IJMS, Vol. 21, Pages 3003: COVID-19 and RAS: Unravelling an Unclear Relationship: IJMS, Vol. 21, Pages 3003: COVID-19 and RAS: Unravelling an Unclear RelationshipInternational Journal of Molecular Sciences doi: 10.3390/ijms21083003Authors: Damiano D'Ardes Andrea Boccatonda Ilaria Rossi Maria Teresa Guagnano Francesca Santilli Francesco Cipollone Marco Bucci The renin-angiotensin system (RAS) plays a main role in regulating blood pressure and electrolyte and liquid balance. Previous...
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ResourcesResources, Vol. 9, Pages 49: Grazing Management, Forage Production and Soil Carbon DynamicsResources, Vol. 9, Pages 49: Grazing Management, Forage Production and Soil Carbon Dynamics Resources doi: 10.3390/resources9040049 Authors: Mark E. Ritchie Soil carbon pools remain a target for sequestering greenhouse gases, but appropriate land management options to achieve such sequestration remain uncertain. Livestock grazing can have profound positive or negative effects on soil carbon. Different...
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MoleculesMolecules, Vol. 25, Pages 1948: Design, Synthesis, and Biological Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Dual Degradation of IGF-1R and SrcMolecules, Vol. 25, Pages 1948: Design, Synthesis, and Biological Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Dual Degradation of IGF-1R and Src Molecules doi: 10.3390/molecules25081948 Authors: Sudhakar Manda Na Keum Lee Dong-Chan Oh Jeeyeon Lee A focused PROTAC library was developed to degrade both IGF-1R...
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MicroorganismsMicroorganisms, Vol. 8, Pages 609: Incidental Prophylactic Appendectomy Is Associated with a Profound Microbial Dysbiosis in the Long-TermMicroorganisms, Vol. 8, Pages 609: Incidental Prophylactic Appendectomy Is Associated with a Profound Microbial Dysbiosis in the Long-Term Microorganisms doi: 10.3390/microorganisms8040609 Authors: Lidia Sánchez-Alcoholado José Carlos Fernández-García Carolina Gutiérrez-Repiso M Rosa Bernal-López Luis Ocaña-Wilhelmi Eduardo García-Fuentes Isabel...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 2961: Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 PathwayIJMS, Vol. 21, Pages 2961: Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21082961 Authors: Ruyi Gao Yongshuai Zhang Yuhui Kang Weiyin Xu Luyao Jiang Tingting Guo Changchao Huan Our previous study...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 2911: Perceptions on Connecting Respite Care Volunteers and CaregiversIJERPH, Vol. 17, Pages 2911: Perceptions on Connecting Respite Care Volunteers and Caregivers International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082911 Authors: Solange Campos-Romero Valeria Herskovic Carolina Fuentes Esmeralda Abarca The most common requirement for informal caregivers is to experience a...
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CellsCells, Vol. 9, Pages 1053: Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis RegulationCells, Vol. 9, Pages 1053: Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation Cells doi: 10.3390/cells9041053 Authors: Vera Miranda-Gonçalves Ana Lameirinhas Catarina Macedo-Silva João Lobo Paula C. Dias Verónica Ferreira Rui Henrique Carmen Jerónimo Background:...
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Adaptive evolution of hybrid bacteria by horizontal gene transfer [NEW RESULTS]: Horizontal gene transfer is an important factor in bacterial evolution that can act across species boundaries. Yet, we know little about rate and genomic targets of cross-lineage gene transfer, and about its effects on the recipient organism's physiology and fitness. Here, we address these questions in a parallel evolution experiment with two Bacillus subtilis lineages of 7% sequence divergence. We observe rapid evolution...
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Rejuvenation ResearchHow Could We Slow or Reverse the Human Aging Process and Extend the Healthy Life Span with Heterochronous Autologous Hematopoietic Stem Cell TransplantationRejuvenation Research, Volume 23, Issue 2, Page 159-170, April 2020.Rejuvenation ResearchFri Apr 17, 2020 10:00Mark above section as read Latest Results for Folia MicrobiologicaCharacterization and optimization of abamectin—a powerful antiparasitic from a local Streptomyces avermitilis isolateAbstract Abamectin (ABA) constitutes...
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Angewandte Chemie International EditionBright Science Award for Marc Hillmyer / Hanwha‐Total IUPAC Young Scientist AwardsAngewandte Chemie International EditionTue Apr 21, 2020 16:28Synthesis of Galactosyl‐Queuosine and Distribution of Hypermodified Q‐Nucleosides in Mouse TissuesThe first total synthesis of the hypermodified RNA nucleoside galactosyl‐queuosine (galQ) was achieved. Moreover, the distribution of this nucleoside as well as mannosyl‐queuosine and queuosine was determined in tissues...
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Wiley: Dermatologic Therapy: Table of ContentsRefractory Classic Juvenile Pityriasis Rubra Pilaris Successfully Treated with a Combination of Etanercept and MethotrexateWiley: Dermatologic Therapy: Table of ContentsMon Apr 20, 2020 18:26Challenges of Covid‐19 Pandemic for DermatologyAbstract SARS‐CoV‐2 is a new corona virus responsible for the pandemic named Coronavirus Disease 2019 (COVID‐19). The disease causes severe acute respiratory syndromes with a significant morbidity and mortality. We provide...
