Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomasElvira Moscarella Cristina Pellegrini Riccardo Pampena Giuseppe Argenziano Marco Manfredini Claudia Martorelli Alessia Ciarrocchi Emi Dika Ketty Peris Ambra Antonini … See all authorsFirst published: 29 April 2019 https://doi.org/10.1111/exd.13951Moscarella and Pellegrini contributed to this work and should be considered co‐first authorsFunding information:Dr Pampena is the recipient of...
Role of interleukin‐24 in the tumor‐suppressive effects of interferon‐β on melanomaYoshinori Watanabe Munenari Itoh Hidemi Nakagawa Akihiko Asahina Yoshimasa NobeyamaFirst published: 09 May 2019 https://doi.org/10.1111/exd.13955Read the full textePDFPDFTOOLS SHAREAbstractBackgroundType 1 interferons (IFNs), including IFN‐β, are widely used in adjuvant therapy for patients who undergo surgery for malignant melanoma to inhibit recurrence and in‐transit metastasis. The precise mechanisms underlying...
The mechanism for differential effect of nelfinavir and indinavir on collagen metabolism in human skin fibroblastsLukasz Szoka Ewa Karna Edyta Andrulewicz‐Botulinska Kornelia Hlebowicz‐Sarat Jerzy A. PalkaFirst published: 11 May 2019 https://doi.org/10.1111/exd.13956Funding information:This study was funded by the Medical University of Bialystok (Grant No. N/ST/ZB/18/008/2214).Read the full textePDFPDFTOOLS SHAREAbstractThe mechanism for differential effects of human immune deficiency virus protease...
Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheresMi H. Kwack Chang H. Seo Prakash Gangadaran Byeong‐Cheol Ahn Moon K. Kim Jung C. Kim Young K. SungFirst published: 29 March 2019 https://doi.org/10.1111/exd.13927Read the full textePDFPDFTOOLS SHAREAbstractDermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing...
Characterization of circadian human facial surface lipid compositionYan Jia Mingyue Zhou Hong Huang Yao Gan Manli Yang Ruiheng DingFirst published: 10 April 2019 https://doi.org/10.1111/exd.13933 Cited by: 1Funding information:This work was supported by National Natural Science Foundation of China (31501415); the Open Research Fund Program of Key Laboratory of Cosmetic (Beijing Technology and Business University), China National Light Industry; grants from Support Project of High‐level Teachers...
Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regionsSimeon Johnson Kevin Cowley Timothy J. Hawkins Arto MäättäFirst published: 25 April 2019 https://doi.org/10.1111/exd.13948Read the full textePDFPDFTOOLS SHAREAbstractThe biomechanical properties of the collagenous dermal matrix are well described but responses to mechanical force by the hair follicles have not been characterised so far. We applied...
E‐cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesionsAmanda M. Nelson Zhaoyuan Cong Samantha L. Gettle Amy L. Longenecker Michal Kidacki Joslyn S. Kirby David R. Adams Douglas B. Stairs Frederick W. DanbyFirst published: 20 May 2019 https://doi.org/10.1111/exd.13973Read the full textePDFPDFTOOLS SHAREAbstractHidradenitis suppurativa (HS) is a chronic, inflammatory skin disease affecting the pilosebaceous units in the axilla, groin and buttocks. While the pathogenesis...
Machine learning for the prediction of sunscreen sun protection factor and protection grade of UVAJiyong Shim Jun Man Lim Sun Gyoo ParkFirst published: 11 May 2019 https://doi.org/10.1111/exd.13958Funding information:The clinical studies presented in this article were funded by LG Household & Health Care, LTD.SECTIONSePDFPDFTOOLS SHAREAbstractWe report a prediction model for sunscreen sun protection factor (SPF) and protection grade of ultraviolet (UV) A (PA) based on machine learning. We illustrate...
Correction to: Gender Differences and Prevalence of Mental Health Problems in Students of Healthcare UnitsThe original version of this article unfortunately contained a typo in the author name. The co-author name should be Ahsan Ehtesham instead it was published as Ahsan Ehtisham.Perceptions of Service Use Among Currently and Formerly Homeless Adults with Mental Health ProblemsAbstractThis qualitative study used in-depth interviews to examine the service experiences of 52 currently and formerly homeless...
