Mechanistic insight of cyclin-dependent kinase 5 in modulating lung cancer growthG. M. Shazzad Hossain Prince, Tsung-Ying Yang, Ho Lin, Mei-Chih ChenChinese Journal of Physiology 2019 62(6):231-240Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase in the central nervous system, has raised much attention...
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Developing Your Career as a Nurse Educator: Try These StrategiesNo abstract availableMentoring Clinical Teachers Using Mobile Telepresence TechnologyNo abstract availableTeamSTEPPS Training for Nursing Students Using Pop Culture MediaNo abstract availableFostering Prioritization Using a Blended Group and Individual Simulation ApproachNo abstract availableGetting to the Heart of the Matter: Drawing Cardiovascular Anatomy to Facilitate LearningNo abstract availableTeaching Quality Improvement in Prelicensure...
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Renal damage in primary aldosteronism: a systematic review and meta-analysisObjectives: In experimental animal models, exogenous aldosterone excess has been linked to the progression of renal disease. However, the evidence of an increased risk of renal damage in patients affected by primary aldosteronism remains controversial. We aimed at evaluating the association between primary aldosteronism and renal damage through a meta-analysis. Methods: We performed a quantitative review of studies evaluating...
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The role of cannabis in treating anxiety: an updatePurpose of review Cannabis use for medical purposes has become increasingly common, including as treatment for mental health disorders such as anxiety. Unfortunately, the evidence examining its use in mental health has been slow to evolve, but is emerging. Given the widespread use of cannabis, it is important for both clinicians and those who suffer with anxiety to understand the effects of cannabis on symptoms of anxiety. In this review, we present...
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Editorial: Body composition measurements in older adultsNo abstract availableVitamin D for the older patient: from hype to hope?Purpose of review The review critically appraises the most recent and important meta-analyses that have assessed the effect of vitamin D supplementation on bone health in the older population. Recent findings Vitamin D status is generally lower in study participants with bone wasting. However, studies on the effects of vitamin D supplementation on bone health, summarized...
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Editorial: Surgical advancements and innovations in cataract surgery for the complex patientNo abstract availableManagement of cataract in the setting of uveitis: a review of the current literaturePurpose of review This review aims to cover the preoperative planning, intraoperative considerations, and postoperative management that aids in successful outcomes of patients with cataract and uveitis. Disease-specific management and pediatric management will also be addressed. Recent findings Dexamethasone...
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Papillary thyroid microcarcinoma: optimal management versus overtreatmentPurpose of review The treatment of small, low-risk papillary thyroid carcinoma has undergone a paradigm shift, with many tumors now initially treated with active surveillance rather than upfront surgery. Further studies on patients enrolled in active surveillance have refined our knowledge of the clinical behavior of papillary thyroid microcarcinomas. Recent findings This article summarizes the major conclusions of landmark...
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Measuring outcomes in complicated intra-abdominal infectionsPurpose of review Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical trials can lead to misleading results on the effectiveness of interventions. This review aims to describe how outcomes are reported in randomized controlled trials evaluating...
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Is the Use of Intraoperative Corticosteroids Harmful in Lumbar Decompression Surgery?No abstract availableManagement of Herniated Lumbar Disk Disease and Cauda Equina Syndrome in PregnancyLower back pain is a commonly reported symptom during pregnancy. However, herniated lumbar disk disease is an uncommon cause for such pain. Cauda equina syndrome (CES) during pregnancy is a rare clinical scenario. This review highlights the epidemiology, diagnostic and treatment strategies, and challenges encountered...
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Is the Use of Intraoperative Corticosteroids Harmful in Lumbar Decompression Surgery?No abstract availableManagement of Herniated Lumbar Disk Disease and Cauda Equina Syndrome in PregnancyLower back pain is a commonly reported symptom during pregnancy. However, herniated lumbar disk disease is an uncommon cause for such pain. Cauda equina syndrome (CES) during pregnancy is a rare clinical scenario. This review highlights the epidemiology, diagnostic and treatment strategies, and challenges encountered...
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Genetic and epigenetic factors interacting with clonal hematopoiesis resulting in chronic myelomonocytic leukemiaPurpose of review Since 2016, the WHO has recognized the significant phenotypic heterogeneity of chronic myelomonocytic leukemia (CMML) as a myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap disease. Although sharing many somatic mutations with MDS and MPN, the purpose of this review is to put recent biological findings of CMML in the context of evolutionary theory,...
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Novel therapeutic approaches in chronic kidney disease and uremia management,Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney diseasePurpose of review In chronic kidney disease (CKD), disturbance of several metabolic regulatory mechanisms cause premature ageing, accelerated cardiovascular disease (CVD), and mortality. Single-target interventions have repeatedly failed to improve the prognosis for CKD patients. Epigenetic interventions have the potential to modulate several...