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Wiley: EFSA Journal: Table of ContentsEvaluation of an alternative method for production of biodiesel from processed fats derived from Category 1, 2 and 3 animal by‐products (submitted by College Proteins)Abstract An alternative method for the production of biodiesel from processed fats derived from Category 1, 2 and 3 animal by‐products was assessed. The method is based on a pre‐cleaning process, acidic esterification/transesterification of tallow using 1.5% methanesulfonic acid w/w; 140°C; 5.5...
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Plastic and Reconstructive Surgery - Published Ahead-of-PrintTissue-Engineered Soft-Tissue Reconstruction Using Noninvasive Mechanical Preconditioning and a Shelf-Ready Allograft Adipose MatrixNo abstract availablePlastic and Reconstructive Surgery - Published Ahead-of-PrintMon Apr 20, 2020 03:00Recipient Site Preconditioning with Deferoxamine Increases Fat-Graft Survival by Inducing VEGF and Neovascularization in a Rat ModelNo abstract availablePlastic and Reconstructive Surgery - Published Ahead-of-PrintMon...
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Evolutionary Biology News -- ScienceDailyDNA may not be life's instruction book -- just a jumbled list of ingredientsThe common view of heredity is that all information passed down from one generation to the next is stored in an organism's DNA. But one research suggests this might not be so. In two new papers, he argues DNA is just the ingredient list, not the set of instructions used to build and maintain a living organism. The instructions, he says, are stored in the molecules that regulate a...
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Journal of CytologyFine-needle cytological characteristics of carcinoma breast with medullary or medullary-like features masquerading as dendritic reticulum cell sarcoma: An attempt to explore the reasons for erroneous cytologic interpretationDilip K Das, Shahed K Pathan, Zafar A Sheikh, Mrinmay K Mallik, Bency John, Fatma MothafferJournal of Cytology 2020 37(2):99-107 Background: Infiltration of tumors by dendritic reticulum cells (DRC) reflects the host immune defense mechanism. We observed three...
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bioRxiv Subject Collection: Evolutionary BiologySources of Intraspecific Morphological Variation in Vipera seoanei: Allometry, Sex, and Colour Phenotype [NEW RESULTS]Snakes frequently exhibit ontogenetic and sexual variation in head dimensions, as well as the occurrence of distinct colour morphotypes which might be fitness-related. In this study, we used linear biometry and geometric morphometrics to investigate intraspecific morphological variation related to allometry and sexual dimorphism in...
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ScienceDirect Publication: European Journal of and Endovascular SurgeryCerebral Small Vessel Disease in Standard Pre-operative Imaging Reports Is Independently Associated with Increased Risk of Cardiovascular Death Following Carotid EndarterectomyPublication date: Available online 21 April 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Nathalie Timmerman, Marjolijn L. Rots, Ian D. van Koeverden, Saskia Haitjema, Constance J.H.C.M. van Laarhoven, Annemiek M. Vuurens,...
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Biomedicine & PharmacotherapyWhite tea and its active polyphenols lower cholesterol through reduction of very-low-density lipoprotein production and induction of LDLR expressionPublication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Kun Luo, Chengmei Ma, Shaofang Xing, Yannan An, Juan Feng, Honglei Dang, Wenting Huang, Liansheng Qiao, Jing Cheng, Lan XieBiomedicine & PharmacotherapyThu Apr 23, 2020 14:23Research progress in use of traditional Chinese medicine...
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DysphagiaSwallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal ModelAbstract Feeding difficulties are especially prevalent in preterm infants, although the mechanisms driving these difficulties are poorly understood due to a lack of data on healthy infants. One potential mechanism of dysphagia in adults is correlated with bolus volume. Yet, whether and how bolus volume impacts swallow safety in infant feeding is unknown. A further complication for safe infant swallowing...
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Scanner thoracique chez l'enfant atteint de mucoviscidose : intérêt d'un protocole en expiration séquentielle pour réduire la dose d'irradiationPublication date: Available online 22 April 2020Source: Revue des Maladies RespiratoiresAuthor(s): S. Simon, C. Baunin, J. Vial, E. Mas, L. Roditis, M. Michelet, M. MittaineRevue des Maladies RespiratoiresThu Apr 23, 2020 14:25Intoxication au monoxyde de carbone chez les fumeurs actifs ou passifs de chichaPublication date: Available online 22 April 2020Source:...
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Nature Communications - current - nature.com science feedsCryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activationNature Communications, Published online: 23 April 2020; doi:10.1038/s41467-020-15862-0Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand...
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Case Reports in OphthalmologyRifabutin-Cobicistat Drug Interaction Resulting in Severe Bilateral PanuveitisWe report a novel case of severe bilateral panuveitis with hypopyon secondary to rifabutin and cobicistat drug interaction in the setting of human immunodeficiency virus (HIV) infection and latent tuberculosis (TB). A 63-year-old woman presented with bilateral conjunctival injection and decreasing vision of 5 days' duration. She had a history of well-controlled HIV infection, latent TB, and...
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Multiple cholangiocarcinomas in the intrahepatic and extrahepatic biliary tree due to dichloromethane exposure: a case report.Related ArticlesMultiple cholangiocarcinomas in the intrahepatic and extrahepatic biliary tree due to dichloromethane exposure: a case report. Surg Case Rep. 2020 Apr 21;6(1):79 Authors: Ogawa D, Hayashi H, Kitamura F, Uemura N, Miyata T, Okabe H, Imai K, Yamasita Y, Kubo S, Baba H Abstract BACKGROUND: An outbreak of cholangiocarcinoma in Japan has led to widespread concern...
