Hidden blood loss and its possible risk factors in cervical open-door laminoplastyShow lessChao Jiang, Tian-He Chen, Ze-Xin Chen, Ze-Ming Sun, Hui Zhang, Yao-Sen WuFirst Published June 24, 2019 Research Article https://doi.org/10.1177/0300060519856987Article information AbstractObjectivesTo evaluate hidden blood loss (HBL) and its possible risk factors among patients following expansive open-door laminoplasty (EOLP) for multilevel, cervical spondylotic myelopathy.MethodsThis was a retrospective...
Stochastic and deterministic approaches to modelling calcium release in cardiac myocytes at different spatial arrangements of ryanodine receptorsAbstract Calcium release sites (CRSs) play a key role in excitation–contraction coupling of cardiac myocytes. Recent studies based on electron tomography and super-resolution imaging revealed that CRSs are not completely filled with ryanodine receptors (RyRs) and that the spatial arrangement of RyRs is neither uniform nor static. In this work, we studied...
Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspringAbstract Rationale Although the influence of gestational cocaine exposure on offspring has been the focus of a sustained research effort, the effect of preconception cocaine self-administration by dams on progeny has received far less attention. Method In the current study, adult female rats were allowed to self-administer cocaine 2 h a day for 60 days and...Latest Results for Psychopharmacology3hThe...
Group Prenatal Care Attendance and Women's Characteristics Associated with Low Attendance: Results from Centering and Racial Disparities (CRADLE Study)Abstract Objectives Group prenatal care (GPC), an alternative to individual prenatal care (IPC), is becoming more prevalent. This study aimed to describe the attendance and reasons of low attendance among pregnant women who were randomly assigned to receive GPC or IPC and explore the maternal characteristics associated with low-attendance. Methods...
The Management of Suspected or Confirmed Laryngopharyngeal Reflux Patients with recalcitrant Symptoms: A Contemporary Review.The Management of Suspected or Confirmed Laryngopharyngeal Reflux Patients with recalcitrant Symptoms: A Contemporary Review. Clin Otolaryngol. 2019 Jun 23;: Authors: Lechien JR, Muls V, Dapri G, Mouawad F, Eisendrath P, Schindler A, Nacci A, Barillari MR, Finck C, Saussez S, Akst LM, Sataloff RT Abstract OBJECTIVE: To summarize current knowledge about the prevalence, etiology...
Germline variants in oculocutaneous albinism genes and predisposition to familial cutaneous melanomaAbstract Approximately 1‐2% of cutaneous melanoma (CM) is classified as strongly familial. We sought to investigate unexplained CM predisposition in families negative for the known susceptibility genes using next generation sequencing of affected individuals. Segregation of germline variants of interest within families was assessed by Sanger sequencing. Several heterozygous variants in oculocutaneous...
Journal of Medical Case Reports - Latest ArticlesEpilepsia partialis continua complicated by disseminated tuberculosis and hemophagocytic lymphohistiocytosis: a case reportWe describe a patient copresenting with epilepsia partialis continua, tuberculosis, and hemophagocytic lymphohistiocytosis. To our knowledge, this is the first documented case of this triad.Journal of Medical Case Reports - Latest Articles6h
G3: .Genes, Genomes, Genetics Mission - Online First ArticlesMolecular Traits of Long Non-protein Coding RNAs from Diverse Plant Species Show Little Evidence of Phylogenetic RelationshipsLong non-coding RNAs (lncRNAs) represent a diverse class of regulatory loci with roles in development and stress responses throughout all kingdoms of life. LncRNAs, however, remain under-studied in plants compared to animal systems. To address this deficiency, we applied a machine learning prediction tool, Classifying...
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)Simultaneous detection of carcinoembryonic antigen and neuron specific enolase in human serum based on time-resolved chemiluminescence immunoassayAnalyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00910H, PaperYanhua Mao, Nana Wang, Fei Yu, Songcheng Yu, Lie Liu, Yongmei Tian, Jia Wang, Yilin Wang, Leiliang He, Yongjun WuIn the clinical diagnosis of tumor, immunology detection of...
Archives of Physical Medicine and RehabilitationEffect of psychomotricity in combination with 3 months of active shoulder exercises in patients with chronic shoulder pain: Primary results from an investigator-blinded, randomised, controlled trialPublication date: Available online 24 June 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Kim Gordon Ingwersen, Jette Wessel Vobbe, Lise Lang Pedersen, Lilli Sørensen, Niels WedderkoppAbstractObjectiveTo evaluate whether psychomotor...
ScienceDirect Publication: European Journal of Vascular and Endovascular SurgeryEffect of Endovascular Treatment on the Pressure in the False Lumen of Type B Aortic DissectionPublication date: Available online 24 June 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Orhan Gokalp, Nihan Karakaş Yeşilkaya, Hasan Iner, Yuksel Besir, Gamze Gokalp, Levent Yilik, Ali GurbuzScienceDirect Publication: European Journal of Vascular and Endovascular Surgery17hIncidence and Predictors...
Representation of shape, space, and attention in monkey cortex17hvia CortexPublication date: Available online 24 June 2019Source: CortexAuthor(s): Anne B. Sereno, Sidney R. Lehky, Margaret E. SerenoAbstractAttentional deficits are core to numerous developmental, neurological, and psychiatric disorders. At the single-cell level, much knowledge has been garnered from studies of shape and spatial properties, as well as from numerous demonstrations of attentional modulation of those properties. Despite...
Improved carotid lumen delineation on non-contrast MR angiography using SNAP (Simultaneous Non-Contrast Angiography and Intraplaque Hemorrhage) imaging17hvia Magnetic Resonance ImagingPublication date: Available online 24 June 2019Source: Magnetic Resonance ImagingAuthor(s): Haining Liu, Jie Sun, Daniel S. Hippe, Wei Wu, Baocheng Chu, Niranjan Balu, Thomas Hatsukami, Chun YuanAbstractPurposeSimultaneous Non-Contrast Angiography and Intraplaque Hemorrhage (SNAP) was developed for improved imaging...
