Keratoacanthoma Centrifugum Marginatum (KCM) after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracilE Silva A Estébanez JM Martín C Monteagudo E MontesinosFirst published: 07 June 2019 https://doi.org/10.1111/dth.12988This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record....
Adolescent SBIRT Practices Among Pediatricians in MassachusettsLevy, Sharon, MD, MPH; Wiseblatt, Aria, BA; Straus, John H., MD; Strother, Heather, MPH; Fluet, Christina, MPH; Harris, Sion K., PhDJournal of Addiction Medicine: June 5, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/ADM.0000000000000551Original Research: PDF OnlyBUYPAPAbstractAuthor InformationArticle MetricsObjectives: Adolescent Screening, Brief Intervention, and Referral to Treatment (SBIRT) in primary care is a key...
Mobility in survivors with chemotherapy-induced peripheral neuropathy and utility of the 6-min walk testAbstractBackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a significant and often lasting side effect of cancer treatment, with increasing CIPN severity associated with increasing deficits in balance, gait, and mobility. The 6-min walk test (6MWT) is a widely validated and utilized measure of general physical functioning and mobility, although its utility in a CIPN context is unclear....
Clinical Applicability of a Preoperative Angular Insertion Depth Prediction Method for Cochlear ImplantationRathgeb, Christoph*; Demattè, Marco† , ‡; Yacoub, Abraam† , §; Anschuetz, Lukas†; Wagner, Franca||; Mantokoudis, Georgios†; Caversaccio, Marco* , †; Wimmer, Wilhelm* , †Otology & Neurotology: June 5, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MAO.0000000000002304Original Study: PDF OnlyBUYSDCPAPAbstractAuthor InformationArticle MetricsObjective: Evaluation of the accuracy...
The Price of Immune Responses and the Role of Vitamin D in the Inner EarBüki, Béla*; Jünger, Heinz*; Zhang, Yan†; Lundberg, Yunxia Wang†Otology & Neurotology: June 5, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MAO.0000000000002258Review Article: PDF OnlyBUYPAPAbstractAuthor InformationArticle MetricsObjective: In this review the authors discuss evidence from the literature concerning vitamin D and temporal bone diseases (benign paroxysmal positional vertigo [BPPV], Menière's...
Do Income Supplemental Programs for Older Adults' Help Reduce Primary Caregiver Burden? Evidence from MexicoAbstractIn countries such as Mexico without formal public long-term care policies, informal care becomes the main source of support for older adults. Alternative social programs, such as supplemental income programs, for older adults could alleviate caregiver burden, especially if supplemental income were to be used for paid care or to compensate non-paid family caregivers. This work is the...
Fallstrick kryothermische Dermatitis artefactaZusammenfassungWir präsentieren 4 klinisch-histologisch korrelierte Fälle junger Patienten mit kryothermischer Dermatitis artefacta, die initial als primär bullöse Dermatosen oder Arzneimittelreaktionen fehldiagnostiziert wurden. Die kryothermische Dermatitis artefacta weist Ähnlichkeiten mit authentischen Dermatosen wie der linearen Ig(Immunglobulin)A-Dermatose, Herpes-Virus-Infektion, dem bullösen Pemphigoid oder einer fixen Arzneimittelreaktion auf....
The Clinical Ethics Consultant: What Role is There for Religious Beliefs?AbstractReligions often operate as comprehensive worldviews, attempting to answer the deepest existential questions that human beings can ask: Who am I? Where do I come from? Where am I going after I die? How should I live? Often ethical systems are embedded and justified within these broader narratives. Inevitably, the clinical ethics consultant will encounter and engage with religiously based ethical systems. In this issue,...
Nosology expansion: not always for health's sakePrevalence of overweight and obesity in Western countries: discrepancies in published estimatesAbstractTwo papers were extracted and pooled data from published sources were used to estimate the distribution of BMI values for adults living in many countries around the world. The NCD Risk Factor Collaboration and the Global Burden of Disease Study 2013 presented data for 200 and 188 countries, respectively. We extracted estimates from the two datasets...
Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic ReviewJudith Gebauer Claire Higham Thorsten Langer Christian Denzer Georg BrabantEndocrine Reviews, Volume 40, Issue 3, June 2019, Pages 711–767, https://doi.org/10.1210/er.2018-00092Published: 23 November 2018 Article historyCitePermissions Icon Permissions ShareAbstractThe number of patients surviving ≥5 years after initial cancer diagnosis has significantly increased during the last decades due to considerable...
Central Mechanisms of Glucose Sensing and Counterregulation in Defense of HypoglycemiaSarah Stanley Amir Moheet Elizabeth R SeaquistEndocrine Reviews, Volume 40, Issue 3, June 2019, Pages 768–788, https://doi.org/10.1210/er.2018-00226Published: 22 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractGlucose homeostasis requires an organism to rapidly respond to changes in plasma glucose concentrations. Iatrogenic hypoglycemia as a result of treatment with insulin or sulfonylureas...
Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated DisordersBernadette Biondi George J Kahaly R Paul RobertsonEndocrine Reviews, Volume 40, Issue 3, June 2019, Pages 789–824, https://doi.org/10.1210/er.2018-00163Published: 14 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractThyroid dysfunction and diabetes mellitus are closely linked. Several studies have documented the increased prevalence of thyroid disorders in patients with diabetes mellitus and vice...
Genetics of Human Primary Hypertension: Focus on Hormonal MechanismsWorapaka Manosroi Gordon H WilliamsEndocrine Reviews, Volume 40, Issue 3, June 2019, Pages 825–856, https://doi.org/10.1210/er.2018-00071Published: 24 December 2018 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractIncreasingly, primary hypertension is being considered a syndrome and not a disease, with the individual causes (diseases) having a common sign—an elevated blood pressure. To determine...
First Responder to Genomic Information: A Guide for Primary Care ProvidersAbstractWith rapid advances in genetics and genomics, the commercialization and access to new applications has become more widespread and omnipresent throughout biomedical research. Thus, increasingly, more patients will have personal genomic information they may share with primary care providers (PCPs) to better understand the clinical significance of the data. To be able to respond to patient inquiries about genomic data,...
Oral or intravenous vinorelbine plus capecitabine in heavily pretreated HER2 negative metastatic breast cancer; similar effect or quality of life?Correction to: Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancerUnfortunately in the original publication of the article, the author's funding support has been mentioned incorrectly. The correct funding statement should read as "This work was supported by the Morgan Welch Inflammatory...
Under inflammatory stimuli mesenteric mesothelial cells transdifferentiate into macrophages and produce pro-inflammatory cytokine IL-6AbstractObjectiveInflammatory stimuli inducing epithelial-to-mesenchymal transition (EMT) can transdifferentiate mesenteric mesothelial cells into macrophages.MethodsSprague Dawley rat mesenteric mesothelial cells were used as a model. 1 ml Freund adjuvant was injected into the peritoneal cavity of rat and GM-CSF treatment was used to induce inflammation. IL-10 and...
Factors controlling the deformation of benthic foraminifera in the Manzala lagoon, EgyptPublication date: June 2019Source: Revue de Micropaléontologie, Volume 63Author(s): A.M. Badr-El Din, A.A. El-Badry, O.H. OrabiAbstractMorphological deformations among hyaline and porcelaneous benthic foraminiferal were observed at stations with high contents of trace metals within the Manzala Lagoon. Energy Dispersive X-ray Analyses (EDX) were conducted on deformed and non-deformed specimens of this population....
Can We Reduce Frame Rate to 15 Images per Second in Pediatric Videofluoroscopic Swallow Studies?AbstractVideofluoroscopic Swallow studies (VFSS) are useful radiological examinations to explore swallowing disorders but which require ionizing radiation. The aim of our study was to evaluate the comparability of pediatric VFSS at 15 frames per second (fps) with 30 fps. Fifty-five loops including 190 swallowings of VFSS at 30 fps performed on 32 consecutive pediatric patients in a University Hospital...
Plasma renin levels are associated with cardiac function in primary adrenal insufficiencyAbstractBackgroundDespite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, primary adrenal insufficiency (AI) is associated with an increased mortality, mainly due to cardiovascular disease. The role of MC replacement is not known. Therefore, we assessed whether renin concentrations during routine GC and MC substitution therapy are associated with heart function and morphology.MethodsThirty...
