aimed to develop a clinical calculator predicting the risk of non-home discharge...
Mon May 04, 2020 16:31
Journal of Neuroscience MethodsUse of viruses for interrogating viscera-specific projections in central nervous systemPublication date: Available online 3 May 2020Source: Journal of Neuroscience MethodsAuthor(s): Li Fan, Boqi Xiang, Jun Xiong, Zhigang He, Hongbing XiangJournal of Neuroscience Methods2mMark above section as read Latest Results for Current Heart Failure ReportsDuchenne Muscular Dystrophy: the Heart of the MatterAbstract Purpose of Review Duchenne muscular dystrophy is one of many...
Mon May 04, 2020 16:30
FRET based fluorescent ratiometric probes for rapid detection of endogenous hydrogen sulphide in living cellsAnalyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00531B, PaperYuming Zhang, Yuncong Chen, Bai Yang, Xueling Xue, Weijiang He, Zijian GuoReal time monitor of hydrogen sulphide (H2S) level change is of crucial importance for the study of its complicated roles in physiology. Herein, we developed a FRET strategy for designing...The content of this RSS Feed (c) The Royal Society of ChemistryRoyal...
Mon May 04, 2020 16:29
Innovative application of helium-neon laser: enhancing the germination of Adansonia digitata and evaluating the hepatoprotective activities in miceAbstract The laser pretreatment of seed is drawing pronounced attention from the scientific community for its positive impact in boosting germination, seedling, and growth of plants. In this study, the laser pretreatment of Adansonia digitata (A. digitata) seeds was evaluated. Eight laser treatments were conducted at different powers, 10, 20, 40, and 80 mW,...
Mon May 04, 2020 16:27
Latest Results for Rheumatology InternationalProbiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trialAbstract Patients with Sjögren's syndrome are at a higher risk to develop oral candidiasis than the general population. As antifungals have many side-effects, new approaches are needed to address this problem. This randomized controlled study aimed to evaluate the short-term efficacy of probiotics in the reduction...
Mon May 04, 2020 16:27
[A comparative study of the P300 wave and evoked theta-rhythm in schizophrenia and personality disorders].[A comparative study of the P300 wave and evoked theta-rhythm in schizophrenia and personality disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(3):41-47 Authors: Bochkarev VK, Solnceva SV, Kirenskaya AV, Tkachenko AA Abstract OBJECTIVE: Amplitude and latency of evoked potential P300 are considered as major correlates of cognitive functions. At the same time the changes in the theta-band...
Mon May 04, 2020 16:26
A systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall.Related ArticlesA systematic review of different treatment strategies for the squamous cell carcinoma of the posterior pharyngeal wall. Eur Arch Otorhinolaryngol. 2020 May 02;: Authors: De Virgilio A, Russo E, Costantino A, Malvezzi L, Colombo G, Cugini G, Miceli S, Rossi V, Spriano G, Mercante G Abstract OBJECTIVE: To perform a systematic review of the literature available about...
Mon May 04, 2020 16:25
Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group.Related ArticlesConsensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group. Med J Aust. 2020 May 01;: Authors: Brewster DJ, Chrimes N, Do TB, Fraser K, Groombridge CJ, Higgs A, Humar MJ, Leeuwenburg TJ, McGloughlin S, Newman FG, Nickson CP, Rehak A, Vokes D, Gatward JJ Abstract...
Mon May 04, 2020 16:24
Latest Results for Journal of Applied GeneticsA complex network of QTL for thousand-kernel weight in the rye genomeAbstract Here, QTL mapping for thousand-kernel weight carried out within a 541 × Ot1-3 population of recombinant inbred lines using high-density DArT-based map and three methods (single-marker analysis with F parametric test, marker analysis with the Kruskal–Wallis K* nonparametric test, and the recently developed analysis named genes interaction assorting by divergent selection with...
Mon May 04, 2020 16:24
Multi-view deep learning for rigid gas permeable lens base curve fitting based on Pentacam imagesAbstract Many studies in the rigid gas permeable (RGP) lens fitting field have focused on providing the best fit for patients with irregular astigmatism, a challenging issue. Despite the ease and accuracy of fitting in the current fitting methods, no studies have provided a high-pace solution with the final best fit to assist experts. This work presents a deep learning solution for identifying features...