Applications of a deep learning method for anti-aliasing and super-resolution in MRI 17hvia Magnetic Resonance Imagingelsevier-non-solus.pngPublication date: Available online 24 June 2019Source: Magnetic Resonance ImagingAuthor(s): Can Zhao, Muhan Shao, Aaron Carass, Hao Li, Blake E. Dewey, Lotta M. Ellingsen, Jonghye Woo, Michael A. Guttman, Ari M. Blitz, Maureen Stone, Peter A. Calabresi, Henry Halperin, Jerry L. PrinceAbstractMagnetic resonance (MR) images with both high resolutions and high signal-to-noise...
Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagyPublication date: Available online 22 June 2019Source: Behavioural Brain ResearchAuthor(s): Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping MaAbstractMitochondrial dynamics regulate mitochondrial autophagy (mitophagy) and apoptosis, which are important events for the quality control of mitochondria...
Editorial Comment on: Inhibition of Suicidal Erythrocyte Death by Chronic Hypoxia by Tang et al. (From: Tang F, Feng L, Li R, Wang W, Liu H, Yang Q, Ge R-L. High Alt Med Biol 2019;20:112–119; DOI: 10.1089/ham.2017.0159)High Altitude Medicine &Biology, Volume 20, Issue 2, Page 120-121, June 2019.High Altitude Medicine & Biology - Table of Contents10hThe Complexity of Diagnosing High-Altitude Pulmonary Edema: A Case Report and Review of the Differential Diagnosis of Greater Than Expected Hypoxemia...
Vitamin D Replacement Mitigates Menopause-Associated Dyslipidaemia and Atherogenic Indices in Ovariectomized Rats; A Biochemical StudyExp Clin Endocrinol DiabetesDOI: 10.1055/a-0934-5666 Background & Aim Dyslipidaemia is highly prevalent among postmenopausal women and its management represents a keystone in the prevention of the worldwide increase in cardiovascular morbidity and mortality. Therapy choices for menopause-associated dyslipidaemia are limited and a matter of debate. So, it becomes...
Insights on the Natural History of Adrenal IncidentalomasIn their article, Elhassan and colleagues report a meta-analysis that addresses key questions about the natural history of adrenal incidentalomas. The editorialists discuss how the findings support current guidelines from the European Society of Endocrinology and European Network for the Study of Adrenal Tumors and identify future study that is necessary to inform decision making concerning the choice between surgery and conservative management...
BMC Research NotesRisk assessment of upper limbs repetitive movements in a fish industryWork-related Musculoskeletal Disorders (WMSDs) have a multifactorial origin: work-related risk factors and individual factors (age, sex, anthropometric characteristics). The purpose of the current study was th...BMC Research Notes2hAdverse birth outcomes and its associated factors among women who delivered in North Wollo zone, northeast Ethiopia: a facility based cross-sectional studyPregnancy is a happy time...
Head and NeckThe Management of Suspected or Confirmed Laryngopharyngeal Reflux Patients with recalcitrant Symptoms: A Contemporary Review.The Management of Suspected or Confirmed Laryngopharyngeal Reflux Patients with recalcitrant Symptoms: A Contemporary Review. Clin Otolaryngol. 2019 Jun 23;: Authors: Lechien JR, Muls V, Dapri G, Mouawad F, Eisendrath P, Schindler A, Nacci A, Barillari MR, Finck C, Saussez S, Akst LM, Sataloff RT Abstract OBJECTIVE: To summarize current knowledge about the prevalence,...
Latest Results for Journal of AnesthesiaMeasuring suction pressure via a scavenging systemLatest Results for Journal of Anesthesia15hTo the Editor:An enhanced modified VA suction system to prevent VA leakage during cardiopulmonary bypass was recently reported [1]. The underlying idea is to use a scavenging system for volatile anesthetic. I report an experiment showing the basis of the suction pressure of volatile anesthetic using a scavenging system.The scavenging system uses an injector type that...
MedgadgetProtecting Implantable Neurostimulators With Graphene to Enhance Device LongevitySurgically implanted neurostimulators are presently used for many diseases, ranging from movement disorders, like Parkinson's Disease, to chronic pain. But as current research efforts suggest, their use will potentially expand to mood disorders, like depression, and memory enhancement for Alzheimer's. Contemporary neurostimulator technology relies on Platinum in its material design, given the element's excellent...
Lasers in Surgery and MedicineImage‐Guided Ablation of Dental Calculus From Root Surfaces Using a DPSS Er:YAG LaserBackground and Objectives Recent studies have demonstrated that near‐infrared (IR) imaging can be used to acquire high‐contrast images of root caries and calculus on the root surfaces of extracted teeth at wavelengths longer than 1450 nm. The purpose of this study was to determine if image‐guided laser ablation can be used to selectively remove calculus from tooth surfaces with minimal...
Clinical TherapeuticsA Simulated Application of the Hartford Hospital Aminoglycoside Dosing Nomogram for Plazomicin Dosing Interval Selection in Patients With Serious Infections Caused by Carbapenem-Resistant EnterobacteralesPublication date: Available online 24 June 2019Source: Clinical TherapeuticsAuthor(s): Tomefa E. Asempa, Joseph L. Kuti, Julie D. Seroogy, Allison S. Komirenko, David P. NicolauAbstractPurposeIn the Phase III Study of Plazomicin Compared With Colistin in Patients With Infection...
Long-term outcomes 1–20 years after autotransplantation of teeth: clinical and radiographic evaluation of 66 premolars and 8 molarsPublication date: Available online 23 June 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): K.J.H. van Westerveld, J.P. Verweij, E.E. Toxopeus, M. Fiocco, G. Mensink, J.P.R. van MerkesteynAbstractIn this retrospective study we investigated the long-term survival of autotransplanted premolars and molars with incompletely developed roots. The presence...
Latest Results for InflammationAlpha7 Nicotinic Acetylcholine Receptor Alleviates Inflammatory Bowel Disease Through Induction of AMPK-mTOR-p70S6K-Mediated AutophagyAbstract Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been reported to be protective in several kinds of disorders through inflammatory suppression. Here, we investigated the role of α7nAChR in inflammatory bowel disease (IBD) on α7nAChR deficient mice (α7nAChR−/−) and the wild-type mice (α7nAChR+/+). Three percent dextran sulfate...