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The association between the diesel exhaust particle exposure from bus emission and the tubular epithelial cell deformation of rats: AbstractThe diesel vehicle emissions regarding particles have become a problem due to human health adversely. Especially ultrafine particles (diameter ≤ 100 nm) can deeply penetrate the human body leading to cell deformation. Investigation of the diesel ultrafine particle exposure to the cell deformation has become a challenge to build up understanding the impacts of...
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Contemporary Considerations in Adjuvant Radioiodine Treatment of Adults with Differentiated Thyroid Cancer: AbstractDifferentiated thyroid cancer (DTC) is the most common endocrine malignancy with a growing incidence worldwide. The initial conventional management is surgery, followed by consideration of 131I treatment that includes 3 options. These are termed remnant ablation (targeting benign thyroid remnant), adjuvant (targeting presumed microscopic DTC) and known disease (targeting macroscopic...
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Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease: AbstractBackgroundOral squamous cell carcinoma (OSCC) occurs in different subsites within the oral cavity. Our goal was to investigate the epidemiological features of OSCC with relation to age and subsite.MethodsRetrospective review of all patients treated for OSCC in a tertiary care center between 2000 and 2018.ResultsA total of 360 patients were included. Five age groups were defined: 0 to 30, 31 to 45, 46 to...
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Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity: AbstractAbstractThis study shows that melanoma-associated fibroblasts (MAFs) suppress cytotoxic T lymphocyte (CTL) activity and reveals a pivotal role played by arginase in this phenomenon. MAFs and normal dermal fibroblasts (DFs) were isolated from surgically resected melanomas and identified as Melan-A-/gp100-/FAP+ cells. CTLs of healthy blood donors...
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11p15.5 epimutations in children with Wilms tumor and hepatoblastoma detected in peripheral blood: BackgroundConstitutional or somatic mosaic epimutations are increasingly recognized as a mechanism of gene dysregulation resulting in cancer susceptibility. Beckwith‐Wiedemann syndrome is the cancer predisposition syndrome most commonly associated with epimutation and is extremely variable in its phenotypic presentation, which can include isolated tumors. Because to the authors' knowledge large‐scale...
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Pembrolizumab for the treatment of programmed death–ligand 1‒positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE‐028 study: BackgroundDespite a protracted disease course and multiple available therapies, patients with well‐differentiated neuroendocrine tumors (NETs) inevitably experience disease progression. Programmed death–ligand 1 (PD‐L1) has been associated with NET progression and prognosis. The multicohort, phase 1 KEYNOTE‐028 study (ClinicalTrials.gov...
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Latest Results for Bulletin of Experimental Biology and MedicineParameters of Experimental Activity in the Study of the Cognitive Abilities of Rhesus Monkeys ( Macaca mulatta ) and Baboons ( Papio hamadryas )We compared experimental activity, behavioral activity in the experiment, of rhesus monkeys (Macaca mulatta) and baboons (Papio hamadryas). Baboons showed higher levels of experimental activity. The contrast in the activity between the species is probably associated with species-specific characteristics...
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BRC : Last 10 articlesSociety BulletinsBreast Care 2020;15:201–204BRC : Last 10 articles21hPharmaNewsBreast Care 2020;15:198–200BRC : Last 10 articles21hPD-L1 IC-positive Patienten im FokusBreast Care 2020;15:197–197BRC : Last 10 articles1dΣήμανση της παραπάνω ενότητας ως αναγνωσμένης Catheterization and Cardiovascular InterventionsManagement of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian"247" National Committee's position paper on...
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Type 2 immunity in the skin and lungs: AbstractThere has been extensive progress in understanding the cellular and molecular mechanisms of inflammation and immune regulation in allergic diseases of the skin and lungs during the last few years. Asthma and atopic dermatitis are typical diseases of type 2‐immune responses. IL‐25, IL‐33 and TSLP are essential cytokines of epithelial cell that activation by allergens, pollutants, viruses, bacteria and toxins that derive type 2 responses. Th2 cells and...
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Measuring vincristine-induced peripheral neuropathy in children with cancer: validation of the Dutch pediatric–modified Total Neuropathy Score: AbstractPurposeThe aims were to evaluate the construct validity and reliability of the Dutch version of the pediatric-modified Total Neuropathy Score (ped-mTNS) for assessing vincristine-induced peripheral neuropathy (VIPN) in Dutch pediatric oncology patients aged 5–18 years.MethodsConstruct validity (primary aim) of the ped-mTNS was determined by testing...
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Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data: AbstractPurposeChemotherapy-induced peripheral neuropathy (CIPN) is a disabling complication of many chemotherapies. We investigated the feasibility of using health plan claims and administrative data to identify CIPN occurrence by comparing patients who received neurotoxic and non-neurotoxic chemotherapies.MethodsThe sample included over 53,000,000 patients from two regional and one national...
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Twelve cases of acneiform eruptions while on anti-CTLA4 therapy: AbstractWe present the first detailed report of acneiform eruptions in patients on CTLA-4 inhibitor therapy. Acneiform eruptions commonly occur (up to 75–100%) as a cutaneous adverse event associated with EGFR inhibition; however, acneiform eruptions have not been highly reported as a cutaneous adverse event associated with CTLA-4 inhibitor therapy. We conducted a retrospective chart review of our institution's database to assess cutaneous...
