Outcome analysis of stage I epithelial‐predominant favorable‐histology Wilms tumors: A report from Children's Oncology Group study AREN03B2: BackgroundStage I epithelial‐predominant favorable‐histology Wilms tumors (EFHWTs) have long been suspected to have an excellent outcome. This study investigates the clinical and pathologic features of patients with stage I EFHWTs to better evaluate the potential for a reduction of chemotherapy and its associated toxicity.MethodsAll patients registered in the...
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Phase I study of lapatinib plus trametinib in patients with KRAS -mutant colorectal, non-small cell lung, and pancreatic cancer: AbstractPurposeKRAS oncogene mutations cause sustained signaling through the MAPK pathway. Concurrent inhibition of MEK, EGFR, and HER2 resulted in complete inhibition of tumor growth in KRAS-mutant (KRASm) and PIK3CA wild-type tumors, in vitro and in vivo. In this phase I study, patients with advanced KRASm and PIK3CA wild-type colorectal cancer (CRC), non-small cell lung...
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Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects: AbstractBackground and ObjectivePeficitinib pharmacokinetics and pharmacodynamics have been characterized mainly in Caucasian subjects. This study investigated the pharmacokinetics, pharmacodynamics, safety, and tolerability of peficitinib in healthy Japanese subjects compared with Caucasian subjects.MethodsIn this single-center, randomized, double-blind, placebo-controlled study,...
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Cancers, Vol. 12, Pages 934: Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 Mutations: Cancers, Vol. 12, Pages 934: Thrombotic Risk Detection in Patients with Polycythemia Vera: The Predictive Role of DNMT3A/TET2/ASXL1 MutationsCancers doi: 10.3390/cancers12040934Authors: Adrián Segura-Díaz Ruth Stuckey Yanira Florido Jesús María González-Martín Juan Francisco López-Rodríguez Santiago Sánchez-Sosa Elena González-Pérez María Nieves...
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Spectroscopic, quantum mechanical studies, ligand protein interactions and photovoltaic efficiency modeling of some bioactive benzothiazolinone acetamide analogs: AbstractIn the present work, the molecules, N-(4-chlorophenyl)-2-[6-(benzoyl)-2-benzothiazolinone-3-yl]acetamide (CBBA), N-(6-methyl-2-pyridyl)-2-[6-(2-chlorobenzoyl)-2-benzothiazolinone-3-yl]acetamide (MCBA), N-(3-Chlorophenyl)-2-[6-(2-fluorobenzoyl)-2-benzothiazolinone-3-yl]acetamide (CFBA) and N-(6-methyl-2-pyridyl)-2-[6-(2-fluorobenzoyl)-2-benzothiazolinone-3-yl]acetamide...
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Antibiotics, Vol. 9, Pages 168: Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to Improve: Antibiotics, Vol. 9, Pages 168: Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to ImproveAntibiotics doi: 10.3390/antibiotics9040168Authors: Beatrice Tiri Paolo Bruzzone Giulia Priante Emanuela Sensi Monya Costantini Carlo Vernelli Lucia Assunta Martella Marsilio...
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Phase I study of lapatinib plus trametinib in patients with KRAS -mutant colorectal, non-small cell lung, and pancreatic cancer: AbstractPurposeKRAS oncogene mutations cause sustained signaling through the MAPK pathway. Concurrent inhibition of MEK, EGFR, and HER2 resulted in complete inhibition of tumor growth in KRAS-mutant (KRASm) and PIK3CA wild-type tumors, in vitro and in vivo. In this phase I study, patients with advanced KRASm and PIK3CA wild-type colorectal cancer (CRC), non-small cell lung...
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An Update on Regional Nodal Irradiation: Indication, Target Volume Delineation, and Radiotherapy Techniques: Background: Tremendous changes have occurred in the treatment of breast cancer. This paper reviews and unifies the available data on modern axillary management of breast cancer patients with focus on the target volume delineation for regional nodal irradiation according to the most important contouring guidelines, the European Society for Radiotherapy and Oncology (ESTRO) and the Radiation...
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Excessive Leukocytosis Leading to a Diagnosis of Aggressive Thyroid Anaplastic Carcinoma: A Case Report and Relevant Review: Introduction: Leukocytosis and particularly neutrophilia are usually caused by acute infection, inflammation, and myeloproliferative neoplasms. However, leukocytosis can also occur in patients with malignancy either due to bone marrow metastases or in the context of a paraneoplastic syndrome. Case Presentation: An 86-year-old female was admitted to our hospital due to marked...
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Gastrostomy in Patients with Previous Abdominal Surgery: A Comparative Study Between the Laparoscopy-Assisted Introducer Percutaneous Endoscopic Gastrostomy Versus Open Gastrostomy in Advanced Esophageal Cancer: AbstractStraightened nutritional status plays a vital role in the treatment outcome of advanced esophageal cancer. Both introducer percutaneous endoscopic gastrostomy (PEG) and open gastrostomy are safe options with avoidance risk of cancer cell seeding. The introducer PEG is an effective...
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Novel biomarkers for the evaluation of aging-induced proteinopathies: AbstractProteinopathies are characterized by aging related accumulation of misfolded protein aggregates. Irreversible covalent modifications of aging proteins may significantly affect the native three dimentional conformation of proteins, alter their function and lead to accumulation of misfolded protein as dysfunctional aggregates. Protein misfolding and accumulation of aberrant proteins are known to be associated with aging-induced...
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Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy: We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. The patient was a 62-year-old woman with a chief complaint...
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A Case of Advanced Hepatocellular Carcinoma with Partial Response after Continuous Ramucirumab Treatment beyond Radiological Progression: A 73-year-old male was initially treated with sorafenib for advanced stage HCC. However, the disease progressed 2 months after starting sorafenib. Progressive disease (PD) was confirmed by radiological examination, which revealed mediastinal and abdominal lymph node metastasis, pulmonary metastasis, and intrahepatic recurrence. The patient was enrolled in the REACH-2...
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Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma: Undifferentiated pleomorphic sarcoma (UPS) was previously known as malignant fibrous histiocytoma (MFH). This sarcoma occurs preferentially in the extremities and retroperitoneal space; primary pulmonary UPS/MFH is rare. We report a 52-year-old woman referred to our hospital with dyspnea and severe cough. Chest computed tomography (CT) revealed a pulmonary mass in the left upper lobe and...
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Three Curative Pancreatectomies for the Metachronous Appearance of Pancreatic Invasive Ductal Adenocarcinoma: We report a rare case of a patient who underwent 3 successful curative operations for the metachronous appearance of pancreatic cancer. In July 2007, a 54-year-old woman underwent pylorus-preserving pancreaticoduodenectomy. In March 2010, a tumor measuring 9 mm in diameter was detected in the tail of the pancreas on computed tomography (CT) and magnetic resonance imaging. The pancreas tail...