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Introduction, vasculitis 2020,A monogenic autoinflammatory disease with fatal vasculitis: deficiency of adenosine deaminase 2Purpose of review To recap the expanding clinical spectrum, genotype–phenotype associations and treatment options in the light of recently published articles regarding the deficiency of adenosine deaminase 2 (DADA2). Recent findings Whole-exome sequencing enabled novel clinical phenotypes associated with ADA2 mutations. Since its discovery, the phenotypic spectrum of DADA2...
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Asthma: a modifiable disease on a crossroadNo abstract availableLong and winding road: from infant wheeze to adult asthmaPurpose of review This review aims to recognize the multifactorial cause of asthma, from the influence of mother until adulthood, highlight the main characteristics of the disease at different ages and summarize the evidence of potential prevention strategies. Recent findings To date, regarding the prenatal period, the presence of specific genes, maternal asthma, drugs, and tobacco...
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Functional outcomes after selective dorsal rhizotomy followed by minimally invasive tendon lengthening procedures in children with spastic cerebral palsyMany surgical options have been proposed to improve the ambulatory status of children with spastic cerebral palsy (CP), but none have focused on addressing both spasticity and lower extremity tendon contractures. The purpose of this study is to evaluate the results of selective dorsal rhizotomy (SDR) followed by minimally invasive tendon lengthening...
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Stabilizing the Metzler matrices with applications to dynamical systemsAbstractReal matrices with non-negative off-diagonal entries play a crucial role for modelling the positive linear dynamical systems. In the literature, these matrices are referred to as Metzler matrices or negated Z-matrices. Finding the closest stable Metzler matrix to an unstable one (and vice versa) is an important issue with many applications. The stability considered here is in the sense of Hurwitz, and the distance between...
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Edentulous left maxillary ridge ulcerative swellingPublication date: Available online 28 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Chih-Huang Tseng, Chang-Wei Su, Ching-Yi Chen, Wen-Chen Wang, Yuk-Kwan ChenRecurrent oral erythema multiforme: a case series report and review of the literaturePublication date: Available online 28 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Yuqi Du, Fei Wang, Tiannan...
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Microbe-mediated sustainable bio-recovery of gold from low-grade precious solid waste: A microbiological overviewPublication date: March 2020Source: Journal of Environmental Sciences, Volume 89Author(s): Supriyanka Rana, Puranjan Mishra, Zularisam ab Wahid, Sveta Thakur, Deepak Pant, Lakhveer SinghAbstractIn an era of electronics, recovering the precious metal such as gold from ever increasing piles of electronic-wastes and metal-ion infested soil has become one of the prime concerns for researchers...
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Extradition and Mental Health in UK LawAbstractThe response of UK extradition law and practice to requested persons presenting with mental health disorders is multi-faceted and unnecessarily complex. There are a number of reasons for this. They centre upon the law failing to adequately recognise that mental health cases can give rise to concerns not present in physical health cases. The deficiencies of the law are found in the three applicable bars to extradition; oppression, human rights and forum....
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The bacteria-positive proportion in the disc tissue samples from surgery: a systematic review and meta-analysisAbstractPurposeThe role of bacteria, especially Propionibacterium acnes (P. acnes), in human intervertebral disc diseases has raised attention in recent years. However, limited sample size of these studies and diverse bacteria-positive proportion made this topic still controversial. We aimed to review related articles and summarize the bacteria-positive proportion in these studies.MethodsWe...
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Surface deformation processes in the Carmel Fault based on 17 years of GPS measurementsAbstractTectonic activity and crustal deformation in northern Israel are mainly related to the Dead Sea Fault (DSF) and the Carmel–Gilboa Fault System (CGFS). The CGFS is composed of several NW–SE trending faults while the main faults are the Carmel Fault (CF) and Gilboa Fault (GF). The CGFS divides the Sinai Sub-Plate into two tectonic domains. In this study, we geodetically investigate surface deformation processes...
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Epistemology and the History of Science: The Problem of Historical Epistemology in the Italian Debate of the Twentieth CenturyAbstractThe essay, based also on unpublished writings, analytically reconstructs the Italian debate concerning the problem of historical epistemology and of the different relationships that can be established between epistemological reflection and the history of science. We start from awareness, à la Lakatos, that a "history of science without philosophy of science is blind,...
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Watch out! Insecure relationships affect vigilance in wild spider monkeys ( Ateles geoffroyi )AbstractVigilance is used to monitor extra-group threats as well as risky group members. We examined whether relationship quality affects vigilance patterns of spider monkeys. We used focal animal sampling to collect data on social interactions and individual vigilance of all adults and subadults (N = 22) in a community of well-habituated Geoffroy's spider monkeys living in the protected area of Otoch Ma'ax...
