International Collaborative Assessment of the Validity of the EAONO-JOS Cholesteatoma Staging System
Objective: Assessment of validity of the Japanese Otological Society and the European Academy of Otology and Neurotology (EAONO–JOS) cholesteatoma staging system (EJS) through international collaboration to investigate: (a) feasibility of retrospectively staging previously acquired data, (b) strengths and weaknesses of the staging system. Method: Nine centers with prospective cholesteatoma databases were recruited. Cases were allocated to EJS Stage at each center using details from time of...
Wed Mar 13, 2019 02:00
Background: Postoperative imaging studies by numerous groups have revealed that final cochlear implant (CI) electrode position impacts audiological outcomes with scalar location consistently shown to be a significant factor. Modiolar proximity has been less extensively studied, and findings regarding the effect of insertion depth have been inconsistent. Methods: Using previously developed automated algorithms, we determined CI electrode position in an Institutional Review Board-approved database...
Wed Mar 13, 2019 02:00
Objective: To report the incidence of vestibular migraine (VM) in patients with Ménière's disease (MD) and investigate whether management outcomes of MD differ by the association of VM. Study Design: Retrospective cohort study. Setting: Tertiary care academic center. Patients: MD patients (n = 251) with/without VM who were managed for 5 years in a dizziness clinic. Main Outcome Measures: Influence of VM on management outcomes and hearing at the latest follow-up in stepwise...
Wed Mar 13, 2019 02:00
Objective: To determine the effect of cochlear coverage on audiological and speech parameters in patients with cochlear implants. Previous work has investigated the effect of tailoring electrode size to a cochlear implant recipient's individual cochlear duct length (CDL). However, no clear relationship has been found between speech development and the extent of electrode insertion, and the benefits of apical stimulation are not yet clear. Methodology: In this retrospective study, we assessed...
Thu Mar 07, 2019 02:00
Objective: To confirm the efficacy and safety of AM-111 (brimapitide), a cell-penetrating c-Jun N-terminal Kinase (JNK) inhibitor, in patients suffering from severe to profound acute unilateral idiopathic sudden sensorineural hearing loss (ISSNHL). Study design: Prospective, double-blind, randomized, placebo-controlled phase 3 study with follow-up visits on Days 3, 7, 28, and 91. Setting: Fifty-one European and Asian sites (tertiary referral centers, private ENT practices). Patients:...
Tue Mar 05, 2019 02:00
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,