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Oral microbial influences on oral mucositis during radiotherapy treatment of head and neck cancer: AbstractPurposeOral mucositis (OM) remains a significant complication developed by many patients undergoing radiotherapy (RT) to the head and neck region. Emerging data suggest oral microbes may contribute to the onset and severity of this acute side effect.MethodsIn this study, saliva and oral swabs from head and neck cancer patients undergoing RT were collected. We employed molecular microbiological...
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Ultrasound systems for risk stratification of thyroid nodules prompt inappropriate biopsy in autonomously functioning thyroid nodules: SummaryObjectiveUltrasound (US) risk stratification systems (RSSs) have been developed to reduce the number of unnecessary fine‐needle aspiration (FNA) biopsies in patients with thyroid nodules. Autonomously functioning thyroid nodules (AFTN) account for 5‐10% of palpable lesions and are very rarely malignant. The present study was undertaken to investigate how RSSs...
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AuntMinnieEurope.com HeadlinesDutch airline makes pledge on radioisotope deliveriesKLM Royal Dutch Airlines has promised to allow medical isotopes to be carried...Read more on AuntMinnieEurope.comRelated Reading: SNMMI, IAEA collaborate on training German team wins SNMMI Image of the Year award SNMMI: FET-PET could have answers for brainstem glioma SNMMI: PET/CT may help guide prostate biopsiesAuntMinnieEurope.com Headlines5mGuerbet forecasts 30%-35% drop in April salesAlthough the company posted...
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A complete lower lip and chin unit resurfacing with expanded cheek flaps: A modified approach with minimal influence on facial cosmetic units.: Related ArticlesA complete lower lip and chin unit resurfacing with expanded cheek flaps: A modified approach with minimal influence on facial cosmetic units.J Plast Reconstr Aesthet Surg. 2019 Oct;72(10):1700-1738Authors: Qiu Y, Gao W, Chen H, Ma G, Jin Y, Lin XPMID: 31444055 [PubMed - indexed for MEDLINE]
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Movement DisordersLower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter SurvivalAbstract Background Multiple system atrophy (MSA) is a neurodegenerative disorder from α‐synuclein aggregation. in vitro studies suggest vitamin B12 may interrupt α‐synuclein‐mediated neurodegeneration. The objective of this study was to determine whether serum vitamin B12 level at MSA diagnosis is associated with survival. Methods One hundred eighty‐two MSA patients evaluated at Mayo...
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A Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia.: Related ArticlesA Mouse Model of Oropharyngeal Papillomavirus-Induced Neoplasia Using Novel Tools for Infection and Nasal Anesthesia.Viruses. 2020 Apr 16;12(4):Authors: Bilger A, King RE, Schroeder JP, Piette JT, Hinshaw LA, Kurth AD, AlRamahi RW, Barthel MV, Ward-Shaw ET, Buehler D, Masters KS, Thibeault SL, Lambert PFAbstract Human head and neck cancers that develop from...
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Metastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases.: Related ArticlesMetastatic Tumors of the Oro-Facial Tissues: Clear Cell Renal Cell Carcinoma. A Clinico-Pathological and Immunohistochemical Study of Seven Cases.J Clin Med. 2020 Apr 17;9(4):Authors: Capodiferro S, Limongelli L, Mastropasqua MG, Favia G, Lajolo C, Colella G, Tempesta A, Maiorano EAbstract Metastases to orofacial tissues are infrequent,...
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Extensive craniospinal disseminated metastasis after the resection of intradural extramedullary ependymoma in the craniocervical junction: A case report and literature review.: Related ArticlesExtensive craniospinal disseminated metastasis after the resection of intradural extramedullary ependymoma in the craniocervical junction: A case report and literature review.Int J Neurosci. 2020 Apr 22;:1-8Authors: Guo Z, Wan J, Zhao BAbstract Purpose/Aim: Intradural extramedullary (IDEM) ependymomas...
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Low rates of airway intervention in adult supraglottitis: A case series and meta-analysis.: Related ArticlesLow rates of airway intervention in adult supraglottitis: A case series and meta-analysis.Am J Otolaryngol. 2020 Apr 04;:102482Authors: Ringel B, Shilo S, Carmel-Neiderman NN, Livneh N, Oestreicher-Kedem Y, Abergel A, Fliss DM, Horowitz GAbstract PURPOSE: Acute supraglottitis (SG) can potentially lead to rapid airway obstruction. The last few decades have witnessed a shift towards a...
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Transient Amnesia Following Prehospital Low-dose Ketamine Administration.: Related ArticlesTransient Amnesia Following Prehospital Low-dose Ketamine Administration.Am J Emerg Med. 2020 Apr 09;:Authors: Aljadeed R, Perona SAbstract Low doses of ketamine have been shown to be safe and effective for pain relief. Adverse effects are generally mild and transient. A 69-year-old woman suffered a witnessed ground-level fall without report of head injury, loss of consciousness, or intoxication. She...
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Clear cell lesions in pathology: Histomorphologic approach to diagnosis.: Related ArticlesClear cell lesions in pathology: Histomorphologic approach to diagnosis.Indian J Pathol Microbiol. 2020 Apr-Jun;63(2):177-187Authors: Kar A, Pattnaik K, Kar T, Biswal P, Mishra C, Guru LAbstract There has been remarkable progress in the field of surgical pathology; however, histomorphology has remained the most important and essential tool of the surgical pathologist in everyday practice till now. It...