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Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian CancerThe article Combination Treatment with an Antibody–Drug Conjugate (A1mcMMAF) Targeting the Oncofetal Glycoprotein 5T4 and Carboplatin Improves Survival in a Xenograft Model of Ovarian Cancer, written by Y. Louise Wan, Puja Sapra, James Bolton, Jia Xin Chua, Lindy G. Durrant and Peter L. Stern, was originally published under...
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Clean technologies and policies for sustainable development in AsiaBarrier properties of cellulose nanofiber film as an external layer of particleboardAbstractThe use of formaldehyde-based adhesives in the wood-based composite industry represents a healthcare concern due to its toxic volatile compounds. For this reason, this work presents the use of a formaldehyde barrier layer based on cellulose nanofibers (CNF) obtained from Manila hemp (Musa textilis) fibers. The elaborated CNF films were firstly...
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Central aortic blood pressure estimation in children and adolescents: results of the KidCoreBP studyBackground: Central aortic SBP (cSBP) may have superior prognostic value compared with peripheral SBP (pSBP), but noninvasive cSBP measurement techniques have not been formally validated in children and adolescents. Method: This study assessed the accuracy of two automated devices and the radial tonometry/transfer function method (RT-TF) for estimating central pressures and pulse pressure amplification...
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Analysis of morphometric and somatoscopic traits of auricle of ear in India: Relation with diversified ethnicitiesM MaitreyeeJournal of Experimental and Clinical Anatomy 2019 18(1):1-5BACKGROUND: India is a country with large population and a mixture of ethnicities with Indo-Aryan, Dravidian, and Mongoloid ethnicities largely located in the six zones of the country, predominantly in North, South, and Northeast zones, respectively. There is a possibility of differences in auricular features among...
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Lung and diaphragm-protective ventilation: setting new concepts in historical contextNo abstract availableTechniques to monitor respiratory drive and inspiratory effortPurpose of review There is increased awareness that derangements of respiratory drive and inspiratory effort are frequent and can result in lung and diaphragm injury together with dyspnea and sleep disturbances. This review aims to describe available techniques to monitor drive and effort. Recent findings Measuring drive and effort...
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Ultrasonography greatly improves the ability of clinicians to diagnose psoriatic arthritisKuo-Lung LaiJournal of Medical Ultrasound 2019 27(4):167-168Transrectal doppler sonography of benign prostatic enlargement in Nigerian MenOlubukola Olayinka Fanimi, Christianah Mopelola Asaleye, Abdulkadir Ayo Salako, Oluwagbemiga Oluwole Ayoola, Tewogbade Adeoye Adedeji, Bukunmi Michael IdowuJournal of Medical Ultrasound 2019 27(4):169-176Background: Transrectal ultrasonography (TRUS) is the best route for...
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Regulation of allergic inflammation by dendritic cellsPurpose of review Dendritic cells are critical in directing inflammatory versus tolerogenic responses. As the burden of allergic disease rises worldwide, increased understanding of mechanisms underlying these diseases is needed. This review highlights research demonstrating how dendritic cells influence allergic disease development, providing important mechanistic insights into current clinical management strategies as well as potential areas...
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Effect of Low-Level LASER Therapy on Wound Recovery and Sequelae After Orthognathic Surgery: A Randomized Controlled TrialAlireza Sadighi, Hasan Momeni, Amir Mansour ShiraniDental Hypotheses 2019 10(3):58-64Introduction: Despite the application of low-level laser therapy (LLLT) in diverse dental procedures, its postoperative effects especially on wound recovery after orthognathic surgery have not been well explored. Therefore, the current study aimed to investigate the effects of 660 nm LLLT on postoperative...
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Augmented reality technology could be an alternative method to treat craniomaxillofacial foreign bodies: A comparative study between augmented reality technology and navigation technologyRemoval of foreign bodies in the craniomaxillofacial region is challenging. The purpose of this study was to explore the feasibility of using augmented reality (AR) technology to treat craniomaxillofacial foreign bodies.Evaluation of the potential risk of benign paroxysmal positional vertigo due to traumatic effect...
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Evaluation of the potential risk of benign paroxysmal positional vertigo due to traumatic effect of osteotomy in septorhinoplasty patients.Publication date: Available online 26 November 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Suha Ertugrul, Malik Abacı, Emre SoylemezAbstractPurposeTo investigate the effect of osteotomy on the vestibular system in septorhinoplasty patients and to determine the potential risk of benign paroxysmal positional vertigo (BPPV) occurrence in these...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,EUS-guided biliary drainage: Moving beyond the cliché of prime timeVinay Dhir, Mouen A KhashabEndoscopic Ultrasound 2019 8(7):1-2Bile duct drainage: TerminologyMajid Abdularahman AlmadiEndoscopic Ultrasound 2019 8(7):3-6EUS-guided antegrade proceduresShuntaro Mukai, Takao ItoiEndoscopic Ultrasound 2019 8(7):7-13De novo EUS-guided biliary drainageKazuo Hara, Nozomi...
Thu Nov 28, 2019 09:27
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,