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A Case of Solitary Lung Metastasis of Breast Cancer Successfully Treated with Stereotactic Body Radiotherapy after Chemotherapy: A 62-year-old woman with triple-negative breast cancer underwent breast-conserving surgery followed by adjuvant chemotherapy and radiotherapy to the breast. The patient developed a solitary lung metastasis at the left hilum 44 months after the operation. The lung metastasis responded partially to capecitabine chemotherapy, but showed regrowth in 7 months. The patient received...
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Renal Squamous Cell Carcinoma with Staghorn Calculus: A 70-year-old Japanese woman was referred to our department due to general fatigue and a persistent low fever. We performed percutaneous nephrostomy and administered antibiotics for the pyelonephritis due to her left staghorn calculus. After the infection had been brought under control and her general condition improved, we performed nephrectomy. A pathologic examination revealed renal squamous cell carcinoma (SCC) in addition to xanthogranulomatous...
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Immune‐related pancytopenia caused by nivolumab and ipilimumab combination therapy for unresectable melanoma of unknown primary:
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BCMA‐specific chimeric antigen receptor T cells for multiple myeloma: Clinical experience and future perspectives: AbstractDespite major advances in the treatment of multiple myeloma (MM) it remains a largely incurable disease with long‐term control often dependent on continuous therapy. More effective, better tolerated treatments are therefore required to achieve durable remissions and to improve the quality of life of MM patients. Adoptive immunotherapy employing T‐cells expressing chimeric antigen...
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Investigating the concordance in molecular subtypes of primary colorectal tumors and their matched synchronous liver metastasis: ABSTRACTTo date, no systematic analyses are available assessing concordance of molecular classifications between primary tumors (PT) and matched liver metastases (LM) of metastatic colorectal cancer (mCRC). We investigated concordsssance between PT and LM for four clinically relevant CRC gene signatures. Twenty‐seven fresh and 55 formalin fixed paraffin embedded pairs of...
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Wearable Cardiorespiratory Monitoring Employing a Multimodal Digital Patch Stethoscope: Estimation of ECG, PEP, LVETand Respiration Using a 55 mm Single-Lead ECG and Phonocardiogram.: Related ArticlesWearable Cardiorespiratory Monitoring Employing a Multimodal Digital Patch Stethoscope: Estimation of ECG, PEP, LVETand Respiration Using a 55 mm Single-Lead ECG and Phonocardiogram.Sensors (Basel). 2020 Apr 04;20(7):Authors: Klum M, Urban M, Tigges T, Pielmus AG, Feldheiser A, Schmitt T, Orglmeister...
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Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy.: Related ArticlesInflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy.J Clin Med. 2020 Apr 05;9(4):Authors: Huang YS, Chin WC, Guilleminault C, Chu KC, Lin CH, Li HYAbstract BACKGROUND: Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before...
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Neoadjuvant chemotherapy followed by surgery in lung cancer: Indian scenario.: Related ArticlesNeoadjuvant chemotherapy followed by surgery in lung cancer: Indian scenario.Curr Probl Cancer. 2020 Mar 04;:100563Authors: Kumar S, Saikia J, Kumar V, Malik PS, Madan K, Jain D, Bharati SAbstract A vast majority of the patients with lung cancer in India present as advanced stage disease and a significant number among them have nonmetastatic locally advanced tumors which require multimodality management...
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The firing of theta state related septal cholinergic neurons disrupt hippocampal ripple oscillations via muscarinic receptors.: Related ArticlesThe firing of theta state related septal cholinergic neurons disrupt hippocampal ripple oscillations via muscarinic receptors.J Neurosci. 2020 Mar 30;:Authors: Ma X, Zhang Y, Wang L, Li N, Barkai E, Zhang X, Lin L, Xu JAbstract The septo-hippocampal cholinergic system is critical for hippocampal learning and memory. However, a quantitative description...
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The Ventrolateral Periaqueductal Gray Contributes to Depressive-Like Behaviors in Recovery of Inflammatory Bowel Disease Rat Model.: Related ArticlesThe Ventrolateral Periaqueductal Gray Contributes to Depressive-Like Behaviors in Recovery of Inflammatory Bowel Disease Rat Model.Front Neurosci. 2020;14:254Authors: Ko CY, Yang YB, Chou D, Xu JHAbstract Background: Patients with inflammatory bowel disease (IBD) experience depression, even in the remission phase of IBD symptoms. Although mapping...
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Inflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation.: Related ArticlesInflammasome Adaptor ASC Is Highly Elevated in Lung Over Plasma and Relates to Inflammation and Lung Diffusion in the Absence of Speck Formation.Front Immunol. 2020;11:461Authors: Gavrilin MA, McAndrew CC, Prather ER, Tsai M, Spitzer CR, Song MA, Mitra S, Sarkar A, Shields PG, Diaz PT, Wewers MDAbstract Rationale: Caspase-1 is a...
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Genome‐wide association study identifies an early onset pancreatic cancer risk locus: AbstractEarly onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore we performed a genome‐wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset ≤60 years,...
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[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].: Related Articles[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].Nervenarzt. 2020 Apr 07;:Authors: Kittel-Schneider S, Reif AAbstract All large population-based administrative studies currently indicate a significant comorbidity of adult attention deficit hyperactivity disorder (ADHD) with addictive, anxiety...
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Rapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.: Related ArticlesRapid anti-depressant-like effects of ketamine and other candidates: Molecular and cellular mechanisms.Cell Prolif. 2020 Apr 07;:e12804Authors: Peng FZ, Fan J, Ge TT, Liu QQ, Li BJAbstract Major depressive disorder takes at least 3 weeks for clinical anti-depressants, such as serotonin selective reuptake inhibitors, to take effect, and only one-third of patients remit....
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Changes in Oxygen Saturation and Mean Arterial Pressure With Inhaled Epoprostenol in Transport.: Related ArticlesChanges in Oxygen Saturation and Mean Arterial Pressure With Inhaled Epoprostenol in Transport.J Intensive Care Med. 2020 Apr 08;:885066620917658Authors: Richards JB, Frakes M, Saia MS, Johnson R, Wilcox SRAbstract OBJECTIVE: Patients with hypoxemic respiratory failure have traditionally been considered one of the riskiest patient populations to transport, given the potential for...
