The predictive value of age, creatinine, ejection fraction score for in-hospital mortality in patients with cardiogenic shockIntroduction: The aim of the present study was to assess the predictive value of the age, creatinine, ejection fraction score for in-hospital mortality in patients with cardiogenic shock secondary to ST-elevation myocardial infarction. Material and methods: This single-center, retrospective study was based on a comprehensive analysis of the hospital records of 318 consecutive...
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Cardiac cachexia: the mandate to increase clinician awarenessPurpose of review Heart failure is a frequent problem in an ageing population, associated with high rates of morbidity and mortality. Today, it is important to not only treat heart failure itself but also the related comorbidities. Among them, cardiac cachexia is one of the major challenges. It is a complex multifactorial disease with a negative impact on quality of life and prognosis. Therefore, prevention, early recognition and treatment...
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What will surgical coronary revascularization look like in 25 years?Purpose of review Coronary artery bypass grafting evolved in incremental but significant steps since its introduction. Here, we provide an update on operative techniques, choice of conduits, patient selection/decision-making and primary and secondary prevention measures with potential of influencing the future of coronary artery bypass grafting (CABG) surgery. Recent findings Associated mortality of off-pump CABG (OPCAB) procedures...
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Duration of allergen immunotherapy for inhalant allergyPurpose of review We evaluated the time-course of clinical and immunologic changes that occur during and after cessation of sublingual and subcutaneous allergen immunotherapy for inhalant allergies. Recent findings Increases in production of inhibitory cytokines, such as IL-10 and allergen-specific IgE and IgG4 antibodies are induced within weeks of starting immunotherapy for both seasonal and perennial allergens. In general, 2–4 months' immunotherapy...
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Tailoring Individualized Evaluation of Pediatric Abdominal Pain Using Ecological Momentary Assessment (EMA): A Pilot Study Testing Feasibility and AcceptabilityObjective: The current study aimed to determine if it was feasible and acceptable to use ecological momentary assessment (EMA) to assess individual associations between biopsychosocial contributors to chronic abdominal pain with two objective sensors and a mobile application. Specifically, we aimed to determine if it was possible to identify...
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Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironmentPublication date: 28 November 2019Source: Cancer Letters, Volume 465Author(s): Ramouna Voshtani, Mei Song, Huan Wang, Xiaoqi Li, Wei Zhang, Mojdeh S. Tavallaie, Wenjun Yan, Joseph Sun, Fang Wei, Xiaojing MaAbstractProgranulin (PGRN) is a growth factor with significant biological effects in different types of cancer. However, its role in melanoma progression has not been explored. In...
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Delayed GALT reconstitution in duodenum compared to rectum in hiv-infected patients initiating antiretroviral therapyBackground: We aimed to characterize the impact of ART initiation on GALT at various sites along the gastrointestinal site. Methodology: Peripheral blood and duodenal and rectal biopsies were obtained from 12 HIV- and 33 treatment-naïve HIV+ subjects at baseline and after 9-months ART. Tissue was digested for immunophenotyping. Inflammatory, bacterial translocation and intestinal damage...
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Suicide prevention strategies for general hospital and psychiatric inpatients: A narrative reviewKarthick Navin, Pooja Patnaik Kuppili, Vikas Menon, Shivanand KattimaniIndian Journal of Psychological Medicine 2019 41(5):403-412Background: In-patient (IP) suicides contribute a small but significant proportion of overall suicides. Despite this, suicide prevention strategies focusing on the general hospital IP population remain relatively underresearched. This paper is intended to provide an overview...
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Role of dermoscopy in the diagnosis of hypertrophic lichen planus and prurigo nodularisBangaru Hanumaiah, Joice Maria JosephIndian Journal of Dermatology 2019 64(5):341-345Background: A dermoscope is an office tool used in the diagnosis of various disorders. At present, studies on hypertrophic lichen planus (HLP) and prurigo nodularis (PN) are limited. Aims and Objectives: The aim of this study was to compare the dermoscopic features of HLP and PN and to determine the role of dermoscopy in the differential...