Platelets are important for the development of immune tolerance: Possible involvement of TGF‐β in the mechanismEri Hotta Risa Tamagawa‐Mineoka Norito KatohFirst published: 16 April 2019 https://doi.org/10.1111/exd.13940Hotta and Tamagawa‐Mineoka equally contributed to this work.Read the full textePDFPDFTOOLS SHAREAbstractPlatelets have diverse roles in immune processes in addition to their key functions in haemostasis and thrombosis. Some studies imply that platelets may be possibly related to...
Particulate matter induces pro‐inflammatory cytokines via phosphorylation of p38 MAPK possibly leading to dermal inflammagingMinJeong Kim Ju Hee Kim Guk Jin Jeong Kui Young Park Mi‐Kyung Lee Seong Jun SeoFirst published: 18 April 2019 https://doi.org/10.1111/exd.13943Read the full textePDFPDFTOOLS SHAREAbstractParticulate matter (PM) is known to have harmful effects on human health. Epidemiological studies have suggested that PM exposure is related to skin diseases and extrinsic skin ageing....
Expression and biological functions of the CCL5‐CCR5 axis in oral lichen planusJing Shan Shan Li Chen Wang Lin Liu Xuewei Wang Dandan Zhu Yuan Fan Juanyong XuFirst published: 21 April 2019 https://doi.org/10.1111/exd.13946Jing Shan and Shan Li are contributed equally to this work.Read the full textePDFPDFTOOLS SHAREAbstractOral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder with T cell‐mediated immunological pathogenesis. C‐C motif chemokine ligand 5 (CCL5) and its receptor...
Lactobacillus reuteri DSM 17938—A comparative study on the effect of probiotics and lysates on human skinIa Khmaladze Éile Butler Susanne Fabre Johanna M. GillbroFirst published: 25 April 2019 https://doi.org/10.1111/exd.13950Khmaladze and Butler are co‐first author.Funding information:This study was fully supported by Skin Research Institute, Oriflame Cosmetics AB.Read the full textePDFPDFTOOLS SHAREAbstractHuman skin microbiota might play an important role in maintaining skin health and potentially...
Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancementMengting Xu Yuyun Hua Yan Qi Guoliang Meng Shengju YangFirst published: 29 March 2019 https://doi.org/10.1111/exd.13930Read the full textePDFPDFTOOLS SHAREAbstractHydrogen sulphide (H2S) is an important gasotransmitter with several physiological functions. However, the roles and the detailed mechanisms of H2S on skin wound healing are not known...
Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytesJin Lu Tianxin Cong Xiang Wen Xiaoxue Li Dan Du Gu He Xian JiangFirst published: 11 April 2019 https://doi.org/10.1111/exd.13934Lu and Cong equally contributed to this article.Read the full textePDFPDFTOOLS SHAREAbstractAcne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over‐keratinization of follicular keratinocytes and...
Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approachesMatthew Moyle Ferda Cevikbas Jamie L. Harden Emma Guttman‐YasskyFirst published: 02 March 2019 https://doi.org/10.1111/exd.13911 Cited by: 1Matthew Moyle: Independent participation.SECTIONSePDFPDFTOOLS SHAREAbstractAtopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is characterized by persistent itch and marked redness. AD is associated with...
The complex role of mast cells in fungal infectionsQingqing Jiao Ying Luo Jörg Scheffel ZuoTao Zhao Marcus MaurerFirst published: 23 February 2019 https://doi.org/10.1111/exd.13907Qingqing Jiao and Ying Luo contributed equally to this work.SECTIONSePDFPDFTOOLS SHAREAbstractIn addition to their critical role in allergic disorders, mast cells (MCs) are well recognized for their protective effector functions during bacteria and parasite infections. This review describes recent advancements of our...
Pediatric NephrologyAugust 2019, Volume 34, Issue 8, pp 1383–1385| Cite asProteinuria in a patient with Graves' disease: AnswersAuthorsAuthors and affiliationsAydilek Dagdeviren Cakir1Email authorNur Canpolat2Seha Saygili2Isin Kilicaslan3Hande Turan1Oya Ercan1Olcay Evliyaoglu11.Department of Pediatric Endocrinology, Cerrahpasa Faculty of MedicineIstanbul University-CerrahpasaFatih, IstanbulTurkey2.Department of Pediatric Nephrology, Cerrahpasa Faculty of MedicineIstanbul University-CerrahpasaIstanbulTurkey3.Department...
