Long term outcome and health related quality of life of elderly patients after meningioma surgery.

Long term outcome and health related quality of life of elderly patients after meningioma surgery.

World Neurosurg. 2019 Feb 05;:

Authors: Timmer M, Seibl-Leven M, Wittenstein K, Grau S, Stavrinou P, Röhn G, Krischek B, Goldbrunner R

Abstract
OBJECTIVE: The incidence of meningiomas is increasing with age. As the median age for the diagnosis is 65 years, general health condition, co-morbidity and procedural risks are influencing the postoperative functional outcome. Aim of our study was to assess the long term impairments of health related quality of life (HRQOL) after meningioma resection in different age groups of elderly patients.
METHODS: We therefore analyzed the HRQOL of 133 patients older than 54 years by time of surgery who underwent surgical meningioma resection between 2004 and 2010. The median age was 67.3 ± 7.4 years. The average time interval between surgery and interview was 3.8 ±2.5 years. Six different age groups, each compromising 5 years of age, were established. Patients were interviewed with the SF36 questionnaire and compared to general population values. For statistical analysis Kruskal-Wallis with subsequent Mann-Whitney U test were used.
RESULTS: We found significant lower levels of physical function, vitality, social role function, mental health, general health perception and significant higher levels of pain when comparing the older groups (especially from 75-79 years) with younger patients from 55-59 years of age. The physical component summary showed a steadily and stepwise decline from younger patients to older ones. However, most significant differences in HRQOL were age unrelated but correlated with co-morbidity.
CONCLUSION: Our findings suggest that both, the KPS- and ASA-scores have a strong impact on long term QoL especially in higher ages after meningioma resection. These data should be a substantial part of the presurgical decision making process.

PMID: 30735873 [PubMed - as supplied by publisher]

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