Microfluidic Droplet Digital PCR Is a Powerful Tool for Detection of BRAF and TERT Mutations in Papillary Thyroid Carcinomas.Related ArticlesMicrofluidic Droplet Digital PCR Is a Powerful Tool for Detection of BRAF and TERT Mutations in Papillary Thyroid Carcinomas. Cancers (Basel). 2019 Dec 02;11(12): Authors: Ylli D, Patel A, Jensen K, Li ZZ, Mendonca-Torres MC, Costello J, Gomes-Lima CJ, Wartofsky L, Burman KD, Vasko VV Abstract We examined the utility of microfluidic digital PCR (dPCR) for detection...
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Principles and Practice of Oral RehydrationAbstractPurpose of ReviewAn understanding of fluid and electrolyte losses from diarrhea and mechanisms of solute cotransport led to development of oral rehydration solution (ORS), representing a watershed in efforts to reduce diarrheal disease morbidity and mortality. This report reviews the scientific rationale and modifications of ORS and barriers to universal application.Recent FindingsSolutions with osmolality and electrolyte composition different from...
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A Life Plan Principle of Voting RightsAbstractWho should have a right to participate in a polity's decision-making? Although the answers to this 'boundary problem' in democratic theory remain controversial, it is widely believed that the enfranchisement of tourists and children is unacceptable. Yet, the two most prominent inclusion principles in the literature – Robert Goodin's 'all (possibly) affected interests'-principle and the 'all subjected to law'-principle – both enfranchise those groups....
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Lymphom am AugeZusammenfassungHintergrundDie personalisierte Medizin ist mittlerweile Standard in der onkologischen Betreuung von Patienten. Ein Paradebeispiel stellt das Lymphom dar, das durch den intra- und periokulären Befall wesentliche Berührungspunkte mit der Augenheilkunde hat.FragestellungEs erfolgt die Darstellung der aktuellen personalisierten Diagnostik und Therapie beim okulären Lymphom.MethodenDieser Beitrag stellt einen Bezug zwischen den aktuellen Kenntnissen in der Literatur, den...
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Effects of ε-Polylysine/Chitosan Composite Coating and Pressurized Argon in Combination with MAP on Quality and Microorganisms of Fresh-Cut PotatoesAbstractEffects of ε-polylysine/chitosan (ε-PL/CS) composite coating and pressurized argon (Ar) in combination with modified atmosphere packaging (MAP) on the quality and the microbial load of fresh-cut potatoes during refrigeration were studied. Sliced potatoes were treated with pressurized Ar at 4 MPa for 1 h, and then immersed in ε-PL (1 g L−1)/CS...
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Exogenous abscisic acid and root volatiles increase sporulation of Rhizophagus irregularis DAOM 197198 in asymbiotic and pre-symbiotic statusAbstractSeveral studies have demonstrated asymbiotic growth and development of arbuscular mycorrhizal (AM) fungi, although AM fungi are regarded as obligately symbiotic root-inhabiting fungi. Phytohormones, root exudates, and volatiles are important factors regulating the host-AM fungi interaction. However, the effects of phytohormones, root exudates, and volatiles...
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Colloid Carcinoma of Pancreas in the Setting of Intraductal Papillary Mucinous Neoplasm (IPMN)Presentation and Outcomes of Hepatocellular Carcinoma in the Arabian Peninsula: A Review of a Single Institution Experience in the Sorafenib EraAbstractPurposeThere is a growing evidence showing that there are geographic differences in hepatocellular carcinoma (HCC). Little is known about the characteristics of hepatocellular carcinoma in the Arabian Peninsula. The present study examines the presentation...
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Cognitive Impairment in Patients with Bipolar Disorder: Impact of Pharmacological TreatmentAbstractBipolar disorder is an illness characterised by periods of elated and depressed mood. These mood episodes are associated with changes in cognitive function and there is evidence to suggest that cognitive dysfunction persists during euthymia. The extent to which this is a function of the illness or a result of treatment is less clear. In this narrative review, we explore the impact of commonly used medications...
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Genetic mapping of a locus controlling the intergeneric hybridization barrier between apple and pearAbstractHybridizations involving different species are often hindered because of incompatibility reactions. Although these reproductive barriers have been observed in many plant species, the underlying mechanisms remain to be comprehensively elucidated. In this study, we detected a hybridization barrier between apple (Malus × domestica) and pear (Pyrus spp.) belonging to different genera in the subtribe...
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Vasodepressor Effects of Adenosine in the Cat are Independent of Cyclooxygenase, Potassium Channels, and Nitric Oxide PathwaysAbstractBackgroundPulmonary arterial hypertension is a hemodynamic disorder. Signs and symptoms are generally difficult to recognize because they are non-specific. The current treatment for pulmonary arterial hypertension offers no cure or prevention; therefore, it is important to explore treatment avenues for novel pulmonary arterial hypertension treatments. In this study,...