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Comparison of therapeutic effect of mucoadhesive nano-triamcinolone gel and conventional triamcinolone gel on oral lichen planusRastin Sadeghian, Bita Rohani, Zahra Golestannejad, Saeid Sadeghian, Shahla MirzaeeDental Research Journal 2019 16(5):277-282Background: Oral lichen planus (OLP) is a chronic disease without any definitive treatment. Local corticosteroids are often prescribed, but their efficacy has been questioned by many studies. The purpose of this study was to investigate the effect...
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Association Between Pulmonary Function and Asthma SymptomsPublication date: September–October 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7Author(s): Patrick W. Sullivan, Vahram H. Ghushchyan, Jessica Marvel, Yu Chen Barrett, Anne L. FuhlbriggeBackgroundFEV1 as a percentage of predicted (FEV1%pred) is commonly measured in asthma clinical studies; however, reports vary on its association with asthma control instruments evaluating symptoms.ObjectiveAssess...
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Dermatology and VenereologyAccepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.Letter to EditorThe prevalence and significance of radiographic incidental findings during initial staging of melanoma: A retrospective studyMadeliene Stump, Jaclyn Keller, Sarah L. Mott, Deirdre Stolmeier, Mohammed Milhem, Vincent LiuFirst Published: 30 August 2019Review ArticlesA Systematic Review of Outcome Reporting in Laser...
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Can your aura be measured ?Sacred texts and Sages have told us that the subtle world exists. Yet for millennia, subtle concepts such as one's aura could only be perceived through the sixth sense of an advanced level. With recent advances in technology, we now have some tangible proof that the subtle world and things like auras exist. One such instrument that can be used to study the subtle world is the Universal Thermo Scanner (UTS). With over 10,000 readings taken by the spiritual research team,...
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OncoCyte to Acquire Razor GenomicsPublished on Sep 05, 2019 uBiome Declares Bankruptcy, Offers Assets for SalePublished on Sep 04, 2019 Biocartis H1 2019 Revenues Rise 39 PercentPublished on Sep 05, 2019 PathoQuest Secures €8M in New FinancingPublished on Sep 05, 2019Featured in Depth Emedgene Technology Shown to Automate Variant ID in 96 Percent of CasesPublished on Sep 04, 2019 Stoller Centre Develops Protein Panel for Early Detection of Lung CancerPublished on Sep 04, 2019 Molecular Aging Initiative...
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Impact of Public Health Interventions on Drinking Water–Associated Outbreaks of Hepatitis A — United States, 1971–2017Catherine E. Barrett, PhD; Bryn J. Pape, DO; Katharine M. Benedict, PhD, DVM; et al.
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Looking for the right way: right coronary artery originating from a left anterior descending acutely occluded just distally to the bifurcationWe describe the case of a patient referred to our cathlab due to anterior ST segment elevation myocardial infarction. Through the right radial artery route, after multiple attempts to cannulate the right coronary artery (RCA), we proceeded to left coronary angiography, which showed an abnormal origin of RCA from the middle segment of the left anterior descending...
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A Retrospective Observational Study of the Neuroendocrine Stress Response in Patients Undergoing Endoscopic Transsphenoidal Surgery for Removal of Pituitary Adenomas: Total Intravenous Versus Balanced AnesthesiaBackground: Anesthetic technique affects the neuroendocrine stress response to surgery. In this retrospective study, we compared the neuroendocrine stress response in patients undergoing endoscopic transsphenoidal pituitary adenoma surgery (ETSPAS) with total intravenous anesthesia (TIVA)...
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Factors associated with organ donation by trauma patients in Nova ScotiaBackground Trauma patients represent a significant pool of potential organ donors (PODs), and previous research suggests that this population is underutilized for organ donation (OD). Our objective was to assess factors associated with OD in the trauma population. Methods We retrospectively analyzed OD in Nova Scotia over a 7-year period (2009-2016) using data from the Nova Scotia Trauma Registry (NSTR) and Nova Scotia Legacy...
