Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem CellsAbstractMesenchymal stem cells (MSCs) are currently being tested in several clinical trials. Mitochondria regulate many aspects of MSC function. Mitochondrial preproteins are rapidly translated and trafficked into the mitochondrion for assembly in their final destination, but whether coexisting cardiovascular risk factors modulate this process is unknown. We hypothesized that metabolic syndrome (MetS)...
The Therapeutic Potential of Mesenchymal Stromal Cells in the Treatment of Chemotherapy-Induced Tissue DamageAbstractChemotherapy constitutes one of the key treatment modalities for solid and hematological malignancies. Albeit being an effective treatment, chemotherapy application is often limited by its damage to healthy tissues, and curative treatment options for chemotherapy-related side effects are largely missing. As mesenchymal stromal cells (MSCs) are known to exhibit regenerative capacity...
The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral BloodAbstractMobilization of stem cells from bone marrow (BM) into peripheral blood (PB) in response to tissue or organ injury, infections, strenuous exercise, or mobilization-inducing drugs is as we postulated result of a "sterile inflammation" in the BM microenvironment that triggers activation of the Complement Cascade (ComC). Therefore, we became interested in the role of the Nlrp3 inflammasome...
Targeting T Cell Malignancies Using CD4CAR T-Cells and Implementing a Natural Safety SwitchAbstractT cell malignancies are aggressive diseases with no standard treatment available, often resulting in poor patient outcomes. Lately, the recent FDA approval of a CD19 CAR T cell therapy for B cell acute lymphoblastic leukemia has earned nationwide attention, leading to the possibility that success of CD19 CAR therapy can be extended to T cell malignancies. However, the impact of T cell depletion due...
Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem CellsAbstractStem cell aging underlies aging-associated disorders, such as steeply increased incidences of tumors and impaired regeneration capacity upon stress. However, whether and how the intestinal stem cells age remains largely unknown. Here we show that intestinal stem cells derived from 24-month-old mice hardly form typical organoids with crypt-villus structures, but rather mainly form big, rounded cysts...
Gelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after...
Gelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after Myocardial InfarctionAbstractBackgroundAcute myocardial infarction (AMI) and the ensuing ischemic heart disease are approaching an epidemic state. Limited stem cell retention following intracoronary administration has reduced the clinical efficacy of this novel therapy. Polymer based cell coating is biocompatible and has been shown to be safe. Here, we assessed the therapeutic utility of gelatin-based...
Evolving Definition of Adult Stem/Progenitor CellsOne-Year Observation of the SCID-Repopulating Cell Activities of Human Cord Blood-Derived CD34-Positive and -Negative Hematopoietic Stem CellsGelatin Based Polymer Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after Myocardial InfarctionAbstractBackgroundAcute myocardial infarction (AMI) and the ensuing ischemic heart disease are approaching an epidemic state. Limited stem cell retention following intracoronary administration...
Gossypol but not cottonseed extracts or lipopolysaccharides stimulates HuR gene expression in mouse cellsPublication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Heping Cao, Kandan SethumadhavanAbstractHuman antigen R (HuR) stabilizes cytokine mRNAs and plays an important role in tumorigenesis and inflammation. Plant extracts and compounds that can regulate HuR gene expression may have nutritional and therapeutic value, but little research has been done in this area....
Appraisal of Urban Heat Island Detection of Peshawar Using Land Surface Temperature and Its Impacts on EnvironmentAbstractLast couple of decades witnessed a rapid escalation in urban temperature of Peshawar city and its neighboring localities. This alarming condition gave birth to climatic term urban heat island-created drastic alteration in surface temperatures. In this study, thermal infrared remote sensing data have been employed to map out and monitor such micro-climatic variation in temperatures...
Accademia dei Lincei was founded in 1603 by Marchese Federico Cesi. The Linceo (lynx) was chosen as the symbol of the institution, because of the presumed keenness of its eye. The aim of the Accademia was, and still is, the study of scientific disciplines from a global point of view, and the fostering of cooperation among researchers in any field all over the world. Some 540 members, both Italian and non-Italian, belong to the Accademia, and are grouped into two classes: Scienze Matematiche, Fisiche...
Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 UpregulationAtsuko Hayata-Takano, Toshihiko Kamo, Harui Kijima, Kaoru Seiriki, Katsuya Ogata, Yukio Ago, Takanobu Nakazawa, Yusuke Shintani, Kosuke Higashino, Kazuki Nagayasu, Norihito Shintani, Atsushi Kasai, James A. Waschek and Hitoshi HashimotoJournal of Neuroscience 29 May 2019, 39 (22) 4208-4220; DOI: https://doi.org/10.1523/JNEUROSCI.2468-18.2019ArticleFigures & DataInfo...
Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET CoactivationCátia P. Frias, Jian Liang, Tom Bresser, Lisa Scheefhals, Matthijs van Kesteren, René van Dorland, Hai Yin Hu, Anna Bodzeta, Paul M.P. van Bergen en Henegouwen, Casper C. Hoogenraad and Corette J. WierengaJournal of Neuroscience 29 May 2019, 39 (22) 4221-4237; DOI: https://doi.org/10.1523/JNEUROSCI.0215-19.2019ArticleFigures & DataInfo & MetricseLetters PDFAbstractChanges in...
Quality of life in pre- and postmenopausal patients with early breast cancer: a comprehensive analysis from the prospective MaLife projectAbstractPurposeQuality of life (QoL) plays an important role in recovery—especially after an incisive diagnosis such as breast cancer. Here, we present a comprehensive assessment of QoL for pre- and postmenopausal patients, starting from initial systemic treatment of early breast cancer until 3 years later, in patients from a so-called "real-world" setting.Methods251...
The effect of scalp cooling on CIA-related quality of life in breast cancer patients: a systematic reviewAbstractPurposeChemotherapy-induced alopecia (CIA) remains a distressing adverse event of cancer treatment but may be prevented by scalp cooling. The effectiveness of scalp cooling, however, is dependent on the chemotherapy regimen with successful hair preservation (i.e., < 50% hair loss) in 41–59% of women on taxane-based therapies in comparison to 16–36% on anthracycline-based therapies....
SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinomaAbstractPurposeInvasive lobular carcinoma (ILC) is a histological subtype of breast cancer that is predominantly estrogen receptor alpha (ER)-positive (+) and is thus treated with endocrine therapies. Herein, we sought to understand the molecular underpinnings of the 4-hydroxytamoxifen (4OHT) resistance in ILC by assessing the potential role of the epithelial-to-mesenchymal transition transcription factor...
Loss of HER2 after HER2-targeted treatmentAbstractPurposeHER2 expression has been reported to be discordant between primary tumor and metastatic tissue.Patients and methodsHER2 discordance and relation to HER2-targeted treatment was investigated in 227 patients with primary breast cancer.ResultsHER2 discordance between primary biopsy and second biopsy after neoadjuvant or adjuvant treatment was observed in 20.7%. This discordance was related only to the use of HER2-targeted treatment: 30 of 33 (90.9%)...
Incidence of peripheral edema in patients receiving PI3K/mTOR/CDK4/6 inhibitors for metastatic breast cancerAbstractPurposeThis study evaluated development of edema in patients receiving PI3K/mTOR/CDK4/6 targeted therapy for metastatic breast cancer (MBC).MethodsWe reviewed medical records of 160 patients receiving targeted therapy with PI3K/mTOR/CDK4/6 inhibitors to treat MBC (n = 160; 185 treatment occurrences). Clinicopathologic data, treatment details, and edema incidence were recorded.ResultsEdema...
Risk of ipsilateral breast tumor recurrence in primary invasive breast cancer following breast-conserving surgery with BRCA1 and BRCA2 mutation in ChinaAbstractPurposeBRCA1/2 germline mutations are associated with a high risk of breast cancer, which may preclude mutation carriers from breast-conserving surgery (BCS). This study retrospectively examined whether mutation status influenced the rate of ipsilateral breast tumor recurrence (IBTR) after BCS in Chinese women.MethodsPatients who underwent...
Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetesAbstractPurposeTo address the possible association between the use of metformin, other forms of antidiabetic medication (ADM) and statins with the incidence of breast cancer in women with type 2 diabetes (T2D).MethodsData were collected from a Finnish nationwide diabetes database (FinDM). The study cohort consisted of women diagnosed with T2D in 1996–2011 in Finland. In full-cohort analysis,...
Influence of adherence to adjuvant endocrine therapy on disease-free and overall survival: a population-based study in Catalonia, SpainAbstractObjectiveTo assess adherence to endocrine therapy and its relation to recurrence and mortality in women with early breast cancer.MethodsThis is a retrospective cohort study in population-based cancer registries in two Catalonian provinces of Spain. We included all cases of invasive stage I–III breast cancer diagnosed from 2007 to 2011 and with follow-up to...