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Epilepsy in LAMA2-related muscular dystrophy: An electro-clinico-radiological characterization.: Related ArticlesEpilepsy in LAMA2-related muscular dystrophy: An electro-clinico-radiological characterization.Epilepsia. 2020 Apr 08;:Authors: Natera-de Benito D, Muchart J, Itzep D, Ortez C, González-Quereda L, Gallano P, Ramirez A, Aparicio J, Domínguez-Carral J, Carrera-García L, Expósito-Escudero J, Pardo Cardozo N, Cuadras D, Codina A, Jou C, Jimenez-Mallebrera C, Palau F, Colomer J, Arzimanoglou...
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Neuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery.: Related ArticlesNeuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery.Eur J Pain. 2020 Apr 08;:Authors: Gandhi W, Pomares FB, Naso L, Asenjo JF, Schweinhardt PAbstract BACKGROUND: Because the development of neuropathic symptoms contributes to pain severity and chronification after surgery, their early prediction is...
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Circadian Activity Rhythms and Fatigue of Adolescent Cancer Survivors and Healthy Controls: A Pilot Study.: Related ArticlesCircadian Activity Rhythms and Fatigue of Adolescent Cancer Survivors and Healthy Controls: A Pilot Study.J Clin Sleep Med. 2020 Apr 08;:Authors: Rogers VE, Mowbray C, Zhu S, Liu L, Ancoli-Israel S, Barr EA, Hinds PSAbstract STUDY OBJECTIVES: The primary objective of this study was to compare circadian activity rhythms (CARs) of adolescents within five years of completing...
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Pulmonary artery hemodynamics are associated with duration of nocturnal desaturation but not apnea-hypopnea index.: Related ArticlesPulmonary artery hemodynamics are associated with duration of nocturnal desaturation but not apnea-hypopnea index.J Clin Sleep Med. 2020 Apr 08;:Authors: Samhouri B, Venkatasaburamini M, Paz Y Mar H, Li M, Mehra R, Chaisson NFAbstract STUDY OBJECTIVES: Sleep-disordered breathing (SDB) and nocturnal hypoxia are prevalent among patients with precapillary pulmonary...
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The Risk of Cardiovascular and Cerebrovascular Disease in Overlap Syndrome: A Meta-Analysis.: Related ArticlesThe Risk of Cardiovascular and Cerebrovascular Disease in Overlap Syndrome: A Meta-Analysis.J Clin Sleep Med. 2020 Apr 08;:Authors: Xu J, Wei Z, Wang X, Li X, Wang WAbstract STUDY OBJECTIVES: To undertake a meta-analysis of literatures comparing the prevalence of cardio- and cerebrovascular comorbidities between overlap syndrome (OS) patients and chronic obstructive pulmonary disease...
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Diagnosis of Sleep Apnea Without Sensors on the Patient's Face.: Related ArticlesDiagnosis of Sleep Apnea Without Sensors on the Patient's Face.J Clin Sleep Med. 2020 Apr 08;:Authors: Sabil A, Marien C, LeVaillant M, Baffet G, Meslier N, Gagnadoux FAbstract STUDY OBJECTIVES: Thermistors, nasal cannulas and respiratory inductance plethysmography (RIP) are the reference sensors (AASM recommendations) for the detection and characterization of apneas and hypopneas. However, these sensors are...
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The Relationship Between Specific Nasopharyngoscopic Features and Treatment Deterioration With Mandibular Advancement Devices: A Prospective Study.: Related ArticlesThe Relationship Between Specific Nasopharyngoscopic Features and Treatment Deterioration With Mandibular Advancement Devices: A Prospective Study.J Clin Sleep Med. 2020 Apr 08;:Authors: Van de Perck E, Op de Beeck S, Dieltjens M, Vroegop AV, Verbruggen AE, Willemen M, Verbraecken J, Van de Heyning PH, Braem MJ, Vanderveken OMAbstract...
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Screening of Obstructive Sleep Apnea in Snoring Patients Using a Patch-Type Device With Electrocardiogram and 3-Axis Accelerometer.: Related ArticlesScreening of Obstructive Sleep Apnea in Snoring Patients Using a Patch-Type Device With Electrocardiogram and 3-Axis Accelerometer.J Clin Sleep Med. 2020 Apr 08;:Authors: Hsu YS, Chen TY, Wu D, Lin CM, Juang JN, Liu WTAbstract STUDY OBJECTIVES: People with obstructive sleep apnea (OSA) remain undiagnosed owing to lack of easy and comfortable...
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Relationship between sleep disturbances, lipid profile and insulin sensitivity in type 1 diabetic patients: a cross-sectional study.: Related ArticlesRelationship between sleep disturbances, lipid profile and insulin sensitivity in type 1 diabetic patients: a cross-sectional study.Arch Endocrinol Metab. 2020 Apr 06;:Authors: Mattos ACMT, Campos YS, Fiorini VO, Sab Y, Tavares BL, Velarde LGC, Lima GAB, Cruz Filho RADAbstract OBJECTIVE: The consequences of sleep deprivation in type 1 diabetes...
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An assessment of a simple clinical technique to estimate pharyngeal collapsibility in people with OSA.: Related ArticlesAn assessment of a simple clinical technique to estimate pharyngeal collapsibility in people with OSA.Sleep. 2020 Apr 08;:Authors: Osman AM, Tong BK, Landry SA, Edwards BA, Joosten SA, Hamilton GS, Cori JM, Jordan AS, Stevens D, Grunstein RR, McEvoy RD, Catcheside PG, Eckert DJAbstract STUDY OBJECTIVES: Quantification of upper airway collapsibility in obstructive sleep apnea...
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Association between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women.: Related ArticlesAssociation between proteomics and obstructive sleep apnea phenotypes in a community-based cohort of women.J Sleep Res. 2020 Apr 08;:e13041Authors: Ljunggren M, Theorell-Haglöw J, Freyhult E, Sahlin C, Franklin KA, Malinovschi A, Janson C, Lindberg EAbstract Proteomic-based technologies offer new opportunities to identify proteins that might reflect the cardiometabolic...
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The Effects of Apnea Training, Using Voluntary Breath Holds, on High Altitude Acclimation: Breathe-High Altitude Study.: Related ArticlesThe Effects of Apnea Training, Using Voluntary Breath Holds, on High Altitude Acclimation: Breathe-High Altitude Study.High Alt Med Biol. 2020 Apr 08;:Authors: Shah N, Bye K, Marshall A, Woods DR, O'Hara J, Barlow M, Rimmer J, Boos CJAbstract Introduction: There is evidence that intermittent hypoxic exposure (IHE) may improve high altitude (HA) performance....
