Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis, Published online: 27 February 2019; doi:10.1038/s41467-019-08811-z

Perivascular cells are essential to the formation and stabilization of new blood vessels during angiogenesis. Here, Hess and Kelly-Goss et al. show that the stem cell pluripotency factor Oct4 promotes perivascular cell survival and migration required for angiogenesis in contexts of tissue injury and hypoxia.

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