Skull base juvenile psammomatoid ossifying fibroma: clinical characteristics, treatment and prognosis.

Skull base juvenile psammomatoid ossifying fibroma: clinical characteristics, treatment and prognosis.

World Neurosurg. 2019 Feb 08;:

Authors: Wang K, Ma XJ, Hao SY, Du J, Zhang LW, Zhang JT, Wu Z

Abstract
OBJECTIVES: The diagnosis and management for juvenile psammomatoid ossifying fibroma of the skull base (JPOF) are challenging, and clinical data is limited.
PATIENTS AND METHODS: A retrospective review of the JPOF was performed, and the clinical characteristics, treatment strategy and prognosis were analyzed.
RESULTS: There were 23 patients pathologically confirmed with JPOF, most of which (19/23, 82.6%) were located at the skull base area; and 43.5% of those tumors presented with dura matter breakthrough. The majority of the chief complaints were of headache (8 cases, 34.8%) and visual impairment (5 cases, 21.7%). Most of the tumors were solid tumors with spherical appearance, frequently accompanied by cysts of various size (14 cases, 60.9%). Craniotomy, mostly via the frontal approach, was the most common approach in the present series, comprising 73.6% (17/23) of all cases. The endoscopic endonasal approach was performed in 6 (26.1%) cases. In total, 62.5% patients (15/23) underwent gross total resection, 8.7% patients (2/23) underwent subtotal resection, and 26.1% patients (6/23) underwent partial resection. After a mean follow up of 66.1±36.1 (3-124) months, 3 (13.6%) patients suffered from tumor recurrence with a mean recurrence time of 13 months.
CONCLUSIONS: The present series of skull base JPOFs showed that radical surgery combined with skull base reconstruction contributed to overall good prognosis. Further studies are needed to evaluate the long-term outcomes, as well as to characterize its pathological characteristics.

PMID: 30743026 [PubMed - as supplied by publisher]

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