An adolescent patient presenting with hyponatremic seizure: QuestionsNephrotic syndrome and mitochondrial disorders: answersCorrection to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patientsThe original version of this article unfortunately contained a mistake. The name of Vimal Chadha was presented incorrectly. The corrected author list is given above.Proteinuria in a patient with Graves' disease: QuestionsWriting a paper for publicationNephrotic syndrome...
Pseudomonas qingdaonensis sp. nov., an aflatoxin-degrading bacterium, isolated from peanut rhizospheric soilAbstractA Gram-stain-negative, aerobic, mobile, and rod-shaped bacterium, designated JJ3T, was isolated from peanut rhizospheric soil in Qingdao, Shandong Province, China, and was characterized using a polyphasic approach. Strain JJ3T grew at 4–40 °C, at pH 5.0–9.0 and 0–4% NaCl. The strain was positive for both catalase and oxidase tests, and was able to degrade aflatoxin B1. According to...
Spread through air spaces (STAS) is a predictor of poor outcome in atypical carcinoids of the lungAbstractSpread through air spaces (STAS) have been recently recognized as a prognostic factor for adenocarcinoma and squamous cell carcinoma of the lung. Pulmonary neuroendocrine neoplasms (NENs) include tumors with different morphology and a heterogeneous clinical behavior. Among atypical carcinoids (ACs), new prognostic factors able to refine prognosis are needed. In the present study, a retrospective...
Machine learning approaches for pathologic diagnosisAbstractMachine learning techniques, especially deep learning techniques such as convolutional neural networks, have been successfully applied to general image recognitions since their overwhelming performance at the 2012 ImageNet Large Scale Visual Recognition Challenge. Recently, such techniques have also been applied to various medical, including histopathological, images to assist the process of medical diagnosis. In some cases, deep learning–based...
Profiles of Emotion Regulation in Young People Accessing Youth Mental Health and Drug TreatmentAbstractDeficits regulating emotions are a core process underlying both substance use and mental health disorders. Research has focused on identifying one-to-one associations between individual emotion regulation (ER) strategies and mental health symptoms. Consequently, little is known about how patterns of ER relate to a broad range of psychopathology, in treatment seeking young people. Latent class analysis...
Correction to: PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple SclerosisThe original version of this article unfortunately contained mistakes. The captured article title and corresponding author were incorrect.Distribution and Functional Implication of Secretin in Multiple Brain RegionsAbstractSecretin is a polypeptide hormone initially identified for its gastrointestinal functions. However, emerging evidences show wide distribution of secretin and secretin...
Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's DiseaseAbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular deposits of fibrillary β-amyloid (Aβ) plaques in the brain that initiate an inflammatory process resulting in neurodegeneration. The neuronal loss associated with AD results in gross atrophy of affected regions causing a progressive loss of cognitive ability and memory...
Das Belegarztwesen in Deutschland: Ende einer sektorenverbindenden Versorgungsform?ZusammenfassungIm klassischen Belegarztsystem ist für Patientinnen und Patienten in idealtypischer Weise die konservative und operative Versorgung sektorenübergreifend garantiert. Neutrale Gutachter bestätigen seit Jahren den ressourcenschonenden Umgang mit dem Aufgrund des demographischen Wandels zunehmenden Leistungsbedarfs im medizinischen Alltag. Dennoch wird diese Versorgungsform durch deren fehlende Unterstützung...
Nachsorge des nicht muskelinvasiven HarnblasenkarzinomsZusammenfassungDie Tumornachsorge des NMIBC („non-muscle invasive bladder cancer") ist eine Abwägung zwischen der Belastung durch die Diagnostik sowie dem Risiko für Rezidiv und insbesondere Progress. Die Einteilung in Hoch‑, Intermediär- und Niedrigrisikotumoren ermöglicht eine risikoadaptierte Tumornachsorge. Durch die Verwendung von Risikokalkulatoren lässt sich das individuelle Rezidiv- und Progressionsrisiko abschätzen. Die Nachsorge basiert...