Effect of Individual and Combined Treatments of Pesticide, Fertilizer, and Salt on Growth and Corticosterone Levels of Larval Southern Leopard Frogs ( Lithobates sphenocephala )AbstractHuman activities have introduced a variety of chemicals, including pesticides, fertilizers, and salt, into the environment, which may have deleterious effects on the organisms inhabiting these areas. Amphibians are especially susceptible to absorption of chemical pollutants. To determine the possible combined effects...
Hospital-acquired acute kidney injury in very elderly men: clinical characteristics and short-term outcomesAbstractObjectivesWe explored the risk factors for, and the clinical characteristics of, acute kidney injury (AKI), and the causes of death 28 days after such injury, in very elderly men.MethodsThis was a retrospective cohort study using data from the Geriatric Department of the Chinese PLA General Hospital. A total of 3464 elderly patients (≥ 75 years) were enrolled from January 2007 to December...
Managing Organizational Paradoxes in Social Enterprises: Case Studies from the MENA RegionAbstractThis study aims to examine the question around how small- and medium-scale hybrid social enterprises within the context of the Middle East and North Africa manage paradoxical tensions they face in their everyday decision-making. By placing a lens on the unique hybrid processes facing organizational members rooted in traditional social and economic rationales, we seek to better understand the breadth...
Dennis R. Young, Elizabeth A. M. Searing, Cassady V. Brewer (Eds.): The Social Enterprise ZooDey, Pascal & Steyaert, Chris (Ed.): Social Entrepreneurship. An Affirmative Critique. Cheltenham UK: Edward Elgar Publishing Ltd., 2018, pp. 328, £85.50 (Hardback)Dennis Young: Financing Nonprofits and Other Social Enterprises: A Benefits ApproachBruce A. Seaman and Dennis R. Young: Handbook of Research on Nonprofit Economics and ManagementDistinctions Between Non-profit, For-profit, and Public Providers:...
Hemoglobin A1c Levels During Pregnancy and Risk of Autism Spectrum Disorders in OffspringAnny H. Xiang, PhD1; Ting Chow, MPH1; Mayra P. Martinez, MPH1; et al Darios Getahun, MD, PhD1; Kathleen A. Page, MD2; Thomas A. Buchanan, MD2; R. Klare Feldman, MD3Author Affiliations Article Information1Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena2Division of Endocrinology and Diabetes, University of Southern California Keck School of Medicine, Los Angeles3Obstetrics...
Lateral nasal wall extension of the nasoseptal flap for skull‐base and medial orbital wall defectsJustin McCormick MD Mark Allen MS Joshua J. Kain MD Jaime A Pena‐Garcia BS Do‐Yeon Cho MD Kristen O. Riley MD Bradford A. Woodworth MDFirst published: 07 June 2019 https://doi.org/10.1002/alr.22364Potential conflict of interest: B.A.W. is a consultant for Olympus, Smith and Nephew, and Cook Medical; he also receives grant support from Cook Medical.Accepted for oral presentation at Rhinoworld 2019,...
Kappa‐carrageenan sinus rinses reduce inflammation and intracellular Staphylococcus aureus infection in airway epithelial cellsCatherine Bennett BMedSc Mahnaz Ramezanpour PhD Clare Cooksley PhD Sarah Vreugde MD, PhD Alkis James Psaltis MD, PhDFirst published: 04 June 2019 https://doi.org/10.1002/alr.22360Funding sources for the study: ENT Technologies Pty, Ltd.Potential conflict of interest statement: A.J.P.: ENT Technologies Pty, Ltd, Aerin Medical, Inc, Lyra Therapeutics, and Medtronic, consultant.AbstractBackgroundChronic...
Clinical predictors of cystic fibrosis chronic rhinosinusitis severityAnna C. Zemke MD, PhD Seyed Mehdi Nouraie MD, PhD John Moore BA Jordan R. Gaston BA Nicholas R. Rowan MD Joseph M. Pilewski MD Jennifer M. Bomberger PhD Stella E. Lee MDFirst published: 04 June 2019 https://doi.org/10.1002/alr.22332Potential conflict of interest: None disclosed.Funding sources for the study: Cystic Fibrosis Foundation (Grant ZEMKE16Q0 to ACZ, BOMBERG14G0 to JMB and RDP Grant to JMP) NIH (K23HL131930 to ACZ,...
Limits to the Politics of Subjective Rights: Reading Marx After LefortAbstractIn response to critiques of rights as moralistic and depoliticising, a literature on the political nature and contestability of rights has emerged. In this view, rights are not merely formal, liberal and moralistic imperatives, but can also be invoked by the excluded in a struggle against domination. This article examines the limits to this practice of rights-claiming and its implication in forms of domination. It does...
From Social Uprising to Legal FormAbstractDoes, or should, social uprising lead to new legal form? Ukraine's current situation following the Revolution of Dignity in 2013–2014, with continuing violent conflict in Donbas and Crimea, suggests that not only is it unclear how a 'new' form is assessed, but existing transitional policies and frameworks are unlikely to be clearly implemented and enforced. An alternative analysis of transformation is necessary to address the conflicting aftermath of uprising...
Policies, Technology and Markets: Legal Implications of Their Mathematical InfrastructuresAbstractThe paper discusses legal implications of the expansion of practical uses of mathematics in social life. Taking as a starting point the omnipresence of mathematical infrastructures underlying policies, technology and markets, the paper proceeds by attending to relevant materials offered by general philosophy, legal philosophy, and the history and philosophy of mathematics. The paper suggests that the...
Property and the Interests of Things: The Case of the Donative TrustAbstractWithin a liberal, 'law of things' understanding of property, the donative trust is seen as a species of gift. Control over trust property passes from the hands of settlors to beneficiaries, from owners to owners. Trust property, like all other property, is silent and passive, its fate determined by its owners. This article questions this understanding of the trust by showing how beneath the facade of ownership, the trust...
IntroductionAgainst Exclusion: Teaching Transsystemically, Learning in CommunityAbstractIn September 2018 the University of Victoria Faculty of Law on Vancouver Island, Canada welcomed its first cohort of students to its cutting edge and innovative joint degree programme in Canadian Common Law (Juris Doctor (JD)) and Indigenous Legal Orders (Juris Indigenarum Doctor (JID)). The JD/JID programme draws on the law faculty's more than two decades of experience and research on Indigenous legal orders,...
The Contradictions of Conscience: Unravelling the Structure of Obligation in EquityAbstractConscience rests within the heart of equity, yet it is a manifestly nebulous and contradictory concept. In particular, equity has never been clear about exactly whose conscience we are concerned with: the Chancellor or judge, or the court, or the defendant? Furthermore, in some lights conscience appears to compel obedience to the authority of law, whilst in others it gives expression to ethical drives that...
Treatment-emergent dhat syndrome in a young male with Obsessive–Compulsive disorder: An alarm for medication nonadherenceSujita Kumar KarActa Medica International 2019 6(1):44-45Dhat syndrome refers to a culture-bound syndrome of Southeast Asia, where patients present with anxiety and depressive and somatic symptoms, which they attribute to semen loss. Common presentation of these patients is the passage of semen-like substance in urine. Retrograde ejaculation may cause spermaturia, and patients...
Evaluation of "point of care" brain natriuretic peptide level in differentiating between cardiogenic and noncardiogenic acute dyspnea (a hospital-based study)Priyanka Singh, Shubham Prasad, Lalit P Meena, Jaya Chakravarty, Madhukar RaiActa Medica International 2019 6(1):38-43Introduction: Acute dyspnea is one of the most common reasons for admission to emergency rooms. It could be due to potentially life-threatening cardiac or respiratory conditions. Differentiation among these three disorders is...
Bedroom design orientation and sleep electroencephalography signalsAmin Hekmatmanesh, Maryam Banaei, Khosro Sadeghniiat Haghighi, Arezu NajafiActa Medica International 2019 6(1):33-37Background: Orientation is a significant factor in architectural design that may affect well-being. Body direction does not change during sleeping, and sleeping is sensitive and affected by environmental factors. Aims: This neuroarchitecture study aimed to assess the effects of bed orientation on sleep quality to enhance...
Personality traits of young men with different diplotypesPavel N Ermakov, Elena V Vorobyeva, Ekaterina M Kovsh, Irina V Abakumova, Olga D Fedotova, Marina P Aralova, Wladimir W Latun, Lubov Ya HoronkoActa Medica International 2019 6(1):28-32Background: Historically in psychogenetic research the attention has been paid to describing personality traits of the carriers of some sole genotypes; but in this work the characteristic traits of carriers of catecholaminergic system MAOA and COMT genes' genotypes...