Mon May 04, 2020 16:23
Latest Results for PsychopharmacologyInfralimbic cortex activity is required for the expression but not the acquisition of conditioned safetyAbstract The ability to discriminate between danger and safety is crucial for survival across species. Whereas danger signals predict the onset of a potentially threatening event, safety signals indicate the non-occurrence of an aversive event, thereby reducing fear and stress responses. While the neural basis of conditioned safety remains to be elucidated,...
Mon May 04, 2020 16:21
Autoimmunity ReviewsSeven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of viewPublication date: Available online 3 May 2020Source: Autoimmunity ReviewsAuthor(s): Andreas Kronbichler, Maria Effenberger, Michael Eisenhut, Keum Hwa Lee, Jae Il ShinAutoimmunity Reviews13:03Imatinib might constitute a treatment option for lung involvement in COVID-19: Comment to: "The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia...
Mon May 04, 2020 16:20
International Journal of CancerAssociation of HPV35 with cervical carcinogenesis among women of African ancestry: evidence of viral‐host interaction with implications for disease interventionAbstract HPV35 has been found in only ~2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub‐Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and race/ethnicity, in relation to the known steps in cervical carcinogenesis, using...
Mon May 04, 2020 16:19
Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19F NMR‐Based ScreeningFragment‐based lead discovery has become a fundamental approach to identify ligands that efficiently interact with disease‐relevant targets. Among the numerous screening techniques, fluorine‐detected NMR has gained popularity owing to its high sensitivity, robustness, and ease of use. To effectively explore chemical space, a universal NMR experiment, a rationally designed fragment library, and a...
Mon May 04, 2020 16:19
Head and NeckOral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series.Related ArticlesOral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series. Int J Oral Maxillofac Surg. 2020 Apr 29;: Authors: Capote-Moreno A, Brabyn P, Muñoz-Guerra MF, Sastre-Pérez J, Escorial-Hernandez V, Rodríguez-Campo FJ, García T, Naval-Gías L Abstract Oral squamous cell carcinoma (OSCC) remains a challenge for head and neck surgeons,...
Mon May 04, 2020 16:18
Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.Related ArticlesAutologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide...
Mon May 04, 2020 16:16
Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1.Related ArticlesNedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1. Exp Cell Res. 2020 Apr 30;:112038 Authors: Chen Y, Du M, Yusuying S, Liu W, Tan Y, Xie P Abstract MLN4924/Pevonedistat, a Nedd8-activating enzyme (NAE, E1) inhibitor, has shown notable anti-cancer...
Mon May 04, 2020 16:16
Upper respiratory tract infectionDecreased prevalence of Moraxella catarrhalis in addition to Streptococcus pneumoniae in children with upper respiratory tract infection after introduction of conjugated pneumococcal vaccine - A retrospective cohort study.Related ArticlesDecreased prevalence of Moraxella catarrhalis in addition to Streptococcus pneumoniae in children with upper respiratory tract infection after introduction of conjugated pneumococcal vaccine - A retrospective cohort study. Clin Microbiol...
Mon May 04, 2020 16:15
The Journal of Prosthetic DentistryInfluence of different surface treatments and universal adhesives on the repair of CAD-CAM composite resins: An in vitro studyPublication date: Available online 4 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Soner Sismanoglu, Zuhal Yildirim-Bilmez, Aysegul Erten-Taysi, Pınar ErcalThe Journal of Prosthetic Dentistry16:09Creating a virtual patient for completely edentulous computer-aided implant surgery: A dental techniquePublication date: Available...
Mon May 04, 2020 16:14
Study Demonstrates Promise for Olaparib in Metastatic Castration-Resistant Prostate CancerOlaparib was found to be associated with longer progression-free survival and improved measures of response and patient-reported end points than either enzalutamide or abiraterone in men with metastatic castration-resistant prostate cancer. (Source: CancerNetwork)CancerNetwork8hPopulation Genomic Screening Efforts May Identify High-Risk Individuals Before Disease OnsetAccording to researchers, these observations...