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Associations of awake and asleep blood pressure and blood pressure dipping with abnormalities of cardiac structure: the Coronary Artery Risk Development in Young Adults studyObjectives: To evaluate the associations of high awake blood pressure (BP), high asleep BP, and nondipping BP, determined by ambulatory BP monitoring (ABPM), with left ventricular hypertrophy (LVH) and geometry. Methods: Black and white participants (n = 687) in the Coronary Artery Risk Development in Young Adults study underwent...
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Recent Posts,Rapid DNA Analysis to ID Boat Fire VictimsPublished on Sep 05, 2019Fox News reports that rapid DNA testing is being used to identify victims of the Santa Barbara boat fire. Read more >uBiome Files for BankruptcyPublished on Sep 05, 2019Microbiome testing firm uBiome has files for bankruptcy months after the FBI searched its offices as part of an investigation into its billing practices. Read more >How to Pay the High PricePublished on Sep 05, 2019Health insurers in the US are devising...
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Adult CranioplastyObjectives: After reading this article, the participant should be able to: Understand the etiology of cranial defects. Understand the anatomy of the cranium. Understand the importance of the preoperative workup in the cranial reconstruction decision-making process. Describe the options available for calvarial reconstruction including autologous and alloplastic materials. Describe the basic differences between available alloplastic materials. Understand the intraoperative and postoperative...
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Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic ShockBackground: Resuscitation from hemorrhagic shock (HS) by blood transfusion restores oxygen (O2) delivery and provides hemodynamic stability. Current regulations allow red blood cells (RBCs) to be stored and used for up to 42 days. During storage, RBCs undergo many structural and functional changes. These storage lesions have been associated with adverse events and increased mortality after transfusion, increasing the...
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Ancient DNA Studies Untangle Genetic History of Indus River Valley CivilizationPublished on Sep 05, 2019Featured in Depth Large-Scale Multigene Panel Study of Hereditary Cancer Risk Refines Gene AssociationsPublished on Sep 05, 2019 Emedgene Technology Shown to Automate Variant ID in 96 Percent of CasesPublished on Sep 04, 2019 Stoller Centre Develops Protein Panel for Early Detection of Lung CancerPublished on Sep 04, 2019 Molecular Aging Initiative to Profile Clonal Hematopoiesis Consequences...
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Regional Anesthesia: A Silver Bullet, Red Herring, or Neither?Eric C. Sun, M.D., Ph.D.; Stavros G. Memtsoudis, M.D., Ph.D., M.B.A.; Edward R. Mariano, M.D., M.A.S.Anesthesiology Published online September 04, 2019. doi:10.1097/ALN.0000000000002964Images in AnesthesiologyVenovenous Extracorporeal Membrane Oxygenation for Rigid Bronchoscopy and Carinal Tumor Resection in Decompensating PatientsDustin Hang, M.D.; Justin N. Tawil, M.D.; Michael A. Fierro, M.D.Anesthesiology Published online September...
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Spotlight on the Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism is Keeping the Highest Risk From Antithyroid Drugs in the Blind SpotJuly 1, 2019, JAMA Internal Medicine released online an article authored by Kitahara et al entitled "Association of radioactive iodine treatment with cancer mortality in patients with hyperthyroidism." The Altmetric Attention Score, a global indicator of interest from lay public and colleagues, skyrocketed to 223 by...
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PCSK9 Inhibitor Use in Heart Transplant Recipients: A Case Series and Review of the LiteratureNo abstract availableConstrictive Pericarditis after Lung TransplantationBackground: Constrictive pericarditis is a rare, but increasingly recognized long-term post-operative complication of lung transplantation. Heightened clinical suspicion, improved diagnostic imaging and effective surgical treatment of the disease have led to progressive awareness of the pathology. We present our institutional experience...
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New Drug Approved to Fight Community-Acquired PneumoniaLast month, the FDA approved Xenleta (lefamulin) to treat adults with community-acquired bacterial pneumonia.READ MORE
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Changes in the Management of Children With Brief Resolved Unexplained Events (BRUEs),Sriram Ramgopal, Kathleen A. Noorbakhsh, Clifton W. Callaway, Paria M. Wilson and Raymond D. PitettiCase ReportMycoplasma pneumoniae Carriage With De Novo Macrolide-Resistance and Breakthrough PneumoniaAmmar Saadoon Alishlash, Thomas Prescott Atkinson, Charles Schlappi, Sixto M. Leal Jr, Ken B. Waites and Li XiaoFrom the American Academy of PediatricsExecutive Summary: Criteria for Critical Care of Infants and Children:...