4-Hydroxytamoxifen enhances sensitivity of estrogen receptor α-positive breast cancer to docetaxel in an estrogen and ZNF423 SNP-dependent fashionAbstractPurposeIn early stage, ERα-positive breast cancer, concurrent use of endocrine therapy and chemotherapy has not been shown to be superior to sequential use. We hypothesized that genetic biomarkers can aid in selecting patients who would benefit from chemo-endocrine therapy. Our previous studies revealed that ZNF423 is a transcription factor for...
Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancerAbstractPurposeTriple-negative breast cancer (TNBC) lacks the receptor targets estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, and thus, it does not respond to receptor-targeted treatments. TNBC has higher recurrence, metastasis, and mortality rates than other subtypes of breast cancer. Mounting data suggest that the MAPK (also known as...
On Why Mathematics Can Not be OntologyAbstractThe formalism of mathematics has always inspired ontological theorization based on it. As is evident from his magnum opus Being and Event, Alain Badiou remains one of the most important contemporary contributors to this enterprise. His famous maxim—"mathematics is ontology" has its basis in the ingenuity that he has shown in capitalizing on Gödel's and Cohen's work in the field of set theory. Their work jointly establish the independence of the continuum...
A Note on Carnap's Result and the ConnectivesAbstractCarnap's result about classical proof-theories not ruling out non-normal valuations of propositional logic formulae has seen renewed philosophical interest in recent years. In this note I contribute some considerations which may be helpful in its philosophical assessment. I suggest a vantage point from which to see the way in which classical proof-theories do, at least to a considerable extent, encode the meanings of the connectives (not by determining...
Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancerAbstractPurposeTriple-negative breast cancer (TNBC) lacks the receptor targets estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, and thus, it does not respond to receptor-targeted treatments. TNBC has higher recurrence, metastasis, and mortality rates than other subtypes of breast cancer. Mounting data suggest that the MAPK (also known as...
Erratum to: Purification and Characterization of β-Glucosidase Produced by Trichoderma Citrinoviride Cultivated on Microalga Chlorella VulgarisThe article is published in the original.Biotransformation of Glycoginsenosides to Intermediate Products and Aglycones using a Hemicellulosome Produced by Cellulosimicrobium cellulanAbstractGinsenosides Rb1, Rb2 and Re were converted into corresponding intermediates and aglycones using a multienzyme complex produced by Cellulosimicrobium cellulans F16. The...
ECG Consult: 63yo Female, Onset of Weakness while CleaningJEMS ECG of the Month: May 2019Wed, May 29, 2019 By John Hayden, MD, EdD, FACEP , Jonathan Barney, BA, EMT, MS3A 63-year-old female complains of a gradual onset of weakness while cleaning as well as, fatigue, nausea and epigastric discomfort.ByJohn Hayden, MD, EdD, FACEPJ. William Hayden, MD, EdD, FACEP, has practiced emergency medicine for more than 28 years in rural and urban hospitals, university medical centers, and single as well as large...
A Push for Push Dose EpinephrinePrehospital use of push dose epinephrine for hypotension By Sammy Hodroge, MD , Amelia Breyre, MDStarting in 2018, push dose epinephrine replaced dopamine as the vasopressor of choice for the management of prehospital shock in Alameda County, California. You transport a 79-year-old woman to the hospital for fever and urinary incontinence. Her family mentions a history of frequent urinary tract infections. Her initial vital signs are a heart rate of 115 bpm,...
Use of Antihypotensive Medications in Shock Patients By Robert P. Girardeau, BS, NREMT-P, FP-C Robert GirardeauAre you still going to reach for that dopamine with this patient in obvious septic shock? Photo Kevin Link LEARNING Objectives Learn how antihypotensive medications work. Identify the main antihypotensive medications (inotropes and vasopressors) that can be used to treat patients suffering from end-organ hypoperfusion. Understand how and when to administer antihyoptensive medications.Key TermsAdrenergic: Chemicals...
Push Dose Epinephrine as a Temporizing Measure for Drugs Causing HypotensionMon, Sep 15, 2014 By William Selde, MD You transport a 55-year-old male to the hospital on continuous positive airway pressure (CPAP) for respiratory distress and fever. Initially, the CPAP at a pressure of 10 cm of water improved the patient's oxygen saturation from 73% to 93%. An IV is established and a bolus of normal saline is started. During transport the patient has increasing difficulty keeping his eyes open....