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UpfrontLipid-associated metabolic signalling networks in pancreatic beta cell functionAbstractSignificant advances have been made in deciphering the mechanisms underlying fuel-stimulated insulin secretion by pancreatic beta cells. The contribution of the triggering/ATP-sensitive potassium (KATP)-dependent Ca2+ signalling and KATP-independent amplification pathways, that include anaplerosis and lipid signalling of glucose-stimulated insulin secretion (GSIS), are well established. A proposed model...
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Redirecting T cells to treat solid pediatric cancersAbstractThe capacity of single-agent therapy with immune checkpoint inhibitors to control solid cancers by unleashing preexisting local antitumor T cell responses has renewed interest in the broader use of T cells as anticancer therapeutics. At the same time, durable responses of refractory B-lineage malignancies to chimeric-receptor engineered T cells illustrate that T cells can be effectively redirected to cancers that lack preexisting tumor antigen-specific...
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Radiology and patient communication: if not now, then when?Key Points• Communication with patients in radiology is, in general, indirect using the referrer as a conduit.• Direct patient communication may be beneficial for radiology departments and radiologists to improve patient awareness about the nature of our role and also to provide correct and measured information about the nature and frequency of discrepancies in radiology.Distinguishing intrahepatic cholangiocarcinoma from hepatocellular carcinoma...
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Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung InjuryObjectives: Determine the intra-tidal regional gas and blood volume distributions at different levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration and blood volume matching is reduced during inspiration in the setting of minimal tidal recruitment/derecruitment and that this mismatching is an important determinant of hypoxemia. Design: Preclinical study. Setting:...
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Evaluation of Longitudinal Assessment for use in Maintenance of CertificationObjective To evaluate a longitudinal assessment process (LA-PM&R) as a replacement for the American Board of Physical Medicine and Rehabilitation (ABPMR) Maintenance of Certification (MOC) Examination. Design In this quality improvement study, randomly selected ABPM&R diplomates were invited to participate in LA-PM&R. Participants' MOC scaled scores were compared to LA-PM&R non-participants. We examined the...
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Development of an Alarm Algorithm, With Nanotechnology Multimodal Sensor, to Predict Impending Infusion Failure and Improve Safety of Peripheral Intravenous Catheters in NeonatesBackground: Peripheral intravenous catheters connected to an infusion pump are necessary for the delivery of fluids, nutrition, and medications to hospitalized neonates but are not without complications. These adverse events contribute to hospital-acquired patient harm. An artificial intelligence theory called fuzzy logic...
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Effect of Hyperoxia on Critical Power and V[Combining Dot Above]O2 Kinetics during Upright CyclingIntroduction/Purpose Critical power (CP) is a fundamental parameter defining high-intensity exercise tolerance, however its physiological determinants are incompletely understood. The present study determined the impact of hyperoxia on CP, the time constant of phase II pulmonary oxygen uptake kinetics (τV[Combining Dot Above]O2), and muscle oxygenation (assessed by near-infrared spectroscopy) in 9 healthy...
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A Case of Nervus Laryngeus Superior Paresis Treated With Novafon Local Vibration Voice TherapyThe aim of the study is to present a case of chronic idiopathic superior laryngeal nerve paresis (SLNp) treated with a novel voice therapy approach called Novafon Local Vibration Voice Therapy (NLVVT).Lateralization of the Vocal Fold: Results of an Exclusive Transoral ApproachVocal fold paralysis in adduction can result in dyspnea. The authors have previously described an original vocal fold lateralization...
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The Hahnemann University Hospital Closure and What Matters: A Department Chair's PerspectiveThe closure of Hahnemann University Hospital (HUH), which was announced on June 26, 2019, resulted in the most significant graduate medical education displacement in history, sending 570 residents to new institutions within a month of the announcement. Over 2,000 physicians, nurses, and staff lost their jobs. While seemingly predictable in retrospect, the closure came as a cataclysmic event to all involved....
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Association Between Marijuana Use and Risk of Cancer: A Systematic Review and Meta-analysisMehrnaz Ghasemiesfe, MD; Brooke Barrow, BA; Samuel Leonard, MS; et alJAMALife Expectancy and Mortality Rates in the United States, 1959-2017Steven H. Woolf, MD, MPH; Heidi Schoomaker, MAEdEditorial: Confronting the Rise and Fall of US Life Expectancy ; Howard K. Koh, MD, MPH; Anand K. Parekh, MD, MPH; John J. Park, MBChB, MPHJAMA PsychiatryLong-term Outcomes of Cognitive Behavioral Therapy for Anxiety-Related...