The jefferson scale of physician empathy: A preliminary study of validity and reliability among physicians in Nigerian tertiary hospitalJuliet Hodo Osim, Emmanuel Aniekan Essien, Joseph Okegbe, Owoidoho UdofiaActa Medica International 2019 6(1):22-27Introduction: Physician empathy has been shown to have a substantial effect on doctor–patient relationship, therapeutic adherence, and overall treatment outcome. Despite its important role, physician empathy is under-researched in Nigeria. Aims: This...
Thyroid-stimulating hormone in hypothyroidism – How high is too high?Ruth Priya Senthiappan, Smitha Bhat, Sudeep KrishnaActa Medica International 2019 6(1):11-16Background: The prevalence of hypothyroidism in the developed world is about 4-5% and in India is 10.9%. The goal of treating hypothyroidism is to maintain thyrotropin (TSH) levels within the normal reference range. Studies have shown that even within the normal range of TSH, patients with low normal TSH (LNT) have better outcomes when compared...
Lymph node biopsies: Evaluation of disease pattern and role of surgery – Our experience from South Punjab, PakistanMuhammad Irshad Hussain, Mulazim Hussain Bukhari, Muhammad Zeeshan AftabActa Medica International 2019 6(1):7-10Objective: The objective of the study was to determine the frequency of different pathologies presenting with lymphadenopathy in patients from South Punjab and to evaluate the role of surgery in reaching the diagnosis. Materials and Methods: It was a cross-sectional study done...
A comparative study of histopathological findings in psoriatic lesions with and without treatmentDeepti Arora, Faiyaz Ahmad, Ankita Mittal, Ashutosh Kumar, Seema Awasthi, Shyamoli DuttaActa Medica International 2019 6(1):2-6Background: Psoriasis is a multifactorial chronic relapsing inflammatory dermatological disorder associated with significant comorbidities. It is characterized by sharply demarcated, erythematous papules, and plaques with abundant silvery-white scales. Due to its variable clinical...
Validating biological research: Role of statisticsSanjeev Kumar Jain, Umme Afifa, Sanya Jain, Sonika SharmaActa Medica International 2019 6(1):1-1A comparative study of histopathological findings in psoriatic lesions with and without treatmentDeepti Arora, Faiyaz Ahmad, Ankita Mittal, Ashutosh Kumar, Seema Awasthi, Shyamoli DuttaActa Medica International 2019 6(1):2-6Background: Psoriasis is a multifactorial chronic relapsing inflammatory dermatological disorder associated with significant comorbidities....
A critical assessment of the quality of radiation therapy in Israel: time to initiation of treatment of spinal cord compression as an index of efficiencyAbstractIntroductionRadiotherapy departments function under workload pressure. We examined the process from referral to treatment initiation for spinal cord compression (SCC), one of the most daunting clinical scenarios in oncology.MethodsWe identified 235 patients with SCC, treated between 2013–2015. Two physicians classified cases as "emergent"...
Radiotherapy for recurrent intracranial epidermoid cysts without malignant transformation: a single-institution case seriesAbstractIntroductionRecurrent intracranial epidermoid cysts may be difficult to address surgically given their proximity to critical neurovascular structures of the skull base. There are emerging reports of using radiotherapy (RT) for the treatment of recurrent epidermoid cysts. Here, we report a case series of adjuvant fractionated external beam RT for recurrent intracranial...
LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cellsAbstractIntroductionTo investigate the effects of lncRNA GAS5 on the proliferation, migration, invasion and apoptosis of brain glioma cells.MethodsThe expression levels of lncRNA GAS5 and GSTM3 in normal glial cells (HEB) and glioma cells (U251 and U87) were detected by RT-qPCR and western blot, respectively. Glioma cells were...
Super-early initiation of temozolomide prolongs the survival of glioblastoma patients without gross-total resection: a retrospective cohort studyAbstractObjectiveThe optimal timing of chemoradiotherapy in patients with newly diagnosed glioblastoma (GBM) remains unclear. In this study, we explored the clinical efficacy of super-early initiation of temozolomide (TMZ) in the treatment interval from surgery to radiotherapy.MethodsWe retrospectively reviewed the clinical data of 375 patients with GBM...
Non-NF2 mutations have a key effect on inhibitory immune checkpoints and tumor pathogenesis in skull base meningiomasAbstractAimsSkull base meningiomas represent approximately 25% of all meningiomas, nearly 20% of which are atypical or anaplastic. To date, effective medical treatments for meningiomas are still lacking. Genetic aberrations (TRAF7, KLF4, AKT1, and SMO) and the effects of genetic aberrations on the expression of inhibitory immune checkpoint molecules (PD-L1, IDO, and TDO2) in skull...
Non-NF2 mutations have a key effect on inhibitory immune checkpoints and tumor pathogenesis in skull base meningiomasAbstractAimsSkull base meningiomas represent approximately 25% of all meningiomas, nearly 20% of which are atypical or anaplastic. To date, effective medical treatments for meningiomas are still lacking. Genetic aberrations (TRAF7, KLF4, AKT1, and SMO) and the effects of genetic aberrations on the expression of inhibitory immune checkpoint molecules (PD-L1, IDO, and TDO2) in skull...
Correction to: FabG: from a core to circumstantial catalystIn the original publication of the article, under section Polyketide synthesis: a pathway similar to fatty acid synthesis, the sentences "Phylogeny of KS domains and proteins of FAS and PKS, inferred by Bayesian estimation. Numbers above branches indicate posterior clade probability values." and "Branch length indicates number of inferred amino acid changes per position." in the first paragraph were included inadvertently.Biocatalytic synthesis...
European Society of Neuroradiology (ESNR)Subtraction CT angiography in the follow-up of treated cerebral aneurysmsApplication of MR morphologic, diffusion tensor, and perfusion imaging in the classification of brain tumors using machine learning schemeAbstractPurposeWhile MRI is the modality of choice for the assessment of patients with brain tumors, differentiation between various tumors based on their imaging characteristics might be challenging due to overlapping imaging features. The purpose...
Dystonia in paediatric intensive care: a retrospective prevalence studyRumsha Ahmed1, Ben Griffiths2, Daniel E Lumsden3Author affiliationshttp://dx.doi.org/10.1136/archdischild-2018-316421Request PermissionsTermed status dystonicus when most severe,1 dystonia is a disorder in which muscle contractions generate abnormal movements and/or postures.2 While it is recognised that severe dystonia may require intensive care management,1 there is a paucity of data addressing the prevalence of dystonia in...
Fatigue in childhood chronic diseaseMerel M Nap-van der Vlist1, Geertje W Dalmeijer2, Martha A Grootenhuis3, Cornelis K van der Ent4, Marry M van den Heuvel-Eibrink5, Nico M Wulffraat6, Joost F Swart6, Raphaële R L van Litsenburg7, Elise M van de Putte1, Sanne L Nijhof1Author affiliationsAbstractBackground and objectives Recently, in adults, the incidence and severity of fatigue was found to exist rather independently from the somatic diagnosis. Since fatigue is distressing when growing up with a...
Parents' and clinicians' views on conducting paediatric diagnostic test accuracy studies without prior informed consent: qualitative insight from the Petechiae in Children study (PiC)Thomas Waterfield1, Mark D Lyttle2,3, Michael Shields1, Derek Fairley4, Damian Roland5, James McKenna4, Kerry Woolfall6 On behalf of Paediatric Emergency Research in the UK and Ireland (PERUKI)Author affiliationsAbstractObjective The Petechiae in Children (PiC) study assesses the utility of presenting features and rapid...
Parents' prioritised outcomes for trials investigating treatments for paediatric severe infection: a qualitative synthesisKerry Woolfall1, Caitlin O'Hara1, Elizabeth Deja1, Ruth Canter2, Imran Khan3, Paul Mouncey2, Anjali Carter4, Nicola Jones4, Jason Watkins4, Mark David Lyttle5,6, Lyvonne Tume5, Rachel Agbeko7, Shane M Tibby8, John Pappachan9, Kent Thorburn10, Kathryn M Rowan2, Mark John Peters11, David Inwald12 on behalf of PERUKI (Paediatric Emergency Research in the UK and Ireland) and PICS...
Can real-time feedback improve the simulated infant cardiopulmonary resuscitation performance of basic life support and lay rescuers?Jeyapal Kandasamy1, Peter S Theobald1, Ian K Maconochie2, Michael D Jones1Author affiliationsAbstractBackground Performing high-quality chest compressions during cardiopulmonary resuscitation (CPR) requires achieving of a target depth, release force, rate and duty cycle.Objective This study evaluates whether 'real time' feedback could improve infant CPR performance...
