A case of occult bilateral optic nerve aplasia with pituitary dysfunction: hidden anomaly missed on ultrasound: We report a case of 'occult' bilateral optic nerve aplasia (ONA) where pituitary dysfunction was discovered subsequently. The initial ultrasonography had missed ONA in a child with bilateral microcornea, small non-dilating pupils and roving eye movements. Due to presence of relevant clinical signs in this case, ONA was re-evaluated with MRI, and was subsequently discovered to be associated...
09:38
Post-traumatic bilateral longitudinal temporal bone fracture with bilateral facial nerve palsy: a rare case: Facial paralysis is a potentially disabling complication of temporal bone fractures. Although unilateral palsy is commonly encountered, bilateral facial nerve palsy is rare, especially in post-traumatic situations. Other recognised causes of bilateral facial palsy are neurologic, infectious, neoplastic, idiopathic or metabolic disorders. A 25-year-old male patient presented with difficulty...
09:26
Successful management of emphysematous gastritis with invasive gastric mucormycosis: The present manuscript reports two extremely rare cases of coexisting emphysematous gastritis with gastric mucormycosis. The cases were managed successfully, considering the high mortality associated with both conditions independently. The aim of the manuscript is to elucidate the importance of prompt diagnosis, early surgical intervention for source control and concomitant application of antifungal therapy for a...
09:26
Systemic septic emboli in tricuspid endocarditis due to an atrial communication with a right-to-left shunt: We present the case of a patient admitted to hospital in septic shock. He had a history of tricuspid valve infective endocarditis (IE) 6 months prior and regularly injected intravenous drugs. A bedside echo on arrival confirmed vegetations on his tricuspid valve, torrential tricuspid regurgitation and signs of significantly raised right-sided pressures. The admission chest radiograph showed...
09:25
Case of paradoxical adverse response to mepolizumab with mepolizumab-induced alopecia in severe eosinophilic asthma: Recent years have seen an increase in use of mepolizumab and other biological therapies for the treatment of severe eosinophilic asthma. A few cases of paradoxical responses to mepolizumab therapy have now been reported and are hypothesised as being a response to immune complex formation. We present a case of mepolizumab-induced alopecia in a patient with paradoxical adverse response...
09:25
Iatrogenic pneumothorax in a 4-week-old girl: new diagnosis of congenital lobar emphysema: A 4-week-old female patient presented with severe respiratory distress, hypoxia and apnoeic episodes on a background of a few-day history of coryza and cough. There was significantly reduced air entry on the left side and a displacement of the apex beat to the right of the chest. The examination findings with oxygen desaturations and a right-sided mediastinal shift on chest X-ray led to a diagnosis of tension...
09:23
Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression: A 56-year-old man undergoing immunotherapy treatment for metastatic melanoma presented with sudden onset testicular pain radiating into his abdomen. On examination, the abdomen was generally tender with associated guarding. Imaging revealed a perforation of the small bowel at the site of a metastatic lesion. Histology revealed that this process was non-inflammatory in nature. A diagnosis of small bowel...
09:22
Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies: ObjectivesThis review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin.MethodsWe conducted a systematic review and exploratory meta-analysis of observational studies. Electronic searches of MEDLINE and Embase, and a manual search of bibliographies was undertaken for studies...
09:21
Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock: BACKGROUND Administration of human mesenchymal stem cell (MSC)–derived exosomes can enhance neurorestoration in models of traumatic brain injury (TBI) and hemorrhagic shock (HS). The impact of early treatment with MSC-derived exosomes on brain injury in a large animal model remains unknown. We sought to evaluate the impact of...
09:20
Urban environment and mental health: the NAMED project, protocol for a mixed-method study: IntroductionMental health issues appear as a growing problem in modern societies and tend to be more frequent in big cities. Where increased evidence exists for positive links between nature and mental health, associations between urban environment characteristics and mental health are still not well understood. These associations are highly complex and require an interdisciplinary and integrated research approach...
09:19
Cross-septal returned flap: modified endoscopic technique for bilateral closure of septal perforation: This article presents a modified technique for endoscopic bilateral surgical repair of nasal septal perforations. A novel cross-septal returned flap was performed in nine patients with nasal septal perforations. The mean size of the perforation was 17.7mm in the sagittal axis and 16.9mm in the vertical axis. (Source: International Journal of Oral and Maxillofacial Surgery)
09:19
Confounding factors in the efficacy of intraosseous and submucosal dexamethasone injection in mandibular third molar surgery: I read with great interest the article by Kaewkumnert et al.1 in a recent issue of the International Journal of Oral and Maxillofacial Surgery. The authors performed a randomized trial of 27 patients undergoing third molar extractions who received an intraosseous injection of dexamethasone 4mg to one side of the mandible and a submucosal injection to the other side. They concluded...