Stop the Bleed & Start the HeartTeaching Texas middle schoolers to 'see something & do a lot'Thu, May 23, 2019 By Ashley Hoppe, BBA, NREMT , Courtney Nesloney, RN, BSN , Kelsey Brown, AS , Elizabeth Dillard, BA, NREMT , Harry "Steve" Stevenson, MPA, NREMT Smithson Valley Middle School students in Spring Branch, Texas, learned to Stop the Bleed and Start the Heart.Smithson Valley Middle School students in Spring Branch, Texas, learned to Stop the Bleed and Start the Heart.On June 14, 2014,...
Three Pillars for Pediatric Resuscitation SuccessWed, Feb 27, 2019 By Peter Antevy, MD, MPH EMS leadership and their communication center counterparts should review all pediatric arrest calls within 72 hours to better understand and correct issues that may exist. Photo Chris SwabbEMS leadership and their communication center counterparts should review all pediatric arrest calls within 72 hours to better understand and correct issues that may exist. Photo Chris Swabb Data from the American...
Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticlesKunneng Liang, Suping Wang, Siying Tao, Shimeng Xiao, Han Zhou, Ping Wang, Lei Cheng, Xuedong Zhou, Michael D. Weir, Thomas W. Oates, Jiyao Li & Hockin H. K. Xu International Journal of Oral Science 11, Article number: 15 (2019) | Download CitationAbstractTooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There...
Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to applicationYuezhi Lu, Wenjie Zhang, Jie Wang, Guangzheng Yang, Shi Yin, Tingting Tang, Chunhua Yu & Xinquan Jiang International Journal of Oral Science 11, Article number: 17 (2019) | Download CitationAbstractBone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage–subchondral bone complex defects caused by trauma...
Strontium stimulates alkaline phosphatase and bone morphogenetic protein-4 expression in rat chondrocytes cultured in vitroPublication date: September 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 55Author(s): Jinfeng Zhang, Xiaoyan Zhu, Yezi Kong, Yan Huang, Xukun Dang, Linshan Mei, Baoyu Zhao, Qing Lin, Jianguo WangAbstractThe trace element strontium has a significant impact on cartilage metabolism. However, the direct effects of strontium on alkaline phosphatase (ALP),...
Issue competition on social media in China: The interplay among media, verified users, and unverified usersPublication date: July 2019Source: Telematics and Informatics, Volume 40Author(s): Pianpian WangThe bifurcation of the Nigerian cybercriminals: Narratives of the Economic and Financial Crimes Commission (EFCC) agentsPublication date: July 2019Source: Telematics and Informatics, Volume 40Author(s): Suleman Lazarus, Geoffrey U. OkolorieAbstractWhile this article sets out to advance our knowledge...
School performance, social networking effects, and learning of school children: Evidence of reciprocal relationships in Abu DhabiAuthor links open overlay panelMasoodBadriaAli AlNuaimibYangGuangbAsma AlRashedibaAbu Dhabi Education Council and UAE University, Khalifa Park Abu Dhabi, United Arab EmiratesbAbu Dhabi Education Council, United Arab EmiratesReceived 1 May 2017, Accepted 11 June 2017, Available online 16 June 2017.Show lesshttps://doi.org/10.1016/j.tele.2017.06.006Get rights and contentUnder...
Aluminium in brain tissue in autismAuthor links open overlay panelMatthewMoldaDorcasUmarbAndrewKingcChristopherExleyaaThe Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, United KingdombLife Sciences, Keele University, Staffordshire, ST5 5BG, United KingdomcDepartment of Clinical Neuropathology, Kings College Hospital, London, SE5 9RS, United Kingdomhttps://doi.org/10.1016/j.jtemb.2017.11.012Get rights and contentUnder a Creative Commons licenseopen accessAbstractAutism...
Treatment for lymphedema following head and neck cancer therapy: A systematic reviewAuthor links open overlay panelAlbinaTykeraJoelFrancobSean T.MassacShaun C.DesaidScott G.WalenbaSaint Louis University School of Medicine, 1402 S Grand Blvd, St. Louis, MO 63104, United States of AmericabSaint Louis University Department of Otolaryngology, 3665 Vista Ave, St. Louis, MO 63110, United States of AmericacWashington University in Saint Louis Department of Otolaryngology, 1 Barnes-Jewish Hospital Plaza,...