Electronic prescribing in paediatric secondary care: are harmful errors prevented?Andy Fox1, Jane Portlock2, David Brown3Author affiliationsAbstractObjective The aim of this research was to ascertain the effectiveness of current electronic prescribing (EP) systems to prevent a standardised set of paediatric prescribing errors likely to cause harm if they reach the patient.Design Semistructured survey.Setting UK hospitals using EP in the paediatric setting.Outcome measures Number and type of erroneous...
Women and children first? Gender equity in paediatric medicineTessa Davis1, Henry Goldstein2,3, Dani Hall4,5, Ben Lawton3,6, Grace Sze Yin Leo7,8, Rie Yoshida4, Andrew Tagg9,10 on behalf of Don't Forget The BubblesAuthor affiliationsAbstractThere has been an increased focus on diversity and inclusion in medicine in recent years—the field of medicine still has a long way to go to reach gender equity. We assess how paediatrics is performing by examining the role gender plays in our specialty; and we...
Update on adrenal steroid hormone biosynthesis and clinical implicationsIrina-Alexandra Bacila, Charlotte Elder, Nils KroneAuthor affiliationsAbstractSteroid biosynthesis is a complex process in which cholesterol is converted to steroid hormones with the involvement of multiple enzymes and cofactors. Inborn conditions affecting adrenal steroidogenesis are relatively common in paediatric practice and have serious implications on patient mortality and morbidity. This paper provides an overview of novel...
Why is there a multi-fold difference in diagnosis of abuse among infants with long bone fracture in East Anglia compared with Sweden?Ulf Högberg1, Jacob Andersson2, Göran Högberg3, Ingemar Thiblin2Author affiliationshttp://dx.doi.org/10.1136/archdischild-2019-317232Linked ArticlesRequest PermissionsThe multicentre hospital study by Mitchell et al 1 provides interesting regional representative data on limb fractures and diagnosis of physical abuse among young children. Their study enables intercountry...
es in comparing physical abuse, fractures and metabolic bone disease in young children in the UK and SwedenPiers D Mitchell1, Richard Brown2, Tengyao Wang3, Rajen D Shah3, Richard J Samworth3Author affiliationshttp://dx.doi.org/10.1136/archdischild-2019-317457Linked ArticlesRequest PermissionsWe were very interested to hear of the views of Högberg et al regarding our paper recently published in ADC.1 We note that they are not criticising our study, but compare data from our paper with theirs on metabolic...
'A bugging feeling': a live foreign body in the earThomas CallejaAuthor affiliationshttp://dx.doi.org/10.1136/archdischild-2019-316881Request PermissionsCase reportWe present a case of a 16-year-old man who presented to our ENT emergency department in Malta with a 2-day history of acute-onset right ear pruritus and otalgia, describing a distressing 'bugging feeling' intermittently. His parents denied having any medical history but they admitted to residing in poor living conditions in a small flat...
Renin–angiotensin system research: from molecules to the whole bodyAbstractHypertension is one of the most important risk factors and a leading cause of death from cardiovascular and cerebrovascular diseases. Based on numerous previous studies, hypertension is thought to be caused by the complex mutual interactions of genetic factors and environmental factors, such as excessive salt intake and stress. However, its detailed mechanisms are not yet clearly understood. The renin–angiotensin system (RAS)...
Enhancement of electroencephalogram activity in the theta-band range during unmatched olfactory-taste stimulationAbstractThe aim of this study was to investigate how odor stimulation affects taste perception. Electroencephalogram (EEG) signals were measured from the frontal region of the head in normal, healthy subjects, and frequency analyses were performed. Each odor stimulation was delivered while the subject was tasting chocolate, using chocolate paste as the odorant for 'matched odor stimulation,'...
Renal involvement in the pathogenesis of mineral and bone disorder in dystrophin-deficient mdx mouseAbstractDuchenne muscular dystrophy is a severe muscular disorder, often complicated with osteoporosis, and impaired renal function has recently been featured. We aimed to clarify the involvement of renal function in the pathogenesis of mineral and bone disorder in mdx mice, a murine model of the disease. We clearly revealed renal dysfunction in adult mdx mice, in which dehydration and hypercalcemia...
Muscle sympathetic nerve activity during exerciseAbstractAppropriate cardiovascular adjustment is necessary to meet the metabolic demands of working skeletal muscle during exercise. The sympathetic nervous system plays a crucial role in the regulation of arterial blood pressure and blood flow during exercise, and several important neural mechanisms are responsible for changes in sympathetic vasomotor outflow. Changes in sympathetic vasomotor outflow (i.e., muscle sympathetic nerve activity: MSNA)...
Mild hyperbaric oxygen: mechanisms and effectsAbstractAdequate oxygen supply by exposure to mild hyperbaric oxygen at appropriately high atmospheric pressure (1266–1317 hPa) and increased oxygen concentration (35–40% oxygen) has a possibility of improving the oxidative metabolism in cells and tissues without barotrauma and excessive production of reactive oxygen species. Therefore, metabolic syndrome and lifestyle-related diseases, including type 2 diabetes and hypertension, in rats were inhibited...
Natural silibinin modulates amyloid precursor protein processing and amyloid-β protein clearance in APP/PS1 miceAbstractSilibinin has been shown to attenuate cognitive dysfunction and inhibit amyloid-beta (Aβ) aggregation in Alzheimer's disease (AD) models. However, the underlying mechanism by which silibinin improves cognition remains poorly understood. In this study, we investigated the effect of silibinin on β-secretase levels, Aβ enzymatic degradation, and oxidative stress in the brains of APP/PS1...
Chronic water insufficiency induced kidney damage and energy dysregulation despite reduced food intake, which improved gut microbiota in female ratsAbstractWater intake is recommended for weight loss, but the relationship between water intake and energy metabolism is not clear. We hypothesized that long-term water insufficiency would influence energy, glucose, and lipid metabolism while modulating gut microbiota. Female rats were provided with high-fat diets with different amounts of water and food...
Chronic water insufficiency induced kidney damage and energy dysregulation despite reduced food intake, which improved gut microbiota in female ratsAbstractWater intake is recommended for weight loss, but the relationship between water intake and energy metabolism is not clear. We hypothesized that long-term water insufficiency would influence energy, glucose, and lipid metabolism while modulating gut microbiota. Female rats were provided with high-fat diets with different amounts of water and food...
20,000 years of interactions between climate, vegetation and land use in Northern GreeceAbstractDetailed knowledge about the history of vegetation, fire and land use is scarce in Northern Greece. We analysed lake sediments from Limni Zazari (Northern Greece) to reconstruct the past local vegetation and fire history with a special focus on land use and its impacts on erosion and lake eutrophication. Our data suggest a rather dense steppic vegetation after ca 20,000 cal bp (18050 cal bc). Forest expansion...
Aristotle's Ethics and Farm Animal WelfareAbstractAlthough telos has been important in farm animal ethics for several decades, clearer understanding of it may be gained from the close reading of Aristotle's primary texts on animals. Aristotle observed and classified animals informally in daily life and through planned evidence gathering and collection development. During this work he theorized his concept of telos, which includes species flourishing and a good life, and drew on extensive and detailed...
Veganism and Children: Physical and Social Well-BeingAbstractI claim that there is pro tanto moral reason for parents to not raise their child on a vegan diet because a vegan diet bears a risk of harm to both the physical and the social well-being of children. After giving the empirical evidence from nutrition science and sociology that supports this claim, I turn to the question of how vegan parents should take this moral reason into account. Since many different moral frameworks have been used...
Rethinking the Ethical Challenge in the Climate Deadlock: Anthropocentrism, Ideological Denial and Animal LiberationAbstractAs critical research has revealed, climate change scepticism and inaction are not about science but ideas, and specifically the ideas that conform our worldview. Drawing on key theoretical approaches to climate change denial from the social sciences and humanities, this paper discusses the ideological dimension and, more especially, the anthropocentric denial underlying our...
The Ethics of BiosurveillanceAbstractGovernments must keep agricultural systems free of pests that threaten agricultural production and international trade. Biosecurity surveillance already makes use of a wide range of technologies, such as insect traps and lures, geographic information systems, and diagnostic biochemical tests. The rise of cheap and usable surveillance technologies such as remotely piloted aircraft systems (RPAS) presents value conflicts not addressed in international biosurveillance...