09:19
Imaging characteristics of the mandible and upper airway in children with Robin sequence and relationship to the treatment strategy: Some patients with Robin sequence (RS) may respond to conservative therapy, while others require surgery; however, there are currently no objective anatomical criteria to gauge surgical indication. The purpose of this study was to explore the imaging characteristics of the mandible and upper respiratory tract in children with RS and examine how individual morphometric...
09:18
A Novel Coronavirus from Patients with Pneumonia in China, 2019: Emerging and reemerging pathogens are global challenges for public health. Coronaviruses are enveloped RNA viruses that are distributed broadly among humans, other mammals, and birds and that cause respiratory, enteric, hepatic, and neurologic diseases. Six coronavirus species are known to cause…
09:18
YEARS Algorithm Versus Wells' Score: Predictive Accuracies in Pulmonary Embolism Based on the Gold Standard CT Pulmonary Angiography: Objectives: This study retrospectively applied Wells' score and YEARS algorithm to the same sample of patients to evaluate the predictive performance of each when compared with the gold standard CT pulmonary angiography.Design: Retrospective analytical study.Setting: A tertiary University Hospital in Ireland.Patients: Data from 794 patients who underwent CT pulmonary...
09:18
Mean Airway Pressure As a Predictor of 90-Day Mortality in Mechanically Ventilated Patients: Objectives: To determine the association between mean airway pressure and 90-day mortality in patients with acute respiratory failure requiring mechanical ventilation and to compare the predictive ability of mean airway pressure compared with inspiratory plateau pressure and driving pressure.Design: Prospective observational cohort.Setting: Five ICUs in Lima, Peru.Subjects: Adults requiring invasive mechanical...
09:17
The Insertion Site Should Be Considered for the Empirical Therapy of Short-Term Central Venous and Arterial Catheter-Related Infections: Objectives: Little is known on causative pathogens of intravascular catheters infection according to the catheter insertion site. The present study aimed to describe the epidemiology of causative microorganisms of catheter-related infection and colonization according to the insertion site.Design: Multicenter observational study using data from four large randomized...
09:17
Early Tracheostomy in Severe Traumatic Brain Injury Patients: A Meta-Analysis and Comparison With Late Tracheostomy: Objectives: To elucidate the impact of early tracheostomy on hospitalization outcomes in patients with traumatic brain injury.Data Sources: Lilacs, PubMed, and Cochrane databases were searched. The close-out date was August 8, 2018.Study Selection: Studies written in English, French, Spanish, or Portuguese with traumatic brain injury as the base trauma, clearly formulated question,...
09:17
Epigenetics of Sepsis: Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term "epigenetics" refers to regulatory mechanisms that control gene expression but are not related to changes in DNA sequence. These include DNA methylation, histone modifications, and regulation of transcription via non-coding RNAs. Epigenetic modifications,...
09:16
Reporting of Outcomes and Outcome Measures in Studies of Interventions to Prevent and/or Treat Delirium in the Critically Ill: A Systematic Review: Objectives: To inform development of a core outcome set, we evaluated the scope and variability of outcomes, definitions, measures, and measurement time-points in published clinical trials of pharmacologic or nonpharmacologic interventions, including quality improvement projects, to prevent and/or treat delirium in the critically ill.Data Sources: We...
09:16
Expression of Stromal Cell–Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis: Objectives: Sepsis results in organ dysfunction caused by a dysregulated host response, in part related to the immune response of a severe infection. Mesenchymal stromal cells are known to modulate the immune response, and expression of stromal cell–derived factor-1 regulates mobilization of neutrophils from the bone marrow. We are investigating the importance of stromal cell-derived...
09:15
Incidentally Discovered Papillary Thyroid Microcarcinomas Are More Frequently Found in Patients with Chronic Lymphocytic Thyroiditis Than with Multinodular Goiter or Graves' Disease: Thyroid, Ahead of Print. AbstractBackground: Incidental finding of differentiated thyroid microcarcinomas (DTMc) in patients undergoing thyroid surgery for benign indications has become increasingly common. Even though carcinogenesis might relate to the background disease of the gland, the incidence of DTMc in the setting...
09:14
Prognostic Value of Pre-Ablation Stimulated Thyroglobulin in Children and Adolescents with Differentiated Thyroid Cancer: Thyroid, Ahead of Print. AbstractPurpose: To systemically investigate the prognostic value of pre-ablation stimulated thyroglobulin (s-Tg) in children and adolescents with differentiated thyroid cancer.Methods: Clinical records from 118 children and adolescents were retrospectively reviewed.Results: The median age was 16 years, and the majority were female (79.7%). All children...
09:14
- Table of ContentsRealizing Clinical Trials with Astatine-211: The Chemistry InfrastructureCancer Biotherapy and Radiopharmaceuticals, Ahead of Print.Cancer Biotherapy & Radiopharmaceuticals - Table of ContentsThu Feb 20, 2020 10:00miR-634 Decreases the Radioresistance of Human Breast Cancer Cells by Targeting STAT3Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.Cancer Biotherapy & Radiopharmaceuticals - Table of ContentsThu Feb 20, 2020 10:00Long Noncoding RNA DLX6-AS1 Promotes...