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Sebaceous lymphadenoma of parotid gland: A case report of a unique presentation in an immunocompromised patient.: Related ArticlesSebaceous lymphadenoma of parotid gland: A case report of a unique presentation in an immunocompromised patient.J Family Med Prim Care. 2020 Feb;9(2):1202-1205Authors: Al-Essa MAbstract Sebaceous lymphadenoma is a rare, benign tumor of the parotid gland accounting for only 0.196% of all adenomas of the parotid gland. Our aim is to present a case of sebaceous lymphadenoma,...
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Stereotactic radiosurgery for head and neck paragangliomas: a systematic review and meta-analysis.: Related ArticlesStereotactic radiosurgery for head and neck paragangliomas: a systematic review and meta-analysis.Neurosurg Rev. 2020 Apr 21;:Authors: Fatima N, Pollom E, Soltys S, Chang SD, Meola AAbstract Head and neck paragangliomas (HNPs) are rare, usually benign hyper vascularized neuroendocrine tumors that traditionally have been treated by surgery, with or without endovascular embolization,...
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PI3K/AKT/mTOR pathway and autophagy regulator genes in paranasal squamous cell carcinoma metastasis.
PI3K/AKT/mTOR pathway and autophagy regulator genes in paranasal squamous cell carcinoma metastasis.: Related ArticlesPI3K/AKT/mTOR pathway and autophagy regulator genes in paranasal squamous cell carcinoma metastasis.Mol Biol Rep. 2020 Apr 21;:Authors: Biray Avci C, Sezgin B, Goker Bagca B, Karci HB, Gode SAbstract Although there are many studies on the role of PI3K/AKT/mTOR pathway and autophagy genes in the mechanism of head and neck cancer formation and prognostic significance, there...
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Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms.: Related ArticlesEffects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms.Int J Oncol. 2020 Mar 12;:Authors: Mosca L, Minopoli M, Pagano M, Vitiello F, Carriero MV, Cacciapuoti G, Porcelli MAbstract S‑Adenosyl‑L‑methionine (AdoMet) is the principal methyl donor...
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Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease.: Related ArticlesSquamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease.Head Neck. 2020 Apr 22;:Authors: Yosefof E, Hilly O, Stern S, Bachar G, Shpitzer T, Mizrachi AAbstract BACKGROUND: Oral squamous cell carcinoma (OSCC) occurs in different subsites within the oral cavity. Our goal was to investigate the epidemiological features of OSCC with relation to age and subsite. ...
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An extensive sclerosing odontogenic carcinoma in mandible: a case report and literature review.: Related ArticlesAn extensive sclerosing odontogenic carcinoma in mandible: a case report and literature review.Dentomaxillofac Radiol. 2020 Apr 22;:20190426Authors: Pakezhati S, Feng Y, Gao A, Lin Z, Huang X, Sun G, Zhang L, Wang TAbstract Sclerosing odontogenic carcinoma (SOC) is a primary intraosseous carcinoma of the jaw that was listed as a separate entity for the first time in the latest...
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The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors.: Related ArticlesThe Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors.Ear Nose Throat J. 2020 Apr 22;:145561320920968Authors: Sancaktar ME, Ağrı İ, Çeçen AB, Akgül G, Çelebi MAbstract OBJECTIVES: Recent studies suggest that elevated neutrophil to lymphocyte...
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ChemosensorsChemosensors, Vol. 8, Pages 30: An Electronic Nose Technology to Quantify Pyrethroid Pesticide Contamination in TeaChemosensors, Vol. 8, Pages 30: An Electronic Nose Technology to Quantify Pyrethroid Pesticide Contamination in Tea Chemosensors doi: 10.3390/chemosensors8020030 Authors: Xiaoyan Tang Wenmin Xiao Tao Shang Shanyan Zhang Xiaoyang Han Yuliang Wang Haiwei Sun The contamination of tea with toxic pesticides is a major concern. Additionally, because of improved detection methods,...
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Ultrasonic Measurement of Lingual Artery and Its Application for Midline Glossectomy.: Related ArticlesUltrasonic Measurement of Lingual Artery and Its Application for Midline Glossectomy.Ann Otol Rhinol Laryngol. 2020 Apr 21;:3489420913581Authors: Liu C, Qin J, Xing D, Lu H, Yue R, Li S, Wu DAbstract OBJECTIVE: To explore the application of lingual artery ultrasound (US) for midline glossectomy in patients with obstructive sleep apnea (OSA). METHODS: Lingual artery US was performed...
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CPAP indication based on clinical data and oximetry for patients with suspicion of obstructive sleep apnea: A multicenter trial.: Related ArticlesCPAP indication based on clinical data and oximetry for patients with suspicion of obstructive sleep apnea: A multicenter trial.Sleep Sci. 2019 Oct-Dec;12(4):249-256Authors: Nigro CA, Borsini EE, Dibur E, Larrateguy LD, Cazaux A, Elias C, de-la-Vega M, Berrozpe C, Maggi S, Grandval S, Cambursano H, Visentini D, Criniti J, Nogueira FAbstract Background...
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The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women.: Related ArticlesThe effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women.J Family Med Prim Care. 2020 Feb;9(2):1086-1092Authors: Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh MAbstract Background: Complications of...