Varieties of the Cruelty-Based Objection to Factory FarmingAbstractTimothy Hsiao defends industrial animal agriculture (hereafter, factory farming) from the "strongest version of the cruelty objection" (J Agric Environ Ethics 30(1):37–54, 2017). The cruelty objection, following Rachels (in: Sapontzis S (ed) Food for thought: the debate over eating meat, Prometheus, Amherst, 2004), is that, because it is wrong to cause pain without a morally good reason, and there is no morally good reason for the...
Progress and Absurdity in Animal EthicsAbstractThe development of animal ethics has been characterized by both progress and absurdity. More activity in animal welfare has occurred in the past 50 years than in the previous 500, with large numbers of legislative actions supplanting the lone anti-cruelty laws. Nonetheless, there remains a tendency to confuse animal ethics with human ethics. I found this to be the case when my colleagues and I were drafting federal law requiring control of pain in invasive...
Correction to: Small things can make a big difference: a comparison of pollen and macrobotanical records of some food plants from medieval and post-medieval cesspits in the Netherlands and northern BelgiumIn the original publication, the caption of Fig. 1 is partly missing. It has been updated in this correction.Small things can make a big difference: a comparison of pollen and macrobotanical records of some food plants from medieval and post-medieval cesspits in the Netherlands and northern BelgiumAbstractThis...
Every child, every time: hospital-wide child abuse screening increases awareness and state reportingAbstractPurposeA review of our child abuse evaluation system demonstrated a lack of standardization leading to low reporting levels. The purpose of this quality improvement initiative was to develop a standard child abuse screening tool; an education program increasing awareness to child abuse; and to measure the impact of the screening tool in reporting.MethodsA screening tool was developed and implemented...
The Moral Complexity of Agriculture: A Challenge for Corporate Social ResponsibilityAbstractOver the past decades, the modernization of agriculture in the Western world has contributed not only to a rapid increase in food production but also to environmental and societal concerns over issues such as greenhouse gas emissions, soil quality and biodiversity loss. Many of these concerns, for example those related to animal welfare or labor conditions, are stuck in controversies and apparently deadlocked...
The effect of maternal grafts in early acute cellular rejection after pediatric living-donor liver transplantationAbstractPurposeLiving-donor liver transplantations (LDLTs) with maternal grafts can be more successful than those with paternal grafts because of their tolerance to non-inherited maternal antigens. We reviewed LDLT patients to investigate the relationship between acute rejection and donor sex.MethodsLDLT patients between January 2010 and November 2015 were enrolled. ACR was defined by...
Comparative analysis of traumatic esophageal injury in pediatric and adult populationsAbstractPurposeDistribution and outcomes of traumatic injury of the esophagus (TIE) in pediatric versus adult populations are unknown. Our study sought to perform a descriptive analysis of TIE in children and adults.MethodsWe reviewed the National Trauma Data Bank (NTDB) for the years 2010–2015. Demographics, characteristics, and outcomes of pediatric (age < 16 years) and adult TIE patients were described and...
Pediatric thymectomy: a study of national trends in demographics, short-term outcomes, and costAbstractBackgroundThymectomy in pediatric patients is an effective treatment for myasthenia gravis (MG), thymic neoplasms, and other rarer pathologies. It is an uncommon procedure in children and studies have focused on small, single-institution cohorts. We sought to better characterize its use by utilizing a national database.MethodsThe Kids' Inpatient Database was used to identify hospital discharge records...
Clinical characteristics and surgical outcome in children with intussusceptions secondary to pathologic lead points: retrospective study in a single institutionAbstractBackgroundIntussusception secondary to pathologic lead points (PLPs) is a potential surgical emergency and almost all cases need surgery. The aim of this study was to evaluate the clinical manifestations, physical examinations and surgical outcomes of secondary intussusception (SI) caused by PLPs, as well as to improve the diagnosis...
Common pediatric surgical diseases of refugee children: health around warzoneAbstractPurposeWe aim to evaluate the sociodemographic and medical features of child-aged refugee patients and identify their health-related problems.MethodsRefugee children admitted to pediatric surgery department of a teaching hospital during the years 2012–2017 were included. Patients' files were reviewed retrospectively for sociodemographic and medical features.ResultsA total of 254 patients with the mean age of 4.6 ± 4.15 years...
Pediatric penetrating oropharyngeal traumaAuthorsAuthors and affiliationsWeiping LeiJing YuYaqin HuangLi ZhaoJianliang Sun1.2.Open AccessImages in AnesthesiaFirst Online: 14 March 2019738DownloadsA two-year-old male patient presented with penetrating oropharyngeal trauma. He had fallen while eating a corncob skewered by a chopstick. The chopstick had lodged in the roof of the patient's mouth and the corncob occluded the entrance (Figure A). A sagittal computed tomography (CT) image showed the chopstick...
Pediatric penetrating oropharyngeal traumaAuthorsAuthors and affiliationsWeiping LeiJing YuYaqin HuangLi ZhaoJianliang Sun1.2.Open AccessImages in AnesthesiaFirst Online: 14 March 2019738DownloadsA two-year-old male patient presented with penetrating oropharyngeal trauma. He had fallen while eating a corncob skewered by a chopstick. The chopstick had lodged in the roof of the patient's mouth and the corncob occluded the entrance (Figure A). A sagittal computed tomography (CT) image showed the chopstick...
Skeletal muscle fibre swelling contributes to force depression in rats and humans: a mechanically-skinned fibre studyAbstractThis study investigated the effects of fibre swelling on force production in rat and human skinned muscle fibres, using osmotic compression to reverse the fibre swelling. In mechanically-skinned fibres, the sarcolemma is removed but normal excitation–contraction coupling remains functional. Force responses in mechanically-skinned fibres were examined with and without osmotic...
Discs large homolog 1 regulates B cell proliferation and antibody productionXuejiao Dong Xinxin Li Ce Liu Kun Xu Yi Shi Wanli LiuInternational Immunology, dxz046, https://doi.org/10.1093/intimm/dxz046Published: 06 June 2019 Article historyCitePermissions Icon Permissions ShareAbstractAntibody production is resulted from B cell activation and proliferation upon antigen binding. Discs large homolog 1 (Dlg1), a scaffold protein from membrane-associated guanylate-kinase family, has been shown to...
Making Sense of Self: An Autoethnographic Study of Identity Formation for Adolescents in Music TherapyAllison Echard, MMT, MT-BCMusic Therapy Perspectives, miz008,https://doi.org/10.1093/mtp/miz008Published: 05 June 2019CitePermissions Icon Permissions Share AbstractTold through my experiences of working with three teenagers who had mild and moderate developmental disabilities, this autoethnographic study considers identity formation as a core concept in music therapy clinical practice. In doing...
Successful Retrograde Visualization and Recanalization of Chronic Ostial Occlusion of the Left Main Coronary Artery via a Saphenous Vein Graft With the Drilled Balloon TechniqueYakup Balaban, Murat Güçlü ElevliFirst Published June 6, 2019 Case Report https://doi.org/10.1177/1179547619852621Article information AbstractWe are representing a case of successful retrograde recanalization of a chronic ostial occlusive lesion of the left main coronary artery (LMCA) via a saphenous vein graft. A 70-year-old...
Coccygeal Polypoid Eccrine Nevus Presenting as a Skin Tag: Case Report and Review of the LiteratureShow all authorsChristopher G Gibson, Amy M Zidron, Ruby S Gibson, ...First Published June 5, 2019 Case Report https://doi.org/10.1177/1179547619853534Article information AbstractCoccygeal polypoid eccrine nevi (CPEN) are rare, benign, cutaneous polypoid lesions localized to the coccyx region that are characterized by areas of hyperplastic eccrine ducts without hyperhidrosis. We present the case of...
CINCA Syndrome With New NLRP3 Mutation and Unreported Complication of Thyroid CarcinomaShow all authorsFarhad Salehzadeh, Manuchehr Barak, Saied Hosseiniasl, ...First Published June 7, 2019 Case Report https://doi.org/10.1177/1179547619854705Article information Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Chronic infantile neurologic cutaneous and articular syndrome (CINCA) is the most severe phenotype of cryopyrin-associated periodic syndromes (CAPS) and...
Serum Chemerin Levels Correlate With Determinants of Metabolic Syndrome in Obese Children and AdolescentsShow all authorsHong-Jun Ba*, Ling-Ling Xu*, You-Zhen Qin, ...First Published June 5, 2019 Research Article https://doi.org/10.1177/1179556519853780Article information Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractObjectives:This study aimed to investigate serum chemerin concentrations in obese children and adolescents and to investigate the associations of chemerin...