What is the evidence for cannabis use in otolaryngology?: A narrative reviewAuthor links open overlay panelWilliam L.ValentinoaBrianMcKinnonbaDepartment of Surgery, Temple University Hospital, United States of AmericabDepartment of Otolaryngology - Head and Neck Surgery, Department of Neurosurgery, Drexel University College of Medicine, United States of AmericaReceived 20 May 2019, Available online 30 May 2019.Show lesshttps://doi.org/10.1016/j.amjoto.2019.05.025Get rights and contentAbstractObjectivesReview...
Evaluating a Fully Automated Pulmonary Nodule Detection Approach and Its Impact on Radiologist PerformanceKai Liu, Qiong Li, Jiechao Ma, Zijian Zhou, Mengmeng Sun, Yufeng Deng, Wenting Tu, Yun Wang, Li Fan, Chen Xia, Yi Xiao, Rongguo Zhang, Shiyuan LiuAuthor AffiliationsFrom the Department of Radiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Rd, Shanghai, China 20003 (K.L., Q.L., W.T., Y.W., L.F., Y.X., S.L.); and Infervision Advanced Institute, Beijing, China (J.M.,...
Fully Automated Diagnosis of Anterior Cruciate Ligament Tears on Knee MR Images by Using Deep LearningFang Liu* , Bochen Guan*, Zhaoye Zhou, Alexey Samsonov, Humberto Rosas, Kevin Lian, Ruchi Sharma, Andrew Kanarek, John Kim, Ali Guermazi, Richard Kijowski* F.L. and B.G. contributed equally to this work.Author AffiliationsFrom the Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53705 (F.L., B.G., A.S., H.R., K.L., R.S., A.K.,...
The Rebirth of CAD: How Is Modern AI Different from the CAD We Know?Luke Oakden-RaynerAuthor AffiliationsFrom the Department of Radiology, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia 5000; School of Public Health, University of Adelaide, Adelaide, Australia; and Australian Institute for Machine Learning, Adelaide, Australia.Address correspondence to the author (e-mail: luke.oakden-rayner@adelaide.edu.au).Published Online:May 29 2019https://doi.org/10.1148/ryai.2019180089PDFToolsShareComputer-aided...
EditorialWill Artificial Intelligence Replace Radiologists? Artificial intelligence algorithms will not replace radiologists but will modify the work of radiologists. Curtis P. LanglotzOriginal ResearchDetection and Classification of Myocardial Delayed Enhancement Patterns on MR Images with Deep Neural Networks: A Feasibility Study Deep learning with deep neural networks can detect the presence of myocardial delayed enhancement (MDE) on cardiovascular MR images and may obtain the ability to classify...
A comprehensive review of surgical margin in oral squamous cell carcinoma highlighting the significance of tumor-free surgical marginsMamata Kamat, Bhagawan Das Rai, Rudrayya S Puranik, Uma Vasant DatarJournal of Cancer Research and Therapeutics 2019 15(3):449-454Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, and surgery is the most accepted line of treatment. The surgical margins (SMs) or resection margins are boundaries of resection specimen excised by the...
Molecular characterization of metastasizing ameloblastoma: A comprehensive reviewAnjali P Ganjre, Gargi Sarode, Sachin SarodeJournal of Cancer Research and Therapeutics 2019 15(3):455-462Metastasizing ameloblastoma (MA) is a very rare odontogenic tumor with 2% of incidence rate. It exhibits benign histopathological features and malignant intrinsic quality in the form of metastasis which makes it a little more than a pathological curiosity. Various molecular aspects related with malignant behavior...
Oral submucous fibrosis: An enigmatic morpho-insightAlka Harish Hande, Minal S Chaudhary, Madhuri N Gawande, Amol R Gadbail, Prajakta R Zade, Shree Bajaj, Swati K Patil, Satyajit TekadeJournal of Cancer Research and Therapeutics 2019 15(3):463-469Oral submucous fibrosis (OSMF) is a chronic progressive, scarring disease affecting oral, oropharyngeal, and sometimes the esophageal mucosa. It is characterized by the progressive fibrosis of the submucosal tissue. The pathogenesis of OSMF has been directly...