09:13
Resveratrol potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid transport and/or its intracellular reduction in HaCaT cells: Abstractl-Ascorbic acid (AsA), a reduced vitamin C (VC), is an important antioxidant, and the internal accumulation and maintenance of AsA are thought to play a significant role in various physiological activities in humans. We focused on resveratrol (RSV), a natural polyphenolic compound, as a candidate for an AsA transport modulator and investigated...
09:11
Outcome of Submucosal Inferior Turbinoplasty in Perennial Allergic Rhinitis: AbstractPharmacotherapy forms mainstay of treatment for allergic rhinitis, and has adverse effects associated with it. Topical steroid therapy is the preferred medication and considered best for long term prophylaxis but with limited compliance. Submucosal turbinoplasty reduces the duration of treatment in comparison to topical steroid which has to be taken daily for a long time . The aim was to evaluate the outcome of...
09:11
Unusual Sites for Extracranial Head –Neck Schwannomas: AbstractSchwannomas are a frequent cause of swellings in the head and neck region. Due to the abundance of peripheral, cranial and autonomic nerves in this region, schwannomas can present in variety of locations, posing a diagnostic and therapeutic challenge to the surgeon. Unusual sites in head and neck region can have varied presentation depending on the site of origin. We identified unusual extracranial locations of head and neck schwannomas,...
09:11
The Effect of Age at Cochlear Implantation on Speech and Auditory Performances in Prelingually Deaf Children: AbstractTo understand the effect of age at implantation on speech and auditory performances of 74 prelingually deaf Indian children after using cochlear implants for 3, 6 and 12 months. We also evaluate the causes of late implantation in this population. Seventy four children who underwent cochlear implantation from December 2013 to December 2015 in the Department of Otorhinolaryngology...
09:11
Timeliness and outcomes of carotid endarterectomy for symptomatic carotid artery stenosis: a single centre audit: Our study showed that the median time from symptom development to carotid endarterectomy was 9 days. Overall, 69% of cases were operated within the current recommended guidelines. AbstractBackgroundFor patients presenting with symptomatic internal carotid artery stenosis, carotid endarterectomy (CEA) surgery is recommended to be performed generally within a 48‐hr to 14‐day window. This...
09:10
Sarcoidal Reaction in a Tattoo: A 42-year-old man presented to the dermatology clinic with a 5-month history of numerous papules along the pattern of his tattoos, which he had received 10 years earlier (Panel A). There was no associated pain or pruritus. He reported that he had not had any dyspnea, fever, arthralgias, visual…
09:09
Ankle Brachial Index Predicts for Difficulties in Performing Microvascular Anastomosis: In reconstructive microsurgery, severe arteriosclerosis is a known predictor for free flap failure because of problems with the vascular anastomosis. We investigated whether the ankle brachial index (ABI) could be a suitable preoperative measurement for the prediction of compromise regarding vascular anastomosis in patients undergoing microsurgical reconstruction. (Source: Journal of Oral and Maxillofacial Surgery)
09:08
Titanium-Prepared Platelet-Rich Fibrin Versus Connective Tissue Graft on Peri-Implant Soft Tissue Thickening and Keratinized Mucosa Width: A Randomized, Controlled Trial: The health of peri-implant tissues is associated with peri-implant soft tissue thickness (STT) and keratinized tissue width (KTW). Resorptive changes in the crestal bone around implant sites are affected by STT. This randomized prospective study aimed to compare the effectiveness of titanium-prepared platelet-rich fibrin (T-PRF)...
09:07
Ectopic parotid main duct on buccal mucosa: A case report and literature review: We report a case in which the patient's left Stensen's duct opened on the left buccal skin. After the operation of parotid duct transposition, the buccal fistula was closed and saliva secreted by parotid gland could overflow smoothly through the new orifice during a 3 years follow-up. A review of the current relevant literature is given following the case report. (Source: Journal of Oral and Maxillofacial Surgery)
09:07
Atypical Spitz Tumor of the Lower Lip in a Pediatric Patient: This case report describes a 2-year-old girl who presented with a lower lip mass with intermittent bleeding, but no discharge, lymphadenopathy, or other oral lesions and was diagnosed with an atypical Spitz tumor.
09:06
Permanent Facial Paralysis and Hearing Loss After Aural Irrigation: This case report describes a woman in her 70s who presented with impacted cerumen in the right ear and underwent bilateral irrigation, which resulted in tympanic membrane perforation and infection, with subsequent permanent facial palsy and mixed hearing loss.
09:04
Hearing Loss After Radiotherapy and Cisplatin Chemotherapy in Patients With Head and Neck Cancer: This cohort study develops a hearing loss prediction model for patients with head and neck cancer after radiotherapy and/or cisplatin chemotherapy.