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction patternSimon F. Roy MD Christine J. Ko MD Gilbert W. Moeckel MD, PhD Jennifer M. McNiff MDFirst published: 03 June 2019 https://doi.org/10.1111/cup.13522This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article...
Eruptive ulcerative follicular spicules heralding progression of smouldering multiple myelomaCarlo Tomasini Andrea Michelerio Valeria BrazzelliFirst published: 03 June 2019 https://doi.org/10.1111/cup.13523This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cup.13523.ePDFPDFTOOLS...
A comparative study of Michel's medium versus honey as a transport medium for skin specimens prior to direct immunofluorescence microscopy and antigen mappingSubraminiam Kumudhini Sathish Pai Chythra Rao Raghavendra RaoFirst published: 13 May 2019 https://doi.org/10.1111/cup.13494Read the full textePDFPDFTOOLS SHAREAbstractBackgroundMichel's medium (MM) is currently the recommended transport medium for skin biopsy specimens prior to direct immunofluorescence (DIF) microscopy.ObjectiveTo compare...
Treating Hernias in Ottoman Crete (c. 1670–1760): The Legal Imprint of a Medical ProcedureAntonis Anastasopoulos Christos KyriakopoulosSocial History of Medicine, hkz047,https://doi.org/10.1093/shm/hkz047Published: 05 June 2019CitePermissions Icon Permissions Share SummaryIn Crete, as in the rest of the Ottoman Empire, patients who suffered from hernias and other diseases that required surgery made statements to the court of law that absolved the surgeons of liability in case of death as a result...
A nomogram integrating reverse phase protein array based proteomic signature and clinical variables improves prognostic prediction in non-metastatic breast cancer after surgery Y Junping Q ChannanAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.023, https://doi.org/10.1093/annonc/mdz095.023Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: surgical procedures, operativepatient prognosissurgery specialtybreast cancernomogramchromatography, reverse-phaseIssue...
Design of a protein signature predicting response to neo-adjuvant treatment with chemotherapy combined with bevacizumab in breast cancer patients M H Haugen O C Lingjærde Ø Garred I Hedenfalk N Loman G MillsA-L Borresen-Dale B Naume G M Mælandsmo O EngebråtenAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.022, https://doi.org/10.1093/annonc/mdz095.022Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: chemotherapy regimenimmunologic adjuvantspharmaceutical...
ESR1 mutations are similarly prevalent in newly metastatic and loco-regional recurrence of endocrine-treated breast cancer patients and carry worse prognosis E Nili Gal Yam A Zundelevich M Dadiani A Itay T Sela M GadotS Kahana A Pavlovsky I Barshack B KaufmanAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.021, https://doi.org/10.1093/annonc/mdz095.021Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: mutationbreast cancerIssue Section: Biomarkers,...
Characteristics of circulating tumor DNA (ctDNA) in patients with ER-positive (ER+), HER2-negative (HER2-) metastatic breast cancer (MBC) on different lines of endocrine treatment M K Bos D T Kruger M P H M Jansen J W M Martens E BovenS SleijferAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.020, https://doi.org/10.1093/annonc/mdz095.020Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: breast cancer metastaticgenes, erbb-2receptor, erbb-2her2 negativecirculating...
ERBB2 mRNA as predictor of response to anti-HER2 antibody-drug conjugates (ADC) in breast cancer (BC) G Griguolo F Brasó-Maristany T Pascual N Chic M Vidal B AdamoT Giarratano M V Dieci V Guarneri A PratAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.019, https://doi.org/10.1093/annonc/mdz095.019Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: genes, erbb-2receptor, erbb-2rna, messengerantibodiesbreast cancerIssue Section: Biomarkers, translational...
The clinical impact of substituting multigene assays: Comparative clinical analysis of PAM50-ROR versus 21-gene assay C J Markopoulos L Hochheiser J Hornberger E HytopoulosM C Stoppler M GitlinAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.018, https://doi.org/10.1093/annonc/mdz095.018Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: oncotype dx breast cancer assaypam50 gene expression signatureIssue Section: Biomarkers, translational research...
Secondary mechanisms of anti-HER2 resistance in breast cancer: NF1 as an actionable target B A Duso C Poletti G Curigliano P G Pelicci L MazzarellaAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.017, https://doi.org/10.1093/annonc/mdz095.017Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: genes, erbb-2receptor, erbb-2breast cancerIssue Section: Biomarkers, translational research and precision medicineBackground: HER2-targeting agents are standard...
Are single hormone receptor-positive phenotypes biologically and clinically distinct breast cancer? A population-based study Y Li Y Wu D Yang H Li G RenAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.016, https://doi.org/10.1093/annonc/mdz095.016Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: phenotypehormonesbreast cancerIssue Section: Biomarkers, translational research and precision medicineBackground: Steroid hormone receptors (HRs), estrogen...
Longitudinal HER2 amplification tracked in circulating tumor DNA for therapeutic effect monitoring and prognostic evaluation in patients with breast cancer X Guan Y Niu B Liu C Li L Li Z Yi X Sun H Chen F Ma S LuAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.015, https://doi.org/10.1093/annonc/mdz095.015Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: genes, erbb-2receptor, erbb-2patient prognosisbreast canceramplificationcirculating tumor dnaIssue...
Influence of PIK3CA mutations on breast cancer proliferation, lymphocyte infiltration and clinical outcome: Pooled analysis of 484 patients from three prospective multicentre GBG trials P Jank S Loibl P A Fasching T Karn F Marmé V Mueller C SchemE Stickeler B Lederer C DenkertAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.014, https://doi.org/10.1093/annonc/mdz095.014Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: mutationlymphocytestreatment...
Outcomes of women at high familial risk for breast cancer in Australia: An 8-year single-centre experience J Lammert A R Skandarajah K Shackleton P Calder S ThomasG J Lindeman G B MannAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.013, https://doi.org/10.1093/annonc/mdz095.013Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: australiabreast cancerIssue Section: Biomarkers, translational research and precision medicineBackground: The value of a...
Dynamic monitoring of ctDNA reveals that acquired NF2 mutations confer resistance to HER2 targeted therapy in HER2-mutant breast cancer X Li J Ma B Pan Z Zhao M LiAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.012, https://doi.org/10.1093/annonc/mdz095.012Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: mutationgenes, erbb-2receptor, erbb-2breast cancermolecular targeted therapycirculating tumor dnaIssue Section: Biomarkers, translational research...
Ductal carcinoma in situ of the breast: Immune cell composition according to subtype M C Agahozo M R Van Bockstal F H GroenendijkT P P van den Bosch P Westenend C H M van DeurzenAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.011, https://doi.org/10.1093/annonc/mdz095.011Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: ductal carcinoma in situbreastIssue Section: Biomarkers, translational research and precision medicineBackground: Ductal carcinoma...
Mammographic density change and risk of breast cancer S Azam M Eriksson A Sjölander R Hellgren M Gabrielson K CzeneP HallAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.010, https://doi.org/10.1093/annonc/mdz095.010Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: breast cancer riskIssue Section: Biomarkers, translational research and precision medicineBackground: Mammographic density (MD) is a strong risk factor for breast cancer. We examined the...
Comparison of patient populations identified by different PD-L1 assays in in triple-negative breast cancer (TNBC)M Scott P Scorer C Barker H Al-MasriAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.009, https://doi.org/10.1093/annonc/mdz095.009Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: triple-negative breast cancerprogrammed cell death 1 ligand 1Issue Section: Biomarkers, translational research and precision medicineBackground: TNBC represents...
Para-necrotic expression of VEGFA metagene signature identified by single-cell profiling T Karn C...
Para-necrotic expression of VEGFA metagene signature identified by single-cell profiling T Karn C Denkert K E Weber P Jank A El-Balat A Rody M UntchS Loibl L Pusztai U HoltrichAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.008, https://doi.org/10.1093/annonc/mdz095.008Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: necrosisparityIssue Section: Biomarkers, translational research and precision medicineBackground: We previously identified a VEGFA...
The mutational profile of IBC reveals higher mutational burden, deficiency of homologous recombination and NOTCH signalling S J Van Laere P Finetti C Rypens D Birnbaum P Vermeulen P ViensL Y Dirix F BertucciAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.007, https://doi.org/10.1093/annonc/mdz095.007Published: 13 May 2019PDF Split ViewCitePermissions Icon Permissions Share Topic: signal transductionrecombination, geneticIssue Section: Biomarkers, translational research and precision...