Kilovoltage cone-beam computed tomography imaging dose estimation and optimization: Need of daily cone-beam computed tomographyGaurav Trivedi, Chandra K Dixit, Arun S Oinam, Rakesh Kapoor, Amit BahlJournal of Cancer Research and Therapeutics 2019 15(3):470-474Aim: The aim of the present study was to access the need of daily cone-beam computed tomography (CBCT) and the requirement of in-house protocols of image acquisition frequency to reduce unnecessary exposure to the patients undergoing radiotherapy...
Optimization of low-energy electron beam production for superficial cancer treatments by Monte Carlo codeRana Akbarpoor, Navid Khaledi, Xufei Wang, Farhad SamieiJournal of Cancer Research and Therapeutics 2019 15(3):475-479Context: Low energy electron beam has been being used widely for superficial cancer treatments. In the current study a design for production of very low energy electron beam, by different thickness of Perspex spoilers, is presented that may be used for skin cancer. Aims: MCNPX...
Development of α-tocopherol surface-modified targeted delivery of 5-fluorouracil-loaded poly-D, L-lactic-co-glycolic acid nanoparticles against oral squamous cell carcinomaSaurabh Srivastava, Shalini Gupta, Shadab Mohammad, Irfan AhmadJournal of Cancer Research and Therapeutics 2019 15(3):480-490Objective: The aim of the study to develop surface modified targeted moiety α-tocopherol (α-t) encapsulated with 5-fluorouracil (5-FU)-poly-D, L-lactic-co-glycolic acid nanoparticles (PLGA NPs) toward the...
A Monte Carlo study on dose perturbation due to dental restorations in a 15 MV photon beamMona Azizi, Ali Asghar Mowlavi, Mehdi Ghorbani, Courtney Knuap, Marziyeh BehmadiJournal of Cancer Research and Therapeutics 2019 15(3):491-497Aim: The main purpose of this study is to evaluate the effect of dose perturbation due to common dental restoration materials in the head and neck radiotherapy with a 15 MV external photon beam. Setting and Design: Teeth with three dental restorations such as tooth filled...
Analysis of induced error by susceptibility effect in low-density gel dosimetersFarideh Pak, Vahid Vaezzadeh, Ehsan Eqlimi, Mona MirheydariJournal of Cancer Research and Therapeutics 2019 15(3):498-503Purpose: In low-density (LD) gel dosimeter, diffusive spin–spin relaxation rate (R2)-dispersion caused by susceptibility-induced internal gradient leads to a significant deviation in the measured R2 from the real value. In this study, the effect of induced internal gradient on R2 was visualized and...
Improvement of dose distribution in ocular brachytherapy with 125I seeds 20-mm COMS plaque followed to loading of choroidal tumor by gold nanoparticlesMansour Zabihzadeh, Hadi Rezaee, Seyed Mohammad Hosseini, Mostafa Feghhi, Amir Danyaei, Mojtaba Hoseini-GhahfarokhiJournal of Cancer Research and Therapeutics 2019 15(3):504-511Aims and Objectives: Brachytherapy using removable ophthalmic plaques loaded with suitable small sealed radioactive seeds adjacent to the ocular's tumor has been widely used...
Murine experimental leprosy: Evaluation of immune response by analysis of peritoneal lavage cells and footpad histopathologyFátima Regina Vilani‐Moreno Adriana Sierra Assêncio Almeida Barbosa Beatriz Gomes Carreira Sartori Suzana Madeira Diório Sônia Maria Usó Ruiz Silva Patrícia Sammarco Rosa … See all authorsFirst published: 24 May 2019 https://doi.org/10.1111/iep.12319Read the full textePDFPDFTOOLS SHARESummaryThis study evaluated the immune response of nude and BALB/c mice inoculated in...
Radioprotective effect of grape seed extract against gamma irradiation in mouse bone marrow cellsReza Ghasemnezhad Targhi, Amin Banaei, Valiallah SabaJournal of Cancer Research and Therapeutics 2019 15(3):512-516Introduction: Ionizing radiations produce free radicals which are often responsible for DNA damage or cell death. Grape seed extract (GSE) is a natural compound having an antioxidant that protects DNA, lipids, and proteins from free radical damages. In this study, radioprotective effect of...
A comprehensive review of surgical margin in oral squamous cell carcinoma highlighting the significance of tumor-free surgical marginsMamata Kamat, Bhagawan Das Rai, Rudrayya S Puranik, Uma Vasant DatarJournal of Cancer Research and Therapeutics 2019 15(3):449-454Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, and surgery is the most accepted line of treatment. The surgical margins (SMs) or resection margins are boundaries of resection specimen excised by the...