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Chemosensors, Vol. 8, Pages 30: An Electronic Nose Technology to Quantify Pyrethroid Pesticide Contamination in Tea: Chemosensors, Vol. 8, Pages 30: An Electronic Nose Technology to Quantify Pyrethroid Pesticide Contamination in TeaChemosensors doi: 10.3390/chemosensors8020030Authors: Xiaoyan Tang Wenmin Xiao Tao Shang Shanyan Zhang Xiaoyang Han Yuliang Wang Haiwei Sun The contamination of tea with toxic pesticides is a major concern. Additionally, because of improved detection methods,...
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edoc: No conditions. Results ordered -Date Deposited.Tick-borne relapsing fever caused by Borrelia persica in Traveler to Central Asia, 2019We report a case of tick-borne relapsing fever caused by Borrelia persica in a traveler returning to Switzerland from central Asia. After the disease was diagnosed by blood smear microscopy, the causative Borrelia species was confirmed by shotgun metagenomics sequencing. PCR and sequencing techniques provide highly sensitive diagnostic tools superior to microscopy.edoc:...
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Diagnostic Criteria for Primary Autoimmune Cerebellar Ataxia—Guidelines from an International Task Force on Immune-Mediated Cerebellar Ataxias: AbstractAside from well-characterized immune-mediated ataxias with a clear trigger and/or association with specific neuronal antibodies, a large number of idiopathic ataxias are suspected to be immune mediated but remain undiagnosed due to lack of diagnostic biomarkers. Primary autoimmune cerebellar ataxia (PACA) is the term used to describe this later group....
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Microbiological ResearchSeed biopriming with antagonistic microbes and ascorbic acid induce resistance in tomato against Fusarium wiltPublication date: Available online 23 April 2020Source: Microbiological ResearchAuthor(s): Prachi Singh, Jyoti Singh, Shatrupa Ray, Rahul Singh Rajput, Anukool Vaishnav, Rakesh Kumar Singh, Harikesh Bahadur SinghMicrobiological Research16hΣήμανση της παραπάνω ενότητας ως αναγνωσμένης Journal of Medical Case Reports - Latest ArticlesVenetoclax in combination with carfilzomib...
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Severe eosinophilic asthma and aspirin-exacerbated respiratory disease associated to eosinophilic gastroenteritis treated with mepolizumab: a case report: Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma.NUCALAΜοιραστείτε Ευρετήριο ΑναφορέςΦάρμακοΕνεργά συστατικά1 Μεπολιζουμάμπη90Z2UF0E52 - MEPOLIZUMABΤρόποι και περιορισμοί διάθεσηςΠροϊόν του οποίου η κυκλοφορία γίνεται με βάση τη νομοθεσία περί φαρμάκων που...
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An unusual onset of pediatric acute lymphoblastic leukemia: AbstractAcute lymphoblastic leukemia is the most frequent cancer in children: it represents 80% of leukemias and about 24% of all neoplasms diagnosed between 0 and 14 years. Acute lymphoblastic leukemia mainly affects children between 2 and 5 years old and in this age group the incidence is about 80–90 cases per million per year. In acute lymphoblastic leukemia, cancer cells multiply rapidly and accumulate in the bone marrow and subsequently...
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Accounting for Heterogeneity: Mixed-Effects Models in Resting-State EEG Data in a Sample of Tinnitus Sufferers: AbstractIn neuroscience, neural oscillations and other features of brain activity recorded by electroencephalography (EEG) are typically statistically assessed on the basis of the study's population mean to identify possible blueprints for healthy subjects, or subjects with diagnosable neurological or psychiatric disorders. Despite some inter-individual similarities, there is reason to...
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Accounting for Heterogeneity: Mixed-Effects Models in Resting-State EEG Data in a Sample of Tinnitus Sufferers: AbstractIn neuroscience, neural oscillations and other features of brain activity recorded by electroencephalography (EEG) are typically statistically assessed on the basis of the study's population mean to identify possible blueprints for healthy subjects, or subjects with diagnosable neurological or psychiatric disorders. Despite some inter-individual similarities, there is reason to...
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edoc: No conditions. Results ordered -Date Deposited.Structure-activity relationship of antischistosomal ozonide carboxylic acidsSemisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes-another hemoglobin-degrading pathogen. Building on this discovery, we now describe the initial structure-activity relationship (SAR) of antischistosomal ozonide carboxylic acids OZ418 (; 2; ) and...
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Latest ResultsDistrict heating networks: an inter-comparison of environmental indicatorsAbstract The installation of district heating (DH) systems constitutes an advantage from the energetic, climate, and air quality aspects. However, the configuration and operational features of a DH system affect significantly its environmental performance. The objective of the present study is the energetic and environmental assessment of DH networks that present differences in size and operating configurations,...
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miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis: Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial-mesenchymal transition. Transcriptional regulators and post-transcriptional effectors like microRNAs orchestrate this process of high cellular plasticity and its malignant consequences. Here, using microRNA sequencing in a time-resolved manner and functional validation, we have identified...
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Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles: Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward, their ultrastructural composition and microenvironment at the nanoscale have remained unclear so far, as has their relevance to aging and certain disease states that involve the sequestration of toxic cellular metabolites. Here, we apply...