PAM50MET: A prognostic model based on PAM50 and clinical variables in metastatic hormone receptor (HR)-positive/HER2 negative breast cancerA Prat Y-H Tsai T Pascual L Paré M Vidal B Adamo J C Brase S R D Johnston E M Ciruelos J S ParkerAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.006, https://doi.org/10.1093/annonc/mdz095.006Published: 13 May 2019 pdfPDF Split View CitePermissions Icon Permissions ShareTopic: hormone receptors patient prognosis breast cancer her2 negative...
Utility of early circulating tumour DNA dynamics as a surrogate for progression free survival in the BEECH phase I/II trial in metastatic breast cancerS Hrebien; V Citi; I Garcia-Murillas; R Cutts; I Kozarewa ...Annals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.005, https://doi.org/10.1093/annonc/mdz095.005ExtractBackground: Dynamic changes in circulating tumour DNA (ctDNA) levels may predict long-term outcome of therapy. We utilised samples from a phase I/II randomised trial (BEECH)...
TILs in ER+/HER2- breast cancerC Criscitiello; A Vingiani; P Maisonneuve; G Viale; G CuriglianoAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.004, https://doi.org/10.1093/annonc/mdz095.004ExtractBackground: The role of tumor-infiltrating lymphocytes (TILs) in ER+/HER2- breast cancer (BC) is debated. We evaluated the association of TILs and clinico-pathological (CP) features with distant disease-free survival (DDFS) in a large series of patients (pts) with ER+/HER2- BC.Methods:...
Relationship between tumor infiltrating lymphocytes (TILs) and response to pembrolizumab (pembro)+chemotherapy (CT) as neoadjuvant treatment (NAT) for triple-negative breast cancer (TNBC): Phase Ib KEYNOTE-173 trialS Loi; P Schmid; G Aktan; V Karantza; R SalgadoAnnals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.003, https://doi.org/10.1093/annonc/mdz095.003ExtractBackground: Higher stromal TILs (sTILs) are associated with higher pathologic complete response (pCR) rates with CT in...
Comprehensive evaluation of methodology to assess abundance of immune infiltrates in breast cancerI Nederlof; D de Bortoli; Y Bareche; G K J Hooijer; C Sotiriou ...Annals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.002, https://doi.org/10.1093/annonc/mdz095.002ExtractBackground: The immune system is critical in modulating therapeutic sensitivity and tumor progression in breast cancer patients. A plethora of methods exists to evaluate the amount and composition of tumor immune infiltrates...
Prognostic value of endopredict for invasive lobular carcinomas in the combined ABCSG-6/8 and TransATAC trialsI Sestak; M Filipits; R Buus; M Rudas; M Knauer ...Annals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.001, https://doi.org/10.1093/annonc/mdz095.001ExtractBackground: Invasive lobular carcinoma (ILC) accounts for approximately 15% of all breast cancer cases. Most of the correlations between multigene assays and patient outcome were derived from studies based on mixed cohorts...
Prognostic value of endopredict for invasive lobular carcinomas in the combined ABCSG-6/8 and TransATAC trialsI Sestak; M Filipits; R Buus; M Rudas; M Knauer ...Annals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095.001, https://doi.org/10.1093/annonc/mdz095.001ExtractBackground: Invasive lobular carcinoma (ILC) accounts for approximately 15% of all breast cancer cases. Most of the correlations between multigene assays and patient outcome were derived from studies based on mixed cohorts...
BIOMARKERS, TRANSLATIONAL RESEARCH AND PRECISION MEDICINE1ODouble PIK3CA mutations in cis enhance PI3Kα oncogene activation and sensitivity to PI3Kα inhibitors in breast cancerN Vasan; P Razavi; J L Johnson; H Shao; E Reznik ...Annals of Oncology, Volume 30, Issue Supplement_3, May 2019, mdz095, https://doi.org/10.1093/annonc/mdz095ExtractBackground: Activating mutations in PIK3CA, the gene coding for the catalytic subunit (p110α) of phosphoinositide-3-kinase (PI3K), are the most frequent oncogenic...
Vitamin D: should public health recommendations also consider cancer outcomes?A Naska P LagiouAnnals of Oncology, Volume 30, Issue 5, May 2019, Pages 667–668, https://doi.org/10.1093/annonc/mdz089Published: 18 March 2019CitePermissions Icon Permissions ShareIssue Section: EditorialsKeum et al. [1] present a meta-analysis of randomized controlled trials (RCTs) to assess whether vitamin D supplementation (in the form of cholecalciferol or ergocalciferol, with or without other nutrients) can have an...
Enthuse for PERUSE: when clinical judgment overcomes regulatory boundariesV GuarneriAnnals of Oncology, Volume 30, Issue 5, May 2019, Pages 665–667, https://doi.org/10.1093/annonc/mdz091Published: 19 March 2019CitePermissions Icon Permissions ShareIssue Section: EditorialsContemporary treatment of human epidermal growth factor 2 (HER2)-positive breast cancers is a successful example of the rationale development of molecularly targeted therapies. The observation that HER2 overexpression or gene amplification...
Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patientsS B van Waalwijk van Doorn-Khosrovani A Pisters-van Roy L van Saase M van der Graaff J Gijzen S Sleijfer L R Hoes J M van Berge Henegouwen H van der Wijngaart D L van der Velden ... Show moreAnnals of Oncology, Volume 30, Issue 5, May 2019, Pages 663–665, https://doi.org/10.1093/annonc/mdz119Published: 26 April 2019CitePermissions Icon Permissions ShareIssue Section: EditorialsPrecision...
Molecular screening to select therapy for advanced cancer?I F Tannock J A HickmanAnnals of Oncology, Volume 30, Issue 5, May 2019, Pages 661–663, https://doi.org/10.1093/annonc/mdz088Published: 13 March 2019CitePermissions Icon Permissions Share Issue Section: EditorialsIn this issue of Annals of Oncology, Trédan et al. [1] describe the results of the ProfiLER trial, in which 2579 adult and paediatric patients with previously treated metastatic cancer underwent molecular profiling. Next-generation...
Question 1Delayed hypersensitivity reactions to iodinated contrast media will most likely present as which of the following?Stevens–Johnson syndrome/toxic epidermal necrolysis.Maculopapular exanthem.Fixed drug eruption.Acute generalized exanthematous pustulosis.Drug‐related eosinophilia and systemic symptoms.Question 2Which of the following statements is correct concerning the recurrence of delayed hypersensitivity reactions, such as fixed drug eruption and Stevens–Johnson syndrome/toxic epidermal...
Contrast media and cutaneous reactions. Part 2: Delayed hypersensitivity reactions to iodinated contrast mediaF. Tasker H. Fleming G. McNeill D. Creamer S. WalshFirst published: 04 June 2019 https://doi.org/10.1111/ced.13991Conflict of interest: none declared.SummaryContrast media (CM) are an indispensable part of modern medical imaging. Adverse reactions to CM are uncommon, but frequently involve cutaneous symptoms. This two‐part article reviews adverse events secondary to CM that are relevant...
Effect of Everolimus in Treatment of Aggressive Prolactin-Secreting Pituitary Adenomas Dongyun Zhang Jennifer S Way Xinhai Zhang Mareninov SergeyMarvin Bergsneider Marilene B Wang William H YongAnthony P HeaneyThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1929–1936, https://doi.org/10.1210/jc.2018-02461Published: 08 January 2019 Article historyPDF Split ViewCitePermissions Icon Permissions Share AbstractContextAggressive prolactin (PRL)-secreting pituitary...
Somatostatin Receptor Ligand Therapy—A Potential Therapy for NeurocytomaDongyun Zhang Sarah S R Kim Daniel F Kelly Sylvia L Asa Masoud Movassaghi Sergey Mareninov William H Yong Timothy F Cloughesy Fausto J Rodriguez Paul McKeever ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2395–2402, https://doi.org/10.1210/jc.2018-02419Published: 05 February 2019 Article historyCitePermissions Icon Permissions ShareAbstractContextNeurocytoma...
Genetics and Epigenetics of Infertility and Treatments on OutcomesMargareta D Pisarska Jessica L Chan Kate Lawrenson Tania L Gonzalez Erica T WangThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1871–1886, https://doi.org/10.1210/jc.2018-01869Published: 17 December 2018 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractContextInfertility affects 10% of the reproductive-age population. Even the most successful treatments...
How to Position Pasireotide LAR Treatment in AcromegalyEva C Coopmans Ammar Muhammad Aart J van der Lely Joseph A M J L Janssen Sebastian J C M M NeggersThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1978–1988, https://doi.org/10.1210/jc.2018-01979Published: 03 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractContextPasireotide long-acting release (LAR) is a somatostatin multireceptor ligand, and in the current consensus...