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Association of bedtime with the risk of nonalcoholic fatty liver disease among middle-aged and elderly Chinese adults with pre-diabetes and diabetes.: Related ArticlesAssociation of bedtime with the risk of nonalcoholic fatty liver disease among middle-aged and elderly Chinese adults with pre-diabetes and diabetes.Diabetes Metab Res Rev. 2020 Apr 08;:Authors: Hu C, Zhang Y, Wang S, Lin L, Peng K, Du R, Qi H, Zhang J, Wang T, Zhao Z, Li M, Xu Y, Xu M, Li D, Bi Y, Wang W, Chen Y, Lu JAbstractAIMS:...
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Paediatric Day Case Tonsillectomy - Audit of a New Programme.: Related ArticlesPaediatric Day Case Tonsillectomy - Audit of a New Programme.Ir Med J. 2020 Apr 03;113(4):56Authors: Grant O, Harper PAbstract Aims The primary objective of this audit was to assess 30-day unplanned admission or readmission rates following day case tonsillectomy. Secondary objectives included assessing demographic characteristics of patients and surgical and anaesthetic techniques employed. Methods Retrospective...
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COVID‐19 pandemic: effects and evidence‐based recommendations for otolaryngology and head and neck surgery practice: AbstractThe 2019 novel coronavirus disease (COVID‐19) is a highly contagious zoonosis produced by SARS‐CoV‐2 that is spread human‐to‐human by respiratory secretions. It was declared by the WHO as a public health emergency. The most susceptible populations, needing mechanical ventilation, are the elderly and people with associated comorbidities.There is an important risk of contagion...
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Ceftriaxone‐induced radiation recall dermatitis: AbstractBackgroundRadiation recall dermatitis (RRD) is an acute inflammatory skin reaction occurring in a skin area previously exposed to radiotherapy and triggered by subsequent intake of a drug, most commonly a chemotherapeutic agent. RRD secondary to antibiotics has also been reported but is a rare phenomenon overall and there are no reports of RRD in association with ceftriaxone exposure.MethodsWe report on a 59‐year‐old patient who had received...
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Multiple metabolic parameters and visual assessment of 18 F-FDG uptake heterogeneity of PET/CT in advanced gastric cancer and primary gastric lymphoma: AbstractPurposeAdvanced gastric cancer (AGC) and primary gastric lymphoma (PGL) are the two most common malignant tumors of the stomach. Conventional imaging examinations have difficulty distinguishing the two. This study explored the values of multiple parameters and visual assessment of 18F-fluorodeoxyglucose(18F-FDG) uptake heterogeneity of positron...
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Cancers, Vol. 12, Pages 919: Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma: Cancers, Vol. 12, Pages 919: Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell CarcinomaCancers doi: 10.3390/cancers12040919Authors: Bhavishya Sarma Christoph Willmes Laura Angerer Christian Adam Jürgen C. Becker Thibault Kervarrec David Schrama Roland Houben Merkel cell carcinoma (MCC) is a rare and highly aggressive...
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Clinical Practice Guideline: Ménière's Disease.: Related ArticlesClinical Practice Guideline: Ménière's Disease.Otolaryngol Head Neck Surg. 2020 Apr;162(2_suppl):S1-S55Authors: Basura GJ, Adams ME, Monfared A, Schwartz SR, Antonelli PJ, Burkard R, Bush ML, Bykowski J, Colandrea M, Derebery J, Kelly EA, Kerber KA, Koopman CF, Kuch AA, Marcolini E, McKinnon BJ, Ruckenstein MJ, Valenzuela CV, Vosooney A, Walsh SA, Nnacheta LC, Dhepyasuwan N, Buchanan EMAbstract OBJECTIVE: Ménière's disease (MD)...
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Plain Language Summary: Ménière's Disease.: Related ArticlesPlain Language Summary: Ménière's Disease.Otolaryngol Head Neck Surg. 2020 Apr;162(4):435-445Authors: Basura GJ, Colandrea M, Walsh SA, Kuch AA, Monjur TMAbstract This plain language summary explains Ménière's (pronounced men-yerz) disease (MD) to patients. The summary applies to patients aged 18 years and older with a suspected diagnosis of definite or probable MD. It is based on the 2020 "Clinical Practice Guideline: Ménière's...
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Clinical Practice Guideline: Ménière's Disease Executive Summary.: Related ArticlesClinical Practice Guideline: Ménière's Disease Executive Summary.Otolaryngol Head Neck Surg. 2020 Apr;162(4):415-434Authors: Basura GJ, Adams ME, Monfared A, Schwartz SR, Antonelli PJ, Burkard R, Bush ML, Bykowski J, Colandrea M, Derebery J, Kelly EA, Kerber KA, Koopman CF, Kuch AA, Marcolini E, McKinnon BJ, Ruckenstein MJ, Valenzuela CV, Vosooney A, Walsh SA, Nnacheta LC, Dhepyasuwan N, Buchanan EMAbstract ...
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Cosmetics, Vol. 7, Pages 24: New Insights on Unique Features and Role of Nanostructured Materials in Cosmetics: Cosmetics, Vol. 7, Pages 24: New Insights on Unique Features and Role of Nanostructured Materials in CosmeticsCosmetics doi: 10.3390/cosmetics7020024Authors: Muhammad Bilal Hafiz M. N. Iqbal The cosmetics industry has boomed in recent years as one of the markets that holds enormous growth potential. Among several industrial sectors, the cosmetics industry has considered nanotechnology-based...
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Tumour mutational burden as a biomarker for immunotherapy: Current data and emerging concepts: Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): Jean-David Fumet, Caroline Truntzer, Mark Yarchoan, Francois Ghiringhelli
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Successful management of refractory immune-mediated enterocolitis with cyclosporine: Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): David Pesántez, Elia Seguí, Ingrid Ordás, Marga Viladot, Ana Arance
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Irrigation fluid volume requirement for conventional arthrocentesis of the temporomandibular joint: a cadaver study: Publication date: Available online 8 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): L.F. Palma, P.R. Rocha, F.E.A. Chaddad Neto, R.L. Smith, L.O.C. de Moraes
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The lingual sulcus release technique for excision of tongue cancer with trismus: Publication date: Available online 8 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): V. Rao, P. Sinha, A. Subash, S. Thakur
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Tophaceous pseudogout of the temporomandibular joint with erosion into the middle cranial fossa: Publication date: Available online 8 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): D. Houghton, N. Munir, A. Triantafyllou, A. Begley
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Interleukin‐11 regulates the fate of adipose‐derived mesenchymal stem cells via STAT3 signalling pathways: AbstractObjectiveAdipose‐derived mesenchymal stem cells (ADSCs) offer great promise as cell therapy for ischaemic diseases. Due to their poor survival in the ischaemic environment, the therapeutic efficacy of ADSCs is still relatively low. Interleukin‐11 (IL‐11) has been shown to play a key role in promoting cell proliferation and protecting cells from oxidative stress injury. The aim of this...