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Aplasia cutis congenita suite à une exposition in utero au carbimazolePublication date: Available online 6 December 2019Source: Annales de Dermatologie et de VénéréologieAuthor(s): W. Kojmane, S. AtmaniLa dermatologie académique française sur TwitterPublication date: Available online 5 December 2019Source: Annales de Dermatologie et de VénéréologieAuthor(s): N. Kluger, D. du CrestRésuméIntroductionLes journaux de dermatologie et les organisations professionnelles s'ouvrent petit à petit aux réseaux...
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PCSK9 Inhibitors' New Users: Analysis of Prescription Patterns and Patients' Characteristics from an Italian Real-world StudyAbstractBackground and ObjectiveCardiovascular (CV) diseases represent a major cause of death and severe medical condition worldwide. Different therapeutic options are available to control low-density lipoprotein cholesterol (LDL-C) level in order to prevent CV events. In recent years, two new drugs were approved for patients who are unable to reduce circulating LDL-C with...
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Disrupted parahippocampal and midbrain function underlie slower verbal learning in adolescent-onset regular cannabis useAbstractRationaleProlonged use of cannabis, the most widely used illicit drug worldwide, has been consistently associated with impairment in memory and verbal learning. Although the neurophysiological underpinnings of these impairments have been investigated previously using functional magnetic resonance imaging (fMRI), while performing memory tasks, the results of these studies...
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Estimation of fuelwood-induced carbon emission from the use of improved cook stoves by selected households in Kwara State, NigeriaAbstractThis study estimates the fuelwood-induced carbon emission of a 4-year national project called National Assembly Intervention on Clean Cooking Initiative (NAICCI), which involved the distribution of improved wood-saving stoves and Liquefied Petroleum Gas (LPG) and burners to poor households in Kwara State of Nigeria between 2014 and 2018. Questionnaires were used...
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Spatiotemporal changes in vegetation coverage and its causes in China since the Chinese economic reformAbstractWith the rapid development of the economy over 40 years since the initiation of Chinese economic reform, terrestrial ecosystems in China have undergone large-scale changes. In this study, we investigated vegetation dynamics in China and their relationships with climatic factors and anthropogenic drivers over 15 progressive periods of 18–32 years starting in 1982. This was accomplished by...
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Spektrum der Refraktiven Chirurgie 2019IOLs mit erweiterter TiefenschärfeZusammenfassungEDOF IOLs eröffnen für Chirurgen eine neue Option, den Patienten nach einer Kataraktoperation oder einem refraktiven Linsentausch ein fast brillenfreies Leben zu ermöglichen. In diesem Artikel soll ein Einblick über die Funktion und die Eigenschaften der EDOF IOLs gegeben werden.Multifokale IntraokularlinsenZusammenfassungMit der Implantation von multifokalen Intraokularlinsen wird es Patienten ermöglicht in mehreren...
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Characteristics of Chinese Medicine Education Under British Education System in New ZealandAbstractWith the globalisation of Chinese medicine (CM), the local CM education institutions were established in many other countries outside of China. These CM education institutions have formed a new mode in CM education after integrating with local culture, law and national conditions. This article takes New Zealand CM education institutions as an example to discuss the characteristics of CM education under...
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Extreme wage laborAbstractThis brief piece is a response to Lee Binford's work on the Canadian guestworker program.Looking at reforestation to consider Leigh Binford's forum statement: 'Assessing Temporary Foreign Worker Programs Through the Prism of Canada's Seasonal Agricultural Worker Program: Can They Be Reformed or Should They Be Eliminated'The hell with abolishing or reforming Canada's guest workers programs: developing a migrant-centred approach to migrationResponse to Leigh Binford's forum...
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An integrated social life cycle assessment of freight transport systemsAbstractPurposeThe climate change concerns have generated the need to develop strategies to reduce the oil dependency in transport sector. Many of these strategies have not achieved the proposed objectives by the scant emphasis on social and socio-economic aspects of the life cycle of the transport system components. Therefore, an approach for the integrated social life cycle assessment (S-LCA) of freight transport services is...
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Spatiotemporal changes in vegetation coverage and its causes in China since the Chinese economic reformAbstractWith the rapid development of the economy over 40 years since the initiation of Chinese economic reform, terrestrial ecosystems in China have undergone large-scale changes. In this study, we investigated vegetation dynamics in China and their relationships with climatic factors and anthropogenic drivers over 15 progressive periods of 18–32 years starting in 1982. This was accomplished by...