Radiochemotherapie des Zervixkarzinoms Zusammenfassung Die primäre kombinierte Radiochemotherapie...
Radiochemotherapie des ZervixkarzinomsZusammenfassungDie primäre kombinierte Radiochemotherapie ist Standard beim lokal fortgeschrittenen und nodal positivem Zervixkarzinom. Eine Kombination aus radikaler Hysterektomie und Radiochemotherapie sollte vermieden werden. Bei histologisch gesicherten Lymphknotenmetastasen paraaortal wird mit EFRT („extended field radiation therapy") eine exzellente lokale Kontrolle erzielt, die Hälfte der Betroffenen erreicht ein Langzeitüberleben. Die neoadjuvante Chemotherapie...
Lokale Therapie des NierenzellkarzinomsZusammenfassungZielZiel der Arbeit ist es, eine Übersicht über den aktuellen Stand in der lokalen Therapie des lokalisierten Nierenzellkarzinom zu geben.Material und MethodenEs wurden die aktuelle Literatur sowie die Leitlinien in der Behandlung des Nierenzellkarzinoms analysiert.ErgebnisseGoldstandard beim lokalisierten Nierenzellkarzinom ist die operative Resektion des Tumors im Gesunden. Die organerhaltende Nierenteilresektion sollte im klinischen Stadium...
Systemtherapie des NierenzellkarzinomsZusammenfassungHintergrundDie medikamentöse Behandlung des metastasierten Nierenzellkarzinoms (mRCC) hat sich in der letzten Dekade massiv verändert und wird sich weiterhin verändern.ZielIm Folgenden soll ein Überblick über die gegenwärtige und zukünftige Behandlungssituation dargestellt werden.Material und MethodenDie Übersicht wurde unter Beachtung, Recherche und kritischer Interpretation der relevanten Phase-II- und -III-Studien (PubMed) sowie aktueller Kongressbeiträge...
Neue Therapieansätze beim metastasierten NierenzellkarzinomZusammenfassungHintergrundDie medikamentöse Therapie des metastasierten Nierenzellkarzinoms (mNZK) basiert derzeit auf Tyrosinkinaseinhibitoren (TKI), „mechanistic target of rapamycin"(mTOR)-Inhibitoren und Immun-Checkpoint-Inhibitoren (ICI). Aktuell belegen Phase-III-Daten eine überlegene Wirksamkeit der Kombination von TKI + ICI bzw. von verschiedenen ICI im Vergleich zu bisherigen Monotherapien in der Erstlinie.Ziel der ArbeitIm Rahmen...
Bildgebung bei NierenzellkarzinomZusammenfassungHintergrundDurch die Zunahme der Ultraschalluntersuchungen und der gleichzeitigen Verbesserung von Labortests (Blutnachweis im Urin) werden heute weiterführende bildgebende Verfahren angewandt, um unklare Läsionen der Nieren weiter abzuklären. Auf der anderen Seite führen bessere Ultraschallgeräte und die Einführung von Ultraschallkontrastmitteln (Ultraschall-KMl) zu einer deutlichen Verbesserung der Ultraschalluntersuchungen mit einer Zunahme an Nachweisraten...
NierenzellkarzinomErratum zu: Bildgebung bei NierenzellkarzinomErratum zu:Onkologe 2019https://doi.org/10.1007/s00761-019-0536-yLeider sind durch ein Versehen die Legenden der Abb. 2 und 3 vertauscht worden. Nachstehend sehen Sie die beiden Abbildungen mit den richtigen Legenden. Der Originalbeitrag wurde korrigiert. Wir bitten den Fehler zu …Viel Neues in Diagnostik und Therapie des NierenzellkarzinomsBildgebung bei NierenzellkarzinomZusammenfassungHintergrundDurch die Zunahme der Ultraschalluntersuchungen...
A Foundational Framework for Andragogy in Oral and Maxillofacial Surgery II: Interactive Andragogies...A Foundational Framework for Andragogy in Oral and Maxillofacial Surgery II: Interactive AndragogiesEric R. Carlson, DMD, MD, EdM ∗,∗,'Correspondence information about the author DMD, MD, EdM Eric R. CarlsonEmail the author DMD, MD, EdM Eric R. Carlson, R. John Tannyhill, DDS, MD †DOI: https://doi.org/10.1016/j.joms.2019.01.054 |AbstractFull TextReferencesInteractive andragogies have been effectively...
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,