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American Journal of NeuroradiologyPublication Preview articles for 5 September 2019ADULT BRAINThe Internal Cerebral Vein: New Classification of Branching Patterns Based on CTAK. Brzegowy, M.P. Zarzecki, A. Musiał, H.M. Aziz, T. Kasprzycki, R.S. Tubbs, T. Popiela and J.A. WalochaAJNR Am J Neuroradiol first published on 5 September 2019 doi:10.3174/ajnr.A6200http://www.ajnr.org/content/early/2019/09/05/ajnr.A6200.abstractDiagnostic Impact of Intracranial Vessel Wall MRI in 205 Patients with Ischemic...
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What Is the Value of Market-Wide Health Care Price Transparency?Anna D. Sinaiko, MPP, PhDAudio Interview: What Is the Value of Market-Wide Health Care Price Transparency?JAMA CLINICAL CHALLENGEJoint Pain and ProteinuriaAbdullah S. Al Saleh, MBBS; M. Hasib Sidiqi, MBBS; Morie A. Gertz, MD, MACPEarn CME creditAUDIOAudio InterviewWhat Is the Value of Market-Wide Health Care Price Transparency?
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Editorial,Value of occupational health researchLin Fritschi, Peter M Smith (2019-09-03)10.1136/oemed-2019-106091Mental health and work: what's next?Sharon A M Stevelink, Alexandra Pollitt, Ira Madan (2019-08-29)10.1136/oemed-2019-105820PostScriptIs burn-out finally a disease or not?Quentin V Durand-Moreau (2019-09-03)10.1136/oemed-2019-106094WorkplacePersistent postoperative pain after inguinal hernia repair in relation to occupational lifting and standing/walking: a 6-month follow-up studyMarie...
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Το Ανζέρ ή μέλι του Πόντου, που λατρεύουν οι αρκούδες (Video),Posted: 05 Sep 2019 12:00 AM PDTΤο Ανζέρ ή μέλι του Πόντου, που λατρεύουν οι αρκούδες Ένας μελισσοκόμος στην Τουρκία ανακάλυψε μια… βαθιά αλήθεια για τα γαστρονομικά γούστα των αρκούδων του Πόντου: πως τα συγκεκριμένα θηλαστικά,...Κάντε κλικ πάνω στον τίτλο για να διαβάσετε όλη την ανάρτηση στο http://www.e-Pontos.gr
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Addressing Opioid Epidemic Through Interprofessional Education and Communication Is KeyNo abstract availableA Retrospective Descriptive Study of Nurses With Substance Use Disorders in TexasThere are approximately 3.1 million nurses in the Unites States (U.S. Census Bureau, 2016), and approximately 8% of them experience substance use disorders (Kunyk, 2015). Nurses with impaired practice are referred to peer assistance programs as they seek rehabilitation. As of 2016, 348 nurses in Texas Peer Assistance...
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Kidney transplantation across minor ABO incompatibility: the use of A: 2: to B transplantsPurpose of review On 4 December 2014, the new kidney allocation system (KAS) went into effect. As part of this system, UNOS approved for the first time a national system with a specific mechanism affording priority to allocate kidneys across so-called 'minor ABO incompatibility' from blood group A2 donors into blood group B recipients. This significantly increased the number of such transplants done and the...
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Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic AlopeciaBACKGROUND 5α-DHT can decrease the cell viability of the hair follicle stem cells (HFSCs) with CD34-positive and CD200-rich in bald scalp area of androgenic alopecia (AGA) patients and the apoptosis of HFSCs may be involved in the pathogenesis of AGA. The expression of Vascular endothelial...