09:04
Unilateral Vocal Fold Immobility After Prolonged Endotracheal Intubation: This subgroup analysis of a cohort study examines the incidence of and risk factors for unilateral vocal fold immobility after more than 12 hours of mechanical ventilation in a medical intensive care unit.
09:04
Some Considerations in Treating Malignant Head and Neck Paragangliomas: To the Editor As academic physicians with an interest in pheochromocytoma/paraganglioma, we read with great interest the article by McCrary et al characterizing malignant head and neck paragangliomas (HNPGLs). The authors used the paraganglioma cohort from an academic tertiary cancer center diagnosed between 1963 and 2018. They found that the prevalence of malignant HNPGLs was 6 of 70 (9%), with 5 of 6 patients carrying the succinate...
09:03
Association Between Microvascular Retinal Signs and Age-Related Hearing Loss in the ARIC-NCS: This cohort study investigates whether microvascular retinal signs are associated with age-related hearing loss among patients in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).
09:03
An Osseous Destructive Mass of the Infratemporal Fossa: A 69-year-old man had new-onset headaches, left ear pain, and persistent unsteadiness; computed tomographic imaging of the head demonstrated osseous destruction of the left temporal bone extending along the left internal jugular vein. What is your diagnosis?
09:03
Phosphorylated vimentin as an immunotherapeutic target against metastatic colorectal cancer: AbstractColorectal cancer (CRC) patients with metastatic lesions have low 5-year survival rates. During metastasis, cancer cells often obtain unique characteristics such as epithelial–mesenchymal transition (EMT). Vimentin a biomarker contributes to EMT by changing cell shape and motility. Since abnormal phosphorylation is a hallmark of malignancy, targeting phosphorylated vimentin is a feasible approach...
09:02
Addition of an Alginate Hydrogel to a Carbohydrate Beverage Enhances Gastric Emptying: Purpose To examine the effect of altering osmolality or adding sodium alginate and pectin to a concentrated carbohydrate (CHO) beverage on gastric emptying (GE) rate.Methods 500 mL boluses of three drinks were instilled double-blind in eight healthy males while seated and GE measured using the double sampling method for 90 min and blood samples collected regularly. Drinks consisted of glucose and fructose (MON,...
09:01
Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy: ConclusionThis review identified that a number of self-management strategies that were initiated by patients, including heat, exercise, meditation, and transcutaneous electrical nerve stimulation (TENS) therapy, may reduce self-reported PN symptoms. As the available studies were of low quality, these strategies warrant further investigation with more...
09:00
Leucine Supplementation Has No Further Effect on Training-induced Muscle Adaptations: Introduction Several acute studies have suggested that leucine is a key amino acid to drive muscle protein synthesis. However, there are very few studies on the long-term effects of leucine supplementation on resistance training-induced gains in muscle mass and strength. We sought to determine the impact of 10 grams of leucine on muscle mass and strength in response to resistance training (RT) in healthy young men.Methods...
08:54
Physical Activity and Mortality among Male Survivors of Myocardial Infarction: Purpose An inverse association between physical activity (PA) and risk of coronary heart disease has been seen in many studies, but evidence for benefits of PA after myocardial infarction (MI) in reducing mortality is limited.Methods Using data from the Health Professionals Follow-up Study cohort, we followed male survivors of MI. Short term and long term changes in PA from before to after MI were calculated, and participants...
08:53
Nature's design solutions in dental enamel: Uniting high strength and extreme damage resistance: Publication date: Available online 19 February 2020Source: Acta BiomaterialiaAuthor(s): Jana Wilmers, Swantje BargmannAbstractThe most important demand of today's high-performance materials is to unite high strength with extreme fracture toughness. The combination of withstanding large forces (strength) and resistance to fracture (toughness), especially preventing catastrophic material failure by cracking,...
08:50
Cardioprotective effect of vanillic acid against doxorubicin-induced cardiotoxicity in rat: Bahar Baniahmad, Leila Safaeian, Golnaz Vaseghi, Mohammad Rabbani, Behnoosh MohammadiResearch in Pharmaceutical Sciences 2020 15(1):87-96Background and purpose: Doxorubicin (DOX) is an effective agent for the treatment of many neoplastic diseases. Cardiotoxicity is the major side effect of this drug and limits its use. Vanillic acid (VA) is a pharmaceutical compound from the phenolic acids family. The present...
08:50
Anti-inflammatory and anti-angiogenesis effect of bee pollen methanolic extract using air pouch model of inflammation: Tahereh Eteraf-Oskouei, Ayda Shafiee-Khamneh, Fariba Heshmati-Afshar, Abbas DelazarResearch in Pharmaceutical Sciences 2020 15(1):66-75Background and purpose: Research on new drugs with a natural source and low side effects is a priority in pharmacology studies. The present study was conducted to investigate the anti-inflammatory and anti-angiogenesis effects of bee pollen extract...