Cognitive Dysfunction in Type 1 Diabetes MellitusAnna Shalimova Beata Graff Dariusz Gąsecki Jacek Wolf Agnieszka Sabisz Edyta Szurowska Krzysztof Jodzio Krzysztof NarkiewiczThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2239–2249, https://doi.org/10.1210/jc.2018-01315Published: 18 January 2019 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractContextWe have summarized key studies assessing the epidemiology, mechanisms,...
Endocytosis and Degradation of Pegvisomant and a Potential New Mechanism That Inhibits the Nuclear Translocation of GHRHainan Lan Wei Li Ruonan Li Xin Zheng Gan LuoThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1887–1899, https://doi.org/10.1210/jc.2018-02063Published: 31 December 2018 Article historyCitePermissions Icon Permissions ShareAbstractContextPegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed...
Discordance Between Imaging and Adrenal Vein Sampling in Primary Aldosteronism Irrespective of Interpretation CriteriaDavis Sam Gregory A Kline Benny So Alexander A LeungThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1900–1906, https://doi.org/10.1210/jc.2018-02089Published: 24 December 2018 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractBackgroundSubtyping of primary aldosteronism (PA) using imaging and adrenal...
HLA-DQB1 Position 57 Defines Susceptibility to Isolated and Polyglandular Autoimmunity in Adults: Interaction With GenderAnna U Kraus Marissa Penna-Martinez Firouzeh Shoghi Christian Seidl Gesine Meyer Klaus BadenhoopThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1907–1916, https://doi.org/10.1210/jc.2018-01621Published: 26 December 2018 Article historyCitePermissions Icon Permissions ShareAbstractContextAutoimmune endocrinopathies result from environmental...
Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin: The H2O Metabolism Pilot StudySofia Enhörning Louise Brunkwall Irina Tasevska Ulrika Ericson Jenny Persson Tholin Margaretha Persson Guillaume Lemetais Tiphaine Vanhaecke Alberto Dolci Erica T Perrier ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1917–1925, https://doi.org/10.1210/jc.2018-02195Published: 18 December 2018 Article history pdfPDF ...
Cardiometabolic Effects of Testosterone in Transmen and Estrogen Plus Cyproterone Acetate in TranswomenDaan M van Velzen Alessia Paldino Maartje Klaver Nienke M Nota Justine Defreyne G Kees Hovingh Abel Thijs Suat Simsek Guy T'Sjoen Martin den HeijerThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1937–1947, https://doi.org/10.1210/jc.2018-02138Published: 02 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractContextThe impact...
Analysis of Activating GCM2 Sequence Variants in Sporadic Parathyroid AdenomasAaliyah Riccardi Tori Aspir Lilia Shen Chia-Ling Kuo Taylor C Brown Reju Korah Timothy D Murtha Justin Bellizzi Kourosh Parham Tobias Carling ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1948–1952, https://doi.org/10.1210/jc.2018-02517Published: 08 January 2019 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractContextSporadic,...
Influence of Sodium Glucose Cotransporter 2 Inhibition on Physiological Adaptation to Endurance Exercise TrainingAlissa A Newman Nathan C Grimm Jessie R Wilburn Hayden M Schoenberg S Raj J Trikha Gary J Luckasen Laurie M Biela Christopher L Melby Christopher BellThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1953–1966, https://doi.org/10.1210/jc.2018-01741Published: 28 December 2018 Article historyCitePermissions Icon Permissions ShareAbstractContextThe...
GI Dysfunctions in Diabetic Gastroenteropathy, Their Relationships With Symptoms, and Effects of a GLP-1 AntagonistSubhankar Chakraborty Magnus Halland Duane Burton Anshuman Desai Bridget Neja Phillip Low Wolfgang Singer Michael Camilleri Alan R Zinsmeister Adil E BharuchaThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1967–1977, https://doi.org/10.1210/jc.2018-01623Published: 24 October 2018 Article historyCitePermissions Icon Permissions ShareAbstractContextDelayed...
Proximal HbA1C Level and First Hypoglycemia Hospitalization in Adults With Incident Type 2 DiabetesVictor W Zhong Juhaeri Juhaeri Stephen R Cole Christina M Shay Penny Gordon-Larsen Evangelos Kontopantelis Elizabeth J Mayer-DavisThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1989–1998, https://doi.org/10.1210/jc.2018-01402Published: 03 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractContextHemoglobin A1C (HbA1C) is an important...
Plasma miRNAs Display Limited Potential as Diagnostic Tools for EndometriosisVictoria Nisenblat David J Sharkey Zhao Wang Susan F Evans Martin Healey E Maria C Ohlsson Teague Cristin G Print Sarah A Robertson M Louise HullThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 1999–2022, https://doi.org/10.1210/jc.2018-01464Published: 03 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractContextDespite extensive searches for novel...
Multigene Sequencing Analysis of Children Born Small for Gestational Age With Isolated Short StatureBruna L Freire Thais K Homma Mariana F A Funari Antônio M Lerario Gabriela A Vasques Alexsandra C Malaquias Ivo J P Arnhold Alexander A L Jorge Author NotesThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2023–2030, https://doi.org/10.1210/jc.2018-01971Published: 02 January 2019 Article historyCitePermissions Icon Permissions ShareAbstractContextPatients...
Sex-Specific Risk of Cardiovascular Disease in Autoimmune Addison Disease—A Population-Based Cohort StudyJakob Skov Anders Sundström Jonas F Ludvigsson Olle Kämpe Sophie BensingThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2031–2040, https://doi.org/10.1210/jc.2018-02298Published: 03 January 2019 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractContextLittle is known of cardiovascular disease (CVD) in autoimmune Addison...
The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy DietStefan Z Lutz Anita M Hennige Andreas Peter Marketa Kovarova Charisis Totsikas Jürgen Machann Stefan M Kröber Bianca Sperl Erwin Schleicher Fritz Schick ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2041–2053, https://doi.org/10.1210/jc.2018-01573Published: 12 December 2018 Article history pdfPDF Split View CitePermissions Icon...
Height as a Clinical Biomarker of Disease Burden in Adult Mitochondrial Disease Rachel L Boal Yi Shiau Ng Sarah J Pickett Andrew M SchaeferCatherine Feeney Alexandra Bright Robert W TaylorDoug M Turnbull Grainne S Gorman Tim Cheetham ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2057–2066, https://doi.org/10.1210/jc.2018-00957Published: 13 November 2018 Article historyPDF Split ViewCitePermissions Icon Permissions Share AbstractContextAbnormal...
Height as a Clinical Biomarker of Disease Burden in Adult Mitochondrial DiseaseRachel L Boal Yi Shiau Ng Sarah J Pickett Andrew M Schaefer Catherine Feeney Alexandra Bright Robert W Taylor Doug M Turnbull Grainne S Gorman Tim Cheetham ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2057–2066, https://doi.org/10.1210/jc.2018-00957Published: 13 November 2018 Article history pdfPDF Split View CitePermissions Icon Permissions ShareAbstractContextAbnormal...
Height as a Clinical Biomarker of Disease Burden in Adult Mitochondrial Disease Rachel L Boal Yi Shiau Ng Sarah J Pickett Andrew M SchaeferCatherine Feeney Alexandra Bright Robert W TaylorDoug M Turnbull Grainne S Gorman Tim Cheetham ... Show moreThe Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2057–2066, https://doi.org/10.1210/jc.2018-00957Published: 13 November 2018 Article historyPDF Split ViewCitePermissions Icon Permissions Share AbstractContextAbnormal...
A Population‐based Time Trend Study in the Incidence of Malignant Otitis ExternaYen‐Fu Cheng Tzong‐Han Yang Chuan‐Song Wu Yi‐Wei Kao Ben‐Chang Shia Herng‐Ching LinFirst published: 06 June 2019 https://doi.org/10.1111/coa.13387This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article...
Role of diffusion‐weighted imaging in the discrimination of purulent intrasinusal content: a retrospective studyThomas Radulesco Ugo Scemama Julien Mancini Guy Moulin Patrick Dessi Justin Michel Arthur VaroquauxFirst published: 06 June 2019 https://doi.org/10.1111/coa.13388This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version...
The use of ARTISSTM in performing parotidectomies as day case surgery: a single‐centre review of 31 casesYanish Seeram Poolovadoo Rohini Aggarwal sean loughranFirst published: 05 June 2019 https://doi.org/10.1111/coa.13386This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:...
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,