The Role of NMDA Receptors in Alzheimer's Disease.

Related Articles

The Role of NMDA Receptors in Alzheimer's Disease.

Front Neurosci. 2019;13:43

Authors: Liu J, Chang L, Song Y, Li H, Wu Y

Abstract
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.

PMID: 30800052 [PubMed]

from A via a.sfakia on Inoreader https://ift.tt/2BWmrzQ