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Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic AlopeciaBACKGROUND 5α-DHT can decrease the cell viability of the hair follicle stem cells (HFSCs) with CD34-positive and CD200-rich in bald scalp area of androgenic alopecia (AGA) patients and the apoptosis of HFSCs may be involved in the pathogenesis of AGA. The expression of Vascular endothelial...
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Heuristics, Overconfidence, and Experience With Management of Neuromuscular Block: Self-Correction Is UnlikelyNo abstract availableIntraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysisBACKGROUND: Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake. It has also been used in several procedures to reduce postoperative...
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Refractance Window Drying of Apple Slices: Mass Transfer Phenomena and Quality ParametersAbstractThe present study investigates the effect of Refractance Window (RW) drying at different temperatures (60 °C, 70 °C, 80 °C, and 90 °C) on drying characteristics and quality of apple slices and its comparison with hot air (HA) drying. Results showed that RW drying requires a shorter time (~ 25–37.5%) as compared to HA drying under similar conditions of drying. Also, RW drying at 90 °C resulted in higher...
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Clinical Pharmacokinetics of Atypical Antipsychotics: An UpdateThe pharmacokinetics of CRP was tested in small short-term studies in both healthy volunteers and in subjects with schizophrenia, with similar results [242].Comment on: "Clinical Pharmacokinetics of Atypical Antipsychotics: An Update"Calculation of the Coefficient of Variation of Log-Normally Distributed Parameter ValuesReply to Periclou et al.: "Clinical Pharmacokinetics of Atypical Antipsychotics: An Update"Clinical Pharmacokinetics...
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Cannabis hyperalgesia: A phenomenon underestimated in the peri-operative period?No abstract availableEffect of positive end-expiratory pressure on gastric insufflation during induction of anaesthesia when using pressure-controlled ventilation via a face mask: A randomised controlled trialBACKGROUND Face mask ventilation (FMV) during induction of anaesthesia is associated with risk of gastric insufflation that may lead to gastric regurgitation and pulmonary aspiration. A continuous positive airway...
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A National Patient Safety Curriculum in Pediatric Emergency MedicineBackground Patient safety has become an important and required topic in medical education. A needs assessment showed that pediatric emergency medicine program directors were interested in a common pediatric emergency-specific safety curriculum. Objective The objective of this study was to describe the development and performance of a web-based patient safety curriculum in pediatric emergency medicine. Methods A web-based curriculum...
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The Link Between Health Literacy & Cancer CommunicationcommunicationIn an era of increasingly complex advances in oncology, how can health professionals help cancer patients with low health literacy better understand their diagnoses and treatment options? In an effort to improve cancer communication strategies with patients, the National Cancer Policy Forum (NCPF) of the National Academies of Sciences, Engineering, and Medicine (NAS) convened a meeting of invited speakers in Washington, D.C....
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"Guanhai Resort of HaiYan, JiaXing, Zhejiang Province, China"
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The Role of Type I Diabetes in Intervertebral Disc DegenerationStudy Design. An experimental laboratory study. Objective. To investigate the pathogenesis of intervertebral disc degeneration (IDD) in a murine model of type 1 diabetes mellitus (DM), namely nonobese diabetic (NOD) mouse. Summary of Background Data. IDD is a leading contributor of low back pain, which represents one of the most disabling symptoms within the adult population. DM is a chronic metabolic disease currently affecting one in...
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Chronic Heart Failure Treatment With the Left Ventricular Assist DeviceThe prevalence of chronic heart failure is increasing in the United States due to the increase in the number of older adults and because many people are surviving acute cardiac events and living longer with chronic heart disease. In end-stage heart failure, heart transplant was once the gold standard of treatment and patients had to wait for a matching heart donor. In the past, the left ventricular assist device (LVAD) was a mechanical...
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Emotional Intelligence in Neonatal Intensive Care Unit Nurses: Decreasing Moral Distress in End-of-Life Care and Laying a Foundation for Improved Outcomes: An Integrative ReviewEnd-of-life care in the neonatal intensive care unit (NICU) is one of the most challenging practices for nurses. Negative emotions associated with moral distress often cause care to be incomplete or nurse disengagement. Emotional intelligence in nurses holds potential to address this issue, while improving patient outcomes....