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Journal of Medical Genetics current issueGenetic variability and potential effects on clinical trial outcomes: perspectives in Parkinsons diseaseBackgroundClassical randomisation of clinical trial patients creates a source of genetic variance that may be contributing to the high failure rate seen in neurodegenerative disease trials. Our objective was to quantify genetic difference between randomised trial arms and determine how imbalance can affect trial outcomes. Methods5851 patients with Parkinson's...
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Brentuximab vedotin treatment associated with acute and chronic inflammatory demyelinating polyradiculoneuropathies: IntroductionBrentuximab vedotin (BV) is an antibody-drug conjugate composed by an anti-CD30 monoclonal antibody and the anti-microtubule agent monomethyl auristatin E, used for the treatment of relapsed/refractory Hodgkin's lymphoma and non-Hodgkin's lymphoma.Peripheral neuropathy is a frequent adverse event of BV treatment, affecting up to 60% to 70% of patients.1 It usually consists...
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Cancers, Vol. 12, Pages 1041: Functional and Clinical Impact of CircRNAs in Oral Cancer: Cancers, Vol. 12, Pages 1041: Functional and Clinical Impact of CircRNAs in Oral CancerCancers doi: 10.3390/cancers12041041Authors: Ion Cristóbal Cristina Caramés Jaime Rubio Marta Sanz-Alvarez Melani Luque Juan Madoz-Gúrpide Federico Rojo Jesús García-Foncillas The increasing number of recently published works regarding the role of circular RNAs (circRNAs) in oral cancer highlights the...
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2-deoxy-2[F-18] fluoro-<span class="small-caps">d-glucose positron emission tomography</span> Deauville scale and core-needle biopsy to determine successful management after six doxorubicin, bleomycin, vinblastine and dacarbazine cycles in advanced-stage Hodgkin lymphoma: Publication date: June 2020Source: European Journal of Cancer, Volume 132Author(s): M. Picardi, R. Fonti, R. Della Pepa, C. Giordano, N. Pugliese, E. Nicolai, M. Salvatore, C. Mainolfi, P. Venetucci, M.G. Rascato, I....
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Cornelia de Lange syndrome: from molecular diagnosis to therapeutic approach: Cornelia de Lange syndrome (CdLS) is a severe genetic disorder characterised by multisystemic malformations. CdLS is due to pathogenetic variants in NIPBL, SMC1A, SMC3, RAD21 and HDAC8 genes which belong to the cohesin pathway. Cohesin plays a pivotal role in chromatid cohesion, gene expression, and DNA repair. In this review, we will discuss how perturbations in those biological processes contribute to CdLS phenotype and...
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ScienceDirect Publication: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchUbiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activityPublication date: Available online 22 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Seung-Joo Yang, Seung-Je Jeon, Thang Van Nguyen, Raymond J. Deshaies, Chul-Seung Park, Kwang Min LeeScienceDirect Publication: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research10hΣήμανση...
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Prevalence of Lymphoid Neoplasia in a Retrospective Analysis of Warthin Tumor: A Single Institution Experience: AbstractWarthin tumor is one of the most common benign salivary gland tumors. Overt lymphoma is known to occur in the lymphoid stroma of Warthin tumor. In situ follicular neoplasia is difficult to identify in routine histologic examination of lymphoid tissue and has not been reported in association with Warthin tumor. Our objective is to determine the prevalence of overt malignant lymphoma...
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Congenital Conditions of Hypophosphatemia in Children: AbstractGreat strides over the past few decades have increased our understanding of the pathophysiology of hypophosphatemic disorders. Phosphate is critically important to a variety of physiologic processes, including skeletal growth, development and mineralization, as well as DNA, RNA, phospholipids, and signaling pathways. Consequently, hypophosphatemic disorders have effects on multiple systems, and may cause a variety of nonspecific signs...
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Latest Results for Drugs in RAn Ex Vivo Evaluation of Cenobamate Administered via Enteral TubesAbstract Background Cenobamate is a new, Food and Drug Administration (FDA)-approved oral antiepileptic drug for treatment of focal seizures in adults. This study examined recovery of cenobamate from suspensions administered through ex vivo enteral feeding tubes. Methods Suspensions containing 100 and 200 mg of cenobamate were prepared (five duplicates for...Latest Results for Drugs in R5hΣήμανση της παραπάνω...
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A phase I study of the VEGFR kinase inhibitor vatalanib in combination with the mTOR inhibitor, everolimus, in patients with advanced solid tumors: SummaryPurpose Combining small-molecule inhibitors of different targets was shown to be synergistic in preclinical studies. Testing this concept in clinical trials is, however, daunting due to challenges in toxicity management and efficacy assessment. This study attempted to evaluate the safety and efficacy of vatalanib plus everolimus in patients with...
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Advances in TherapyThe Impact of Patient Support Programs on Adherence to Disease-Modifying Therapies of Patients with Relapsing-Remitting Multiple Sclerosis in Germany: A Non-Interventional, Prospective StudyAbstract Introduction Disease-modifying therapies (DMTs) in multiple sclerosis (MS) are chronic therapies, and patients are likely to face challenges in adhering to DMT dosing regimens over time. DMT manufacturers offer patient support programs (PSPs) to increase adherence. PSPs are managed...
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Stromal platelet-derived growth factor receptor-{beta} signaling promotes breast cancer metastasis in the brain: Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is dependent on paracrine ligand induction, and its preferred ligand PDGFB is released by neighboring epithelial and endothelial cells. While expression of both PDGFRβ and PDGFB has been noted in patient...