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JCDD, Vol. 7, Pages 12: Right Ventricular Function in Chronic Heart Failure: From the Diagnosis to the Therapeutic Approach: JCDD, Vol. 7, Pages 12: Right Ventricular Function in Chronic Heart Failure: From the Diagnosis to the Therapeutic ApproachJournal of Cardiovascular Development and Disease doi: 10.3390/jcdd7020012Authors: Francesco Monitillo Vito Di Terlizzi Margherita Ilaria Gioia Roberta Barone Dario Grande Giuseppe Parisi Natale Daniele Brunetti Massimo Iacoviello There...
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Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome: erythrocyanotic vascular patches associated with an underlying rib plasmacytoma:
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Cancers, Vol. 12, Pages 922: Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma: Cancers, Vol. 12, Pages 922: Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell CarcinomaCancers doi: 10.3390/cancers12040922Authors: Salvatore Alfieri Andrea Carenzo Francesca Platini Mara S. Serafini Federica Perrone Donata Galbiati Andrea P. Sponghini Roberta Depenni Andrea Vingiani Pasquale Quattrone...
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Old Era Continues in Modern World: A Case Report of Scurvy Induced Myopathy in Patient with Chronic Alcoholism: We report a case of myopathy in a chronic alcoholic patient with scurvy who presented with generalized weakness, myalgias, and arthralgia. Our case raises awareness regarding rare interaction between vitamin C deficiency and myopathy which is seen more commonly in patients with history of chronic alcoholism and low socioeconomic status. Early treatment with vitamin C replacement is helpful...
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Effects of Flash Glucose Monitoring on Dietary Variety, Physical Activity, and Self-Care Behaviors in Patients with Diabetes: The aim of this study was to evaluate the effects of flash glucose monitoring on dietary variety, physical activity, and self-care behavior in patients with diabetes. This study included outpatients with diabetes using insulin who presented at the Department of Diabetes and Metabolism of the Ise Red Cross Hospital. Before initiating flash glucose monitoring and 12 weeks after...
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A Case of Cardiac Tamponade in a Patient with Metastatic Renal Cell Carcinoma on Pazopanib Treatment
A Case of Cardiac Tamponade in a Patient with Metastatic Renal Cell Carcinoma on Pazopanib Treatment: Asymptomatic minimal pericardial effusion may be frequently found in patients with hypothyroidism. Cardiac tamponade secondary to hypothyroidism is rarely referenced in medical literature. Hypothyroidism as an adverse effect of pazopanib (tyrosine kinase inhibitor) treatment leading to cardiac tamponade is an even rarer occurrence. Here, we report an unusual case of a 71-year-old male, with a case...
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Acute Kidney Injury Caused by Superior Mesenteric Artery Syndrome: Background. Superior mesenteric artery (SMA) syndrome is a rare cause of upper gastrointestinal obstruction leading to acute kidney injury (AKI). Methods. We report a case of 23-year-old army personnel who presented with persistent vomiting leading to severe hypokalaemia, metabolic alkalosis, and acute kidney injury resulting in cardiorespiratory arrest. Results. After successful resuscitation, he was supported with haemodialysis...
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Guided Periodontal Surgery: Association of Digital Workflow and Piezosurgery for the Correction of a Gummy Smile: Digital flow has become a part of currently practiced dentistry. Virtual planning ensures predictable aesthetic and functional rehabilitation, painless postoperative recovery, and better communication with patients, thus meeting their expectations. The purpose of this case report is to demonstrate the digital planning for the correction of a gummy smile with a personalized preparation...
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Impact of Genetic Variation in TLR4 3′UTR on NSCLC Genetic Susceptibility: Toll-like receptors (TLRs) are expressed not only in immune cells but also in a variety of tumor cells. Single-nucleotide polymorphisms (SNPs) located in the TLRs' promoter or the 3′ untranslated region may affect gene expression by affecting the activity of the promoter or regulating the binding of mRNA to miRNA. This study aimed to investigate the association of the SNPs in TLR genes with the susceptibility to NSCLC. This...
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Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis: Alcoholic cirrhosis (AC) leads to enormous disease burden and occupies a substantial proportion in the etiology of hepatocellular carcinoma (HCC), but scarce attention has been paid to this topic. Besides, propranolol has been reported to decrease the rate of HCC in viral hepatitis. We conducted a retrospective...
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A 16-Day-Old Infant with a Clinical Diagnosis of Classical Cornelia de Lange Syndrome: Cornelia de Lange syndrome (CdLS) is a rare syndromic genetic disorder characterized by multiple congenital anomalies with upper limb reduction defects, along with cardiac, gastrointestinal, and genitourinary defects. It is caused by genetic variations in the chromatin regulator genes, most commonly, the cohesin complex. Even though molecular genetic testing is highly recommended to confirm the diagnosis, high...
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A Case Report of Monkeypox in a 4-Year-Old Boy from the DR Congo: Challenges of Diagnosis and Management: Monkeypox (MP) is a rare zoonotic disease that most commonly transmits from bush animals to humans in the Congo Basin of Africa. However, an increase in cases of MP has been observed over the past decades with frequent outbreaks as well as export of the disease out of the African continent. MP belongs to the same genus of viruses as smallpox, the Orthopoxvirus, and vaccination against smallpox...
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Effectiveness of pediatric drug-induced sleep endoscopy for REM-predominant obstructive sleep apnea: AbstractStudy objectivesBecause dexmedetomidine (DEX)-induced sedation mimics non-rapid eye movement (NREM) sleep, its utility in sedating children with REM-predominant disease is unclear. We sought to determine the effectiveness of pediatric drug-induced sleep endoscopy (DISE) using DEX and ketamine for children with REM-predominant OSA, specifically whether or not at least one site of obstruction...
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Wearable Sensors Measure Ankle Joint Changes of Patients with Parkinson's Disease before and after Acute Levodopa Challenge: Background. Previous studies found levodopa could improve the activity of the ankle joints of patients with Parkinson's disease (PD). But ankle joint movement is composed of four motion ranges. The specific changes of four motion ranges in PD remain unknown. Objective. The purpose of this study was to decompose the complex ankle joint movement, measure ankle joint changes before...
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Integrated Analysis Identifies an Immune-Based Prognostic Signature for the Mesenchymal Identity in Gastric Cancer: Background. Gastric cancer (GC) has been divided into four molecular subtypes, of which the mesenchymal subtype has the poorest survival. Our goal is to develop a prognostic signature by integrating the immune system and molecular modalities involved in the mesenchymal subtype. Methods. The gene expression profiles collected from 6 public datasets were applied to this study, including...