08:49
Cardiovascular Risk Assessment and Therapeutic Implications in Rheumatoid Arthritis: AbstractPatients with rheumatoid arthritis (RA) suffer from a magnitude of excess cardiovascular risk. A paradoxical lipid pattern has been observed in rheumatoid arthritis patients where low levels of total cholesterol and low-density lipoprotein are associated with a higher risk of cardiovascular disease. This paper aims to break down the evidence explaining why patients with low to normal LDL, and total cholesterol...
08:49
Human In Vitro Models for Assessing the Genomic Basis of Chemotherapy-Induced Cardiovascular Toxicity: AbstractChemotherapy-induced cardiovascular toxicity (CICT) is a well-established risk for cancer survivors and causes diseases such as heart failure, arrhythmia, vascular dysfunction, and atherosclerosis. As our knowledge of the precise cardiovascular risks of each chemotherapy agent has improved, it has become clear that genomics is one of the most influential predictors of which patients will...
08:49
From Da Vinci Si to Da Vinci Xi: realistic times in draping and docking the robot: AbstractRobot-assisted surgery is assumed to be time consuming partially due to extra time needed in preparing the robot. The objective of this study was to give realistic times in Da Vinci Xi draping and docking and to analyse the learning curve in the transition from the Si to the Xi in an experienced team. This prospective study was held in a hospital with a high volume of robot-assisted surgery in general surgery,...
08:48
The effect of secondhand smoking on dental caries among schoolchildren in Riyadh, Saudi Arabia: A cross-sectional study: Abed Al-Hadi Hamasha, Ashwaq A Alfadhel, Asma A Alshareef, Manal M ALjamal, Nouf B Albesher, Nourah M Alaqaili, Thoraya S KinaniJournal of International Society of Preventive and Community Dentistry 2020 10(1):69-75Aim: The aim of this study was to explore the relationship between dental caries and exposure to secondhand smoking in mixed teeth among Saudi children. Materials and...
08:47
Intra-lesional medicaments for the management of intra-osseous lesions of maxilla and mandible - systematic review: Komal Smriti, Evit John, Kalyana-Chakravarthy Pentapati, Srikanth Gadicherla, Manish BhaganiaJournal of International Society of Preventive and Community Dentistry 2020 10(1):36-45Aims and Objectives: This study aimed to review the success or remission of intralesional medicaments in the management of intraosseous lesions in the oral cavity. Materials and Methods: A comprehensive search...
08:47
Oral Manifestations in HIV-TB Co- infected Patients and Their Correlation with CD4 Count in Telangana State, India: Ashalata Gannepalli, Ayinampudi B Krishna, Pacha V Baghirath, Balistty Hari Vinay, Sana Khaled, Bushra AnjumJournal of International Society of Preventive and Community Dentistry 2020 10(1):21-35Aims and Objectives: Human immunodeficiency virus (HIV)-related oral lesions are often an early finding, and they reflect the underlying immunosuppression, and tuberculosis (TB) coinfection...
08:46
Effect of hyaluronic acid in modifying tensile strength of nonabsorbable suture materials: An in vitro study: Sudhir R Varma, Mohammed Jaber, Salim A Fanas, Vijay Desai, Arij M Al Razouk, Sara NasserJournal of International Society of Preventive and Community Dentistry 2020 10(1):16-20Background and Aims: In periodontics and other surgical disciplines, sutures play a detrimental role in healing of wound. The use of chemical adjuncts to boost healing has been experimented in recent years. The aim...
08:46
Accuracy of panoramic radiography for degenerative changes of the temporomandibular joint: Silvio R Oliveira, Rudyard dos Santos Oliveira, Ernesto D Rodrigues, José Luiz C Junqueira, Francine K PanzarellaJournal of International Society of Preventive and Community Dentistry 2020 10(1):96-100Background: Temporomandibular joint (TMJ) morphologies are complex, and changes in joint components have been studied extensively. TMJ conditions have many different etiologies, appearances, and relevant clinical...
08:46
Comparison of the anchorage value of the first molars supported with implant and first molars supported with second molar during en masse retraction: M Kaladhar Naik, Garadappagari Dharmadeep, Yellampalli Muralidhar Reddy, Sreekanth Cherukuri, Kranthi Praveen Raj, Vishnuvardhan ReddyJournal of International Society of Preventive and Community Dentistry 2020 10(1):9-15Aims and Objectives: The aim of this study was to determine the efficacy of mini-implants as adjuncts for intraoral anchorage units...
08:46
Assessing dental light-curing units' output using radiometers: A narrative review: Cendrella Assaf, Jean-Claude Fahd, Joseph SabbaghJournal of International Society of Preventive and Community Dentistry 2020 10(1):1-8Introduction: This review aimed to describe dental radiometers and discuss their effectiveness compared to other light-testing devices. Materials and Methods: The search for light-curing units (LCUs), radiometers, and other light-measuring tools available on the market was accomplished...