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Spinal cord toxoplasmosis in a young immunocompetent patientAbstractWe report a case of spinal cord toxoplasmosis occurring as a primary infection in a 31-year-old immunocompetent man. Exhaustive immunologic and genetic investigations did not identify any immunodeficiency. The causative agent was a typical type 2 strain. In cases of spinal cord lesions, toxoplasmosis should be considered, even in an immunocompetent patient.Correction to: Prognostic factors of mortality after surgery in infective...
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Characteristics of Chinese Medicine Education Under British Education System in New ZealandAbstractWith the globalisation of Chinese medicine (CM), the local CM education institutions were established in many other countries outside of China. These CM education institutions have formed a new mode in CM education after integrating with local culture, law and national conditions. This article takes New Zealand CM education institutions as an example to discuss the characteristics of CM education under...
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The Impact of Adaptive Functioning and Oral Hygiene Practices on Observed Tooth-Brushing Performance Among Preschool Children with Special Health Care NeedsAbstractObjectivesTo investigate the impact of adaptive functioning and oral hygiene practices on tooth-brushing performance among preschool children with special health care needs (SHCN).MethodsA cross-sectional study was conducted in Special Child Care Centers. Children's tooth-brushing performance was assessed by a standardized 13-step pro...
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Schwere euglykämische Ketoacidose unter SGLT-2-Inhibitoren – eine seltene, aber schwerwiegende KomplikationZusammenfassungDie Natrium-Glucose-Cotransporter-2-Inhibitoren(SGLT-2i)-induzierte Ketoacidose ist selten, im Falle ihres Eintreffens jedoch für den Patienten schwerwiegend und erfordert sofortiges korrektes Handeln. Momentan hat eine ketoacidotische Krise das dauerhafte Sistieren des SGLT-2i zur Folge. Klare Vorgaben bezüglich des Zeitpunkts des Absetzens von SGLT-2i vor geplanten operativen...
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Mechanisms of Future Predicted Changes in the Zonal Mean Mid-Latitude CirculationAbstractState-of-the-art climate models predict the zonal mean mid-latitude circulation will undergo a poleward shift and seasonally and hemispherically dependent intensity changes in the future. Here I review the mechanisms put forward to explain the zonal mean mid-latitude circulation response to increased carbon dioxide (CO2) concentration. The mechanisms are grouped according to their thermodynamic starting point,...
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Plant capacity notions in a non-parametric framework: a brief review and new graph or non-oriented plant capacitiesAbstractOutput-oriented plant capacity in a non-parametric framework is a concept that has been rather widely applied since about twenty-five years. Conversely, input-oriented plant capacity in this framework is a notion of more recent date. In this contribution, we unify the building blocks needed for determining both plant capacity measures and define new graph or non-oriented plant...
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Liquid Biopsy for Hepatocellular CarcinomaAbstractPurpose of ReviewClinically available biomarkers for hepatocellular carcinoma (HCC) early diagnosis and prognostication have limited utility. Further lack of routine biopsy in hepatocellular carcinoma limits the availability of molecular information to guide drug development. Recent studies investigating liquid biopsy using circulating tumor cells (CTCs) and cell-free deoxyribonucleic acid (cfDNA) have yielded promising data that could address both...
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Artery/vein classification of retinal vessels using classifiers fusionAbstractThe morphological changes in retinal blood vessels indicate cardiovascular diseases and consequently those diseases lead to ocular complications such as Hypertensive Retinopathy. One of the significant clinical findings related to this ocular abnormality is alteration of width of vessel. The classification of retinal vessels into arteries and veins in eye fundus images is a relevant task for the automatic assessment of...
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Drug-induced anaphylaxis—elicitors, mechanisms and diagnosisAbstractDrugs are one of the major causes of anaphylaxis. For example 2346 cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs; n = 902) and antibiotics (n = 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been...
The SiLaC procedure for pilonidal sinus disease: long-term outcomes of a single institution prospective studyAbstractBackgroundIn 2014, we started to treat pilonidal sinus disease in our institution with sinus laser-assisted closure (SiLaC) procedure. The aim of the present study was to evaluate the safety and efficacy of the SiLaC procedure in a single institution prospective study on a large cohort of patients and with a long follow-up period, and try to determine what factors that could influence...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,Pharmaceutics, Vol. 11, Pages 650: Composite Cryogel with Polyelectrolyte Complexes for Growth Factor DeliveryPharmaceutics, Vol. 11, Pages 650: Composite Cryogel with Polyelectrolyte Complexes for Growth Factor Delivery Pharmaceutics doi: 10.3390/pharmaceutics11120650 Authors: Bolat Sultankulov Dmitriy Berillo Sholpan Kauanova Sergey Mikhalovsky Lyuba Mikhalovska...
Wed Dec 04, 2019 10:00
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,