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Managing the Internet of Things in Health Care OrganizationsNo abstract availableLet's be civil: Elaborating the link between civility climate and hospital performanceBackground: The importance of interpersonal behavior at the workplace is increasingly recognized in the health care industry and related literature. An unresolved issue in the existing health care research is how a climate of courteous interpersonal behavior may form the foundation for strong hospital care performance. Purpose: The...
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Editorial: Media magic or mayhem?No abstract availableA primary care pediatrician's guide to assessing problematic interactive media usePurpose of review To review the literature and provide a guide to assessing patients with problematic interactive media use (PIMU). Recent findings 0.3–1.0% of the world population meets criteria for internet gaming disorder (IGD). 26.8–83.3% of adolescents meeting criteria for internet addiction have comorbid attention-deficit/hyperactivity disorder. IGD is associated...
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The Dangers of Over-Reading an EEGNo abstract availableNormal Awake, Drowsy, and Sleep EEG Patterns That Might Be Overinterpreted as AbnormalSummary: Knowledge of normal patterns is essential for correct EEG interpretation. The overinterpretation of EEG (i.e., ascribing abnormality to EEG patterns that are not associated with disease) is a common problem and can contribute to misdiagnosis and mismanagement. Here, the authors concisely review normal patterns that might be improperly interpreted as...
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Big Pharma's big lie: Most new drugs have zero new benefits, research confirmsBy Isabelle Z. | Read the full story
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Long before pills, our ancestors used these 11 natural antibiotics to survive infectionsWatch this video
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Βόρεια Κέρκυρα: Τα ομορφότερα χωριά της !Πατήστε εδώ
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Hematologic malignancies of the larynx: A single institution review☆☆☆☆☆☆Author links open overlay panelKarunaDewanRossCampbellEdward J.DamroseDivision of Laryngology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, United States of AmericaReceived 3 June 2019, Available online 4 September 2019.Show lesshttps://doi.org/10.1016/j.amjoto.2019.102285Get rights and contentAbstractBackgroundPrimary hematologic malignancies of the larynx are rare diagnoses, accounting...
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Nanoparticles: Properties, applications and toxicities,Arabian Journal of ChemistryEarth system impacts of the European arrival and Great Dying in the Americas after 1492Quaternary Science Reviews, Volume 207School performance, social networking effects, and learning of school children: Evidence of reciprocal relationships in Abu …Telematics and Informatics, Volume 34, Issue 8
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ACMG TECHNICAL STANDARDS,Technical laboratory standards for interpretation and reporting of acquired copy-number abnormalities and copy-neutral loss of heterozygosity in neoplastic disorders: a joint consensus recommendation from the American College of Medical Genetics and Genomics (ACMG) and the Cancer Genomics Consortium (CGC)Fady M. Mikhail, Jaclyn A. Biegel, Linda D. Cooley, Adrian M. Dubuc, Betsy Hirsch et al.Genetics in Medicine 2019 21 :1903 - 1915; May 29, 2019; 10.1038/s41436-019-0545-7Abstract | Full...
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Preoperative Risk Index Among Patients Undergoing Thyroid or Parathyroid SurgeryMarco Antonio Mascarella, MD; Daniel Milad, BSc; Keith Richardson, MD, FRCSC; et alPrognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell CarcinomaMatthew E. Spector, MD; Emily Bellile, MS; Lahin Amlani, BS; et alTRENDING NOW ON JAMA OTOLARYNGOLOGY—HEAD & NECK SURGERYHyperbaric Oxygen Therapy vs Medical Therapy for Sudden Sensorineural Hearing LossVariation in Surgical Practice for Differentiated...
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How I Approach the Management of Stricturing Crohn's DiseaseINTRODUCTIONDespite major advances in biologic anti-inflammatory therapies for Crohn's disease (CD), more than 50% of patients with CD will develop clinically apparent stricturing disease throughout their lifetime (1). There are no current medications that reverse established fibrosis in CD. CD strictures comprise both fibrosis and inflammation. We present our approach to this frequent but challenging clinical situation.Back to Top | Article...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,