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Antibiotics, Vol. 9, Pages 169: Nontraditional Antibiotics—Challenges and Triumphs: Antibiotics, Vol. 9, Pages 169: Nontraditional Antibiotics—Challenges and TriumphsAntibiotics doi: 10.3390/antibiotics9040169Authors: Karl A. Hansford The pursuit of nontraditional antibiotics is becoming an increasingly important means to tackle seemingly insurmountable challenges faced by contemporary antibiotic researchers as they overcome the shifting landscape of bacterial pathogenesis, particularly for Gram-negative...
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Sorafenib administered using a high-dose, pulsatile regimen in patients with advanced solid malignancies: a phase I exposure escalation study: AbstractBackground(Pre)clinical evidence is accumulating that intermittent exposure to increased doses of protein kinase inhibitors may improve their treatment benefit. In this phase I trial, the safety of high-dose, pulsatile sorafenib was studied.Patients and methodsHigh-dose sorafenib was administered once weekly in exposure escalation cohorts according...
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Infection control in non‐clinical areas during COVID‐19 pandemic: AbstractLarge numbers of healthcare workers have acquired coronavirus disease (COVID‐19) in the workplace [1]. SARS‐CoV‐2 is easily transmissible as each person with COVID‐19 infects approximately 2.2 close contacts, and asymptomatic transmission has been reported [2,3]. SARS‐CoV‐2 survives in aerosols and on surfaces from hours to days, respectively [4]. Therefore, we believe non‐clinical areas are potentially high‐risk for transmission...
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Glucocorticoids Enhanced Osteoclast Autophagy Through the PI3K/Akt/mTOR Signaling Pathway: AbstractAutophagy is an evolutionarily conserved dynamic process and present in variety of cells at basal levels to maintain homeostasis and to promote cell survival in response to stresses. The early bone loss with excessive glucocorticoids (GCs) was reported to be related with the extension of the life span of osteoclasts. However, the connection between GCs induced bone loss and osteoclast autophagy remains...
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Primary fungal laryngitis: Our experiences at a tertiary care teaching hospital of Eastern India: Santosh Kumar Swain, Priyanka Debta, Nibi ShajahanInternational Journal of Health & Allied Sciences 2020 9(2):153-158INTRODUCTION: Primary fungal laryngitis is a fungal infection of the larynx without affecting the other body parts such as the lungs, pharynx, and oral cavity. It is an extremely rare clinical entity. Hoarseness of the voice is common clinical presentations.OBJECTIVE: This study aimed...
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Otomycosis due to Aspergillus versicolor: Santosh Kumar Swain, Priyanka Debta, Mahesh Chandra Sahu, Jatindra Nath MohantyInternational Journal of Health & Allied Sciences 2020 9(2):192-194Otomycosis is a common clinical entity seen in both immunocompetent and immunocompromised patients. Aspergillus and Candida are the most common causative fungi in otomycosis. Aspergillus versicolor is an extremely rare causative agent for otomycosis. The clinical symptoms presented by patients are usually itching...
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Comparison of omentoplasty and tube drainage as treatment option in hydatid liver disease: A retrospective hospital-based observational study: Jehangir Allam Bhat, Shahida Akhter, Sajad Ahmad SheikhInternational Journal of Health & Allied Sciences 2020 9(2):143-146BACKGROUND: Hydatid disease remains an important parasitic infection requiring surgical intervention. The liver is the most common site of infection, and several methods of surgery have been described to treat this common disease. Extensive...
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Otological and rhinological manifestations in pregnancy: Our experiences at a tertiary care teaching hospital of East India: Santosh Kumar Swain, Tapan Pattnaik, Jatindra Nath MohantyInternational Journal of Health & Allied Sciences 2020 9(2):159-163BACKGROUND: Hormonal variations during pregnancy can lead to otological and rhinological manifestations. Majority of the manifestations have no harm to the expectant mother or fetus but some of them can become pathological. The objective of this study...
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Walk with mobile app to fight depression: An interventional study: Pradeep Tarikere Satyanarayana, Suhas ChandranInternational Journal of Health & Allied Sciences 2020 9(2):122-126BACKGROUND: Mobile health solutions can address looming problems of health. Smartphones have been integrated into global population with minimal constraints. Walking is the most convenient exercise as it can be self-regulated in intensity, duration, and frequency.MATERIALS AND METHODS: A single group pre–post experimental...
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An isolated case of maxillomandibular syngnathia in a new born: Khemraj Agrawal, B Sreevidya Reddy, Swapnil Jain, Swati AgrawalInternational Journal of Health & Allied Sciences 2020 9(2):188-191Congenital maxillomandibular syngnathia is a rare disorder. It is usually seen in association with various syndromes such as Van der Woude, popliteal pterygium syndrome, or in association with other defects. Isolated case reports of bony fusion of jaws are sparse. We report an isolated case of congenital...
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Oligometastasis liver in carcinoma breast treated with stereotactic body radiotherapy: Anshuma Bansal, Neeru Bedi, Ripanpreet Kaur, Jaspinder Kaur, Gurpreet Singh, Harjot Bagga, Vinod DangwalInternational Journal of Health & Allied Sciences 2020 9(2):195-197This case report highlights the management of single metastasis in the liver with stereotactic body radiotherapy in a previously treated case of carcinoma breast.
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Menstrual hygiene and infections: Menacing women health: Priya Sharma, NL GuptaInternational Journal of Health & Allied Sciences 2020 9(2):99-104Good menstrual hygiene is fundamental to health, education, work and wellbeing of women everywhere. Menstruation is a natural part of human existence. Yet it has been neglected for decades in all sectors as well as at individual level. Menstruation remains a taboo in many societies and various negative cultural attitudes and beliefs are still associated...
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Beware of the cortical ribboning: The spectrum – Experience from a case series: Sadanandavalli Retnaswami Chandra, Abhishek Gohel, Sindhu Dodmalur Mallikarjuna, Kalyani Bangalore Gangadhar, Sarada Subramanian, Maya D BhatInternational Journal of Health & Allied Sciences 2020 9(2):175-180INTRODUCTION: Creutzfeldt–Jakob disease (CJD) is an uncommon, fatal, genetic, transmissible and degenerative, brain disorder. It affects one person in every one million in the United States. A definite diagnosis...