Annals of Allergy, Asthma & ImmunologyExhaled nitric oxide as a marker of chlorine exposure in young asthmatic swimmersAllergic asthma is a Type 2 (T2) inflammatory disease commonly presented in childhood. A complex interplay between genetic and environmental factors has been implicated in its pathogenesis.1 Environmental exposures seem to play an important role in the rising trend of the disease prevalence.1,2 There are several preventable environmental factors known to increase the risk of...
JoVE: Journal of Visualized ExperimentsIntravital Imaging of Intraepithelial Lymphocytes in Murine Small IntestineWe describe a method to visualize GFP-labeled γδ IELs using intravital imaging of murine small intestine by inverted spinning disk confocal microscopy. This technique enables the tracking of live cells within the mucosa for up to 4 h and can be used to investigate a variety of intestinal immune-epithelial interactions. JoVE: Journal of Visualized Experiments10hExamination of Mitotic...
Applied and Industrial MicrobiologyStable and transient transformation, and a promoter assay in the selective lignin-degrading fungus, Ceriporiopsis subvermisporaA genetic transformation system was developed for the selective white rot basidiomycete Ceriporiopsis subvermispora using a modified protocol with polyethylene glycol and CaCl2 treatment of the protoplasts and pl...Applied and Industrial Microbiology6hMark above section as read Antimicrobial Resistance and Infection Control - Latest ArticlesGlycerol...
Strahlentherapie und OnkologieLong-term cosmetic outcome after preoperative radio-/chemotherapy in locally advanced breast cancer patientsAbstract Background Preoperative radiotherapy and chemoradiotherapy (PRT/PCRT) represent an increasingly used clinical strategy in different tumor sites. We have previously reported on a PRT/PRCT protocol in patients with locally advanced non-inflammatory breast cancer (LABC) with promising clinical results. However, concerns regarding a possible unfavorable influence...
MicrosurgeryThe thin profunda femoral artery perforator flap for tongue reconstructionAbstract Background With the ongoing global epidemic of obesity in the Western countries, thigh flaps such as the profunda artery perforator (PAP) free flap, have been less favorable for glossectomy reconstruction due to large bulk of adipose tissue associated with traditional subfascial harvest. In this article, we present a series of 10 patients who underwent reconstruction with suprafascial PAP free flaps following...
Journal of AnatomyNormal craniovascular variation in two modern European adult populationsAbstract The vascular networks running into the meningeal layers, between the brain and braincase, leave imprints on the endocranial surface. These traces are visible in osteological specimens and skeletal collections, providing indirect evidence of vascular patterns in those cases in which bone remains are the only source of anatomical information, such as in forensic science, bioarchaeology and paleontology....
Oral and Maxillofacial SurgeryDealing with vascular anomalies during radial forearm free flap harvest: report of two cases and review of the literaturePublication date: Available online 22 June 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): O. Breik, U. Selbong, D. Laugharne, K. JonesAbstractRadial forearm free flap reconstruction for head and neck cancer is very common, and it is widely considered a workhorse flap. Although this flap has a relatively reliable anatomy,...
NeuroReport - Published Ahead-of-PrintOncostatin M, a muscle-secreted myokine, recovers high-glucose-induced impairment of Akt phosphorylation by Fos induction in hippocampal neuron cellsOncostatin M is a muscle-secreted myokine that has various effects on neuronal function, however, the underlying molecular mechanism has been poorly defined. In this study, we showed that Oncostatin M increased the phosphorylation of Akt and ERK, proteins crucial for neuron cell survival and proliferation. Furthermore,...
Medical Image AnalysisCell Mitosis Event Analysis in Phase Contrast Microscopy Images Using Deep LearningPublication date: Available online 22 June 2019Source: Medical Image AnalysisAuthor(s): Yunxiang Mao, Liang Han, Zhaozheng YinAbstractIn this paper, we solve the problem of mitosis event localization and its stage localization in time-lapse phase-contrast microscopy images. Our method contains three steps: first, we formulate a Low-Rank Matrix Recovery (LRMR) model to find salient regions from...
pubmed: cell cycle arrestThe role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis.The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis. Hepatology. 2019 Jun 23;: Authors: Papatheodoridi AM, Chrysavgis L, Koutsilieris M, Chatzigeorgiou A Abstract In recent years cellular senescence has generated a lot of interest among researchers due to its involvement...
Latest Results for Journal of the Association for Research in OtolaryngologyRapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In VitroAbstract Gentamicin, one of the most widely used aminoglycoside antibiotics, is known to have toxic effects on the inner ear. Taken up by cochlear hair cells and spiral ganglion neurons (SGNs), gentamicin induces the accumulation of reactive oxygen species (ROS) and initiates apoptosis or programmed cell death, resulting in a permanent...
Helicobacter pylori infection and gastric cancer biology: tempering a double-edged swordAbstractHelicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Moreover, H. pylori presents the most significant risk factor for gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, and it is the first example of bacterial infection linked to carcinogenesis. Here, we contend that H. pylori research, which focuses on a cancer-causing pathogen resident...
Progress on chicken T cell immunity to virusesAbstractAvian virus infection remains one of the most important threats to the poultry industry. Pathogens such as avian influenza virus (AIV), avian infectious bronchitis virus (IBV), and infectious bursal disease virus (IBDV) are normally controlled by antibodies specific for surface proteins and cellular immune responses. However, standard vaccines aimed at inducing neutralizing antibodies must be administered annually and can be rendered ineffective...
Adult stem cells at work: regenerating skeletal muscleAbstractSkeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling pathways as well as by interactions with the stem cell niche. Here, we discuss the properties of satellite cells, including heterogeneity regarding...
Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomyAbstractPurposeSleeve gastrectomy with duodenojejunal bypass (SG-DJB) is expected to become a popular procedure in East Asia. The aim of this study was to evaluate the effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy (SG).MethodsTwenty-four Sprague–Dawley rats were divided into two groups: SG-DJB and SG alone. 6 weeks after surgery, body weight, feed intake,...
Keys to successful induction chemoradiotherapy followed by surgery for stage III/N2 non-small cell lung cancerAbstractSurgical intervention after induction chemoradiation is designed as curative treatment for resectable stage III/N2 non-small cell lung cancer. However, there is no definitive evidence to support this approach, possibly because successful treatment requires certain "arts", such as proper patient selection, an appropriate induction regimen, and choice of the best surgical procedure....