Molekulares Tumorboard – NierenzellkarzinomZusammenfassungDie Einführung molekularer zielgerichteter Substanzen hat die Therapie des metastasierten Nierenzellkarzinoms grundlegend verändert. Eine erste Welle der Entwicklung basiert auf dem verbesserten Verständnis der Tumorbiologie seit der Entdeckung der Bedeutung des VHL-Gens für die Progression, was den Weg für Therapieoptionen geebnet hat, die v. a. die Neoangiogenese hemmen. Relevant sind hier die Überexpression proangiogener und proliferationsfördernder...
Neurological Sciences July 2019, Volume 40, Issue 7, pp 1475–1476| Cite as Report on a child with...
Neurological SciencesJuly 2019, Volume 40, Issue 7, pp 1475–1476| Cite asReport on a child with neurofibromatosis type 2 and unilateral moyamoya: further evidence of cerebral vasculopathy in NF2AuthorsAuthors and affiliationsClaudia SantoroFederica PalladinoPia BernardoGiuseppe CinalliGiuseppe MironeTeresa GiuglianoGiulio PilusoSilverio PerrottaLetter to EditorRecently, Lascelles et al. reported on three children with neurofibromatosis type 2 (NF2) and intracerebral vasculopathy and/or ischemic strokes...
Cancer and motor neuron disease—causal or coincidental? Two contrasting casesAbstractIntroductionMotor neuron disease (MND) can occur in patients with cancer, but there is minimal evidence that this is more than by chance. We contrast two cases of motor neuronopathies occurring in the context of systemic malignancy and argue that in one case the cause was most likely paraneoplastic, while in the other it was not.Case 1A 61-year-old woman developed progressive walking difficulties over 9 months with...
Uremia presented as acute cranial neuropathyAuthorsAuthors and affiliationsWook Hur1Ji Yeon Chung1Pahn Kyu Choi1Hyun Goo Kang23Email authorView author's OrcID profile1.Department of NeurologyChosun University HospitalGwang-juSouth Korea2.Department of NeurologyChonbuk National University Medical SchoolJeonjuSouth Korea3.Department of NeurologyResearch Institute of Clinical Medicine of Chonbuk National University - Biomedical Research Institute of Chonbuk National University HospitalJeonjuSouth KoreaLetter...
Ictal dancing-like semiology in frontal lobe epilepsyPeculiar EEG signatures, ictal drinking and long-term follow-up in anti-LGI1 encephalitisG327E mutation in SCN9A gene causes idiopathic focal epilepsy with Rolandic spikes: a case report of twin sistersAbstractThe voltage-gated sodium channel NaV1.7, encoded by the gene SCN9A, is located in peripheral neurons and plays an important role in epileptogenesis. Previous studies have identified an increasing number of SCN9A mutations in patients with...
Desensitization of two young patients with infantile-onset Pompe disease and severe reactions to alglucosidase alfaAbstractPompe disease is a metabolic myopathy, due to deficiency of alpha glucosidase, with a wide clinical spectrum. Enzyme replacement therapy is the only available treatment to improve morbidity and mortality, especially in infantile-onset form. However, some patients experience infusion-associated reactions, which may restrict their access to this treatment. We report on two patients...
Lack of inter-muscular coherence of axial muscles in Pisa syndromeAbstractBackgroundPisa syndrome is a lateral deviation of the trunk described in Parkinson's disease (PD). Its etiology is still unknown; advanced muscular signal analysis techniques, such as inter-muscular coherence, could help clarifying its pathophysiology and suggest therapeutic strategies.MethodsFourteen idiopathic PD subjects with a lateral deviation of the trunk of at least 10° were included. Electromyographic (EMG) signal was...
Diagnostic performance of thromboelastometry in trauma-induced coagulopathy: a comparison between two level I trauma centres using two different devicesAbstractPurposeThe implementation of a ROTEM®-based algorithm requires reliable thresholds to mirror a prothrombin time (PT) ratio > 1.2 and/or a fibrinogen concentration < 1.5 g l−1. Our goal was to compare the diagnostic performances of two devices (ROTEM® Sigma and Delta, IL Werfen, Munich, Germany) in two level-I trauma centres for the diagnostic...
