Visible Light Reductive Cyclization of Unactivated Alkyl Chlorides with Tethered Alkenes

The chemical inertness of abundant and commercially available alkyl chlorides precludes their widespread use as reactants in chemical transformations. In this work, we present a metallaphotoredox methodology to achieve the catalytic intramolecular reductive cyclization of unactivated alkyl chlorides with tethered alkenes. The cleavage of strong Csp3‐Cl bonds is mediated by a highly nucleophilic low‐valent cobalt or nickel intermediate generated via visible light photoredox reduction employing a copper photosensitizer. The high basicity and multidentate nature of the ligands are key to obtain efficient metal catalysts for the functionalization of unactivated alkyl chlorides

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