A novel dual-covering method in video-assisted thoracic surgery for pediatric primary spontaneous pneumothoraxAbstractBackgroundPrimary spontaneous pneumothorax (PSP) generally occurs in young adults, whereas pediatric PSP is uncommon. It is difficult to source reliable data on pediatric PSP, the management of which is based on guidelines for adult PSP; however, the rate of recurrence after video-assisted thoracoscopic surgery (VATS) for pediatric PSP is reported to be higher.MethodsWe reviewed retrospectively...
Cancer-induced spiculation on computed tomography: a significant preoperative prognostic factor for colorectal cancerAbstractPurposeCancer-induced spiculation (CIS) on computed tomography, which is reticular or linear opacification of the pericolorectal fat tissues around the cancer site, is generally regarded as cancer infiltration into T3 or T4, but its clinicopathological significance is unknown. This study examines the correlation between CIS and clinicopathological findings to establish its...
The overall survival of breast cancer patients without adjuvant therapyAbstractPurposeThere are little data regarding the overall survival (OS) of patients without adjuvant systemic therapy, because most patients have been subject to standardized systemic therapies. We evaluated the baseline risk to facilitate making decisions about adjuvant therapy.Patients and methodsA total of 1835 breast cancer patients who did not receive adjuvant systemic therapy between 1964 and 1992 were retrospectively evaluated....
Clinical outcome of patients with recurrent non-small cell lung cancer after trimodality therapyAbstractPurposesThe purpose of this study was to review the clinical course of patients with recurrence after induction chemoradiotherapy followed by surgery (trimodality therapy) for locally advanced non-small cell lung cancer (LA-NSCLC) and to identify the factors associated with favorable clinical outcome after recurrence.MethodsWe analyzed the records of 140 patients with LA-NSCLC who were treated...
Lung-diffusing capacity for carbon monoxide predicts early complications after cardiac surgeryAbstractPurposePreoperative pulmonary dysfunction has been associated with increased operative mortality and morbidity after cardiac surgery. This study aimed to determine whether values for the diffusing capacity of the lung for carbon monoxide (DLCO) could predict postoperative complications after cardiac surgery.MethodsThis study included 408 consecutive patients who underwent cardiac surgery between...
No inflammatory benefit obtained by single-incision laparoscopic surgery for right hemicolectomy compared with conventional laparoscopyAbstractPurposeWe evaluated the perioperative inflammatory mediators in a right hemicolectomy performed with single-incision laparoscopic surgery (SILS) and traditional multi-port laparoscopic surgery (MLS) to compare the postoperative inflammatory response and feasibility of SILS with that of MLS.MethodsIn this retrospective study, we enrolled 56 consecutive colorectal...
Robotic versus laparoscopic surgery for rectal cancer: an overview of systematic reviews with quality assessment of current evidenceAbstractPurposeThe clinical benefits of robotic surgery for patients with rectal cancer have been reported and many systematic reviews have been published. However, they have investigated a variety of outcomes and differ remarkably in quality. In this overview, we summarize the findings of these reviews and evaluate their quality.MethodsThe PubMed, Scopus, and Cochrane...
Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasmsAbstractBackgroundWe evaluated the clinicopathological factors associated with lymph node metastasis in patients with non-functioning pancreatic neuroendocrine neoplasms (PanNENs), focusing on the risk factors and range of lymph node metastasis for tumors ≤ 2 cm in diameter.MethodsThe subjects of this study were patients with PanNENs consecutively diagnosed at our hospital between...
Characterization of polyphenolic constituents from Sanguisorba officinalis L. and its antibacterial activityAbstractSanguisorba officinalis L., one kind of perennial plants, has been widely distributed in southern Europe, northern Africa and China. The objective of the present work was to evaluate the antibacterial captivities of polyphenolic extract (PE) of S. officinalis L. on five pathogenic bacteria, including Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) and Gram-positive...
Gluten-free bread: effect of soy and corn co-products on the quality parametersAbstractBread is one of the most consumed products in the world and the most studied among the gluten-free foods. Agroindustry co-products are rich sources of functional ingredients, and their chemical composition suggests great potential as a raw material for the food industry. The objective of this study was to evaluate the effect of the addition of 10–30% of okara flour (OF), and 15–45% of corn bran (CB) on the physical...
High temperature and heating effect on the oxidative stability of dietary cholesterol in different real food systems arising from eggsAbstractCholesterol, a monounsaturated sterol present in food of animal origin, can be oxidized during food processing and storage, thus generating a series of oxidation products, collectively called oxysterols. These compounds are increasingly considered of potential interest in the onset and development of vascular disease due to their ability to trigger irreversible...
Occurrence of cerebral small vessel disease at diagnosis of MPO-ANCA-associated vasculitisAbstractBackgroundAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) often causes peripheral nervous system impairments. However, little is known about subclinical involvements of the central nervous system in AAV. We investigated the frequency and progression of cerebral small vessel disease (SVD) in patients with AAV.MethodsThis single-center, case–control study comprised 56 patients with...
"Can't seem to keep my mind to it": did Arthur Miller's Salesman have dementia with Lewy bodies?AbstractWe present evidence that Willy Loman, the protagonist of Arthur Miller's play "Death of a Salesman", meets current diagnostic criteria for probable dementia with Lewy bodies. In particular, he presents with attentional deficits and executive dysfunction (with additional subtle visuoperceptual deficits) in addition to dramatic fluctuations in attention and vivid visual hallucinations. Dementia with...
High-intensity training in patients with spinal and bulbar muscular atrophyAbstractObjectiveLong duration, moderate-intensity exercise is not well tolerated in patients with spinal and bulbar muscular atrophy (SBMA). This study investigated whether patients with SBMA can benefit from high-intensity training (HIT).MethodsTen patients with SBMA were randomized to 8 weeks of supervised HIT [n = 5; age = 50 (25–63) years] followed by 8 weeks of self-training or 8 weeks of no training followed by 8 weeks...