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Diurnal rhythmicity in breast-milk glucocorticoids, and infant behavior and sleep at age 3 months: AbstractPurposeIn previous studies, associations between breast-milk cortisol levels obtained on one occasion and infant neurodevelopment were demonstrated. However, more recent evidence indicates that breast-milk cortisol and cortisone concentrations follow the diurnal rhythm of maternal hypothalamus-pituitary-adrenal axis, peaking in the early morning and with a nadir at midnight. We studied associations...
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Diagnosis of Flier's syndrome in a patient with nondiabetic hypoglycemia: a case report and critical appraisal of the literature: AbstractPurposeAutoimmune hypoglycemia includes rare syndromes characterized by the presence of either anti-insulin antibodies (IAA) (Hirata's disease) or anti-insulin receptor (anti-ISR) antibodies (Flier's syndrome). Diagnosis is usually based on identification of the specific antibodies, in presence of the Whipple triad. However, most of these cases are classified as...
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JPM, Vol. 10, Pages 22: The "develOpment of metabolic and functional markers of Dementia IN Older people" (ODINO) Study: Rationale, Design and Methods: JPM, Vol. 10, Pages 22: The "develOpment of metabolic and functional markers of Dementia IN Older people" (ODINO) Study: Rationale, Design and MethodsJournal of Personalized Medicine doi: 10.3390/jpm10020022Authors: Anna Picca Daniela Ronconi Hélio J. Coelho-Junior Riccardo Calvani Federico Marini Alessandra Biancolillo Jacopo Gervasoni...
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Emergence Delirium in Perioperative Pediatric Care: A Review of Current Evidence and New Directions: AbstractEmergence delirium (ED) is defined as psychomotor agitation and delirium that typically occurs within 45 min from emergence of anesthesia. Preoperative patient conditions such as anxiety and confusion are risk factors for the development of postoperative ED. Common signs of ED are general non-purposeful resistive movements such as kicking, pulling, flailing as well as lack of eye contact and...
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Emergence Delirium in Perioperative Pediatric Care: A Review of Current Evidence and New Directions: AbstractEmergence delirium (ED) is defined as psychomotor agitation and delirium that typically occurs within 45 min from emergence of anesthesia. Preoperative patient conditions such as anxiety and confusion are risk factors for the development of postoperative ED. Common signs of ED are general non-purposeful resistive movements such as kicking, pulling, flailing as well as lack of eye contact and...
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Distinct Serum and Vitreous Inflammation-Related Factor Profiles in Patients with Proliferative Vitreoretinopathy: AbstractIntroductionProliferative vitreoretinopathy (PVR), which is regulated by growth factors and cytokines, is the leading cause of failure in vitreoretinal surgery. In this study, we aimed to investigate the role of the human serum and vitreous inflammation-related factors in the development of proliferative vitreoretinopathy (PVR).MethodsBlood and vitreous samples were obtained...
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Validation of the Farsi version of the revised Adolescent Sleep Hygiene Scale (ASHSr): a cross-sectional study: Restoring sleep is associated with a broad variety of favorable cognitive, emotional, social and behavioral benefits during the day. This holds particularly true for adolescents, as maturational, social, cognitive, emotional and behavioral changes might unfavorably impact on adolescents' sleep. Among adolescents, poor sleep hygiene practices are a potentially modifiable risk factor that...
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Inflammatory Biomarkers and Clinical Judgment in the Emergency Diagnosis of Urgent Abdominal Pain: The early diagnosis of urgent abdominal pain (UAP) is challenging. Most causes of UAP are associated with extensive inflammation. Therefore, we hypothesized that quantifying inflammation using interleukin-6 and/or procalcitonin would provide incremental value in the emergency diagnosis of UAP.; This was an investigator-initiated prospective, multicenter diagnostic study enrolling patients presenting...
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Comparison of high-sensitivity cardiac troponin I and T for the prediction of cardiac complications after non-cardiac surgery: We aimed to directly compare preoperative high-sensitivity cardiac troponin (hs-cTn) I and T concentration for the prediction of major cardiac complications after non-cardiac surgery.; We measured hs-cTnI and hs-cTnT preoperatively in a blinded fashion in 1022 patients undergoing non-cardiac surgery. The primary endpoint was a composite of major cardiac complications including...
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Evaluation of Two 3D Printers for Guided Implant Surgery: To compare the suitability of a fused filament fabrication (FFF) consumer 3D printer with a professional digital light processing (DLP) printer for the production of surgical templates for guided oral implant surgery.; Eight virtual templates were printed with two different 3D printers. These were optically scanned and the incongruences between virtual and printed templates were determined after alignment of the surface scans and the virtual...
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StarD13: a potential star target for tumor therapeutics: AbstractStarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is either downregulated or completely inhibited, depending on the tumor type. As such, and through the dysregulation of Rho GTPases, this affects adhesion dynamics, actin dynamics, and leads to an increase or a decrease...
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Time-space Fourier κ ω ′ filter for motion artifacts compensation during transcranial fluorescencebrain imaging: Intravital imaging of brain vasculature through the intact cranium in vivo is based on the evolution of the fluorescence intensity and provides an ability to characterize various physiological processes in the natural context of cellular resolution. The involuntary motions of the examined subjects often limit in vivo non-invasive functional optical imaging. Conventional imaging diagnostic...
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Reducing 4D CT imaging artifacts at the source: first experimental results from the respiratoryadaptive computed tomography (REACT) system: Breathing variations during 4D CT imaging often manifest as geometric irregularities known asrespiratory-induced image artifacts and ultimately effect radiotherapy treatment efficacy. To reducesuch image artifacts we developed Respiratory Adaptive Computed Tomography (REACT) to trigger CTacquisition during periods of regular breathing. For the first time, we...
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Patient-Specific Surgical Implants Made of 3D Printed PEEK: Material, Technology, and Scope of Surgical Application: Additive manufacturing (AM) is rapidly gaining acceptance in the healthcare sector. Three-dimensional (3D) virtual surgical planning, fabrication of anatomical models, and patient-specific implants (PSI) are well-established processes in the surgical fields. Polyetheretherketone (PEEK) has been used, mainly in the reconstructive surgeries as a reliable alternative to other alloplastic...
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Retrospective Evaluation of Changes in Gait Patterns in Children and Adolescents With Cerebral Palsy After Multilevel Surgery: The purpose of this study was to retrospectively investigate changes in gait patterns after single-event multilevel surgery in children and adolescents with bilateral cerebral palsy. Three-dimensional instrumented pre- and postoperative gait data of 12 patients were compared to data of 12 healthy control subjects using principal component analysis to reduce the dimensionality...