Mon May 04, 2020 16:14
Uterine myeloid sarcomaLatest Results4hΣήμανση της παραπάνω ενότητας ως αναγνωσμένης Latest Results for European Archives of Oto-Rhino-LaryngologyLateral cervical approach for salvage total laryngectomy without pharyngeal reinforcement with pedicled or free flaps: our preliminary experience in six patientsAbstract Purpose To analyze the surgical outcomes in terms of postoperative wound complications in a small case series of six patients treated with lateral cervical approach (LCA) for salvage total...
Mon May 04, 2020 16:13
Head & NeckUse of narrowband imaging for the diagnosis and screening of laryngeal cancer: A systematic review and meta‐analysisAbstract We evaluated the diagnostic accuracy of narrowband imaging (NBI) in terms of detecting laryngeal cancer compared to that of white light endoscopy (WLE). Two reviewers individually searched the six databases for studies published between the first record date and December 31, 2019. We recorded the numbers of true positives, true negatives, false positives, and...
Mon May 04, 2020 16:12
pubmed: sleepThe chimeric antigen receptor-intensive care unit (CAR-ICU) initiative: Surveying intensive care unit practices in the management of CAR T-cell associated toxicities.Related ArticlesThe chimeric antigen receptor-intensive care unit (CAR-ICU) initiative: Surveying intensive care unit practices in the management of CAR T-cell associated toxicities. J Crit Care. 2020 Apr 15;58:58-64 Authors: Gutierrez C, Brown ART, Herr MM, Kadri SS, Hill B, Rajendram P, Duggal A, Turtle CJ, Patel K, Lin...
Mon May 04, 2020 16:11
pubmed: "oral oncol"[jour]Post-treatment 18F-FDG PET/CT for predicting survival and recurrence in patients with advanced-stage head and neck cancer undergoing curative surgery.Related ArticlesPost-treatment 18F-FDG PET/CT for predicting survival and recurrence in patients with advanced-stage head and neck cancer undergoing curative surgery. Oral Oncol. 2020 Apr 30;107:104750 Authors: Jung AR, Roh JL, Kim JS, Choi SH, Nam SY, Kim SY Abstract OBJECTIVES: Pre- and post-treatment 18F-FDG PET/CT may...
Mon May 04, 2020 16:10
Surgical Instructions in Revision Endoscopic Sinus Surgery: Pearls and PitfallsAbstract Functional endoscopic sinus surgery (FESS) has become one of the most common surgical techniques performed by otolaryngologists with significant data demonstrating its efficacy in managing patients with chronic rhinosinusitis (CRS). However, despite this initial success, patients may continue to present with recurrent symptoms and approximately 10–15% of them will require revision surgery. Failure of FESS may...
Mon May 04, 2020 16:08
Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.: Related ArticlesRare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.BMC Med Genet. 2020 May 01;21(1):87Authors: Bieder A, Einarsdottir E, Matsson H, Nilsson HE, Eisfeldt J, Dragomir A, Paucar M, Granberg T, Li TQ, Lindstrand A, Kere J, Tapia-Páez IAbstract BACKGROUND: Developmental dyslexia (DD)...
Mon May 04, 2020 07:53
Protocol for the trial to establish a causal linkage between mycotoxin exposure and child stunting: a cluster randomized trial.: Related ArticlesProtocol for the trial to establish a causal linkage between mycotoxin exposure and child stunting: a cluster randomized trial.BMC Public Health. 2020 May 01;20(1):598Authors: Phillips E, Ngure F, Smith LE, Makule E, Turner PC, Nelson R, Kimanya M, Stoltzfus R, Kassim NAbstract BACKGROUND: The number of stunted children has fallen globally but continues...
Mon May 04, 2020 07:52
Rhinovirus impairs the immune response of alveolar macrophages to facilitate Streptococcus pneumonia infection.: Related ArticlesRhinovirus impairs the immune response of alveolar macrophages to facilitate Streptococcus pneumonia infection.Pathog Dis. 2020 May 02;:Authors: Wei H, Zhao H, Li R, Yang F, Wu YAbstract Pneumonia is one important cause of mortality in neonates. However, the mechanism remains still unclear. Viral infection greatly enhances the morbidity of Streptococcus pneumonia....