08:46
Variations and morphometrics of palmaris longus in fetuses: a meta-analysis of cadaveric studies: AbstractThe palmaris longus muscle, and its tendon, is one of the most variable muscles in humans. Though it has been extensively researched in the adult population, its variations and development in the fetal period were rarely investigated. The aim of this meta-analysis is to conduct an evidence synthesis on PL variations and the prevalence of its agenesis during intrauterine development. Seven studies...
08:45
Growth dynamic of the geniculate ganglion in children: a retrospective computed tomography study: AbstractPurposeThe main aim of this retrospective computed tomography (CT) study was to examine the morphometric development of the geniculate ganglion (GG) in children aged between 1 and 18 years for surgical approaches.MethodsThis study was placed on 41 patients (20 females and 21 males) including cochlear implantation cases aged from one to 18 (at mean, 6.44 ± 5.79) years. All the measurements belonging...
08:45
The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future: Publication date: Available online 20 February 2020Source: Microbes and InfectionAuthor(s): Jin-Yan Li, Zhi You, Qiong Wang, Zhi-Jian Zhou, Ye Qiu, Rui Luo, Xing-Yi GeAbstractAt the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health...
08:43
Outcome and Characteristics of Invasive Fungal Infections in critically ill burn patients: A multicenter retrospective study: AbstractBackgroundCharacteristics and outcome of Invasive fungal infection (IFI) in critically ill burn patients have been poorly explored.ObjectivesWe report the factors associated with 90‐day mortality in a multicenter retrospective European study.Patients/MethodsAll burn patients with confirmed IFI admitted between 1st January 2010 to 31st December 2015 in 10 centers in...
08:42
A Review of Sleep-Related Violence: The Demographics of Sleep Forensics Referrals to a Single Center.: Related ArticlesA Review of Sleep-Related Violence: The Demographics of Sleep Forensics Referrals to a Single Center.Chest. 2019 05;155(5):1059-1066Authors: Cramer Bornemann MA, Schenck CH, Mahowald MWAbstract This review of sleep-related violence reports the nature of the underlying sleep-suspected conditions enountered and helps establish the spectrum of sleep-related behaviors resulting...
08:41
Microscopic markers of an infradian biorhythm in human juvenile ribs.: Related ArticlesMicroscopic markers of an infradian biorhythm in human juvenile ribs.Bone. 2019 03;120:403-410Authors: Pitfield R, Miszkiewicz JJ, Mahoney PAbstract Recent studies have indicated that there may be an infradian systemic biorhythm that coordinates aspects of human hard tissue growth and influences adult body size. Here we investigate if evidence of this biorhythm retained in human teeth as the periodicity...
08:41
Risk factors for child sexual abuse victimization: A meta-analytic review.: Related ArticlesRisk factors for child sexual abuse victimization: A meta-analytic review.Psychol Bull. 2019 05;145(5):459-489Authors: Assink M, van der Put CE, Meeuwsen MWCM, de Jong NM, Oort FJ, Stams GJJM, Hoeve MAbstract Experiencing child sexual abuse (CSA) is a major public health problem with serious consequences for CSA victims. For effective assessment and (preventive) intervention, knowledge on risk factors...
08:41
Cannabidiol Adverse Effects and Toxicity.: Related ArticlesCannabidiol Adverse Effects and Toxicity.Curr Neuropharmacol. 2019;17(10):974-989Authors: Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FPAbstract BACKGROUND: Currently, there is a great interest in the potential medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD occurred in the 1970s and intensified recently with many discoveries about the endocannabinoid...
08:41
Epicardial adipocyte size does not correlate with body mass index.: Related ArticlesEpicardial adipocyte size does not correlate with body mass index.Cardiovasc Pathol. 2019 Nov - Dec;43:107144Authors: Aitken-Buck HM, Babakr AA, Coffey S, Jones PP, Tse RD, Lamberts RRAbstract BACKGROUND: Epicardial adipose tissue (EAT) deposition has a strong association with aspects of metabolic dysfunction, including obesity. The size of the EAT adipocytes in relation to obesity, however, has rarely been...
08:41
Latest Results for Cancer Immunology, ImmunotherapyCD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapiesAbstract Esophageal and gastric cancers collectively cause over 1.1 million deaths annually and only 20–30% of patients respond favorably to current therapies. Cellular therapies using invariant natural killer T (iNKT) cells are showing promise for patients with other cancers;...
08:40
New Psychoactive Substances: A Matter of Time.: Related ArticlesNew Psychoactive Substances: A Matter of Time.Curr Neuropharmacol. 2019;17(9):818-822Authors: Pantano F, Graziano S, Pacifici R, Busardò FP, Pichini SAbstract In the last few years, a wide range of new psychoactive substances (NPS) have been produced and marketed to elude the controlled substance lists. These molecules enter the traditional illegal and web market with poor knowledge about their toxicity, mechanism of action,...