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High rate incidence of post-surgical adverse events in patients with low-risk papillary thyroid cancer who did not accept active surveillance: AbstractPurposeTo describe the outcomes and the incidence of adverse events following active surveillance (AS) versus immediate surgery in patients with low-risk papillary thyroid carcinoma (PTC).MethodsWe prospectively evaluated 286 patients who attended the Hospital de Clínicas, with a single thyroid nodule <1.5 cm classified as Bethesda category V or...
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Thyroid function and lipid profile in euthyroid adults: the TCLSIH cohort study: AbstractPurposeThyroid hormones (THs) have multiple effects on lipid synthesis, mobilization, and degradation, suggesting that THs may affect the development of dyslipidemia. However, prospective studies on the association between serum THs levels and incident dyslipidemia in euthyroid subjects are limited. Therefore, we conducted a cohort study (~5-year follow-up period, median: 3.0 years) to explore whether THs can...
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Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model: AbstractFeeding difficulties are especially prevalent in preterm infants, although the mechanisms driving these difficulties are poorly understood due to a lack of data on healthy infants. One potential mechanism of dysphagia in adults is correlated with bolus volume. Yet, whether and how bolus volume impacts swallow safety in infant feeding is unknown. A further complication for safe infant swallowing is recurrent...
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Rare case of basilar artery aneurysm in a young child: A previously well, 14-month-old girl presented with acute decreased level of consciousness. There was no history of trauma, systemic upset or significant family history. Blood pressure was within normal range and no focal neurological deficit was elicited on examination. Neuroimaging revealed a subarachnoid haemorrhage secondary to a basilar tip aneurysm. Patient underwent endovascular embolisation with good clinical outcome. Follow-up MRI revealed...
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Ovoid palatal patch: a clue to anti-TIF1{gamma} dermatomyositis: An 80-year-old woman presented with a several-year history of progressive hair loss and scalp pruritus. No other rashes or muscle weakness were noted on examination. Scalp biopsy showed interface dermatitis, dense perivascular and periadnexal lymphocytic infiltrate, mucin and scarring alopecia. Laboratory analysis did not show evidence of myositis. The patient was started on hydroxychloroquine for possible cutaneous lupus erythematosus....
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Developing Classifications of Laryngeal Dysplasia: The Historical Basis: AbstractDuring the last 60 years numerous significant attempts have been made to achieve a widely acceptable terminology and histological grading for laryngeal squamous intraepithelial lesions. While dysplasia was included in the pathology of the uterine cervix already in 1953, the term dysplasia was accepted in laryngeal pathology first after the Toronto Centennial Conference on Laryngeal Cancer in 1974. In 1963 Kleinsasser...
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Hindawi Publishing CorporationIsoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent MechanismBackground & Aims. Chronic hepatitis (CH) has emerged as a distinct outcome of drug-induced liver injury (DILI). Combination therapy of Isoniazid (INH) and Rifampicin (RMP) which is widely used for prolonged periods can cause acute hepatotoxicity and has been also incriminated in chronic DILI. We sought evidence of the production of hepatic fibrosis on long-term INH-RMP...
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Association between Lymph Node Status and Expression Levels of Androgen Receptor, miR-185, miR-205, and miR-21 in Breast Cancer Subtypes: Breast cancer is the most commonly diagnosed cancer among women. Difficulties in treating breast cancer are associated with the occurrence of metastases at early stages of disease, leading to its further progression. Recent studies have shown that changes in androgen receptor (AR) and microRNAs' expressions are associated with mammary gland carcinogenesis, in particular,...
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Latest ResultsHyperspectral inversion of mercury in reed leaves under different levels of soil mercury contaminationAbstract High mercury (Hg) affects biochemical-physiological characteristics of plant leaves such as leaf chlorophyll, causing refractive discontinuity and modifications in leaf spectra. Furthermore, the hyperspectroscopy provides a potential tool for fast non-destructive estimation of leaf Hg. However, there are few studies that have investigated Hg for wetland plants via hyperspectral...
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Still's disease is a type of inflammatory arthritis that causes fevers, rashes, and inflammation of joints and, sometimes, internal organs.Oct 23, 2018Still's Disease: Symptoms, Causes, Diagnosis, TreatmentElevated Expression of C-Type Lectin Domain Family 5-Member A (CLEC5A) and Its Relation to Inflammatory Parameters and Disease Course in Adult-Onset Still's Disease: C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes...
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Streptococcus pseudoporcinus: Case Reports and Review of the Literature: Streptococcus pseudoporcinus is a beta-hemolytic Gram-positive, catalase-negative, nonmotile coccus arranged in short chains, usually found in the female genitourinary tract and differentiated from Streptococcus porcinus in 2006. Only two human infections associated with this organism have been reported to date: one in a patient with a first digit wound infection and another with lower extremity cellulitis. We describe two novel...
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l -Carnitine and vitamin E ameliorate cardiotoxicity induced by tilmicosin in rats: AbstractThe present study aimed to investigate the possible mitigating effect of l-carnitine (LC) and/or α-tocopherol (Vit. E) administration against tilmicosin (TIL)-induced cardiotoxicity in rats. Fifty-six male albino rats were divided into seven groups according to LC, Vit. E, and/or TIL administration. Control, LC, and Vit. E groups were given saline, 150 mg LC/kg body weight (BW)/day and 100 mg Vit. E/kg BW/day,...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,