Nannochloropsis sp. and Spirulina sp. as a Source of Antifungal Compounds to Mitigate Contamination by Fusarium graminearum Species ComplexAbstractPhenolic (free, conjugated and bound) and carotenoid extracts from microalgae Nannochloropsis sp. and Spirulina sp. were investigated regarding their potential to mitigate contamination by Fusarium complex fungal pathogens. Free phenolic acid extracts from both microalgae were the most efficient, promoting the lowest mycelial growth rates of 0.51 cm day− 1 (Spirulina sp.)...
Probiotic Bacteria: A Promising Tool in Cancer Prevention and TherapyAbstractGut microbiota is widely considered to be one of the most important components to maintain balanced homeostasis. Looking forward, probiotic bacteria have been shown to play a significant role in immunomodulation and display antitumour properties. Bacterial strains could be responsible for detection and degradation of potential carcinogens and production of short-chain fatty acids, which affect cell death and proliferation...
Prospective evaluation of finger two-point discrimination and carpal tunnel syndrome among women with breast cancer receiving adjuvant aromatase inhibitor therapyAbstractPurposeAromatase inhibitors (AIs) are associated with musculoskeletal symptoms and risk of developing carpal tunnel syndrome (CTS), which can impair quality of life and prompt treatment discontinuation. The incidence of CTS and clinical utility of diagnostic tests such as 2-point discrimination (2-PD) have not been prospectively...
Adult weight gain accelerates the onset of breast cancerAbstractPurposeWeight gain in adulthood is a risk factor for breast cancer; however, the impact on age of onset is unknown. The objective of this study was to investigate whether weight gain from early- to mid-adulthood influenced the timing of breast cancer onset.MethodsIncrease in body mass index (BMI) from lowest adult BMI to BMI at diagnosis and age at which these events occurred were calculated from breast cancer survivors enrolled in a...
The utility of DHL-HisZnNa, a novel antioxidant, against anticancer agent-induced alopecia in breast cancer patients: a multicenter phase II clinical trialAbstractPurposeChemotherapy-induced alopecia (CIA) is a distressing adverse effect of anticancer drugs; however, there are currently no mechanisms to completely prevent CIA. In this study, we performed a clinical trial to examine whether sodium N-(dihydrolipoyl)-l-histidinate zinc complex (DHL-HisZnNa), an alpha-lipoic acid derivative, prevents...
T-bet + lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancerAbstractPurposeT-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.MethodsThis study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy...
Effects of tea consumption and the interactions with lipids on breast cancer survivalAbstractPurposeThe effect of tea consumption on breast cancer survival remained to be explored. Meanwhile, green tea favorably facilitates lipid metabolisms in breast cancer survivors. This study aimed to examine the effect of tea consumption and the interactions with lipids on breast cancer survival.MethodsA total of 1551 breast cancer patients were recruited between April 2008 and March 2012 and followed up until...
De-escalation of bone-modifying agents in patients with bone metastases from breast cancer: a systematic review and meta-analysisAbstractPurposeBone-modifying agents (BMAs) such as bisphosphonates and denosumab are usually administered every 4 weeks (standard) in patients with bone metastases from breast cancer to prevent skeletal-related events (SREs). Recent randomized controlled trials suggest every 12-week (de-escalated) dosing interval may be non-inferior. The objective of this systematic review...
Clinicopathological implications of TIM3 + tumor-infiltrating lymphocytes and the miR-455-5p/Galectin-9 axis in skull base chordoma patientsAbstractChordoma is difficult to eradicate due to high local recurrence rates. The immune microenvironment is closely associated with tumor prognosis; however, its role in skull base chordoma is unknown. The expression of Galectin-9 (Gal9) and tumor-infiltrating lymphocyte (TIL) markers was assessed by immunohistochemistry. Kaplan–Meier and multivariate Cox analyses...
Combination of denosumab and immune checkpoint inhibition: experience in 29 patients with metastatic melanoma and bone metastasesAbstractBackgroundPD-1 inhibition (PD-1i) is the standard of care in melanoma and other malignancies. In patients with bone metastases of solid tumors, the monoclonal antibody denosumab directed against RANKL is approved for the prevention of skeletal-related events. However, RANKL is not only relevant in osteoclastogenesis, but also has immunological effects. Hence, we...
Impact of combination immunochemotherapies on progression of 4NQO-induced murine oral squamous cell carcinomaAbstractAdvanced oral squamous cell carcinomas (OSCC) have limited therapeutic options. Although immune therapies are emerging as a potentially effective alternative or adjunct to chemotherapies, the therapeutic efficacy of combination immune chemotherapies has yet to be determined. Using a 4-nitroquinolone-N-oxide (4NQO) orthotopic model of OSCC in immunocompetent mice, we evaluated the therapeutic...
Pembrolizumab as first-line treatment for metastatic uveal melanomaAbstractBackgroundNo standard treatment has been defined for metastatic uveal melanoma (mUM). Although clinical trials testing Nivolumab/Pembrolizumab for cutaneous melanoma did not include mUM, anti PD-1 agents are commonly used for this disease.Patients and methodsIn this prospective observational cohort single arm study, we investigated efficacy and safety of Pembrolizumab as first-line therapy for mUM. The efficacy was evaluated...
An HER2 DNA vaccine with evolution-selected amino acid substitutions reveals a fundamental principle for cancer vaccine formulation in HER2 transgenic miceAbstractEnhancement of endogenous immunity to tumor-associated self-antigens and neoantigens is the goal of preventive vaccination. Toward this goal, we compared the efficacy of the following HER2 DNA vaccine constructs: vaccines encoding wild-type HER2, hybrid HER2 vaccines consisting of human HER2 and rat Neu, HER2 vaccines with single residue...
Patterns of immune-cell infiltration in murine models of melanoma: roles of antigen and tissue site in creating inflamed tumorsAbstractImmune-cell infiltration is associated with improved survival in melanoma. Human melanoma metastases may be grouped into immunotypes representing patterns of immune-cell infiltration: A (sparse), B (perivascular cuffing), and C (diffuse). Immunotypes have not been defined for murine melanomas, but may provide opportunities to understand mechanism-driving immunotype...