Mon May 04, 2020 07:42
A novel patient with White-Sutton syndrome refines the mutational and clinical repertoire of the POGZ-related phenotype and suggests further observations.: Related ArticlesA novel patient with White-Sutton syndrome refines the mutational and clinical repertoire of the POGZ-related phenotype and suggests further observations.Am J Med Genet A. 2020 May 02;:Authors: Pascolini G, Agolini E, Fleischer N, Gulotta E, Cesario C, D'Elia G, Novelli A, Majore S, Grammatico PAbstract A rare developmental...
Mon May 04, 2020 07:42
Apatinib, a novel VEGFR-2 tyrosine kinase inhibitor, for relapsed and refractory nasopharyngeal carcinoma: data from an open-label, single-arm, exploratory study: SummaryPurpose Apatinib, a new tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, has shown promising efficacy against several solid cancers, but evidence of its efficacy against relapsed and refractory nasopharyngeal carcinoma is limited. We investigated the efficacy and safety of apatinib for relapsed and...
Mon May 04, 2020 07:39
The efficacy of vitamin D combined with clomiphene citrate in ovulation induction in overweight women with polycystic ovary syndrome: a double blind, randomized clinical trial: AbstractPurposeThe aim of this study was to assess the effect of vitamin D supplementation on ovulation rate in overweight subfertile women with PCOS undergoing ovulation induction.MethodsThis was a single center, parallel-groups, double-blind, and placebo-controlled randomized trial involving 186 eligible women undergoing...
Mon May 04, 2020 07:39
Gemcitabine and cisplatin versus docetaxel and cisplatin as induction chemotherapy followed by concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma from non-endemic area of China: AbstractPurposeAlthough several trials have confirmed the treatment efficacy of induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in locoregionally advanced nasopharyngeal carcinoma (NPC) from endemic area of China, little is known about the best regime for induction chemotherapy...
Mon May 04, 2020 07:38
Predicting prolonged length of stay after endoscopic transsphenoidal surgery for pituitary adenoma: BackgroundEndoscopic transsphenoidal surgery (ETS) for the resection of pituitary adenoma has become more common throughout the past decade. Although most patients have a short postoperative hospitalization, others require a more prolonged stay. We aimed to identify predictors for prolonged hospitalization in the setting of ETS for pituitary adenomas.MethodsA retrospective chart review as performed...
Mon May 04, 2020 07:35
Contributing factors for delayed postoperative cerebrospinal fluid leaks and suggested treatment algorithm: BackgroundDelayed postoperative cerebrospinal fluid (CSF) leaks are uncommon and largely unstudied complications. In this study we aim to identify their etiology and understand the efficacy of various reconstruction strategies.MethodsA retrospective chart analysis of 1017 endonasal skull base surgeries performed by a single neurosurgeon was completed identifying delayed CSF leaks (occurring...
Mon May 04, 2020 07:35
Human exposure to bisphenol A through dietary sources and development of diabetes mellitus: a cross-sectional study in Pakistani population: AbstractBisphenol A (BPA) is considered as xenoestrogen, a crucial component utilized for the manufacturing of plastic products. It has a potential to disrupt the endocrine system and induces endocrine-related metabolic disorders. We aimed to investigate the exposure of BPA in Pakistani population and its association with sociodemographic features, dietary habits,...
Mon May 04, 2020 07:34
British Journal of Cancer - Issue - nature.com science feedsTumour budding and tumour–stroma ratio in hepatocellular carcinomaBritish Journal of Cancer - Issue - nature.com science feeds5hEffects of effective stereotactic radiosurgery for brain metastases on the adjacent brain parenchymaBritish Journal of Cancer - Issue - nature.com science feeds5hIntegrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab...
Mon May 04, 2020 07:33
Detection of Group A Beta Hemolytic Streptococci Species, emm , and Exotoxin Genes Isolated from Patients with Tonsillopharyngitis: AbstractGroup A Beta Hemolytic Streptococci (GAS) is the most critical human pathogen that leads to tonsillopharyngitis. The aims of this study were to identify GAS isolates and to determine emm typing, the coverage rate of available vaccines, and the distribution of superantigen gene profiles. 15 GAS isolates were isolated from throat cultures of 200 patients with tonsillopharyngitis,...
Mon May 04, 2020 07:31
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,