Blunt cerebrovascular injury: incidence and long-term follow-upAbstractPurposeBlunt cerebrovascular injuries (BCVI), which can result in ischemic stroke, are identified in 1–2% of all blunt trauma patients. Computed tomography angiography (CTA) scanning has improved and is the diagnostic modality of choice in BCVI suspected patients. Data about long-term functional outcomes and the incidence of ischemic stroke after BCVI are limited. The aim of this study was to determine BCVI incidence in relation...
Spectral analysis of heart rate variability for trauma outcome prediction: an analysis of 210 ICU multiple trauma patientsAbstractPurposeThis study aimed to test and compare short-term spectral HRV indices with most used trauma scorings in outcome prediction of multiple trauma, and then to explore the efficacy of their combined application.MethodsA prospective study was conducted for patients with blunt multiple trauma admitted to an emergency intensive care unit (ICU) between January 2016 and December...
Reappraising the need for a control CT in mild head injury patients on anticoagulationAbstractBackgroundHead injury is a frequent reason for admission to the emergency department. In parallel, there is a growing use of anticoagulants in an increasingly aging population, which renders this particular group of trauma patients more frequent. In several countries, including Portugal, a 24-h surveillance period followed by repetition of head computed tomography (CT) is the standard procedure for these...
Prevalence and patterns of maxillofacial trauma: a retrospective descriptive studyAbstractIntroductionWe aimed to describe the prevalence and pattern of maxillofacial trauma in Qatar.MethodsThis is a retrospective study of trauma registry data at Hamad General Hospital during the period from January 2011 to December 2014. The study included all traumatic maxillofacial patients who underwent CT scan and were admitted during the study period.ResultsA total of 1187 patients with maxillofacial injuries...
Blunt aortic injuries in the new era: radiologic findings and polytrauma risk assessment dictates management strategyAbstractPurposeBlunt aortic injuries (BAI) have historically been considered an indication for emergent surgical intervention. Nevertheless, the observation that the outcome of the concomitant traumatic injuries has a major impact on prognosis and the rise of thoracic endovascular aortic repair (TEVAR) as an effective therapy for BAI have significantly changed in recent years the treatment...
Prevalence and patterns of maxillofacial trauma: a retrospective descriptive studyAbstractIntroductionWe aimed to describe the prevalence and pattern of maxillofacial trauma in Qatar.MethodsThis is a retrospective study of trauma registry data at Hamad General Hospital during the period from January 2011 to December 2014. The study included all traumatic maxillofacial patients who underwent CT scan and were admitted during the study period.ResultsA total of 1187 patients with maxillofacial injuries...
Molecular identification of spotted fever group Rickettsia in ticks collected from dogs and small ruminants in GreeceAbstractSpotted fever group (SFG) Rickettsia are zoonotic and emerging pathogens with considerable impact in public and animal health. Greece is an endemic country of diseases caused by SFG Rickettsia. This work aims to evaluate the prevalence of SFG Rickettsia in ticks collected from domestic hosts including sheep, goats and dogs. Several genetic markers for bacterial genes, such...
A relapsing fever Borrelia and spotted fever Rickettsia in ticks from an Andean valley, central ChileAbstractIn humans, emerging infectious diseases are mostly zoonoses with ticks playing an important role as vectors. Tick-borne relapsing fever Borrelia and spotted fever Rickettsia occur in endemic foci along tropical and subtropical regions of the globe. However, both are widely neglected etiologic agents. In this study, we performed molecular analyses in order to assess the presence of Borrelia and Rickettsia DNA...
Ticks (Acari: Ixodidae) infesting dogs in Nigeria: epidemiological and public health implications...
Ticks (Acari: Ixodidae) infesting dogs in Nigeria: epidemiological and public health implicationsAbstractTicks are haematophagous arthropods that exert direct and indirect effects on their hosts. Their global importance as reservoirs and vectors of diseases of veterinary and public health importance is well recognized. However, the level of understanding of their role in disease epidemiology varies from one country to the other based on available data. Information on ticks infesting dogs across Nigeria...
Coexistence of genetically different Varroa destructor in Apis mellifera coloniesAbstractThe aim of this study was to investigate the genetic diversity of Varroa destructor parasitizing Apis mellifera colonies and to test for possible host–parasite association at the mitochondrial DNA (mtDNA) level. Six A. melliferahaplotypes (including a novel C2aa) and five haplotypes of V. destructor were detected in 29 analyzed colonies from eight sampling sites in Serbia. We revealed the presence of the K and...
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,