Transendothelial migration (TEM) of in vitro generated dendritic cell vaccine in cancer immunotherapyAbstractMany efforts have been made to improve the efficacy of dendritic cell (DC) vaccines in DC-based cancer immunotherapy. One of these efforts is to deliver a DC vaccine more efficiently to the regional lymph nodes (rLNs) to induce stronger anti-tumor immunity. Together with chemotaxis, transendothelial migration (TEM) is believed to be a critical and indispensable step for DC vaccine migration...
T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancerAbstractTh17 cells are a specialized subset of CD4+ T cells that are essential in driving inflammation during autoimmune disease and infection through a signature cytokine IL-17. Th17 cells have been found in various human cancers. The function of these cells in cancers is highly context-dependent; both tumor-promoting and tumor-suppressing activity have been reported. IL-17 and IL-22, Th17-derived cytokines, influence the tumor microenvironment...
Roles of NKT cells in cancer immunotherapyAbstractCancer immunotherapy has emerged as an effective therapeutic strategy to treat cancer. Among diverse immune populations, invariant natural killer T (iNKT) cells have shown potent antitumor activity by linking innate and adaptive immune systems. Upon activation by lipid antigens on CD1d molecules, iNKT cells rapidly produce various cytokines and trigger antitumor immunity directly or indirectly by activating other antitumor immune cells. Administration...
Natural compound inducers of immunogenic cell deathAbstractAccumulating evidence shows that the anti-cancer potential of the immune response that can be activated by modulation of the immunogenicity of dying cancer cells. This regulated cell death process is called immunogenic cell death (ICD) and constitutes a new innovating anti-cancer strategy with immune-modulatory potential thanks to the release of damage-associated molecular patterns (DAMPs). Some conventional clinically-used chemotherapeutic...
Evolution of chimeric antigen receptor (CAR) T cell therapy: current status and future perspectivesAbstractEngineering T cells with a chimeric antigen receptor (CAR) that reprograms their antigen selectivity and signaling has recently emerged as one of the most promising therapeutic approaches for treating cancers. For example, two CD19-specific CAR T cell (CAR-T) therapies have shown remarkable responses in patients with relapsed/refractory B-cell cancers, and were approved by the US Food and Drug...
Interventions to reduce morbidity from vault hematoma following vaginal hysterectomy: a systematic review and meta-analysisAbstractIntroduction and hypothesisA frequent complication following vaginal hysterectomy is the formation of vaginal vault hematoma. The objective of our systematic review was to assess the impact of various interventions in reducing the incidence of vault hematoma or postoperative febrile morbidity following vaginal hysterectomy.MethodsWe carried out a systematic search of...
Perioperative adverse events in women undergoing concurrent urogynecologic and gynecologic oncology surgeries for suspected malignancyAbstractIntroduction and hypothesisThis study's objectives were to compare the incidence of adverse events after concurrent urogynecologic and gynecologic oncology surgery to gynecologic oncology surgery alone and to describe the frequency of modification in planned urogynecologic procedures. The authors hypothesized there would be no difference in major complications.MethodsThis...
Effects of wearing supportive underwear versus pelvic floor muscle training or no treatment in women with symptoms of stress urinary incontinence: an assessor-blinded randomized control trialAbstractIntroduction and hypothesisIn our previous single-arm pilot study, we reported that ready-made supportive underwear (shaper) was effective in elevating the bladder neck and reducing urinary incontinence (UI) symptoms. The aim of this study was to determine the effects of wearing a shaper compared with...
Laparoscopic bilateral cervicosacropexy: introduction to a new tunneling techniqueAbstractIntroduction and hypothesisTo elevate and suspend the apical end of the vagina, the uterosacral ligaments (USL) were replaced by polyvinylidene fluoride (PVDF) structures. These PVDF structures were placed in the peritoneal folds of the USL at the pelvic wall to mimic the lateral and backward tension and to avoid rectal obstruction. A special tunneling device was used, which allowed the semi-circular placement...
Laparoscopic management of a large urethral leiomyomaAbstractIntroduction and hypothesisA 42-year-old female presented with a 12-cm mass bulging the anterior vaginal wall and causing urgency urinary incontinence and bulk symptoms.MethodsImaging showed a tumor originating from the dorsal and cranial part of the urethra and developing in the vesicouterine space and vesicovaginal septum, dislocating the bladder ventrally and the uterus cranial-dorsally.ResultsTranvaginal biopsy showed a benign leiomyoma....
Intratympanic mixture gentamicin and dexamethasone versus dexamethasone for unilateral Meniere's diseaseAuthor links open overlay panelKayhanÖztürkNurdoğanAtaDepartment of Otorhinolaryngology, KTO Karatay University Medical Faculty, Medicana Konya Hospital, Konya, TurkeyReceived 23 February 2019, Available online 24 June 2019.Show lesshttps://doi.org/10.1016/j.amjoto.2019.06.008Get rights and contentAbstractObjectiveThis study aimed to determine the effectiveness of an intratympanic (IT) injection...
Helicobacter pylori infection and gastrointestinal tract cancer biology: considering a double-edged sword reflectionAdult stem cells at work: regenerating skeletal muscleAbstractSkeletal muscle regeneration is a finely tuned process involving the activation of various cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are indispensable for skeletal muscle regeneration. Their functionality is critically modulated by intrinsic signaling pathways as well as by interactions...
Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasmsAbstractBackgroundWe evaluated the clinicopathological factors associated with lymph node metastasis in patients with non-functioning pancreatic neuroendocrine neoplasms (PanNENs), focusing on the risk factors and range of lymph node metastasis for tumors ≤ 2 cm in diameter.MethodsThe subjects of this study were patients with PanNENs consecutively diagnosed at our hospital between...
Triticum aestivum ssp. vulgare and ssp. spelta cultivars: 2. Bread-making optimisationAbstractIn this study, we analysed the bread quality parameters of five bread-making flour from single cultivars, namely two spelt wheats ('Espelta Álava' and 'Espelta Navarra') and three bread wheats ('Bonpain', 'Craklin' and 'Sensas'). The grain from the five cultivars, all grown in an organic system, had been milled using the same procedure. Given that bread-making value of flour is closely linked to the dough...