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Removal of pharmaceutical compounds from aqueous solution by novel activated carbon synthesized from lovegrass ( Poaceae ): AbstractIn this work, lovegrass (Cpa), an abundant grass of the Poaceae family, was employed as feedstock for the production of activated carbon in a conventional furnace using ZnCl2 as a chemical activator. The prepared material (Cpa-AC) was characterized by pH of the point of zero charges (pHpzc), Boehm's titration method, CHN/O elemental analysis, ATR-FTIR, N2 adsorption/desorption...
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Cancers, Vol. 12, Pages 924: PD-L1–PD-1 Pathway in the Pathophysiology of Multiple Myeloma: Cancers, Vol. 12, Pages 924: PD-L1–PD-1 Pathway in the Pathophysiology of Multiple MyelomaCancers doi: 10.3390/cancers12040924Authors: Hideto Tamura Mariko Ishibashi Mika Sunakawa-Kii Koiti Inokuchi PD-L1 expressed on tumor cells contributes to disease progression with evasion from tumor immunity. Plasma cells from multiple myeloma (MM) patients expressed higher levels of PD-L1 compared with healthy...
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A 24-year-old Immigrant With Rash: A 24-year-old woman was evaluated 12 weeks after normal vaginal delivery for recurrent painful nodular skin rash present on and off for the last 2 years. Two days before presentation, red, painful, and nonpruritic rash had appeared on her upper and lower extremities. The patient denied fever, weight loss, night sweat, cough, shortness of breath, or any other symptoms. Upon physical examination, multiple tender violaceous nodules with no fluctuation, ulceration,...
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Repeatability of spatiotemporal, plantar pressure and force parameters during treadmill walking and running: Instrumented treadmills with integrated pressure mats measure spatiotemporal, pressure and force parameters and are often used to investigate changes in gait patterns due to injury or rehabilitation.; What is the within- and between-day repeatability of such an instrumented treadmill for spatiotemporal parameters, peak pressures and forces during walking and running?; Treadmill gait and running...
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Decompression surgery improves gait quality in patients with symptomatic lumbar spinal stenosis: We aimed to fully understand the extent of limitations associated with symptomatic lumbar spinal stenosis (LSS) and the functional outcome of its treatment, including not only function during daily activities (eg, using the 6-minute walk test [6MWT]) but also the quality of function that should be objectively assessed.; This study was performed to test the hypothesis that the Oswestry Disability Index...
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Artificial Intelligence in Ophthalmology: A Meta-Analysis of Deep Learning Models for Retinal Vessels Segmentation.: Related ArticlesArtificial Intelligence in Ophthalmology: A Meta-Analysis of Deep Learning Models for Retinal Vessels Segmentation.J Clin Med. 2020 Apr 03;9(4):Authors: Islam MM, Poly TN, Walther BA, Yang HC, Li YJAbstract BACKGROUND AND OBJECTIVE: Accurate retinal vessel segmentation is often considered to be a reliable biomarker of diagnosis and screening of various diseases,...
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miR-155 inhibits oxidized low-density lipoprotein–induced apoptosis in different cell models by targeting the p85α/AKT pathway: AbstractThe apoptosis of vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), and macrophages directly causes the instability or rupture of atherosclerotic plaques. Accumulating evidence suggests that oxidized low-density lipoprotein (OxLDL) could induce apoptosis via endogenous or exogenous pathways. Interestingly, it has been reported that microRNA155...
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Good vibrations: Itch induction by whole body vibration exercise without the need of a pruritogen: Mechanically induced itch is an important cofactor in many patients with chronic itch. However, studying mechanical itch in a controlled environment is challenging because it is difficult to evoke. We investigated the use of whole body vibration (WBV) exercise, a training method used for musculoskeletal rehabilitation, to experimentally evoke mechanical itch. Mild to severe itch ascending from the soles...
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Preclinical human models and emerging therapeutics for advanced systemic mastocytosis: Mastocytosis is a term used to denote a group of rare diseases characterized by an abnormal accumulation of neoplastic mast cells in various tissues and organs. In most patients with systemic mastocytosis, the neoplastic cells carry activating mutations in; KIT; Progress in mastocytosis research has long been hindered by the lack of suitable; in vitro; models, such as permanent human mast cell lines. In fact, only...
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The role of mast cells in autoimmune bullous dermatoses: Skin mast cells (MCs), a resident immune cell type with broad regulatory capacity, play an important role in sensing danger signals as well as in the control of the local immune response. It is conceivable to expect that skin MCs regulate autoimmune response and are thus involved in autoimmune diseases in the skin, e.g., autoimmune bullous dermatoses (AIBD). Therefore, exploring the role of MCs in AIBD will improve our understanding of the...
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Although abundant in tumor tissue, mast cells have no effect on immunological micro-milieu or growth of HPV-induced or transplanted tumors: High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology....
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Variability of PD-L1 expression in mastocytosis: Mastocytosis is a rare disease with heterogeneous clinical manifestations and few effective therapies. Programmed death-1 (PD-1) and its ligands (PD-L1 and PD-L2) protect tissues from immune-mediated damage and permit tumors to evade immune destruction. Therapeutic antibodies against PD-1 and PD-L1 are effective in the treatment of a variety of neoplasms. In the present study, we sought to systematically analyze expression of PD-1 and PD-L1 in a large...
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Cancers, Vol. 12, Pages 929: The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat: Cancers, Vol. 12, Pages 929: The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of FebuxostatCancers doi: 10.3390/cancers12040929Authors: Mohannad Ashtar Hirofumi Tenshin Jumpei Teramachi Ariunzaya Bat-Erdene Masahiro Hiasa Asuka Oda Kotaro Tanimoto So Shimizu Yoshiki Higa Takeshi Harada Masahiro Oura ...
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Cancers, Vol. 12, Pages 927: Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells: Cancers, Vol. 12, Pages 927: Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer CellsCancers doi: 10.3390/cancers12040927Authors: Abdulaziz B. Hamid Ruben C. Petreaca Secondary resistant mutations in cancer cells arise in response to certain small molecule inhibitors. These mutations inevitably cause recurrence and often progression to a more aggressive form. Resistant...
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Cancers, Vol. 12, Pages 928: Cytotoxic Effect of Trabectedin In Human Adrenocortical Carcinoma Cell Lines and Primary Cells: Cancers, Vol. 12, Pages 928: Cytotoxic Effect of Trabectedin In Human Adrenocortical Carcinoma Cell Lines and Primary CellsCancers doi: 10.3390/cancers12040928Authors: Andrea Abate Elisa Rossini Sara Anna Bonini Martina Fragni Deborah Cosentini Guido Albero Massimo Tiberio Diego Benetti Constanze Hantel Marta Laganà Salvatore Grisanti Massimo...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,