08:40
Unusual Sites for Extracranial Head–Neck Schwannomas: AbstractSchwannomas are a frequent cause of swellings in the head and neck region. Due to the abundance of peripheral, cranial and autonomic nerves in this region, schwannomas can present in variety of locations, posing a diagnostic and therapeutic challenge to the surgeon. Unusual sites in head and neck region can have varied presentation depending on the site of origin. We identified unusual extracranial locations of head and neck schwannomas,...
08:39
The Effect of Age at Cochlear Implantation on Speech and Auditory Performances in Prelingually Deaf Children: AbstractTo understand the effect of age at implantation on speech and auditory performances of 74 prelingually deaf Indian children after using cochlear implants for 3, 6 and 12 months. We also evaluate the causes of late implantation in this population. Seventy four children who underwent cochlear implantation from December 2013 to December 2015 in the Department of Otorhinolaryngology and...
08:39
Melanotic Oncocytic Metaplasia of the Nasopharynx: A Case Report With Review of Literature: Ear, Nose &Throat Journal, Ahead of Print. A 75-year-old Taiwanese man presented with recurrent epistaxis, rhinorrhea, chronic cough with blood-tinged sputum. He was a heavy smoker with the consumption of 30 cigarettes per day for 50 years. Nasopharyngoscopic examination revealed several brown nodules near the opening of right Eustachian tube, which was tentatively diagnosed as nevus or melanoma. The overlying...
08:36
Chronic Granulomatous Invasive Fungal Sinusitis: A Case Series and Literature Review: Ear, Nose &Throat Journal, Ahead of Print. Chronic granulomatous invasive fungal sinusitis (CGIFS) is a peculiar disease of the paranasal sinuses due to its rarity, patient subset, and disease course. We describe 7 cases of histopathologically confirmed CGIFS with different treatment plans and varying outcomes. Of particular note was that one of these patients developed allergic fungal rhinosinusitis after complete...
08:35
Steroids Inhibit Eosinophil Accumulation and Downregulate Hematopoietic Chemotaxic Prostaglandin D2 Receptor in Aspirin-Exacerbated Respiratory Disease: Ear, Nose &Throat Journal, Ahead of Print. Background:Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, aspirin sensitivity, and asthma. Aims/Objectives: This study aims to identify a mechanism to target for the future treatment of AERD via the elucidation of the effect of systemic...
08:35
Sleep architecture and factors associated with sleep bruxism diagnosis scored by polysomnography recordings: a case-control study: Publication date: Available online 19 February 2020Source: Archives of Oral BiologyAuthor(s): Thiago Azario de Holanda, Clarissa Delpizo Castagno, Fabiola Jardim Barbon, Yuri Martins Costa, Marília Leão Goettems, Noéli BoscatoAbstractObjectiveThis study evaluated the association between the diagnosis of sleep bruxism (SB), scored by way of polysomnographic (PSG) recordings,...
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Effect of xylitol chewing gum enriched with propolis on dentin remineralization <em>in vitro</em>: Publication date: Available online 19 February 2020Source: Archives of Oral BiologyAuthor(s): Wafa Gargouri, Rym Kammoun, Mazen Elleuche, Mahdi Tlili, Nabil Kechaou, Sonia Ghoul-MazgarAbstractObjectivesThe aim of this study was to evaluate the efficiency of xylitol chewing gums enriched with propolis, remineralizing softly demineralized dentin in vitro.DesignFour groups of chewing gum were...
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Reliable measurement of incisal bite force for understanding the control of masticatory muscles: Publication date: Available online 20 February 2020Source: Archives of Oral BiologyAuthor(s): Luciana S. Moreira, Leonardo A. Elias, Carina M. Germer, Evanisi T. PalomariAbstractObjectiveIn the present study, we aimed at evaluating the steadiness of incisal bite force during isometric contractions of masticatory muscles.DesignTwo separate experiments were carried out in 11 healthy young women. A first...
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Mesenchymal Stem/Stromal Cells from the Placentae of Growth Restricted Pregnancies Are Poor Stimulators of Angiogenesis: AbstractThe extensively branched vascular network within the placenta is vital for materno-fetal exchange, and inadequate development of this network is implicated in the pregnancy disorder fetal growth restriction (FGR), where babies are born pathologically small. Placental mesenchymal stem/stromal cells (pMSCs) and placental macrophages both reside in close proximity to blood...
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Gradenigo's Syndrome with Carotid Septic Stenosis: Gradenigo's syndrome was firstly described in 1907 by Giusseppe Gradenigo and is defined as the clinical triad of suppurative otitis media, ipsilateral abducens nerve palsy, and pain in the distribution of the first and the second branches of the trigeminal nerve. Since the advent of antibiotics, the incidence of this potentially life-threatening complication has diminished, but occasional cases still occur. We herein report a pediatric case of otitis...