Livedo racemosa generalisata: an anthological vision through Vladímir Lébedev paintingObituary for Prof. Dr. Dr. h.c. Dipl. Ing. Frank Lehmann-HornHigh-intensity training in patients with spinal and bulbar muscular atrophyAbstractObjectiveLong duration, moderate-intensity exercise is not well tolerated in patients with spinal and bulbar muscular atrophy (SBMA). This study investigated whether patients with SBMA can benefit from high-intensity training (HIT).MethodsTen patients with SBMA were randomized...
Correction to: The Isolation and Characterization of Kronos, a Novel Caulobacter Rhizosphere Phage that is Similar to Lambdoid PhagesThe original version of this article unfortunately contained mistakes in Table 1 values. Some of the values in "TAY-ASD who received services" were incorrect. The corrected Table 1 is given below.Correction to: Common findings of bla CTX-M-55 -encoding 104–139 kbp plasmids harbored by extended-spectrum β-lactamase-producing Escherichia coli in pork meat, wholesale market...
HER2+ and triple-negative phenotypes in invasive lobular carcinoma might have different specific biological featuresCorrection to: Breast cancer risk in relation to plasma metabolites among Hispanic and African American womenIn the original publication of the article, the sixth author name Krita A. Zanetti was mistakenly included as co-author. The corrected author group is given in the correction article. The original article has been corrected.Microinvasion: could it be sufficient diagnostic criteria...
Patterns of immune-cell infiltration in murine models of melanoma: roles of antigen and tissue site in creating inflamed tumorsAbstractImmune-cell infiltration is associated with improved survival in melanoma. Human melanoma metastases may be grouped into immunotypes representing patterns of immune-cell infiltration: A (sparse), B (perivascular cuffing), and C (diffuse). Immunotypes have not been defined for murine melanomas, but may provide opportunities to understand mechanism-driving immunotype...
Evolution of chimeric antigen receptor (CAR) T cell therapy: current status and future perspectivesAbstractEngineering T cells with a chimeric antigen receptor (CAR) that reprograms their antigen selectivity and signaling has recently emerged as one of the most promising therapeutic approaches for treating cancers. For example, two CD19-specific CAR T cell (CAR-T) therapies have shown remarkable responses in patients with relapsed/refractory B-cell cancers, and were approved by the US Food and Drug...
Commentary on 'Defecatory dysfunction and other clinical variables are predictors of pessary discontinuation'Commentary on: Sacral neuromodulation treating chronic pelvic pain: a meta-analysis and systematic review of the literatureLetter to the editor: The negative predictive value of preoperative urodynamics for stress urinary incontinence following prolapse surgeryCommentary on: Effects of mesh-related complications in vaginal surgery on quality of lifeLaparoscopic management of a large urethral...
Aortic RegurgitationAbstractPurpose of ReviewAortic regurgitation (AR) is a common form of valvular disease which is characterized by reflux of blood from the aorta into the left ventricle (LV) during diastole. AR results from various etiologies, affecting the aortic valve cusps or the aortic root. The clinical presentation of patients with AR depends on the severity of the regurgitation and differs whether AR develops acutely or if it progresses over a prolonged period, allowing the cardiac chambers...
Left Atrial Occlusion Device Implantation: the Role of the EchocardiographerAbstractPurpose of ReviewAtrial fibrillation is the most common arrhythmia worldwide and is a major risk factor for embolic stroke. For patients with atrial fibrillation who are unable to tolerate systemic anticoagulation, left atrial appendage (LAA) occlusion has been shown to mitigate stroke risk. In this article, we describe the vital role of the echocardiographer in intraprocedural guidance of percutaneous LAA occlusion...
Genetics, Dyslipidemia, and Cardiovascular Disease: New InsightsAbstractPurpose of ReviewThe cardiovascular (CV) risk related to lipid disorders is well established and is based on a robust body of evidence from well-designed randomized clinical trials, as well as prospective observational studies. In the last two decades, significant advances have been made in understanding the genetic basis of dyslipidemias. The present review is intended as a comprehensive discussion of current knowledge about...
Control of Low-Density Lipoprotein Cholesterol to Prevent Cardiovascular DiseaseAbstractPurpose of ReviewLow-density lipoprotein cholesterol (LDL-C) is one major cause of cardiovascular disease (CVD). In this review, we discuss current developments in the understanding of LDL-C as lifelong risk factor, treatment targets, and emerging approaches to reduce cardiovascular risk by lowering LDL-C.Recent FindingsRecent evidence underscores the importance of LDL-C lowering in CVD prevention by mechanisms...
Emerging Role of Coronary Computed Tomography Angiography in Lipid-Lowering Therapy: a Bridge to Image-Guided Personalized MedicineAbstractPurpose of ReviewTo summarize the current status of coronary computed tomography angiography (CTA) in the assessment of coronary plaques and discuss the ability of serial coronary CTA to quantitatively measure changes in the plaque burden in response to lipid-lowering therapy.Recent FindingsRecent advances in coronary CTA have allowed identification of high-risk...
Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease TreatmentAbstractPurpose of ReviewCardiovascular disease is the leading cause of mortality worldwide. Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential to treat heart disease, owing to their capacity of engraftment and remuscularization in the host heart after transplantation. In the current review, we provide an overview of PSC-CMs for clinical transplantation.Recent FindingsStudies have shown...
Minimizing Occupational Radiation Exposure in Cardiac ImagingAbstractPurpose of ReviewRadiation safety has been at the center of interest of both researchers and healthcare institutions. This review will summarize and shed light on the various techniques adapted to reduce staff exposure to ionizing radiation (IR) in the field of cardiac imaging.Recent FindingsIn the last years, with the advance of awareness and the development of new technologies, there have been several tools and techniques adapted....
Renal Artery Stenosis and Congestive Heart Failure: What Do We Really Know?AbstractPurpose of ReviewCongestive heart failure (CHF) is a major cause of morbidity, mortality, and health care expenditure. Although the role of renal artery stenosis (RAS) in CHF has been known, there are a number of areas of uncertainty.Recent FindingsThe prevalence of RAS in subjects with CHF varies from 15 to 54% depending on the cohort studied and the diagnostic modality used to identify RAS. In subjects with CHF,...
Mental imagery in animals: Learning, memory, and decision-making in the face of missing informationAbstractWhen we open our eyes, we see a world filled with objects and events. Yet, due to occlusion of some objects by others, we only have partial perceptual access to the events that transpire around us. I discuss the body of research on mental imagery in animals. I first cover prior studies of mental rotation in pigeons and imagery using working memory procedures first developed for human studies....
Mesh fixation in open IPOM procedure with tackers or sutures? A randomized clinical trial with preliminary resultsAbstractPurposeIn open intra-peritoneal onlay mesh (IPOM) hernia repair, mesh fixation can be done by tacks, sutures or fibrin glue. There are randomized controlled trials (RCTs) on laparoscopic IPOM procedure, but no RCT so far has examined mesh fixation techniques in open IPOM repair.MethodsIn a single-center RCT, 48 patients undergoing open IPOM repair of an abdominal wall hernia were...
Correction to: Building Behavioral Health Homes: Clinician and Staff Perspectives on Creating Integrated Care TeamsThe Publisher regrets that due to a malfunction in production, there are duplications and errors and rogue addresses in the author affiliations of the published article. The correct author affiliations are listed below.Looking Back and Looking Ahead: Meeting the Test of Our Times"Creative Financing": Funding Evidence-Based Interventions in Human Service SystemsAbstractImplementation...
Oral and Penile Lesions in a Young ManGordon T. Moffat, MD1; Franco Falcone, MD1Author Affiliations Article Information1Department of Internal Medicine, State University of New York, Downstate Medical Center, BrooklynJAMA. Published online June 24, 2019. doi:10.1001/jama.2019.7804CaseA 28-year-old man presented to the emergency department with diffuse oral lesions, fever, and nonproductive cough for 1 week. He was diagnosed with herpes simplex virus (HSV) and discharged home with acyclovir. Two days...
Predictive value of the milking patency test when performing the arterial microanastomosis in head and neck surgeryFabien Podeur MD Benjamin Peyrachon MD Lara Nokovitch MD Maria Adèle Dammacco MD Quentin Qassemyar MD, PhD Sophie Deneuve MDFirst published: 22 June 2019 https://doi.org/10.1002/hed.25841Read the full textePDFPDFTOOLS SHAREAbstractBackgroundThe milking patency test (MPT) is widely used to assess the patency of microanastomosis, despite it being proven to be a traumatic test.MethodsWe...
Prevalence of trismus in patients with head and neck cancer: A systematic review with meta‐analysisAmber L. Watters DDS, MPH, MS Shane Cope DDS, MS Meir N. Keller DDS, MS Mariela Padilla DDS, MEd Reyes Enciso PhDFirst published: 19 June 2019 https://doi.org/10.1002/hed.25836Read the full textePDFPDFTOOLS SHAREAbstractBackgroundThe purpose of this systematic review and meta‐analysis was to determine the prevalence of trismus in patients with head and neck cancer.MethodsFour electronic databases...
Outcomes of dental and craniofacial osseointegrated implantation in head and neck cancer patientsPhillip Moore BSc (Hons), MD Damien Grinsell MBBS, FRACS Bernard Lyons MBBS, FRACS Ian Hewson BDSc, FRACDSFirst published: 19 June 2019 https://doi.org/10.1002/hed.25845Read the full textePDFPDFTOOLS SHAREAbstractBackgroundTreatment of head and neck cancer may result in disfiguring and debilitating anatomical changes. Osseointegrated implants may be used in these patients to facilitate attachment of...
Primary organ preservation vs total laryngectomy for T4a larynx cancerJustin Oh MD Eitan Prisman MD Robert Olson MSc, MD Eric Berthelet MD Jonn Wu MD Eric Tran MD Brendan Bakos MSc Rojin Kaviani BS Sarah Nicole Hamilton MDFirst published: 19 June 2019 https://doi.org/10.1002/hed.25838Read the full textePDFPDFTOOLS SHAREAbstractBackgroundThere is a lack of consensus regarding the management of T4a larynx cancer. We evaluated the outcomes of organ preservation and laryngectomy for T4a laryngeal...
High‐grade radiologic extra‐nodal extension predicts distant metastasis in stage II nasopharyngeal carcinomaYujun Hu MD Tianzhu Lu MD Shao Hui Huang MSc, MD Shaojun Lin MD Yunbin Chen MD Yanhong Fang MD Han Zhou MD Yiping Chen MD Jingfeng Zong MD, PhD Yu Zhang MD … See all authorsFirst published: 17 June 2019 https://doi.org/10.1002/hed.25842Yujun Hu and Tianzhu Lu contributed equally to this study.Funding information: National Natural Science Foundation of China, Grant/Award Number: U1405221;...
Efficacy of indocyanine green fluorescence in predicting parathyroid vascularization during thyroid surgeryAlexander C. Razavi MPH Kareem Ibraheem MD Antoine Haddad MD Lachin Saparova MD Hosam Shalaby MD Mohamed Abdelgawad MD, MD Emad Kandil MD, MBAFirst published: 17 June 2019 https://doi.org/10.1002/hed.25837Research Presentations: The findings from this paper were presented as a poster presentation at the American Association of Endocrine Surgeons Annual Meeting, May 6‐8, 2018, Durham, North...
Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta‐analysisKyriaki Seremidi MSc Dimitrios Kloukos Dr Med Dent Argy Polychronopoulou PhD Antonis Kattamis PhD Katerina Kavvadia PhDFirst published: 22 June 2019 https://doi.org/10.1002/hed.25840Section Editor: David EiseleRead the full textePDFPDFTOOLS SHAREAbstractBackgroundThis systematic review summarizes the prevalence of dental defects after chemo and radiation therapy...
Validation of the olfactory disorders questionnaire for English‐speaking patients with olfactory disorders...Validation of the olfactory disorders questionnaire for English‐speaking patients with olfactory disordersLorna Langstaff Nisha Pradhan Allan Clark Duncan Boak Mahmoud Salam Thomas Hummel Carl M. PhilpottFirst published: 30 April 2019 https://doi.org/10.1111/coa.13351Read the full textePDFPDFTOOLS SHAREAbstractObjectivesTo adapt the existing German language olfactory disorders questionnaire...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,