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Is Dietary Milk Intake Associated with Cataract Extraction History in Older Adults? An Analysis from the US Population: Background. Galactose accumulation in the lens tissue is known to be cataractogenic. Whether consistent dietary intake of lactose—which consists of glucose and galactose—predisposes to senile cataract remains unclear. This study was conducted to investigate the association between a number of dietary milk intake indicators and cataract extraction history in a representative sample...
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Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats: Objective. Propofol is a classical anesthetic and induces consciousness loss, and gamma-aminobutyric-acid-type-A (GABA-A) receptor is its target. Righting reflex is associated with conscious response. The nucleus basalis (NB) acts as a major relay between the reticular activating system and the frontal cortex (FC). Propofol may mediate righting reflex by affecting GABA-A receptor in NB. Methods. Fifty...
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Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity: It has been recognized that people with obesity are more likely to have low growth hormone secretion. Recent studies have also confirmed that the abnormalities of the growth hormone/insulin-like growth factor 1 axis were associated with cardiovascular complications in people with obesity. However, little is known about whether recombinant human growth hormone therapy could improve cardiovascular and metabolic...
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Herbaspirillum Infection in Humans: A Case Report and Review of Literature: Introduction. Herbaspirillum seropedicae are Gram-negative oxidase-positive nonfermenting rods of Betaproteobacteria class, commonly found in rhizosphere. More recently, some Herbaspirillium species have transitioned from environment to human hosts, mostly as opportunistic (pathogenic) bacteria. We present a 58-year-old female with non-small-cell lung cancer (NSCLC) who presented with pneumonia and was found to have Herbaspirillum...
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Pulmonary Onset of Adult Onset Still's Disease Complicated with Kikuchi Lymphadenitis: Background. Adult onset Still's disease (AOSD) is a rare inflammatory disorder with a variety of clinical presentations. Even though pneumonitis and pleurisy are known to occur in AOSD, pulmonary onset presentations are exceedingly rare. Case Presentation. We present a 40-year-old male, presenting with fever and bilateral alveolar shadows with pleural effusions mimicking community-acquired severe pneumonia. He...
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RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling: Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism....
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Vagus Nerve Stimulation Ameliorates Renal Ischemia-Reperfusion Injury through Inhibiting NF-κB Activation and iNOS Protein Expression: Objective. In renal ischemia/reperfusion injury (RIRI), nuclear factor κB (NF-κB) initiates the expression of multiple genes involved in inflammatory disease. Inhibition of NF-κB-mediated inducible nitric oxide synthase (iNOS) expression can ameliorate RIRI. Vagus nerve stimulation (VNS) protects against various organs I/R injury. The present study was designed to...
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Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome: Purpose. To report an unusual presentation of commercial cannabidiol (CBD) oil-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis (SJS-TEN). Methods. A 56-year-old woman presented with acute onset of a diffuse, blistering, maculopapular rash with over 30% total body surface area (BSA) involvement two days after taking CBD oil sublingually for chronic pain. Biopsy confirmed SJS-TEN. Ophthalmology was consulted and mild eye involvement...
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Leiomyoma of the Cheek: Leiomyomas are rare benign tumors that grow in the tunica media of smooth muscle cells. Leiomyomas occur most frequently in the uterus or gastrointestinal tract and only very rarely in the area of the cheek. This study reports on a rare case of a leiomyoma in the cheek of a 43-year-old woman, who presented with a well-circumscribed, asymptomatic, mobile swelling in the right cheek. This swelling was slightly purplish in color and measured approximately . Surgical excision...
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Perioperative Nursing of Patients with Reoperation of Recurrent Parathyroid Carcinoma Invading the Upper Digestive or Respiratory Tract: Objective. The aim of this study was to summarize the perioperative nursing care of patients with recurrent parathyroid carcinoma. Methods. A retrospective analysis of 10 patients with recurrent parathyroid carcinoma was performed. The clinical data, diagnosis, treatment process, and nursing process (including clinical nursing intervention of various complications)...
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Impact of the Glycemic Control and Duration of Type 2 Diabetes on Vitamin D Level and Cardiovascular Disease Risk: Background and Aims. To investigate the impact of glycemic control and T2D duration on vitamin D status and cardiovascular disease (CVD) risk among Saudi patients. Methods. This case-control study was conducted in King Faisal Specialist Hospital, Saudi Arabia. A total of 25 nondiabetic controls and 92 patients with confirmed T2D, aged 20–60 years, were included. Patients with T2D were...
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Vocal Fold Paralysis Secondary to Subclavian Venous Thrombosis: The etiology of vocal fold paralysis is multifaceted. One of the rare causes is internal jugular vein thrombosis secondary to central venous catheterization. The palsy is usually ipsilateral to the site of indwelled catheterization, self-limited and reversible. The authors of this manuscript report a rare case of contralateral recurrent laryngeal nerve palsy induced by subclavian vein thrombosis following central venous catheterization....
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,